AiPD: Autoinhibited Protein Database

Q9P2E2

Gene name	KIF17 (KIAA1405, KIF3X)
Protein name	Kinesin-like protein KIF17
Names	VEGFR-2, Fetal liver kinase 1, FLK-1, Kinase insert domain receptor, KDR, Protein-tyrosine kinase receptor flk-1, KIF3-related motor protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:57576
EC number
Protein Class	CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED (PTHR47969)

Descriptions

KIF17 is dendrite-specific motor protein which, in association with the Apba1-containing complex (LIN-10-LIN-2-LIN-7 complex), transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules.
Two molecular mechanisms contribute to autoinhibition of KIF17. First, the C-terminal tail interferes with microtubule binding. Second, a CC2 segment blocks processive motility.The CC2 and tail segments inhibit KIF17 motility via direct interactions with the motor domain.

Autoinhibitory domains (AIDs)

Target domain	3-343 (Kinesin motor domain)
Relief mechanism
Assay	Mutagenesis experiment, Deletion assay, Split protein assay

AID

764-772 (CC2 segment)

Target domain

3-343 (Kinesin motor domain)

Relief mechanism

Assay

Mutagenesis experiment, Deletion assay, Split protein assay

Target domain	3-343 (Kinesin motor domain)
Relief mechanism	Partner binding
Assay	Deletion assay

AID

847-1029 (C-terminal tail)

Target domain

3-343 (Kinesin motor domain)

Relief mechanism

Partner binding (Cargo protein binding to the C-terminal tail)

Assay

Deletion assay

Accessory elements

No accessory elements

References

Hammond JW et al. (2010) "Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms", The Journal of cell biology, 189, 1013-25

Autoinhibited structure

Activated structure

1 structures for Q9P2E2

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9P2E2-F1	Predicted				AlphaFoldDB

