AiPD: Autoinhibited Protein Database

Q9P289

Gene name	STK26
Protein name	Serine/threonine-protein kinase 26
Names	MST3 and SOK1-related kinase, Mammalian STE20-like protein kinase 4, MST-4, STE20-like kinase MST4, Serine/threonine-protein kinase MASK
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51765
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-98 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-98 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

161-184 (Activation loop from InterPro)

Target domain	19-295 (Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

10 structures for Q9P289

Entry ID	Method	Resolution	Chain	Position	Source
3GGF	X-ray	235 A	A/B	1-300	PDB
3W8I	X-ray	240 A	B	346-416	PDB
4FZA	X-ray	315 A	B	18-297	PDB
4FZD	X-ray	325 A			PDB
4FZF	X-ray	364 A	B	18-297	PDB
4GEH	X-ray	195 A	B/D	325-413	PDB
5XY9	X-ray	230 A	C/D	314-325	PDB
5YF4	X-ray	190 A	B	320-335	PDB
7B36	X-ray	211 A	A/C	1-300	PDB
AF-Q9P289-F1	Predicted				AlphaFoldDB

173 variants for Q9P289

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1214330679 CA414674358	2	A>S		No	ClinGen TOPMed
rs1349105877 CA414674370	4	S>T		No	ClinGen TOPMed
rs1012985497 CA335853743	5	P>L		No	ClinGen TOPMed gnomAD
rs369364323 CA335853745	9	Q>H		No	ClinGen gnomAD
VAR_040844 rs56035648 CA335853744	9	Q>R		No	ClinGen UniProt TOPMed dbSNP gnomAD
CA414674406 rs1298750841	10	V>L		No	ClinGen TOPMed
rs1352965697 CA414674421	12	G>A		No	ClinGen TOPMed
rs1023444788 CA335853746	12	G>R		No	ClinGen TOPMed gnomAD
rs1179091753 CA414675541	17	I>T		No	ClinGen TOPMed gnomAD
rs769287786 CA10518557	18	A>G		No	ClinGen ExAC gnomAD
CA10518558 rs779501452	19	D>G		No	ClinGen ExAC TOPMed gnomAD
CA414675612 rs1177202461	28	E>K		No	ClinGen gnomAD
CA10518559 rs375587063	29	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA10518560 rs777461974	29	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA414675656 rs1330194851	34	S>L		No	ClinGen gnomAD
VAR_040845	36	G>W	a gastric adenocarcinoma sample; somatic mutation [UniProt]	No	UniProt
TCGA novel	39	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760833845 CA10518562	44	N>K		No	ClinGen ExAC TOPMed gnomAD
CA10518563 RCV000908840 VAR_040846 rs56044451	45	R>C		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10518564 rs776577670	45	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA414675731 rs776577670	45	R>P		No	ClinGen ExAC TOPMed gnomAD
CA10518566 COSM755334 rs777377443	50	V>I	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA335856036 rs866425721	52	I>N		No	ClinGen Ensembl
CA10518567 rs751563470	60	A>T		No	ClinGen ExAC gnomAD
CA335856037 rs193206254	60	A>V		No	ClinGen 1000Genomes TOPMed
rs1336172162 CA414675849	62	D>E		No	ClinGen TOPMed
rs138637956 CA10518570	86	Y>C		No	ClinGen ESP ExAC gnomAD
rs138637956 CA335856039	86	Y>F		No	ClinGen ESP ExAC gnomAD
CA414676021 rs1206689970	86	Y>H		No	ClinGen gnomAD
rs893843399 CA335856635	92	G>W		No	ClinGen TOPMed
CA414674232 rs1201368098	95	L>I		No	ClinGen TOPMed
TCGA novel	96	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767444619 CA10518586	99	M>T		No	ClinGen ExAC gnomAD
rs775574052 CA10518603	112	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1261821703 CA414674465	113	A>G		No	ClinGen gnomAD
CA414674463 rs1277594088	113	A>S		No	ClinGen TOPMed
CA10518604 rs749295578	115	P>A		No	ClinGen ExAC gnomAD
TCGA novel	115	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	117	D>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1278407920 CA414674490	117	D>G		No	ClinGen gnomAD
rs1462068167 CA414674519	121	I>V		No	ClinGen gnomAD
rs146294919 CA335856917	122	A>S		No	ClinGen ESP TOPMed gnomAD
TCGA novel	124	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs375206609 CA335856918	126	K>R		No	ClinGen ESP TOPMed gnomAD
TCGA novel	128	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA335856919 rs771528253	131	G>S		No	ClinGen Ensembl
rs1235992140 CA414674598	133	D>Y		No	ClinGen gnomAD
