Q9QUK0

PR
Gene name
Cdkl2
Protein name
Cyclin-dependent kinase-like 2
Names
Serine/threonine-protein kinase KKIAMRE
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:53886
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

301-486 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

143-166 (Activation loop from InterPro)

Target domain

4-289 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9QUK0

Entry ID Method Resolution Chain Position Source
AF-Q9QUK0-F1 Predicted AlphaFoldDB

28 variants for Q9QUK0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388770914 40 D>Y No EVA
rs3395637726 49 M>L No EVA
rs3388763739 53 K>E No EVA
rs3388763359 65 N>G* No EVA
rs3388756141 68 E>G No EVA
rs3388768158 82 F>I No EVA
rs3395865301 149 R>P No EVA
rs3395865287 150 T>P No EVA
rs3395716558 152 A>E No EVA
rs3413130312 153 A>P No EVA
rs3388770570 194 E>D No EVA
rs3388763368 197 M>L No EVA
rs3388770897 211 L>Q No EVA
rs218506431 329 A>S No EVA
rs250679519 331 G>C No EVA
rs31766084 348 I>V No EVA
rs3395837163 360 K>E No EVA
rs3388768170 366 M>L No EVA
rs3388771096 394 R>K No EVA
rs3388763325 407 P>T No EVA
rs253061447 415 T>A No EVA
rs3388770870 429 M>T No EVA
rs3388763776 433 P>R No EVA
rs3388770044 439 R>SE* No EVA
rs3388751414 442 E>G No EVA
rs3388763724 444 T>P No EVA
rs3388773154 478 L>F No EVA
rs3388763783 526 S>P No EVA

No associated diseases with Q9QUK0

3 regional properties for Q9QUK0

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 289 IPR000719
active_site Serine/threonine-protein kinase, active site 122 - 134 IPR008271
binding_site Protein kinase, ATP binding site 10 - 34 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q00532 CDKL1 Cyclin-dependent kinase-like 1 Homo sapiens (Human) PR
Q5MAI5 CDKL4 Cyclin-dependent kinase-like 4 Homo sapiens (Human) PR
Q92772 CDKL2 Cyclin-dependent kinase-like 2 Homo sapiens (Human) PR
Q3UMM4 Cdk10 Cyclin-dependent kinase 10 Mus musculus (Mouse) PR
O35495 Cdk14 Cyclin-dependent kinase 14 Mus musculus (Mouse) PR
Q8K0D0 Cdk17 Cyclin-dependent kinase 17 Mus musculus (Mouse) PR
Q8R3L8 Cdk8 Cyclin-dependent kinase 8 Mus musculus (Mouse) PR
Q8BWD8 Cdk19 Cyclin-dependent kinase 19 Mus musculus (Mouse) PR
Q99J95 Cdk9 Cyclin-dependent kinase 9 Mus musculus (Mouse) PR
Q3TZA2 Cdkl4 Cyclin-dependent kinase-like 4 Mus musculus (Mouse) PR
Q8CEQ0 Cdkl1 Cyclin-dependent kinase-like 1 Mus musculus (Mouse) PR
Q8BLF2 Cdkl3 Cyclin-dependent kinase-like 3 Mus musculus (Mouse) PR
Q9JHU3 Cdk20 Cyclin-dependent kinase 20 Mus musculus (Mouse) PR
Q9JM01 Cdkl3 Cyclin-dependent kinase-like 3 Rattus norvegicus (Rat) PR
Q66HE7 Cdkl1 Cyclin-dependent kinase-like 1 Rattus norvegicus (Rat) PR
Q5XIT0 Cdkl2 Cyclin-dependent kinase-like 2 Rattus norvegicus (Rat) PR
Q6AXJ9 cdkl1 Cyclin-dependent kinase-like 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH
70 80 90 100 110 120
ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LKLFPNGLDY QVVQKYLFQI INGIGFCHSH
130 140 150 160 170 180
NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG
190 200 210 220 230 240
KAVDIWAIGC LVIEMLMGQP LFPGESDIDQ LHHIMTCLGN LIPRHQELFY KNPVFAGVRL
250 260 270 280 290 300
PEVKDAEAEP LESRYPKLPE AVISLAKKCL HIDPDKRPFC ADLLRHDFFQ MDGFAERFSQ
310 320 330 340 350 360
ELQLKIEKDA RNNSLPKKSQ NRKKEKDDAL GEERKTLVVQ DTNADPKIKD SKVFKVKGSK
370 380 390 400 410 420
IDVEKMEKGS RASNANCLHD NGTNHKGLAS TSLRDCSNVN IDHSRNPGTA IPPLTHNLSA
430 440 450 460 470 480
VAPGINAGMG TIPGVQNYRV DEKTKKYCNP FVKPNQPPPA GIYNMNVSTS VSGEKYLLQA
490 500 510 520 530 540
NKKRKEYPKA DVRLPELNYN HLPELRALEG IARNSRLIKK ENKCLSESRI PSLAAIDLHV
550 560
SSVASHQGAG SPLSDDSEAD LPRMEHQH