954 variants for Q9P2E2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA662497 rs780706160	2	A>P		No	ClinGen ExAC gnomAD
rs780706160 CA338839883	2	A>S		No	ClinGen ExAC gnomAD
rs1004763870 CA18987430	2	A>V		No	ClinGen TOPMed
rs1219845071 CA338839852	3	S>F		No	ClinGen TOPMed
CA662494 rs778812661	4	E>K		No	ClinGen ExAC gnomAD
CA662493 rs757530650	5	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1215142599 CA338839795	6	V>A		No	ClinGen gnomAD
CA338839769 rs1553153537	7	K>N		No	ClinGen Ensembl
CA662491 rs532543247	8	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1570493902 CA338839766	8	V>I		No	ClinGen Ensembl
CA338839750 rs1406373329	9	V>A		No	ClinGen gnomAD
CA338839751 rs1406373329	9	V>D		No	ClinGen gnomAD
CA662490 rs755892107	9	V>I		No	ClinGen ExAC gnomAD
CA338839734 rs1465882937	10	V>L		No	ClinGen gnomAD
rs754531858 CA662487	11	R>H		No	ClinGen ExAC gnomAD
CA338839723 rs1553153532	11	R>S		No	ClinGen Ensembl
rs765763185 CA662485	13	R>C		No	ClinGen ExAC gnomAD
rs765763185 CA662486	13	R>G		No	ClinGen ExAC gnomAD
rs762667120 CA662484	13	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1402270155 CA338839641	15	M>T		No	ClinGen TOPMed
CA662482 rs572876276	18	R>P		No	ClinGen 1000Genomes ExAC gnomAD
CA338839586 rs1446601141	18	R>W		No	ClinGen gnomAD
rs1482142319 CA338839555	20	R>*		No	ClinGen gnomAD
rs1171298954 CA338839552	20	R>P		No	ClinGen TOPMed
CA18987355 rs1055605715	23	R>C		No	ClinGen TOPMed gnomAD
CA662481 rs776191053	23	R>H		No	ClinGen ExAC gnomAD
CA662480 rs776191053	23	R>L		No	ClinGen ExAC gnomAD
CA338839474 rs1247534798	25	Q>R		No	ClinGen gnomAD
CA338839463 rs772732709	26	P>L		No	ClinGen ExAC gnomAD
CA662479 rs772732709	26	P>R		No	ClinGen ExAC gnomAD
rs1393974990 CA338839456	27	V>A		No	ClinGen gnomAD
rs746325098 CA662478	29	T>A		No	ClinGen ExAC gnomAD
rs1300330264 CA338839431	30	V>L		No	ClinGen TOPMed gnomAD
rs774494609 CA662477	31	D>Y		No	ClinGen ExAC
CA338839409 rs1430894315	32	C>G		No	ClinGen gnomAD
CA662476 rs770860704	34	R>C		No	ClinGen ExAC gnomAD
CA338839383 rs1166754399	34	R>H		No	ClinGen gnomAD
rs1369181089 CA338839374	35	A>D		No	ClinGen gnomAD
rs1426654302 CA338839376	35	A>S		No	ClinGen TOPMed gnomAD
rs1426654302 CA338839379	35	A>T		No	ClinGen TOPMed gnomAD
CA662474 rs777852742	36	Q>K		No	ClinGen ExAC gnomAD
rs1422351187 CA338839364	36	Q>P		No	ClinGen gnomAD
rs1482647850 CA338839336	38	C>F		No	ClinGen gnomAD
CA338839343 rs1182640737	38	C>R		No	ClinGen gnomAD
rs1182640737 CA338839341	38	C>S		No	ClinGen gnomAD
rs1272428360 CA338839320	40	Q>E		No	ClinGen TOPMed gnomAD
CA338839314 rs1224008918	40	Q>R		No	ClinGen TOPMed gnomAD
COSM1338594 CA662472 rs747916325	42	P>L	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1242146201 CA338839276	43	G>A		No	ClinGen gnomAD
rs146128405 CA662470	44	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA662466 rs750134074	46	D>A		No	ClinGen ExAC TOPMed gnomAD
rs915491135 CA338839250	46	D>H		No	ClinGen TOPMed gnomAD
rs915491135 CA18987249	46	D>N		No	ClinGen TOPMed gnomAD
rs764963538 CA338838707	47	E>K		No	ClinGen ExAC TOPMed gnomAD
rs764963538 CA662465	47	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA338838648 rs1391544356	48	P>L		No	ClinGen TOPMed gnomAD
CA338838651 rs1391544356	48	P>R		No	ClinGen TOPMed gnomAD
CA338838639 rs1397978042	49	P>R		No	ClinGen TOPMed
CA662463 rs149468609	50	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA338838625 rs1159571483	50	K>R		No	ClinGen gnomAD
CA338838598 rs1369184277	51	Q>E		No	ClinGen TOPMed
rs1472154347 CA338838591	51	Q>R		No	ClinGen gnomAD
rs1249408167 CA338838532	52	F>L		No	ClinGen gnomAD
rs767926945 CA662462	53	T>A		No	ClinGen ExAC gnomAD
rs979546888 CA18987206	53	T>I		No	ClinGen TOPMed gnomAD
rs1443052196 CA338838516	54	F>I		No	ClinGen TOPMed
CA338838492 rs1570493434	54	F>L		No	ClinGen Ensembl
rs369480851 CA338838475	55	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs369480851 CA18987201	55	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs749295230 CA662458	57	A>S		No	ClinGen ExAC gnomAD
CA338838390 rs1328875785	60	V>G		No	ClinGen gnomAD
CA338838399 rs1227456930	60	V>M		No	ClinGen gnomAD
rs770025824 CA662456	61	D>H		No	ClinGen ExAC gnomAD
rs780967251 CA662454	62	H>R		No	ClinGen ExAC TOPMed gnomAD
CA662455 rs748329683	62	H>Y		No	ClinGen ExAC gnomAD
rs1385187567 CA338838319	64	T>A		No	ClinGen gnomAD
rs147438943 CA662453	65	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA18987091 rs142917123	67	I>M		No	ClinGen ESP
CA662450 rs779848495	67	I>T		No	ClinGen ExAC TOPMed gnomAD
CA338838261 rs1478277348	68	Y>H		No	ClinGen TOPMed gnomAD
CA338838255 rs1355347449	68	Y>S		No	ClinGen TOPMed
rs757978308 CA662449	69	N>S		No	ClinGen ExAC gnomAD
CA662448 rs749926705	70	E>D		No	ClinGen ExAC gnomAD
rs778529576 CA662447	72	A>T		No	ClinGen ExAC gnomAD
rs1248154006 CA338838189	72	A>V		No	ClinGen TOPMed gnomAD
CA662445 rs554062697	74	P>L		No	ClinGen ExAC gnomAD
CA662446 rs756978243	74	P>S		No	ClinGen ExAC TOPMed gnomAD
rs756978243 CA338838167	74	P>T		No	ClinGen ExAC TOPMed gnomAD
CA662444 rs768053338	77	E>D		No	ClinGen ExAC gnomAD
rs765354547 CA662419	78	G>D		No	ClinGen ExAC gnomAD
COSM328041 rs748366715 CA662417	79	V>I	pancreas large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs944238547 CA18985761	80	T>A		No	ClinGen TOPMed
rs768786059 CA662416	80	T>S		No	ClinGen ExAC gnomAD
rs865804340 CA18985754	82	G>D		No	ClinGen Ensembl
rs143703360 CA18985749	83	Y>H		No	ClinGen ESP TOPMed gnomAD
CA338837958 rs1385441279	84	N>D		No	ClinGen TOPMed
CA18985738 rs1013323046	84	N>S		No	ClinGen TOPMed
rs12046928 CA662411	90	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA338837886 rs1407962161	90	Y>C		No	ClinGen gnomAD
rs770606552 CA338837868	91	G>R		No	ClinGen ExAC gnomAD
CA662409 rs770606552	91	G>S		No	ClinGen ExAC gnomAD
rs748782808 CA662408	92	Q>H		No	ClinGen ExAC gnomAD
rs1196391038 CA338837793	94	G>V		No	ClinGen TOPMed
CA338837756 rs1163164589	95	S>I		No	ClinGen TOPMed gnomAD
CA338837747 rs1570490449	96	G>E		No	ClinGen Ensembl
rs991182633 CA18985688	96	G>R		No	ClinGen gnomAD
rs755751918 CA662406	97	K>Q		No	ClinGen ExAC gnomAD
rs1253040464 CA338837697	98	S>Y		No	ClinGen gnomAD
CA338837665 rs1570490427	100	T>P		No	ClinGen Ensembl
CA338837645 rs1180451049	101	M>V		No	ClinGen gnomAD
rs139355427 CA338837549	105	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs139355427 CA662404	105	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs758746393 CA662402	107	P>L		No	ClinGen ExAC TOPMed gnomAD
CA18985642 rs1003177478	108	P>L		No	ClinGen Ensembl
CA338837408 rs1288016031	110	Q>L		No	ClinGen gnomAD
COSM3360618 CA662399 rs35835983	111	R>G	kidney [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA338837336 rs1287560260	112	G>D		No	ClinGen TOPMed gnomAD
CA338837331 rs1287560260	112	G>V		No	ClinGen TOPMed gnomAD
rs1293535419 CA338837257	115	P>S		No	ClinGen gnomAD
rs138931507 CA662397	116	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs760824096 CA662396	117	A>D		No	ClinGen ExAC gnomAD
rs79832278 CA338836685	118	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs79832278 CA662394	118	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338836675 COSM3418702 rs376781948	119	E>K	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
CA662393 rs376781948	119	E>Q		No	ClinGen ESP ExAC gnomAD
CA662392 rs574280002	120	H>L		No	ClinGen 1000Genomes ExAC gnomAD
CA18985608 rs138024708	121	V>L		No	ClinGen ESP ExAC gnomAD
CA662390 rs138024708	121	V>M		No	ClinGen ESP ExAC gnomAD
rs539132183 CA18985605	123	E>K		No	ClinGen TOPMed gnomAD
CA18985597 rs146714930	125	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1320507 CA662387 rs146714930	125	V>I	ovary [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA18985598 rs146714930	125	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA338836167 rs1381787904	127	C>Y		No	ClinGen gnomAD
rs781378925 CA662360	131	T>A		No	ClinGen ExAC gnomAD
CA338836136 rs1237749465	132	K>E		No	ClinGen TOPMed
rs751773843 CA662358	135	V>I		No	ClinGen ExAC gnomAD
rs750363854 CA662356	136	R>P		No	ClinGen ExAC TOPMed gnomAD
rs750363854 CA662355	136	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA662357 rs766334139	136	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1002067440 CA18983859	139	Y>H		No	ClinGen gnomAD
CA662354 rs536519322	140	L>M		No	ClinGen ExAC TOPMed gnomAD
rs761604974 CA662353	142	I>M		No	ClinGen ExAC gnomAD
CA662351 rs768097968	143	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA662352 rs776211913	143	Y>C		No	ClinGen ExAC gnomAD
rs760379606 CA662350	144	N>S		No	ClinGen ExAC gnomAD
CA662349 rs775119585	146	D>E		No	ClinGen ExAC gnomAD
CA662348 rs200770891	147	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs114164909 CA338836038	148	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs371219583 CA662346	148	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs371219583 CA662345	148	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs114164909 CA662347	148	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1411048825 CA338836028	150	L>I		No	ClinGen gnomAD
CA662344 rs376897579	155	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs781431910 CA662343	157	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs1163754002 CA338835764	157	Q>R		No	ClinGen gnomAD
CA338834766 rs1174242812	161	L>V		No	ClinGen gnomAD
CA338834739 rs1337253002	163	E>Q		No	ClinGen TOPMed
rs1376516475 CA338834714	165	P>S		No	ClinGen gnomAD
rs752238928 CA662314	166	E>G		No	ClinGen ExAC gnomAD
CA662315 rs539396446	166	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs547253363 CA662312	169	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs547253363 CA662311	169	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338834613 rs1282683938	170	Y>F		No	ClinGen gnomAD