CA10518607 rs760501879	134	Y>C		No	ClinGen ExAC gnomAD
CA335856920 rs1003298205	138	E>A		No	ClinGen Ensembl
TCGA novel	138	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10518608 rs766248504	141	I>L		No	ClinGen ExAC gnomAD
CA10518610 rs369853762	143	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	144	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1602778284 CA414674686	145	I>M		No	ClinGen Ensembl
CA414674681 rs1569336050	145	I>V		No	ClinGen Ensembl
CA10518628 rs746991327	160	L>V		No	ClinGen ExAC gnomAD
rs866909210 CA335856922	171	D>N		No	ClinGen TOPMed
CA10518629 rs770738278	176	R>S		No	ClinGen ExAC TOPMed gnomAD
rs142833022 CA10518631	177	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	179	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1187121810 CA414674933	180	V>A		No	ClinGen TOPMed
TCGA novel	186	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	193	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	195	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1456976138 CA414675040	195	A>V		No	ClinGen gnomAD
rs968861561 CA335856923	197	D>N		No	ClinGen Ensembl
CA10518633 rs201522308	198	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA10518657 rs148760250	210	I>V		No	ClinGen ESP ExAC gnomAD
CA10518658 rs201758864	216	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA414675188 rs1383136302	216	E>K		No	ClinGen gnomAD
CA10518660 rs762687456	220	S>F		No	ClinGen ExAC gnomAD
rs768152859 CA10518661	221	D>N		No	ClinGen ExAC TOPMed gnomAD
CA414675234 rs1214295570	222	M>I		No	ClinGen gnomAD
CA10518662 rs781583712	222	M>K		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	226	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414675269 rs1486033600	227	V>A		No	ClinGen gnomAD
rs1188119769 CA414675305	233	K>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA414675323 rs1277811601	235	N>S		No	ClinGen TOPMed
CA335856987 rs201682759	238	T>I		No	ClinGen TOPMed gnomAD
TCGA novel	242	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA335856988 rs1033144324	244	T>I		No	ClinGen TOPMed
rs750992266 CA10518665	246	S>F		No	ClinGen ExAC gnomAD
CA414675407 rs1422332468	248	K>E		No	ClinGen gnomAD
rs1602780008 CA414675435	251	I>S		No	ClinGen Ensembl
CA10518667 rs376757777	256	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1426641906 CA414675482	258	D>Y		No	ClinGen gnomAD
TCGA novel	262	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414676276 rs1292332155	267	E>K		No	ClinGen TOPMed
TCGA novel	282	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1602781394 CA414676410	286	E>*		No	ClinGen Ensembl
CA414676421 rs1443919026	288	I>V		No	ClinGen gnomAD
TCGA novel	289	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10518686 rs144238597	290	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1389846139 CA414676450	292	K>E		No	ClinGen TOPMed
rs777071702 CA414676465 CA10518687	294	W>R		No	ClinGen ExAC TOPMed gnomAD
CA10518688 rs759876402	294	W>S		No	ClinGen ExAC gnomAD
rs988810135 CA335857071	301	D>G		No	ClinGen TOPMed gnomAD
CA414676519 rs988810135	301	D>V		No	ClinGen TOPMed gnomAD
CA414676527 rs1223965777	302	D>V		No	ClinGen gnomAD
CA10518690 rs752904389	303	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1462866157 CA414676554	306	S>F		No	ClinGen gnomAD
CA10518692 rs764289150 COSM3405972	307	E>K	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs764289150 CA10518693	307	E>Q		No	ClinGen ExAC gnomAD
CA10518694 rs141248916	308	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs981132606 CA414676586	311	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs981132606 CA335857072	311	S>W		No	ClinGen TOPMed
rs1272580053 CA414676629	316	R>T		No	ClinGen gnomAD
TCGA novel	317	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775876961 CA10518707	319	N>S		No	ClinGen ExAC gnomAD
CA414676657 rs1335757601	320	T>A		No	ClinGen TOPMed
CA414676665 rs1267363197	321	H>P		No	ClinGen gnomAD
CA335857134 rs3210622	323	E>K		No	ClinGen Ensembl
