AiPD: Autoinhibited Protein Database

Q9P246

Gene name	STIM2 (KIAA1482)
Protein name	Stromal interaction molecule 2
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:57620
EC number
Protein Class	STROMAL INTERACTION MOLECULE HOMOLOG (PTHR15136)

Descriptions

STIM2 plays a role in mediating store-operated Ca2+ entry (SOCE), a Ca2+ influx following depletion of intracellular Ca2+ stores and functions as a highly sensitive Ca2+ sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca2+-influx. EF-SAM in STIM2 regulates CRAC channels through a divergent balance between EF-hand Ca2+ affinity and SAM domain stability. The Ca2+-binding EF-hand and SAM domain are major contributors to the autoinhibition of oligomerization in each respective isoform.

Autoinhibitory domains (AIDs)

Target domain	345-445 (SOAR domain)
Relief mechanism	Others
Assay	Deletion assay, Structural analysis

AID

67-204 (EF-SAM domain)

Target domain

345-445 (SOAR domain)

Relief mechanism

Others (Dissociation of Ca2+ ion from EF hands)

Assay

Deletion assay, Structural analysis

Accessory elements

No accessory elements

References

Zheng L et al. (2011) "Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry", Proceedings of the National Academy of Sciences of the United States of America, 108, 1337-42

Korzeniowski MK et al. (2010) "Activation of STIM1-Orai1 involves an intramolecular switching mechanism", Science signaling, 3, ra82

Autoinhibited structure

Activated structure

2 structures for Q9P246

Entry ID	Method	Resolution	Chain	Position	Source
2L5Y	NMR	-	A	62-205	PDB
AF-Q9P246-F1	Predicted				AlphaFoldDB