rs370161843 CA338834587	171	V>A		No	ClinGen ESP ExAC gnomAD
rs370161843 CA662306	171	V>E		No	ClinGen ESP ExAC gnomAD
rs149625740 CA662308	171	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149625740 CA662307	171	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1232225620 CA338834556	173	G>E		No	ClinGen gnomAD
rs143810502 CA662304	176	M>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA662302 rs778972017	176	M>T		No	ClinGen ExAC gnomAD
rs143810502 CA662303	176	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA338834491 rs1324453257	177	H>N		No	ClinGen gnomAD
CA18981076 rs958533619	177	H>Q		No	ClinGen gnomAD
CA338834468 COSM1338591 rs1414901196	178	T>M	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA662299 rs777507035	181	S>R		No	ClinGen ExAC gnomAD
rs377444908 CA662297	182	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA338834390 rs1474258144	183	A>T		No	ClinGen TOPMed gnomAD
CA338834320 rs1240669341	185	C>R		No	ClinGen gnomAD
CA338834296 rs1190059844	186	E>*		No	ClinGen gnomAD
CA662296 rs200398452	186	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557604743 CA338834283	187	H>R		No	ClinGen Ensembl
rs771781577 CA18981001	189	M>R		No	ClinGen Ensembl
CA18981007 rs970813515	189	M>V		No	ClinGen TOPMed gnomAD
CA338834193 rs1257461920	190	E>D		No	ClinGen gnomAD
CA338834188 rs1384691104	191	T>A		No	ClinGen TOPMed
rs79606717 CA662294	194	K>E		No	ClinGen Ensembl
rs754438385 CA662293	196	R>C		No	ClinGen ExAC TOPMed gnomAD
rs144250827 CA662292	196	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA662290 rs762645455	197	S>L		No	ClinGen ExAC TOPMed gnomAD
CA662291 rs762645455	197	S>W		No	ClinGen ExAC TOPMed gnomAD
CA662288 rs369376665	199	G>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA338833993 rs1354632834	199	G>D		No	ClinGen gnomAD
CA662287 rs369376665	199	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA338833950 rs1168143846	201	T>A		No	ClinGen TOPMed
CA662286 rs775858871	201	T>M		No	ClinGen ExAC TOPMed gnomAD
CA662285 rs772235015	203	M>L		No	ClinGen ExAC gnomAD
COSM1212383 rs1407793115 CA338833722	210	S>L	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA338833653 rs1165316751	212	S>C		No	ClinGen gnomAD
rs1570479590 CA338833644	213	I>F		No	ClinGen Ensembl
rs762611471 CA18980906	213	I>T		No	ClinGen TOPMed gnomAD
rs200568311 CA662281	216	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777560283 CA662280	218	I>F		No	ClinGen ExAC gnomAD
CA662279 rs748147904	218	I>M		No	ClinGen ExAC TOPMed gnomAD
rs780956478 CA662277	219	E>K		No	ClinGen ExAC TOPMed gnomAD
CA338833524 rs1292262756	220	M>K		No	ClinGen gnomAD
rs751053357 CA662275	223	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1449795682 CA338833416	224	D>Y		No	ClinGen gnomAD
CA338873313 rs1570474092	225	E>K		No	ClinGen Ensembl
rs201696480 CA662237	226	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA662238 rs762937507 COSM678771	226	R>W	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs771757364 CA662235	227	G>D		No	ClinGen ExAC gnomAD
CA662236 rs775538844	227	G>R		No	ClinGen ExAC gnomAD
CA662234 rs745395112	229	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1570474055 CA338873282	230	H>P		No	ClinGen Ensembl
rs778529699 CA662233	231	L>F		No	ClinGen ExAC gnomAD
CA19013243 rs927719157	231	L>H		No	ClinGen Ensembl
CA662231 rs557415265	232	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA662232 COSM1212382 rs756868351	232	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA662230 rs781470496	233	A>V		No	ClinGen ExAC TOPMed gnomAD
rs766846267 CA662227	235	K>R		No	ClinGen ExAC gnomAD
CA338873240 rs1434163456	237	N>K		No	ClinGen gnomAD
rs758850766 CA662226	242	A>V		No	ClinGen ExAC TOPMed gnomAD
CA19013196 rs140286098	244	S>N		No	ClinGen ESP TOPMed gnomAD
CA19013188 rs964409495	246	R>Q		No	ClinGen TOPMed gnomAD
CA662224 rs765233832	246	R>W		No	ClinGen ExAC gnomAD
rs1484166382 CA338873173	248	S>F		No	ClinGen gnomAD
rs776643012 CA662219	251	G>R		No	ClinGen ExAC TOPMed gnomAD
rs776643012 CA662220	251	G>R		No	ClinGen ExAC TOPMed gnomAD
rs772168049 CA662218	253	T>A		No	ClinGen ExAC gnomAD
rs745736271 CA662217	253	T>M		No	ClinGen ExAC TOPMed gnomAD
CA19013131 rs372872118	255	E>K		No	ClinGen ESP TOPMed gnomAD
CA662213 rs777448525	256	R>Q		No	ClinGen ExAC gnomAD
CA662214 rs534767695	256	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA662212 rs768947896	257	L>I		No	ClinGen ExAC gnomAD
rs1399009603 CA338873118	258	K>N		No	ClinGen TOPMed
rs780352465 CA662210	258	K>R		No	ClinGen ExAC gnomAD
CA338873104 rs1372741853	260	A>G		No	ClinGen gnomAD
rs1462629326 CA338873106	260	A>T		No	ClinGen gnomAD
CA338873103 rs1372741853	260	A>V		No	ClinGen gnomAD
CA338873095 rs1168664491	262	K>E		No	ClinGen gnomAD
rs750870052 CA662208	262	K>N		No	ClinGen ExAC gnomAD
CA662209 rs116683388	262	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA662207 rs200488493	263	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA662206 rs757329825	266	S>L		No	ClinGen ExAC TOPMed gnomAD
CA19013080 rs770330549	267	L>F		No	ClinGen Ensembl
rs567226732 CA662204	268	S>L		No	ClinGen 1000Genomes ExAC gnomAD
CA338873056 rs1478383271	269	A>T		No	ClinGen TOPMed
CA338873053 rs1438881063	269	A>V		No	ClinGen TOPMed gnomAD
rs1214369075 CA338873047	270	L>P		No	ClinGen TOPMed
rs1256373121 CA338873035	272	N>S		No	ClinGen Ensembl
rs759607594 CA662200	274	I>T		No	ClinGen ExAC gnomAD
rs201078177 CA662198	275	S>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA662199 rs201078177	275	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs762499616 CA662197	276	A>V		No	ClinGen ExAC gnomAD
rs760901035 CA19013046	279	D>N		No	ClinGen Ensembl
CA662195 rs769513525	279	D>V		No	ClinGen ExAC gnomAD
CA662192 rs772411168	280	G>E		No	ClinGen ExAC gnomAD
CA662193 rs780409575	280	G>R		No	ClinGen ExAC TOPMed gnomAD
rs746439314 CA662191	281	R>C		No	ClinGen ExAC TOPMed gnomAD
CA662190 rs779454886	281	R>H		No	ClinGen ExAC TOPMed gnomAD
rs757658677 CA662189	284	H>P		No	ClinGen ExAC gnomAD
COSM1501170 CA19013026 rs755947089	284	H>Y	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1005064749 CA19013018	285	V>A		No	ClinGen Ensembl
rs777648602 CA19013021	285	V>F		No	ClinGen ExAC TOPMed gnomAD
rs777648602 COSM146437 CA662187	285	V>I	stomach [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA662184 rs767489017	288	R>C		No	ClinGen ExAC TOPMed
CA662183 rs199932440	288	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs766360804 CA662181	290	S>L		No	ClinGen ExAC gnomAD
rs762755460 CA662180	293	T>A		No	ClinGen ExAC gnomAD
CA662179 rs772780186 COSM1741236	293	T>M	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs776259696 CA662176	294	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs140621013 CA662177	294	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557601957 CA338872869	301	G>C		No	ClinGen Ensembl
CA19012888 rs989132100	301	G>D		No	ClinGen Ensembl
rs142534674 CA662171	302	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA338872859 rs1159074768	303	N>D		No	ClinGen gnomAD
rs144287595 CA338872848	304	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144287595 CA662170	304	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA662168 rs756260623	305	K>E		No	ClinGen ExAC TOPMed gnomAD
CA338872842 rs748423151	305	K>N		No	ClinGen ExAC gnomAD
CA338872846 rs756260623	305	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs1454417381 CA338872844	305	K>R		No	ClinGen TOPMed gnomAD
COSM3376955 CA662166 rs370700388	306	T>M	pancreas [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs766018489 CA662163	309	V>L		No	ClinGen ExAC
rs750314557 CA662161	310	A>T		No	ClinGen ExAC gnomAD
rs761281123 CA662159	311	C>F		No	ClinGen ExAC TOPMed gnomAD
CA338872803 rs1019450527	312	L>M		No	ClinGen TOPMed gnomAD
rs1019450527 CA19012750	312	L>V		No	ClinGen TOPMed gnomAD
CA662157 rs144903116	313	S>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM903383 rs144903116 CA662158	313	S>L	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA662156 rs528572676	315	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs749874856 CA662153	316	D>N		No	ClinGen ExAC gnomAD
rs773566005 CA662152	317	N>H		No	ClinGen ExAC gnomAD
CA338872766 rs1381513869	318	N>S		No	ClinGen gnomAD
rs1239398735 CA338872758	319	Y>C		No	ClinGen TOPMed
rs139202591 CA662148	320	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs139202591 CA662149	320	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA662147 rs755253390	322	T>I		No	ClinGen ExAC gnomAD
CA338872728 rs1203964412	324	S>G		No	ClinGen Ensembl
CA662145 rs779956063	325	T>A		No	ClinGen ExAC gnomAD
rs758122496 CA662144	325	T>M		No	ClinGen ExAC TOPMed gnomAD
rs201625621 CA662141	327	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338872711 COSM1338586 rs1260237300	327	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA662142 rs201625621	327	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338872702 rs116806262	328	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs760437431 CA662138	330	N>I		No	ClinGen ExAC gnomAD
rs760437431 CA662139	330	N>S		No	ClinGen ExAC gnomAD
CA662136 rs202087220	331	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
COSM2151840 rs139912475 CA662137	331	R>W	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA662135 rs368424833	332	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1270514571 CA338872680	333	K>Q		No	ClinGen gnomAD
CA338872668 rs1366650655	334	N>S		No	ClinGen TOPMed
CA662132 rs762341534	336	R>S		No	ClinGen ExAC gnomAD
rs776860804 CA338872645	337	N>K		No	ClinGen ExAC gnomAD
CA662131 rs776860804	337	N>K		No	ClinGen ExAC gnomAD