TCGA novel	325	S>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763298386 CA10518708	327	T>A		No	ClinGen ExAC TOPMed gnomAD
rs764344025 CA10518709	328	T>A		No	ClinGen ExAC gnomAD
rs777801661 CA335857135	329	V>I		No	ClinGen TOPMed gnomAD
CA414676724 rs1477057424	330	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA335857136 rs867174020	330	R>L		No	ClinGen Ensembl
rs1166896711 CA414676739	332	K>R		No	ClinGen gnomAD
CA10518710 CA414676769 rs370089311	336	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA10518711 rs757469739	337	K>E		No	ClinGen ExAC gnomAD
rs145082590 CA414676802	341	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs145082590 CA10518712	341	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	342	A>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414676805 rs753756225	342	A>P		No	ClinGen ExAC gnomAD
rs753756225 CA10518713	342	A>T		No	ClinGen ExAC gnomAD
TCGA novel	343	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414676841 rs1476215119	345	D>G		No	ClinGen TOPMed gnomAD
CA414676840 rs1476215119	345	D>V		No	ClinGen TOPMed gnomAD
TCGA novel	346	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1384030035 CA414676853	347	V>L		No	ClinGen gnomAD
rs746451882 CA10518724	348	Q>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	355	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1245911969 CA414676906	355	M>V		No	ClinGen TOPMed
CA10518727 rs763350441	356	I>V		No	ClinGen ExAC gnomAD
rs1318778078 CA414676936	359	P>H		No	ClinGen gnomAD
CA414676943 rs1345975479	360	A>V		No	ClinGen gnomAD
TCGA novel	363	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1459258018 CA414676981	364	L>F		No	ClinGen TOPMed gnomAD
rs1459258018 CA414676979	364	L>I		No	ClinGen TOPMed gnomAD
rs1303617299 CA414676983	364	L>P		No	ClinGen gnomAD
rs1349223000 CA414677007	367	Q>R		No	ClinGen gnomAD
rs1204886939 CA414677013	368	D>G		No	ClinGen gnomAD
CA10518733 rs762060484	369	E>K		No	ClinGen ExAC TOPMed gnomAD
rs767540770 CA10518734	370	N>S		No	ClinGen ExAC gnomAD
rs371247497 CA414677038	371	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA10518736 rs759399972	376	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA335857168 rs981028398	377	A>E		No	ClinGen TOPMed gnomAD
CA414677121 rs981028398	377	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	379	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414677186 COSM75470 rs1469596591	382	E>K	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs201251228 CA10518739	386	A>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201251228 CA10518738	386	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10518740 rs777513211	388	A>G		No	ClinGen ExAC
rs769558719 CA335857171	391	A>S		No	ClinGen ExAC TOPMed gnomAD
CA10518742 rs769558719 COSM95215	391	A>T	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA10518743 rs141969228	392	C>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	393	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA335857172 rs913623944	394	G>S		No	ClinGen Ensembl
rs1453446460 CA414677340	396	T>A		No	ClinGen gnomAD
TCGA novel	396	T>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs918675999 CA335857173	399	M>V		No	ClinGen TOPMed
rs745308311 CA10518744	402	K>E		No	ClinGen ExAC TOPMed gnomAD
rs770215066 CA10518745	402	K>T		No	ClinGen ExAC gnomAD
CA10518747 rs749808677	403	L>I		No	ClinGen ExAC TOPMed gnomAD
rs751317992 CA10518758	409	K>N		No	ClinGen ExAC gnomAD
rs756862221 CA10518759	410	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA10518760 rs780838141	412	A>P		No	ClinGen ExAC gnomAD
CA335857249 COSM1715560 rs1025837586	414	E>K	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs779679751 CA414677488	415	S>C		No	ClinGen ExAC TOPMed gnomAD
rs779679751 CA414677487	415	S>F		No	ClinGen ExAC TOPMed gnomAD
rs779679751 CA10518763	415	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA335857250 rs149095600	416	P>S		No	ClinGen ESP