501 variants for Q9P246

Variant ID(s)	Position	Change	Diseaes Association	Provenance
CA2882569 rs764210656	2	L>P	No	ClinGen ExAC gnomAD
rs992266576 CA94424728	5	G>W	No	ClinGen TOPMed
rs751772322 CA2882570	8	V>A	No	ClinGen ExAC TOPMed gnomAD
rs1410817385 CA356676217	8	V>L	No	ClinGen gnomAD
CA356676235 rs1402287719	11	A>E	No	ClinGen gnomAD
CA356676237 rs1402287719	11	A>V	No	ClinGen gnomAD
rs779833394 CA2882572	12	A>T	No	ClinGen ExAC gnomAD
rs1352750063 CA356676258	15	C>R	No	ClinGen gnomAD
rs1288092910 CA356676274	17	L>V	No	ClinGen gnomAD
CA2882576 rs754897368	19	P>L	No	ClinGen ExAC TOPMed gnomAD
CA2882575 rs754897368	19	P>R	No	ClinGen ExAC TOPMed gnomAD
CA356676289 rs1344332903	20	R>G	No	ClinGen TOPMed gnomAD
rs1344332903 CA356676290	20	R>W	No	ClinGen TOPMed gnomAD
rs757966871 CA94424731	21	H>N	No	ClinGen ExAC TOPMed gnomAD
CA2882579 rs777492101	21	H>Q	No	ClinGen ExAC TOPMed gnomAD
CA2882578 rs757966871	21	H>Y	No	ClinGen ExAC TOPMed gnomAD
CA2882580 rs746591670	23	R>H	No	ClinGen ExAC TOPMed gnomAD
CA94424732 rs746591670	23	R>L	No	ClinGen ExAC TOPMed gnomAD
rs1249541056 CA356676311	24	G>R	No	ClinGen gnomAD
CA356676324 rs1185591183	26	R>P	No	ClinGen gnomAD
rs1423104391 CA356676328	27	A>E	No	ClinGen TOPMed
CA356676336 rs1437307687	28	T>I	No	ClinGen TOPMed
CA356676348 rs1469583500	30	S>F	No	ClinGen TOPMed
rs1377710819 CA356676350	31	A>P	No	ClinGen gnomAD
CA356676355 rs1171166084	32	A>T	No	ClinGen TOPMed gnomAD
CA2882583 rs746247493	32	A>V	No	ClinGen ExAC TOPMed gnomAD
CA94424736 rs989163908	35	A>S	No	ClinGen TOPMed
CA94424737 rs555325789	35	A>V	No	ClinGen 1000Genomes gnomAD
rs770231794 CA2882584	36	S>F	No	ClinGen ExAC TOPMed gnomAD
CA94424740 rs1033660341	37	S>A	No	ClinGen TOPMed
CA94424739 rs1033660341	37	S>P	No	ClinGen TOPMed
CA356676390 rs1388759897	38	P>L	No	ClinGen gnomAD
CA356676386 rs1291515169	38	P>S	No	ClinGen TOPMed
rs1014057458 CA94424741	39	A>S	No	ClinGen TOPMed gnomAD
rs1014057458 CA356676391	39	A>T	No	ClinGen TOPMed gnomAD
rs572134717 CA94424743	40	A>S	No	ClinGen 1000Genomes TOPMed gnomAD
rs572134717 CA94424742	40	A>T	No	ClinGen 1000Genomes TOPMed gnomAD
rs978458090 CA94424744	40	A>V	No	ClinGen TOPMed
CA356676404 rs1276833697	41	A>V	No	ClinGen gnomAD
rs1205777827 CA356676407	42	A>T	No	ClinGen gnomAD
rs1193796376 CA356676414	43	G>D	No	ClinGen TOPMed
rs1250553612 CA356676419	44	D>G	No	ClinGen gnomAD
rs778412917 CA94424745	44	D>H	No	ClinGen TOPMed
rs778412917 CA94424746	44	D>Y	No	ClinGen TOPMed
CA356676436 rs1560546233	46	P>L	No	ClinGen Ensembl
CA94424747 rs966906039	47	A>T	No	ClinGen TOPMed gnomAD
rs775840841 CA2882585	48	L>F	No	ClinGen ExAC TOPMed gnomAD
CA2882586 rs763511783	49	M>L	No	ClinGen ExAC
CA2882599 rs373220365	51	D>E	No	ClinGen ESP ExAC TOPMed gnomAD
rs1294709028 CA356675859	51	D>V	No	ClinGen gnomAD
CA2882600 rs758413160	54	M>R	No	ClinGen ExAC gnomAD
rs777357647 CA2882601	57	S>C	No	ClinGen ExAC TOPMed gnomAD
rs565106502 CA2882602	57	S>N	No	ClinGen 1000Genomes ExAC gnomAD
CA2882603 rs756891715	58	P>L	No	ClinGen ExAC gnomAD
CA2882605 rs745586309	59	P>A	No	ClinGen ExAC gnomAD
CA2882606 rs745586309	59	P>S	No	ClinGen ExAC gnomAD
rs775904809 CA2882607	62	T>I	No	ClinGen ExAC gnomAD
CA2882608 rs749732490	63	E>K	No	ClinGen ExAC gnomAD
CA356675944 rs1272128982	64	E>D	No	ClinGen TOPMed
rs769165474 CA2882609	68	S>N	No	ClinGen ExAC gnomAD
CA356675980 rs1322738764	69	L>R	No	ClinGen gnomAD
CA356676007 rs767677334	73	Q>H	No	ClinGen ExAC TOPMed gnomAD
rs761022239 CA2882614	76	H>Q	No	ClinGen ExAC gnomAD
CA356676026 rs1229958452	76	H>R	No	ClinGen gnomAD
CA356676042 rs1231100522	78	Q>L	No	ClinGen gnomAD
CA356676058 rs1409698484	80	D>G	No	ClinGen TOPMed
rs1269589764 CA356676062	81	D>N	No	ClinGen gnomAD
CA94431321 rs554858949	86	G>E	No	ClinGen Ensembl
CA356676165 rs1465047025	94	E>D	No	ClinGen TOPMed gnomAD
CA2882634 rs760750420	96	I>F	No	ClinGen ExAC gnomAD
CA94435113 rs940991778	101	K>R	No	ClinGen TOPMed
CA356676550 rs1427385290	104	D>G	No	ClinGen gnomAD
rs1175646259 CA356676546	104	D>N	No	ClinGen gnomAD
CA356676561 rs1217129195	106	T>A	No	ClinGen gnomAD