rs368021087 CA662130	339	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA662128 COSM1166358 rs780108776	340	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs149337781 CA662127	340	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA338872627 rs2296225	341	I>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs778612010 CA662125	341	I>N		No	ClinGen ExAC TOPMed gnomAD
VAR_055983 CA662126 rs2296225	341	I>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs757201811 CA662124	342	N>H		No	ClinGen ExAC TOPMed gnomAD
CA662123 rs147080288	342	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1220009686 CA338872597	345	P>L		No	ClinGen TOPMed
rs1475830383 CA338872590	346	K>R		No	ClinGen TOPMed gnomAD
CA338872585 rs1256816711	347	D>H		No	ClinGen gnomAD
CA338872574 rs150946378	348	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs150946378 CA662121	348	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA338872568 COSM903382 rs1195511154	350	L>F	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs767101609 CA662119	351	R>C		No	ClinGen ExAC gnomAD
CA19012486 rs374159508	351	R>H		No	ClinGen ESP TOPMed gnomAD
CA662117 rs141566878	352	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA662116 rs765637388	355	E>G		No	ClinGen ExAC gnomAD
rs762464381 CA662115	356	E>D		No	ClinGen ExAC gnomAD
rs868344609 CA19012480	356	E>K		No	ClinGen Ensembl
CA662114 rs777271601	357	I>V		No	ClinGen ExAC
CA338872514 rs1290017757	358	K>*		No	ClinGen TOPMed
CA338872493 rs1354654743	361	K>E		No	ClinGen gnomAD
CA662111 rs368449465	363	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1570473126 CA338872476	363	I>T		No	ClinGen Ensembl
rs1480534082 CA338872479	363	I>V		No	ClinGen TOPMed
CA662109 rs772189322	365	T>A		No	ClinGen ExAC gnomAD
CA662108 rs376173045	365	T>I		No	ClinGen ESP ExAC gnomAD
CA662106 rs114221851	366	Q>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA662105 rs749266864	366	Q>L		No	ClinGen ExAC gnomAD
rs1479276190 CA338872449	368	M>L		No	ClinGen gnomAD
CA662104 rs56750936 VAR_061282	369	S>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA662103 rs201716162	370	P>A		No	ClinGen 1000Genomes ExAC
rs752176653 CA662102	371	S>G		No	ClinGen ExAC gnomAD
COSM903381 rs1467421996 CA338872413	373	L>P	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs146004450 CA662100	375	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA338872017 rs1570465963	381	V>G		No	ClinGen Ensembl
rs748057322 CA662083	381	V>L		No	ClinGen ExAC TOPMed gnomAD
CA338871995 rs1427405044	383	P>L		No	ClinGen TOPMed
CA338871988 rs1346325838	384	D>G		No	ClinGen gnomAD
CA338871971 rs1417902463	385	P>L		No	ClinGen gnomAD
CA338871977 rs1159074407	385	P>S		No	ClinGen gnomAD
rs1557598599 CA338871965	386	V>E		No	ClinGen Ensembl
rs1174486481 CA338871931	389	E>Q		No	ClinGen TOPMed gnomAD
rs754503405 CA662080	392	L>M		No	ClinGen ExAC TOPMed gnomAD
CA19006914 rs754503405	392	L>V		No	ClinGen ExAC TOPMed gnomAD
rs926634552 CA19006912	393	L>W		No	ClinGen Ensembl
rs746697901 CA662079	394	P>L		No	ClinGen ExAC gnomAD
CA662078 rs779828987	395	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA19006898 rs1045368209	395	Q>H		No	ClinGen TOPMed gnomAD
CA662077 rs758075169	397	V>M		No	ClinGen ExAC gnomAD
rs754285551 CA662076	399	Q>P		No	ClinGen ExAC gnomAD
CA662075 rs764463105	400	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs522496 CA338871770	402	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA662074 rs522496 VAR_023527	402	V>M		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA19006853 rs76966292	403	E>*		No	ClinGen Ensembl
CA338871738 rs1570465808	404	A>V		No	ClinGen Ensembl
rs199771446 CA662071	405	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA662072 rs199771446	405	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1332615959 CA338871702	407	Q>*		No	ClinGen TOPMed
CA662067 rs373523975 COSM903376	410	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA662068 rs369680598	410	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs758439125 CA662027	412	E>G		No	ClinGen ExAC gnomAD
CA338870905 rs1158360201	413	Y>*		No	ClinGen TOPMed
CA338870924 rs1164110018	413	Y>D		No	ClinGen gnomAD
CA338870887 rs1456340363	414	E>G		No	ClinGen gnomAD
CA338870872 rs1312763468	415	E>*		No	ClinGen gnomAD
rs750658619 CA662026	416	R>C		No	ClinGen ExAC TOPMed gnomAD
CA662025 rs148294907	416	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs148294907 CA18998759	416	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1570456067 CA338870823	417	L>P		No	ClinGen Ensembl
CA338870827 rs1356843958	417	L>V		No	ClinGen TOPMed gnomAD
rs527764404 CA338870792	419	R>L		No	ClinGen 1000Genomes ExAC TOPMed
rs527764404 CA662021	419	R>P		No	ClinGen 1000Genomes ExAC TOPMed
CA662020 rs527764404	419	R>Q		No	ClinGen 1000Genomes ExAC TOPMed
CA662022 rs369702366	419	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs967670614 CA18998720	422	A>T		No	ClinGen TOPMed
rs560262440 CA662017	423	D>E		No	ClinGen 1000Genomes ExAC gnomAD
rs770624460 CA662016	426	A>S		No	ClinGen ExAC gnomAD
CA662015 rs748839142	426	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1353120814 CA338870625	427	E>G		No	ClinGen gnomAD
rs138004364 CA662012	427	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs138004364 CA662013	427	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA338870608 rs1307341539	428	Q>*		No	ClinGen gnomAD
CA662011 rs780513841	429	E>D		No	ClinGen ExAC gnomAD
rs1570455963 CA338870575	430	S>A		No	ClinGen Ensembl
CA662009 rs750546120	431	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA662010 rs201195116	431	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338870524 rs1570455941	433	R>S		No	ClinGen Ensembl
CA18998683 rs965429035	434	L>M		No	ClinGen Ensembl
CA338870474 rs1327263707	436	E>A		No	ClinGen TOPMed
CA18998670 rs759239961	440	A>T		No	ClinGen Ensembl
CA338870419 rs1570455916	440	A>V		No	ClinGen Ensembl
CA662006 rs754109592	441	M>I		No	ClinGen ExAC gnomAD
CA662007 rs757513855	441	M>T		No	ClinGen ExAC TOPMed gnomAD
CA338870415 rs1317971715	441	M>V		No	ClinGen TOPMed
CA662004 rs562792585 COSM1338573	442	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA662005 rs562792585	442	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs140125368 CA662003	442	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA662002 rs767597163	444	S>L		No	ClinGen ExAC gnomAD
CA338870371 rs1396024580	445	Y>H		No	ClinGen gnomAD
CA661998 rs141125042	447	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA661996 rs769055081	451	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1570455853 CA338870266	451	T>P		No	ClinGen Ensembl
rs1283989151 CA338870220	454	E>K		No	ClinGen gnomAD
rs1236686639 CA338870183	455	N>K		No	ClinGen TOPMed gnomAD
rs1202754771 CA338870170	456	L>P		No	ClinGen TOPMed
rs186246358 CA661991 COSM182838	457	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
COSM1338572 rs746302711 CA661992	457	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs112930242 CA338870129	458	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA661989 rs749572531	459	E>G		No	ClinGen ExAC gnomAD
CA18997224 rs936575779	462	A>D		No	ClinGen Ensembl
CA661968 rs553516160	463	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338869369 rs1475574613	464	L>V		No	ClinGen gnomAD
rs1030234102 CA18997218 COSM131050	466	V>L	liver [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA338869345 rs1030234102	466	V>M		No	ClinGen TOPMed gnomAD
rs371293452 CA661967	469	L>F		No	ClinGen ESP ExAC gnomAD
rs1371663412 CA338869304	472	A>P		No	ClinGen TOPMed
CA338869295 rs1197754955	473	E>G		No	ClinGen gnomAD
CA661963 rs781103880	475	M>I		No	ClinGen ExAC TOPMed gnomAD
CA661964 rs756582673	475	M>T		No	ClinGen ExAC TOPMed gnomAD
CA661962 rs754694005	477	R>G		No	ClinGen ExAC gnomAD
CA338869271 rs1281927521	477	R>K		No	ClinGen gnomAD
CA661960 rs200416385	478	A>D		No	ClinGen 1000Genomes ExAC gnomAD
CA661961 rs751561906	478	A>T		No	ClinGen ExAC gnomAD
rs758293573 CA661959	480	F>C		No	ClinGen ExAC TOPMed gnomAD
rs867454014 CA18997198	481	A>V		No	ClinGen Ensembl
CA338869241 rs1163395535	482	S>G		No	ClinGen TOPMed
CA338869238 rs147249030	482	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA661958 rs147249030	482	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA661957 rs764670643	483	S>G		No	ClinGen ExAC TOPMed gnomAD
rs200073708 CA661956	484	A>T		No	ClinGen ExAC gnomAD
rs1406478222 CA338869208	485	E>*		No	ClinGen gnomAD
rs753401086 CA661955	486	Y>*		No	ClinGen ExAC gnomAD
rs1570452775 CA338869193	486	Y>S		No	ClinGen Ensembl
CA661954 rs534971002	487	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338869163 rs1233633573	489	A>T		No	ClinGen gnomAD
CA18997171 rs191996405	490	F>L		No	ClinGen 1000Genomes
CA661951 rs771343541	491	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA338869116 rs1254671886	492	Y>C		No	ClinGen gnomAD
rs773479871 CA661949	493	E>K		No	ClinGen ExAC gnomAD
CA661947 rs200910771	495	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA661948 rs769986016	495	V>M		No	ClinGen ExAC gnomAD
CA338869075 rs1350815390	496	V>M		No	ClinGen gnomAD
CA338869036 rs1210483010	499	K>E		No	ClinGen TOPMed
CA338869027 rs1308071543	499	K>N		No	ClinGen gnomAD
CA338869037 rs1210483010	499	K>Q		No	ClinGen TOPMed
CA338868985 rs1261338046	502	S>F		No	ClinGen TOPMed
rs74956681 CA18997122	502	S>P		No	ClinGen Ensembl
rs768877673 CA661945	503	T>M		No	ClinGen ExAC gnomAD
rs768877673 CA338868974	503	T>R		No	ClinGen ExAC gnomAD
rs746813758 CA661943	506	T>S		No	ClinGen ExAC gnomAD
CA661942 rs115228567	507	L>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA661938 COSM532446 rs756737847	513	S>F	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA338868770 rs1557592625	515	T>I		No	ClinGen Ensembl
CA338868755 rs1158209957	516	Q>*		No	ClinGen gnomAD
CA338868759 rs1158209957	516	Q>K		No	ClinGen gnomAD
CA338868746 rs1437838319	517	V>I		No	ClinGen TOPMed