No associated diseases with Q9P289

1 regional properties for Q9P289

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	61 - 308	IPR000719

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Golgi apparatus	Colocalized with RIPOR1 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with RIPOR1 upon serum stimulation in a Rho- and PDCD10-dependent manner (PubMed:27807006)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

10 GO annotations of cellular component

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
cell periphery	The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi-associated vesicle	Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
vesicle membrane	The lipid bilayer surrounding any membrane-bounded vesicle in the cell.

7 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding	Binding to an identical protein or proteins.
magnesium ion binding	Binding to a magnesium (Mg) ion.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

9 GO annotations of biological process

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cellular response to starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
microvillus assembly	Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.
negative regulation of cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of apoptotic process	Any process that modulates the occurrence or rate of cell death by apoptotic process.
regulation of hydrogen peroxide-induced cell death	Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced cell death.
response to hydrogen peroxide	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

19 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3SWY6	STK25	Serine/threonine-protein kinase 25	Bos taurus (Bovine)	PR
P41279	MAP3K8	Mitogen-activated protein kinase kinase kinase 8	Homo sapiens (Human)	EV
Q9H2G2	SLK	STE20-like serine/threonine-protein kinase	Homo sapiens (Human)	PR
O94804	STK10	Serine/threonine-protein kinase 10	Homo sapiens (Human)	PR
O95747	OXSR1	Serine/threonine-protein kinase OSR1	Homo sapiens (Human)	PR
Q9UEW8	STK39	STE20/SPS1-related proline-alanine-rich protein kinase	Homo sapiens (Human)	PR
Q9Y4K4	MAP4K5	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (Human)	PR
Q92918	MAP4K1	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (Human)	EV
Q12851	MAP4K2	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (Human)	EV
Q8IVH8	MAP4K3	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (Human)	SS
Q9Y6E0	STK24	Serine/threonine-protein kinase 24	Homo sapiens (Human)	PR
O00506	STK25	Serine/threonine-protein kinase 25	Homo sapiens (Human)	PR
Q07174	Map3k8	Mitogen-activated protein kinase kinase kinase 8	Mus musculus (Mouse)	SS
Q9Z2W1	Stk25	Serine/threonine-protein kinase 25	Mus musculus (Mouse)	PR
Q99KH8	Stk24	Serine/threonine-protein kinase 24	Mus musculus (Mouse)	PR
Q99JT2	Stk26	Serine/threonine-protein kinase 26	Mus musculus (Mouse)	PR
Q63562	Map3k8	Mitogen-activated protein kinase kinase kinase 8	Rattus norvegicus (Rat)	SS
B0LT89	Stk24	Serine/threonine-protein kinase 24	Rattus norvegicus (Rat)	PR
H2L099	gck-1	Germinal center kinase 1	Caenorhabditis elegans	PR

10	20	30	40	50	60
MAHSPVAVQV	PGMQNNIADP	EELFTKLERI	GKGSFGEVFK	GIDNRTQQVV	AIKIIDLEEA
70	80	90	100	110	120
EDEIEDIQQE	ITVLSQCDSS	YVTKYYGSYL	KGSKLWIIME	YLGGGSALDL	LRAGPFDEFQ
130	140	150	160	170	180
IATMLKEILK	GLDYLHSEKK	IHRDIKAANV	LLSEQGDVKL	ADFGVAGQLT	DTQIKRNTFV
190	200	210	220	230	240
GTPFWMAPEV	IQQSAYDSKA	DIWSLGITAI	ELAKGEPPNS	DMHPMRVLFL	IPKNNPPTLV
250	260	270	280	290	300
GDFTKSFKEF	IDACLNKDPS	FRPTAKELLK	HKFIVKNSKK	TSYLTELIDR	FKRWKAEGHS
310	320	330	340	350	360
DDESDSEGSD	SESTSRENNT	HPEWSFTTVR	KKPDPKKVQN	GAEQDLVQTL	SCLSMIITPA
370	380	390	400	410
FAELKQQDEN	NASRNQAIEE	LEKSIAVAEA	ACPGITDKMV	KKLIEKFQKC	SADESP