Q9QUK0
Gene name |
Cdkl2 |
Protein name |
Cyclin-dependent kinase-like 2 |
Names |
Serine/threonine-protein kinase KKIAMRE |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:53886 |
EC number |
2.7.11.22: Protein-serine/threonine kinases |
Protein Class |
|

Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
143-166 (Activation loop from InterPro)
Target domain |
4-289 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure

Activated structure

1 structures for Q9QUK0
Entry ID | Method | Resolution | Chain | Position | Source |
---|---|---|---|---|---|
AF-Q9QUK0-F1 | Predicted | AlphaFoldDB |
28 variants for Q9QUK0
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
rs3388770914 | 40 | D>Y | No | EVA | |
rs3395637726 | 49 | M>L | No | EVA | |
rs3388763739 | 53 | K>E | No | EVA | |
rs3388763359 | 65 | N>G* | No | EVA | |
rs3388756141 | 68 | E>G | No | EVA | |
rs3388768158 | 82 | F>I | No | EVA | |
rs3395865301 | 149 | R>P | No | EVA | |
rs3395865287 | 150 | T>P | No | EVA | |
rs3395716558 | 152 | A>E | No | EVA | |
rs3413130312 | 153 | A>P | No | EVA | |
rs3388770570 | 194 | E>D | No | EVA | |
rs3388763368 | 197 | M>L | No | EVA | |
rs3388770897 | 211 | L>Q | No | EVA | |
rs218506431 | 329 | A>S | No | EVA | |
rs250679519 | 331 | G>C | No | EVA | |
rs31766084 | 348 | I>V | No | EVA | |
rs3395837163 | 360 | K>E | No | EVA | |
rs3388768170 | 366 | M>L | No | EVA | |
rs3388771096 | 394 | R>K | No | EVA | |
rs3388763325 | 407 | P>T | No | EVA | |
rs253061447 | 415 | T>A | No | EVA | |
rs3388770870 | 429 | M>T | No | EVA | |
rs3388763776 | 433 | P>R | No | EVA | |
rs3388770044 | 439 | R>SE* | No | EVA | |
rs3388751414 | 442 | E>G | No | EVA | |
rs3388763724 | 444 | T>P | No | EVA | |
rs3388773154 | 478 | L>F | No | EVA | |
rs3388763783 | 526 | S>P | No | EVA |
No associated diseases with Q9QUK0
Functions
Description | ||
---|---|---|
EC Number | 2.7.11.22 | Protein-serine/threonine kinases |
Subcellular Localization |
|
|
PANTHER Family | ||
PANTHER Subfamily | ||
PANTHER Protein Class | ||
PANTHER Pathway Category | No pathway information available |
4 GO annotations of cellular component
Name | Definition |
---|---|
centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
Name | Definition |
---|---|
ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
1 GO annotations of biological process
Name | Definition |
---|---|
protein phosphorylation | The process of introducing a phosphate group on to a protein. |
17 homologous proteins in AiPD
UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
---|---|---|---|---|
Q00532 | CDKL1 | Cyclin-dependent kinase-like 1 | Homo sapiens (Human) | PR |
Q5MAI5 | CDKL4 | Cyclin-dependent kinase-like 4 | Homo sapiens (Human) | PR |
Q92772 | CDKL2 | Cyclin-dependent kinase-like 2 | Homo sapiens (Human) | PR |
Q3UMM4 | Cdk10 | Cyclin-dependent kinase 10 | Mus musculus (Mouse) | PR |
O35495 | Cdk14 | Cyclin-dependent kinase 14 | Mus musculus (Mouse) | PR |
Q8K0D0 | Cdk17 | Cyclin-dependent kinase 17 | Mus musculus (Mouse) | PR |
Q8R3L8 | Cdk8 | Cyclin-dependent kinase 8 | Mus musculus (Mouse) | PR |
Q8BWD8 | Cdk19 | Cyclin-dependent kinase 19 | Mus musculus (Mouse) | PR |
Q99J95 | Cdk9 | Cyclin-dependent kinase 9 | Mus musculus (Mouse) | PR |
Q3TZA2 | Cdkl4 | Cyclin-dependent kinase-like 4 | Mus musculus (Mouse) | PR |
Q8CEQ0 | Cdkl1 | Cyclin-dependent kinase-like 1 | Mus musculus (Mouse) | PR |
Q8BLF2 | Cdkl3 | Cyclin-dependent kinase-like 3 | Mus musculus (Mouse) | PR |
Q9JHU3 | Cdk20 | Cyclin-dependent kinase 20 | Mus musculus (Mouse) | PR |
Q9JM01 | Cdkl3 | Cyclin-dependent kinase-like 3 | Rattus norvegicus (Rat) | PR |
Q66HE7 | Cdkl1 | Cyclin-dependent kinase-like 1 | Rattus norvegicus (Rat) | PR |
Q5XIT0 | Cdkl2 | Cyclin-dependent kinase-like 2 | Rattus norvegicus (Rat) | PR |
Q6AXJ9 | cdkl1 | Cyclin-dependent kinase-like 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
10 | 20 | 30 | 40 | 50 | 60 |
MEKYENLGLV | GEGSYGMVMK | CRNKDSGRIV | AIKKFLESDD | DKMVKKIAMR | EIKLLKQLRH |
70 | 80 | 90 | 100 | 110 | 120 |
ENLVNLLEVC | KKKKRWYLVF | EFVDHTILDD | LKLFPNGLDY | QVVQKYLFQI | INGIGFCHSH |
130 | 140 | 150 | 160 | 170 | 180 |
NIIHRDIKPE | NILVSQSGVV | KLCDFGFART | LAAPGEVYTD | YVATRWYRAP | ELLVGDVKYG |
190 | 200 | 210 | 220 | 230 | 240 |
KAVDIWAIGC | LVIEMLMGQP | LFPGESDIDQ | LHHIMTCLGN | LIPRHQELFY | KNPVFAGVRL |
250 | 260 | 270 | 280 | 290 | 300 |
PEVKDAEAEP | LESRYPKLPE | AVISLAKKCL | HIDPDKRPFC | ADLLRHDFFQ | MDGFAERFSQ |
310 | 320 | 330 | 340 | 350 | 360 |
ELQLKIEKDA | RNNSLPKKSQ | NRKKEKDDAL | GEERKTLVVQ | DTNADPKIKD | SKVFKVKGSK |
370 | 380 | 390 | 400 | 410 | 420 |
IDVEKMEKGS | RASNANCLHD | NGTNHKGLAS | TSLRDCSNVN | IDHSRNPGTA | IPPLTHNLSA |
430 | 440 | 450 | 460 | 470 | 480 |
VAPGINAGMG | TIPGVQNYRV | DEKTKKYCNP | FVKPNQPPPA | GIYNMNVSTS | VSGEKYLLQA |
490 | 500 | 510 | 520 | 530 | 540 |
NKKRKEYPKA | DVRLPELNYN | HLPELRALEG | IARNSRLIKK | ENKCLSESRI | PSLAAIDLHV |
550 | 560 | ||||
SSVASHQGAG | SPLSDDSEAD | LPRMEHQH |