rs760306635 CA661935	522	A>V		No	ClinGen ExAC TOPMed gnomAD
rs138561064 CA661932	523	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA338868633 rs1284703378	525	P>L		No	ClinGen gnomAD
rs1213927356 CA338868622	526	K>R		No	ClinGen TOPMed gnomAD
rs1213927356 CA338868624	526	K>T		No	ClinGen TOPMed gnomAD
CA661931 rs773829153	527	V>A		No	ClinGen ExAC gnomAD
CA338868605 rs773829153	527	V>G		No	ClinGen ExAC gnomAD
rs761824033 CA661929	528	E>K		No	ClinGen ExAC gnomAD
CA18997071 rs947124230	535	S>F		No	ClinGen TOPMed gnomAD
CA338868462 rs1297692808	538	S>P		No	ClinGen gnomAD
CA338868447 rs1377478877	539	S>N		No	ClinGen gnomAD
rs115071410 CA661925	539	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747197585 CA661926	539	S>R		No	ClinGen ExAC gnomAD
rs986188668 CA18997063	541	S>L		No	ClinGen TOPMed gnomAD
rs1422872853 CA338868397	542	S>C		No	ClinGen gnomAD
rs140327262 CA661923	543	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs142146939 CA661918	545	E>D		No	ClinGen ESP ExAC TOPMed
rs367672816 COSM3803773 CA661920	545	E>K	breast [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA661919 rs367672816	545	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA338868362 rs1231258919	547	T>A		No	ClinGen TOPMed
CA338868360 rs1327469752	547	T>N		No	ClinGen TOPMed
rs755778084 CA661917	549	V>L		No	ClinGen ExAC gnomAD
rs766885886 CA338868339	551	E>K		No	ClinGen ExAC TOPMed gnomAD
rs766885886 CA661915	551	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA338868315 rs1311912772	552	A>V		No	ClinGen gnomAD
CA661914 rs762663001	553	F>I		No	ClinGen ExAC TOPMed gnomAD
CA18997026 rs1039642164	554	P>T		No	ClinGen gnomAD
rs528825687 CA661913	555	G>R		No	ClinGen 1000Genomes ExAC gnomAD
rs201867180 CA661910	559	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201867180 CA338868222	559	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338868190 rs775659554	562	V>L		No	ClinGen ExAC TOPMed gnomAD
rs775659554 CA338868188	562	V>L		No	ClinGen ExAC TOPMed gnomAD
CA661907 rs775659554	562	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1475709320 CA338868179	563	E>Q		No	ClinGen TOPMed
rs987566615 CA18997008	564	V>A		No	ClinGen Ensembl
CA661906 rs772233726	564	V>F		No	ClinGen ExAC gnomAD
rs745693652 CA661905	565	S>F		No	ClinGen ExAC TOPMed gnomAD
CA661902 rs770866526	566	M>R		No	ClinGen ExAC
CA661904 rs770866526	566	M>T		No	ClinGen ExAC
rs1422807383 CA338868120	567	P>L		No	ClinGen TOPMed gnomAD
CA338868112 rs1553150613	568	T>N		No	ClinGen Ensembl
rs749233289 CA661901	570	E>G		No	ClinGen ExAC gnomAD
CA338868090 rs1168527505	570	E>K		No	ClinGen gnomAD
rs1256254922 CA338868069	571	S>C		No	ClinGen gnomAD
CA338868050 rs1553150610	573	S>G		No	ClinGen Ensembl
CA18996990 rs370414135	573	S>N		No	ClinGen ESP TOPMed gnomAD
rs200690761 CA18996984	574	R>K		No	ClinGen ExAC gnomAD
CA661899 rs200690761	574	R>T		No	ClinGen ExAC gnomAD
CA661898 rs747808678	575	Y>H		No	ClinGen ExAC gnomAD
rs1319082149 CA338868020	575	Y>S		No	ClinGen gnomAD
rs1485428184 CA338867972	579	E>Q		No	ClinGen TOPMed
rs116376356 CA661894	582	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757763220 CA661893	583	Q>*		No	ClinGen ExAC gnomAD
CA661892 rs754366304	583	Q>R		No	ClinGen ExAC gnomAD
rs1399342658 CA338867907	584	E>*		No	ClinGen gnomAD
CA661890 rs149437507	586	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA661889 rs149437507	586	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA18996945 rs896454556	590	L>M		No	ClinGen TOPMed
CA338867830 rs1421595233	591	G>E		No	ClinGen gnomAD
rs1373183872 CA338867817	593	Q>*		No	ClinGen TOPMed
rs1309458094 CA338867812	593	Q>H		No	ClinGen TOPMed
rs1410389829 CA338867804	594	N>K		No	ClinGen TOPMed
CA338867800 rs1570452127	595	Y>S		No	ClinGen Ensembl
CA18996924 rs138626725	596	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs138626725 CA18996929	596	L>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA661885 rs138626725	596	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA661883 rs114593671	597	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA18996900 rs386629316	597	P>LE		No	ClinGen Ensembl
rs114066292 CA661880	598	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA661879 rs768439593	600	E>K		No	ClinGen ExAC gnomAD
rs114229809 CA661878	601	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757612024 CA661876	605	P>T		No	ClinGen ExAC TOPMed gnomAD
CA661875 rs754352442	607	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs778375616 CA661874	607	Q>P		No	ClinGen ExAC gnomAD
rs1442949792 CA338867708	610	L>V		No	ClinGen TOPMed gnomAD
CA661871 rs767569965	613	Q>*		No	ClinGen ExAC
CA661870 rs759819527	613	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1158816257 CA338867675	615	P>L		No	ClinGen TOPMed gnomAD
CA661869 rs751746162	615	P>S		No	ClinGen ExAC gnomAD
CA661866 rs772846814	618	E>K		No	ClinGen ExAC TOPMed gnomAD
rs772846814 CA338867660	618	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs147702971 CA661865	621	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1268635212 CA338867616	624	A>V		No	ClinGen gnomAD
rs761787665 CA661864	626	L>V		No	ClinGen ExAC gnomAD
rs141623204 CA661863	627	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141623204 CA661862	627	S>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA18996809 rs919387255	628	S>F		No	ClinGen Ensembl
CA661858 rs150046748	630	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1470613330 CA338867577	631	A>V		No	ClinGen TOPMed
rs370703332 CA661857	632	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA661856 rs749668565	635	A>V		No	ClinGen ExAC gnomAD
CA661854 rs777941088	636	P>H		No	ClinGen ExAC TOPMed gnomAD
rs756670874 CA661853	637	Q>R		No	ClinGen ExAC gnomAD
CA661852 rs753195541	638	A>V		No	ClinGen ExAC gnomAD
CA338867526 rs1453525688	640	V>I		No	ClinGen TOPMed gnomAD
rs751586466 CA661850	641	P>H		No	ClinGen ExAC TOPMed gnomAD
rs751586466 CA661849	641	P>R		No	ClinGen ExAC TOPMed gnomAD
rs969571905 CA18996779	644	P>S		No	ClinGen Ensembl
rs951888567 CA18996775	646	Q>R		No	ClinGen TOPMed
rs1339484294 CA338866969	647	V>F		No	ClinGen TOPMed gnomAD
rs1331835621 CA338866959	648	P>S		No	ClinGen gnomAD
rs187149276 CA18996040	649	A>S		No	ClinGen 1000Genomes gnomAD
CA661827 rs200283228	649	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA661826 rs41310420	650	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1557591237 CA338866926	651	T>K		No	ClinGen Ensembl
CA661825 rs757096227	653	L>R		No	ClinGen ExAC
CA338866892 rs1230157568	654	L>P		No	ClinGen TOPMed gnomAD
rs866676069 CA18996035	655	E>D		No	ClinGen Ensembl
rs137916833 CA661824	655	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs868019414 CA18996032	656	P>L		No	ClinGen gnomAD
rs1238580943 CA338866838	659	A>D		No	ClinGen gnomAD
CA18996008 rs201618051	661	P>H		No	ClinGen 1000Genomes TOPMed gnomAD
CA18996012 rs554741213	661	P>T		No	ClinGen gnomAD
CA338866814 rs1228359913	662	E>K		No	ClinGen gnomAD
CA18996001 rs866155205	663	A>S		No	ClinGen gnomAD
rs766931618 CA661820	663	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1420708527 CA338866781	664	E>G		No	ClinGen TOPMed
CA661818 rs773850446	664	E>K		No	ClinGen ExAC gnomAD
CA661817 rs770517273	665	A>T		No	ClinGen ExAC gnomAD
rs748540355 CA661816	665	A>V		No	ClinGen ExAC TOPMed gnomAD
rs769169459 CA661814	666	A>D		No	ClinGen ExAC gnomAD
CA338866754 rs769169459	666	A>V		No	ClinGen ExAC gnomAD
CA338866743 rs1406026608	667	D>E		No	ClinGen TOPMed gnomAD
CA661812 rs780249724	668	D>G		No	ClinGen ExAC TOPMed gnomAD
CA661813 rs747461477	668	D>H		No	ClinGen ExAC
CA661811 rs758379251	669	F>L		No	ClinGen ExAC TOPMed gnomAD
CA661810 rs41312008	670	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA338866699 rs1437634271	671	P>H		No	ClinGen gnomAD
rs1437634271 CA338866695	671	P>L		No	ClinGen gnomAD
rs1248378586 CA338866676	673	P>R		No	ClinGen gnomAD
CA661774 rs774638949	674	E>K		No	ClinGen ExAC TOPMed gnomAD
CA661773 rs558760 VAR_055984	675	V>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA18995508 rs532054254	676	D>G		No	ClinGen gnomAD
CA338866651 rs572966268	676	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs572966268 CA661772	676	D>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA338866641 rs1250202188	677	L>R		No	ClinGen gnomAD
CA661770 rs770015366	679	S>L		No	ClinGen ExAC TOPMed gnomAD
CA661768 rs560975253	681	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs560975253 CA338866621	681	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA661767 rs754931904	682	A>P		No	ClinGen ExAC gnomAD
rs1357587938 CA338866600	684	E>G		No	ClinGen TOPMed gnomAD
rs1240591492 CA338866591	685	V>G		No	ClinGen gnomAD
rs1288491634 CA338866596	685	V>M		No	ClinGen TOPMed gnomAD
rs1375947500 CA338866589	686	V>M		No	ClinGen gnomAD
rs542213034 CA338866584	687	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs779582888 CA661765	687	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs542213034 CA661766	687	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1322391307 CA338866580	688	T>A		No	ClinGen TOPMed
rs1367645667 CA338866575	689	A>T		No	ClinGen gnomAD
rs1292455232 CA338866570	689	A>V		No	ClinGen gnomAD
CA18995487 rs1055989695	690	E>D		No	ClinGen TOPMed gnomAD
rs1158946568 CA338866558	691	P>L		No	ClinGen gnomAD
CA18995486 rs937549224	691	P>S		No	ClinGen gnomAD
rs937549224 CA338866562	691	P>T		No	ClinGen gnomAD
rs1363587083 CA338866549	693	V>L		No	ClinGen TOPMed gnomAD
rs1363587083 CA338866551	693	V>M		No	ClinGen TOPMed gnomAD
CA338866542 rs1180209726	694	W>*		No	ClinGen gnomAD
CA338866532 rs1239630847	695	L>W		No	ClinGen gnomAD
CA338866528 rs1268092158	696	E>K		No	ClinGen gnomAD
CA338866516 rs1198742909	697	A>V		No	ClinGen gnomAD
CA338866513 rs1265611333	698	Q>*		No	ClinGen TOPMed gnomAD
CA338866514 rs1265611333	698	Q>K		No	ClinGen TOPMed gnomAD
CA661763 rs139742596	698	Q>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764831126 CA661762	699	A>G		No	ClinGen ExAC gnomAD
rs764831126 CA338866504	699	A>V		No	ClinGen ExAC gnomAD
CA661761 rs541953044	700	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1570448262 CA338866493	701	V>G		No	ClinGen Ensembl
rs1055036974 CA18995474	702	A>D		No	ClinGen TOPMed
rs1282616813 CA338866492	702	A>T		No	ClinGen gnomAD
CA661759 rs373137026	703	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1298355858 CA338866476	705	A>T		No	ClinGen gnomAD
CA18995469 rs879010222	706	Q>*		No	ClinGen Ensembl
CA338866463 rs1226540105	707	P>A		No	ClinGen Ensembl
rs1384636925 CA338866459	707	P>L		No	ClinGen gnomAD
rs1467934221 CA338866455	708	E>G		No	ClinGen gnomAD
rs760160254 CA338866458	708	E>K		No	ClinGen ExAC gnomAD
rs760160254 CA661758	708	E>Q		No	ClinGen ExAC gnomAD
rs763152449 CA661755	709	P>L		No	ClinGen ExAC gnomAD
CA661756 rs766940874	709	P>S		No	ClinGen ExAC TOPMed gnomAD
CA338866451 rs766940874	709	P>T		No	ClinGen ExAC TOPMed gnomAD
CA661753 rs143758204	711	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA338866441 rs773357079	711	P>S		No	ClinGen ExAC gnomAD
CA661754 rs773357079 COSM331167	711	P>T	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1201941334 CA338866438	712	A>T		No	ClinGen gnomAD
rs989888717 CA18995448	712	A>V		No	ClinGen Ensembl
rs748888738 CA661751	713	T>I		No	ClinGen ExAC gnomAD
CA338866420 rs1221615632	715	G>A		No	ClinGen gnomAD
CA661750 rs768471031	715	G>R		No	ClinGen ExAC gnomAD
CA18995438 rs957040956	717	K>T		No	ClinGen TOPMed
CA661748 rs779989905	718	R>K		No	ClinGen ExAC TOPMed gnomAD
CA338866394 rs1478893100	719	E>G		No	ClinGen TOPMed
CA338866398 rs1174552890	719	E>K		No	ClinGen TOPMed
CA661746 rs745389399	721	V>M		No	ClinGen ExAC TOPMed gnomAD
CA338866364 rs1403367510	723	M>I		No	ClinGen gnomAD
CA338866367 rs1398157225	723	M>T		No	ClinGen gnomAD
CA338866350 rs1427081452	725	V>A		No	ClinGen TOPMed
CA338866343 rs1336586069	726	A>V		No	ClinGen gnomAD
CA661744 rs149255241	729	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1371542914 CA338866322	730	D>G		No	ClinGen gnomAD
CA338866314 rs1318236443	731	D>G		No	ClinGen TOPMed
rs1424108281 CA338866317	731	D>H		No	ClinGen TOPMed gnomAD
CA338866318 rs1424108281	731	D>N		No	ClinGen TOPMed gnomAD
CA661741 rs566583367	732	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA661740 rs112270148	732	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA661742 rs566583367	732	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338866307 rs1194711601	733	L>M		No	ClinGen gnomAD
CA18995405 rs886260380	734	P>S		No	ClinGen Ensembl
CA661737 VAR_055985 rs13375609	735	V>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA338866291 rs1383931789	736	V>M		No	ClinGen gnomAD
rs1467247107 CA338866286	737	D>N		No	ClinGen TOPMed
rs765357529 CA661736	738	Q>K		No	ClinGen ExAC
CA338866252 rs1570447882	741	V>G		No	ClinGen Ensembl
rs1403057752 CA338866242	743	A>T		No	ClinGen gnomAD
CA338866239 rs1330215620	743	A>V		No	ClinGen gnomAD
CA661734 COSM1667215 rs569249224	744	R>C	breast [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs768818031 CA661733	744	R>H		No	ClinGen ExAC TOPMed gnomAD
rs768818031 CA338866236	744	R>P		No	ClinGen ExAC TOPMed gnomAD
CA661705 rs747794960	747	L>P		No	ClinGen ExAC TOPMed gnomAD
CA661704 rs549777277	748	L>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1283768573 CA338865524	749	E>V		No	ClinGen gnomAD
CA338865518 rs1317338619	750	Q>*		No	ClinGen gnomAD
CA338865519 rs1317338619	750	Q>E		No	ClinGen gnomAD
rs1570444856 CA338865514	750	Q>R		No	ClinGen Ensembl
rs146864100 CA338865479	751	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA661703 rs146864100	751	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1348537861 CA338865476	751	Q>R		No	ClinGen gnomAD
CA661701 rs531505555	752	V>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA661702 rs531505555	752	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338865430 rs1264815655	753	V>E		No	ClinGen TOPMed
rs757638344 CA661700	753	V>M		No	ClinGen ExAC gnomAD
CA18994148 rs985786933	754	G>S		No	ClinGen Ensembl
rs1195332776 CA338865407	754	G>V		No	ClinGen gnomAD
CA661697 rs760925611	755	G>R		No	ClinGen ExAC gnomAD
CA338865381 rs1215486830	756	E>Q		No	ClinGen gnomAD
CA338865354 rs1279275381	757	Q>*		No	ClinGen gnomAD
rs1445692501 CA338865334	758	A>T		No	ClinGen gnomAD
rs578074180 CA661694	759	K>N		No	ClinGen ExAC TOPMed gnomAD
rs578074180 CA661695	759	K>N		No	ClinGen ExAC TOPMed gnomAD
CA661696 rs549469387	759	K>T		No	ClinGen ExAC TOPMed gnomAD
rs386629315 CA18994131	759	K>T		No	ClinGen Ensembl
CA18994124 rs972563859	760	N>D		No	ClinGen Ensembl
rs1217578002 CA338865250	761	K>T		No	ClinGen TOPMed
rs1220590811 CA338865213	762	D>E		No	ClinGen gnomAD
CA661692 rs770910500	762	D>N		No	ClinGen ExAC TOPMed gnomAD
rs374049433 CA661689	769	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
COSM903369 rs376783254 CA661690	769	R>W	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs186978787 CA661688 COSM173573	770	R>C	large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC gnomAD
rs1050038782 CA18994107	770	R>H		No	ClinGen TOPMed gnomAD
rs768156873 CA661686	772	R>C		No	ClinGen ExAC gnomAD
CA661685 rs139870251	772	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs373972661 CA661683	773	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs779090340 CA661684	773	Y>D		No	ClinGen ExAC TOPMed gnomAD
CA18994087 rs777878864	774	A>S		No	ClinGen ExAC TOPMed gnomAD
rs777878864 CA661681	774	A>T		No	ClinGen ExAC TOPMed gnomAD
rs200888075 CA338865005	775	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA661680 rs116367430	775	D>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA661678 rs767729742	776	E>K		No	ClinGen ExAC gnomAD
rs151177164 COSM1165671 CA661677	777	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA661676 rs148629128	777	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA661675 rs766080010	778	R>G		No	ClinGen ExAC gnomAD
rs1254201254 CA338864927	780	Q>R		No	ClinGen TOPMed
rs762986160 CA338864897	782	V>E		No	ClinGen ExAC gnomAD
rs762986160 CA661674	782	V>G		No	ClinGen ExAC gnomAD
rs999725624 CA18994057	783	A>S		No	ClinGen Ensembl
rs773263008 CA661673	785	L>P		No	ClinGen ExAC gnomAD
rs768677101 CA18994048	786	Q>K		No	ClinGen TOPMed gnomAD
rs761442869 CA661671	786	Q>P		No	ClinGen ExAC gnomAD
rs761442869 CA338864850	786	Q>R		No	ClinGen ExAC gnomAD
CA338864829 rs1462044202	787	N>K		No	ClinGen gnomAD
CA661670 COSM2156655 rs370565385	788	S>L	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA338864176 rs1406771753	789	D>V		No	ClinGen gnomAD
CA338864144 rs1385526649	791	D>E		No	ClinGen gnomAD
CA338864137 rs1184571027	792	S>N		No	ClinGen gnomAD
rs116005658 CA661668	792	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs114242123 CA18994030	793	G>E		No	ClinGen 1000Genomes
CA661666 rs200844482	793	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA18994021 rs200472696	794	D>G		No	ClinGen TOPMed gnomAD
rs756546397 CA661663	794	D>N		No	ClinGen ExAC gnomAD
rs756546397 CA661664	794	D>Y		No	ClinGen ExAC gnomAD
rs1202644244 CA338864103	795	W>*		No	ClinGen TOPMed gnomAD
CA338864100 rs1202644244	795	W>C		No	ClinGen TOPMed gnomAD
rs781115691 CA661661	796	V>A		No	ClinGen ExAC gnomAD
rs748236046 CA661662	796	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1215346342 CA338864074	798	L>P		No	ClinGen gnomAD
rs1317544011 CA338864067	799	N>D		No	ClinGen gnomAD
CA338864046 rs1356655583	800	V>D		No	ClinGen gnomAD
COSM425219 CA661659 rs139817126	800	V>I	upper_aerodigestive_tract breast [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs147429225 CA338864034	801	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA661658 rs766248541	801	Y>C		No	ClinGen ExAC gnomAD
CA661656 rs150132550 COSM903367	802	D>N	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs150132550 CA338864029	802	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs558038200 CA661655	803	S>F		No	ClinGen 1000Genomes ExAC gnomAD
CA338864007 rs1570444347	804	I>F		No	ClinGen Ensembl
rs1187755747 CA338863995	805	Q>*		No	ClinGen TOPMed
CA661653 rs776340258	806	E>V		No	ClinGen ExAC TOPMed gnomAD
rs115257742 CA661651	807	E>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs115257742 CA661652	807	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA661650 rs775026398	808	V>A		No	ClinGen ExAC TOPMed gnomAD
CA338863953 rs145153675	809	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs145153675 CA661648	809	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs114545284 CA661649	809	R>W		No	ClinGen 1000Genomes ExAC gnomAD
rs770339243 CA661646	817	K>N		No	ClinGen ExAC gnomAD
CA338863842 rs1222026892	818	M>I		No	ClinGen gnomAD
CA338863846 rs1421035466	818	M>T		No	ClinGen gnomAD
CA338863836 rs1245860700	819	Q>K		No	ClinGen TOPMed
rs748646545 CA661645	821	K>*		No	ClinGen ExAC gnomAD
CA661627 rs149211267	823	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs770110174 CA661628	823	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1235197360 CA338862514	826	E>Q		No	ClinGen gnomAD
CA661625 rs769169857	827	V>E		No	ClinGen ExAC TOPMed gnomAD
rs777029545 CA661626	827	V>L		No	ClinGen ExAC gnomAD
CA338862499 rs777029545	827	V>M		No	ClinGen ExAC gnomAD
CA18985799 rs1026200394	831	D>E		No	ClinGen Ensembl
CA338862445 rs1557582957	831	D>G		No	ClinGen Ensembl
rs772481150 CA661622	835	E>K		No	ClinGen ExAC gnomAD
rs1299243091 CA338862367	837	Q>L		No	ClinGen TOPMed
rs993330925 CA18985780	838	L>V		No	ClinGen Ensembl
rs1194177953 CA338862332	840	K>E		No	ClinGen gnomAD
rs1327530958 CA338862303	842	D>G		No	ClinGen TOPMed
CA661621 rs200369420	842	D>N		No	ClinGen ExAC TOPMed gnomAD
CA338862308 rs200369420	842	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA661620 rs778893284	845	A>S		No	ClinGen ExAC gnomAD
CA338862211 rs1376188528	846	T>N		No	ClinGen gnomAD
CA338862225 rs1570433580	846	T>P		No	ClinGen Ensembl
CA18985752 rs750824801	847	I>V		No	ClinGen Ensembl
rs577775020 CA661618	848	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338862181 rs577775020	848	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757864428 CA338862154	849	R>L		No	ClinGen ExAC TOPMed gnomAD
rs757864428 CA661617	849	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1340945762 CA338862165	849	R>W		No	ClinGen gnomAD
rs1557582847 CA338862115	851	E>K		No	ClinGen Ensembl
CA661615 rs139517726	852	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA661614 rs752207289	854	S>F		No	ClinGen ExAC gnomAD
CA661613 rs767006007	855	M>K		No	ClinGen ExAC gnomAD
rs1469710171 CA338862026	855	M>V		No	ClinGen TOPMed
rs905924251 CA18985741	858	Q>R		No	ClinGen Ensembl
CA18985724 rs1014637541	862	E>K		No	ClinGen Ensembl
CA661611 rs113995871	862	E>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1570433476 CA338861866	864	V>G		No	ClinGen Ensembl
CA661608 rs769060306	866	P>L		No	ClinGen ExAC gnomAD
CA661607 rs769060306	866	P>R		No	ClinGen ExAC gnomAD
CA661605 rs761234884	868	I>T		No	ClinGen ExAC gnomAD
rs141369367 CA661604	869	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772247964 COSM1338564 CA661603	869	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs141369367 CA338861841	869	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA661602 rs148681058	870	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs868472952 CA18985699	871	D>N		No	ClinGen Ensembl
CA661601 rs774743101	872	C>Y		No	ClinGen ExAC gnomAD
rs749049783 CA661599	873	N>H		No	ClinGen ExAC gnomAD
rs1374061088 CA338861776	878	E>V		No	ClinGen TOPMed
rs1314896182 CA338861772	879	K>E		No	ClinGen TOPMed gnomAD
rs1314896182 CA338861773	879	K>Q		No	ClinGen TOPMed gnomAD
CA661597 rs199941525	882	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA661596 rs34232864	882	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA661595 rs780726306	886	W>*		No	ClinGen ExAC TOPMed gnomAD
rs141985868 CA661593 COSM110103	888	E>K	lung NS skin [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs766027861 CA661592	889	D>G		No	ClinGen ExAC gnomAD
rs954319097 CA18985650	889	D>H		No	ClinGen TOPMed
rs954319097 CA338861704	889	D>N		No	ClinGen TOPMed
CA661590 rs754217663	891	G>S		No	ClinGen ExAC gnomAD
rs1195634212 CA338861684	892	F>L		No	ClinGen TOPMed
CA338861659 rs1233422608	895	I>V		No	ClinGen gnomAD
CA338861651 rs1180454286	896	P>S		No	ClinGen gnomAD
CA661586 rs768090350	897	H>Y		No	ClinGen ExAC gnomAD
rs774513929 CA661583	899	V>I		No	ClinGen ExAC TOPMed gnomAD
rs144953741 CA661580	900	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA661581 rs749520746	900	I>V		No	ClinGen ExAC TOPMed gnomAD
CA661579 rs769607660	902	K>Q		No	ClinGen ExAC gnomAD
rs747847448 CA661578	903	T>N		No	ClinGen ExAC gnomAD
CA338861609 rs1570433242	903	T>P		No	ClinGen Ensembl
CA661577 rs781137040	904	S>R		No	ClinGen ExAC gnomAD
rs1348713519 CA338861600	904	S>T		No	ClinGen gnomAD
rs1219476254 CA338861596	905	L>V		No	ClinGen gnomAD
CA661576 rs756083234	907	V>G		No	ClinGen ExAC TOPMed gnomAD
rs779584544 CA661557	910	S>A		No	ClinGen ExAC gnomAD
rs1012342151 CA18984526	911	T>S		No	ClinGen gnomAD
rs1243078145 CA338861322	912	G>A		No	ClinGen TOPMed gnomAD
CA338861318 rs1243078145	912	G>E		No	ClinGen TOPMed gnomAD
rs1476561096 CA338861330	912	G>R		No	ClinGen gnomAD
rs1374243521 CA338861281	914	Q>H		No	ClinGen Ensembl
CA338861231 rs1570431663	916	K>N		No	ClinGen Ensembl
CA338860883 rs1265591759	917	P>L		No	ClinGen gnomAD
CA338861220 rs1463908475	917	P>S		No	ClinGen TOPMed gnomAD
rs376988005 CA661555	919	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs200150083 CA661554	919	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs200150083 CA18984494	919	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA338860857 rs1209001003	920	K>Q		No	ClinGen TOPMed
rs1570431620 CA338860843	921	T>P		No	ClinGen Ensembl
rs530985178 CA661553	922	S>C		No	ClinGen 1000Genomes ExAC
rs184119745 CA18984487	922	S>T		No	ClinGen 1000Genomes
CA18984482 rs370376315	924	A>G		No	ClinGen ESP TOPMed
rs1354237292 CA338860810	924	A>T		No	ClinGen TOPMed
CA338860785 rs1242421094	926	N>D		No	ClinGen TOPMed
rs753167464 CA338860780	926	N>I		No	ClinGen ExAC TOPMed gnomAD
rs753167464 CA661552	926	N>T		No	ClinGen ExAC TOPMed gnomAD
rs755577581 CA661550	927	G>S		No	ClinGen ExAC TOPMed gnomAD
CA338860762 rs1384893072	928	E>K		No	ClinGen TOPMed gnomAD
rs766746687 CA661548	929	P>L		No	ClinGen ExAC gnomAD
rs1172021731 CA338860716	931	M>V		No	ClinGen TOPMed gnomAD
rs773948871 CA661520	932	E>G		No	ClinGen ExAC gnomAD
rs149655237 CA661521	932	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_023528 rs631357 CA661519	933	D>E		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA338860121 rs1406427087	934	D>N		No	ClinGen gnomAD
CA661518 rs748758210	935	R>H		No	ClinGen ExAC TOPMed gnomAD
CA18981494 rs942654205	935	R>S		No	ClinGen Ensembl
CA18981486 rs912829749	936	Y>F		No	ClinGen gnomAD
rs1457770099 CA338860046	937	R>K		No	ClinGen gnomAD
rs769503970 CA661515	937	R>S		No	ClinGen ExAC gnomAD
CA338860002 rs1330144121	939	M>R		No	ClinGen gnomAD
CA661511 rs369950539	940	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA661510 rs746331222	940	L>P		No	ClinGen ExAC TOPMed gnomAD
rs369950539 CA661512	940	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs146340669 CA661508	942	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA661509 rs779099245	942	R>W		No	ClinGen ExAC gnomAD
CA18981376 rs918800612	943	S>C		No	ClinGen TOPMed gnomAD
CA338859883 rs1216441576	946	E>K		No	ClinGen gnomAD
rs764308721 CA661506	947	N>D		No	ClinGen ExAC gnomAD
CA661504 rs769167703	948	I>T		No	ClinGen ExAC TOPMed gnomAD
CA661502 rs144236031	950	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1386500234 CA338859746	952	Y>F		No	ClinGen gnomAD
CA338859716 rs1298712226	954	R>P		No	ClinGen TOPMed
CA338859721 rs1298712226	954	R>Q		No	ClinGen TOPMed
CA338859695 rs1417729108	955	S>F		No	ClinGen gnomAD
CA18981331 rs934975745	957	R>Q		No	ClinGen TOPMed gnomAD
CA338859657 rs1570426137	957	R>W		No	ClinGen Ensembl
CA661498 rs766378781	958	A>T		No	ClinGen ExAC gnomAD
CA338859579 rs1157001562	960	Q>H		No	ClinGen TOPMed gnomAD
rs1304131327 CA338859587	960	Q>R		No	ClinGen TOPMed
rs749750923 CA661496	961	I>T		No	ClinGen ExAC gnomAD
CA338859574 rs1570426097	961	I>V		No	ClinGen Ensembl
rs769629585 CA661495	964	T>I		No	ClinGen ExAC gnomAD
rs528089648 CA18981292	965	D>E		No	ClinGen 1000Genomes ExAC gnomAD
CA661493 rs371204342	966	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs371204342 CA661492	966	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA338859469 rs1266230699	970	L>F		No	ClinGen TOPMed gnomAD
rs138351244 CA661462	972	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs909983519 CA18980097	972	H>Y		No	ClinGen Ensembl
rs758451928 CA661460	974	N>K		No	ClinGen ExAC gnomAD
rs779992520 CA661461	974	N>S		No	ClinGen ExAC gnomAD
CA661459 rs376184055	975	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1250707675 CA338859257	977	P>T		No	ClinGen TOPMed gnomAD
CA338859244 rs1570423673	978	G>R		No	ClinGen Ensembl
rs150479537 CA661457	979	L>F		No	ClinGen ESP ExAC gnomAD
CA661456 rs753326202	979	L>P		No	ClinGen ExAC gnomAD
CA18980079 rs982482345	981	C>*		No	ClinGen TOPMed gnomAD
CA338859193 rs1248691105	982	P>L		No	ClinGen gnomAD
rs1248691105 CA338859197	982	P>Q		No	ClinGen gnomAD
rs1026911845 CA18980073	986	N>T		No	ClinGen TOPMed
CA661453 rs368653467	988	A>V		No	ClinGen ExAC TOPMed gnomAD
CA338859092 rs1289171004	992	T>P		No	ClinGen TOPMed gnomAD
CA338859070 rs1175259431	993	Q>P		No	ClinGen TOPMed
CA338859049 rs1304705468	994	A>D		No	ClinGen gnomAD
rs1035758826 CA18980063	994	A>T		No	ClinGen TOPMed
CA338858990 rs1405795990	997	M>K		No	ClinGen gnomAD
CA338858960 rs1389913702	999	Q>*		No	ClinGen gnomAD
CA338858953 rs1189345846	999	Q>P		No	ClinGen TOPMed
CA338858939 rs1161395137	1000	P>S		No	ClinGen TOPMed gnomAD
CA338858943 rs1161395137	1000	P>T		No	ClinGen TOPMed gnomAD
CA338858919 rs574381737	1001	R>L		No	ClinGen ExAC TOPMed gnomAD
CA338858924 rs574381737	1001	R>P		No	ClinGen ExAC TOPMed gnomAD
COSM182818 CA661451 rs574381737	1001	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs771261049 CA661452	1001	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1570423458 CA338858900	1003	F>L		No	ClinGen Ensembl
rs370246172 CA661450	1004	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
COSM903327 rs770268573 CA661449	1004	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA338858861 rs1570423428	1005	L>P		No	ClinGen Ensembl
CA18980046 rs763275738	1006	E>K		No	ClinGen gnomAD
rs781316184 CA661447	1007	S>C		No	ClinGen ExAC gnomAD
CA661446 rs768825310	1008	L>P		No	ClinGen ExAC TOPMed gnomAD
CA661444 rs780045651	1009	D>N		No	ClinGen ExAC TOPMed gnomAD
rs758290008 CA661443	1010	I>V		No	ClinGen ExAC gnomAD
CA338858659 rs1227913401	1016	K>N		No	ClinGen gnomAD
rs147784710 CA661442	1017	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs377443985 CA661441	1017	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs377443985 CA338858644	1017	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1321451203 CA338858556	1021	K>R		No	ClinGen gnomAD
CA18980011 rs879085340	1022	S>T		No	ClinGen Ensembl
rs1031897189 CA18980010	1023	N>S		No	ClinGen TOPMed
rs199731544 CA18979992	1028	P>H		No	ClinGen TOPMed
CA338858390 rs199731544	1028	P>R		No	ClinGen TOPMed
CA338858397 rs1389352826	1028	P>S		No	ClinGen gnomAD

No associated diseases with Q9P2E2

2 regional properties for Q9P2E2

Type	Name	Position	InterPro Accession
domain	Kinesin motor domain	3 - 343	IPR001752
conserved_site	Kinesin motor domain, conserved site	234 - 245	IPR019821

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton Cell projection, cilium Cell projection, dendrite	Localizes to dendrites of pyramidal neurons (By similarity) Does not localize to the axons or nuclei in cerebral cortex, hippocampus or olfactory bulb (By similarity) Co-localizes with NR2B-containing vesicles along microtubules (By similarity)
PANTHER Family	PTHR47969	CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED
PANTHER Subfamily	PTHR47969:SF32	KINESIN-LIKE PROTEIN
PANTHER Protein Class	cytoskeletal protein microtubule binding motor protein microtubule or microtubule-binding cytoskeletal protein
PANTHER Pathway Category	No pathway information available

11 GO annotations of cellular component

Name	Definition
axoneme	The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
ciliary basal body	A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cilium	A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite cytoplasm	All of the contents of a dendrite, excluding the surrounding plasma membrane.
kinesin complex	Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
microtubule organizing center	An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
periciliary membrane compartment	A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis.
photoreceptor connecting cilium	The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone.

5 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.
microtubule motor activity	A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.
plus-end-directed microtubule motor activity	A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis.

5 GO annotations of biological process

Name	Definition
anterograde dendritic transport of neurotransmitter receptor complex	The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse.
cell projection organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
microtubule-based movement	A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
vesicle-mediated transport	A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

13 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P33176	KIF5B	Kinesin-1 heavy chain	Homo sapiens (Human)	EV
O60282	KIF5C	Kinesin heavy chain isoform 5C	Homo sapiens (Human)	EV
Q12840	KIF5A	Kinesin heavy chain isoform 5A	Homo sapiens (Human)	EV
Q2M1P5	KIF7	Kinesin-like protein KIF7	Homo sapiens (Human)	EV
Q86VH2	KIF27	Kinesin-like protein KIF27	Homo sapiens (Human)	SS
Q7Z4S6	KIF21A	Kinesin-like protein KIF21A	Homo sapiens (Human)	EV
O75037	KIF21B	Kinesin-like protein KIF21B	Homo sapiens (Human)	EV
O00139	KIF2A	Kinesin-like protein KIF2A	Homo sapiens (Human)	PR
Q9NQT8	KIF13B	Kinesin-like protein KIF13B	Homo sapiens (Human)	EV
Q9H1H9	KIF13A	Kinesin-like protein KIF13A	Homo sapiens (Human)	SS
O43896	KIF1C	Kinesin-like protein KIF1C	Homo sapiens (Human)	SS
Q99PW8	Kif17	Kinesin-like protein KIF17	Mus musculus (Mouse)	SS
P46864	KIN14M	Kinesin-like protein KIN-14M	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MASEAVKVVV	RCRPMNQRER	ELRCQPVVTV	DCARAQCCIQ	NPGAADEPPK	QFTFDGAYHV
70	80	90	100	110	120
DHVTEQIYNE	IAYPLVEGVT	EGYNGTIFAY	GQTGSGKSFT	MQGLPDPPSQ	RGIIPRAFEH
130	140	150	160	170	180
VFESVQCAEN	TKFLVRASYL	EIYNEDVRDL	LGADTKQKLE	LKEHPEKGVY	VKGLSMHTVH
190	200	210	220	230	240
SVAQCEHIME	TGWKNRSVGY	TLMNKDSSRS	HSIFTISIEM	SAVDERGKDH	LRAGKLNLVD
250	260	270	280	290	300
LAGSERQSKT	GATGERLKEA	TKINLSLSAL	GNVISALVDG	RCKHVPYRDS	KLTRLLQDSL
310	320	330	340	350	360
GGNTKTLMVA	CLSPADNNYD	ETLSTLRYAN	RAKNIRNKPR	INEDPKDALL	REYQEEIKKL
370	380	390	400	410	420
KAILTQQMSP	SSLSALLSRQ	VPPDPVQVEE	KLLPQPVIQH	DVEAEKQLIR	EEYEERLARL
430	440	450	460	470	480
KADYKAEQES	RARLEEDITA	MRNSYDVRLS	TLEENLRKET	EAVLQVGVLY	KAEVMSRAEF
490	500	510	520	530	540
ASSAEYPPAF	QYETVVKPKV	FSTTDTLPSD	DVSKTQVSSR	FAELPKVEPS	KSEISLGSSE
550	560	570	580	590	600
SSSLEETSVS	EAFPGPEEPS	NVEVSMPTEE	SRSRYFLDEC	LGQEAAGHLL	GEQNYLPQEE
610	620	630	640	650	660
PQEVPLQGLL	GLQDPFAEVE	AKLARLSSTV	ARTDAPQADV	PKVPVQVPAP	TDLLEPSDAR
670	680	690	700	710	720
PEAEAADDFP	PRPEVDLASE	VALEVVRTAE	PGVWLEAQAP	VALVAQPEPL	PATAGVKRES
730	740	750	760	770	780
VGMEVAVLTD	DPLPVVDQQQ	VLARLQLLEQ	QVVGGEQAKN	KDLKEKHKRR	KRYADERRKQ
790	800	810	820	830	840
LVAALQNSDE	DSGDWVLLNV	YDSIQEEVRA	KSKLLEKMQR	KLRAAEVEIK	DLQSEFQLEK
850	860	870	880	890	900
IDYLATIRRQ	ERDSMLLQQL	LEQVQPLIRR	DCNYSNLEKI	LRESCWDEDN	GFWKIPHPVI
910	920	930	940	950	960
TKTSLPVAVS	TGPQNKPARK	TSAADNGEPN	MEDDRYRLML	SRSNSENIAS	NYFRSKRASQ
970	980	990	1000	1010	1020
ILSTDARKSL	THHNSPPGLS	CPLSNNSAIP	PTQAPEMPQP	RPFRLESLDI	PFTKAKRKKS

KSNFGSEPL