CA356676586 rs1481845294	109	H>R	No	ClinGen TOPMed
CA2882635 rs771297230	111	H>R	No	ClinGen ExAC gnomAD
CA356676633 rs1374832328	116	D>N	No	ClinGen gnomAD
rs1336056224 CA356676653	118	H>R	No	ClinGen TOPMed gnomAD
CA356676658 rs1277356845	119	I>V	No	ClinGen gnomAD
rs1292582185 CA356676669	120	T>M	No	ClinGen TOPMed
rs1358771017 CA356676671	121	I>V	No	ClinGen TOPMed
CA356676678 rs1278977074	122	E>Q	No	ClinGen gnomAD
CA356676718 rs1275818660	127	R>*	No	ClinGen gnomAD
rs761878747 CA2882640	127	R>Q	No	ClinGen ExAC
rs1179969347 CA356676741	130	T>I	No	ClinGen gnomAD
rs971300045 CA94435117	132	E>K	No	ClinGen TOPMed gnomAD
CA2882657 rs768569978	134	H>L	No	ClinGen ExAC gnomAD
rs1560233787 CA356581761	134	H>N	No	ClinGen Ensembl
rs768569978 CA2882658	134	H>R	No	ClinGen ExAC gnomAD
CA2882660 rs143071033	139	E>K	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs148199305 CA2882661	140	D>A	No	ClinGen ESP ExAC gnomAD
CA2882662 rs148199305	140	D>G	No	ClinGen ESP ExAC gnomAD
rs1166007773 CA356581805	140	D>Y	No	ClinGen gnomAD
rs993011869 CA93710244	141	T>A	No	ClinGen TOPMed
CA93710246 rs371543285	143	Q>H	No	ClinGen ESP TOPMed
CA2882663 rs375787750	146	I>V	No	ClinGen ESP ExAC TOPMed gnomAD
rs372691474 CA2882664	152	P>A	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1225876473 CA356581907	155	E>A	No	ClinGen gnomAD
CA2882668 rs758791089	155	E>K	No	ClinGen ExAC TOPMed gnomAD
CA93710258 rs566478508	156	K>N	No	ClinGen gnomAD
CA2882669 rs778308298	157	N>K	No	ClinGen ExAC gnomAD
CA2882670 rs369386905	159	R>I	No	ClinGen ESP ExAC TOPMed gnomAD
rs1369641381 CA356581941	160	D>H	No	ClinGen TOPMed gnomAD
CA356581948 rs1560233864	161	N>H	No	ClinGen Ensembl
CA2882672 rs372734758	162	N>H	No	ClinGen ESP ExAC TOPMed gnomAD
rs1205845580 CA356581960	162	N>S	No	ClinGen TOPMed gnomAD
CA356581967 rs1446361993	163	V>A	No	ClinGen gnomAD
rs1190862846 CA356581975	164	K>N	No	ClinGen TOPMed gnomAD
rs140208879 CA2882674	166	T>A	No	ClinGen ESP ExAC TOPMed gnomAD
CA2882675 rs560356253	166	T>M	No	ClinGen 1000Genomes ExAC gnomAD
rs1415271295 CA356582000	169	P>A	No	ClinGen gnomAD
rs1051823993 CA93710956	173	V>A	No	ClinGen Ensembl
rs999271692 CA93710959	175	E>G	No	ClinGen gnomAD
rs776078709 CA2882706	175	E>K	No	ClinGen ExAC gnomAD
CA2882708 rs764698334	176	P>H	No	ClinGen ExAC gnomAD
CA356582094 rs1481467127	178	F>C	No	ClinGen gnomAD
rs142156031 CA93710962	179	M>I	No	ClinGen TOPMed gnomAD
rs142156031 CA356582105	179	M>I	No	ClinGen TOPMed gnomAD
CA2882710 rs139037227	181	S>Y	No	ClinGen ESP ExAC TOPMed gnomAD
rs1173415174 CA356582141	182	Q>R	No	ClinGen TOPMed
rs1560235216 CA356582176	185	I>T	No	ClinGen Ensembl
CA2882711 rs764455082	185	I>V	No	ClinGen ExAC gnomAD
rs369379067 CA93710967	186	S>N	No	ClinGen ESP
rs1414376640 CA356582208	187	D>E	No	ClinGen TOPMed
CA2882713 rs762364163	188	R>Q	No	ClinGen ExAC gnomAD
CA2882712 rs373462253	188	R>W	No	ClinGen ESP ExAC TOPMed gnomAD
CA356582280 rs1462849538	194	L>F	No	ClinGen gnomAD
CA2882715 rs751007560	198	A>T	No	ClinGen ExAC gnomAD
rs756197716 CA93710972	200	D>H	No	ClinGen ExAC TOPMed gnomAD
CA2882716 rs756197716	200	D>N	No	ClinGen ExAC TOPMed gnomAD
rs755167041 CA2882719	209	R>C	No	ClinGen ExAC gnomAD
CA93711455 rs745860886	209	R>H	No	ClinGen Ensembl
rs1234782360 CA356582654	210	P>T	No	ClinGen gnomAD
rs753883702 CA356582661	211	P>A	No	ClinGen ExAC TOPMed gnomAD
CA2882738 rs753883702	211	P>S	No	ClinGen ExAC TOPMed gnomAD
rs372680108 CA2882739	212	H>R	No	ClinGen ESP ExAC gnomAD
rs1328871866 CA356582667	212	H>Y	No	ClinGen TOPMed
CA2882740 rs779075717	213	N>T	No	ClinGen ExAC TOPMed gnomAD
rs752966483 CA2882741	214	W>R	No	ClinGen ExAC gnomAD
CA2882742 rs757028333	215	M>L	No	ClinGen ExAC gnomAD
CA2882743 rs781028780	216	K>E	No	ClinGen ExAC gnomAD
rs930809838 CA93711462	218	F>V	No	ClinGen TOPMed gnomAD
CA356582719 rs1417477000	219	I>F	No	ClinGen TOPMed gnomAD
rs779571203 CA2882746	222	V>I	No	ClinGen ExAC TOPMed gnomAD
rs1159656766 CA356582762	223	S>F	No	ClinGen TOPMed
rs748783981 CA2882747	224	I>M	No	ClinGen ExAC TOPMed gnomAD
rs1471358856 CA356582772	224	I>T	No	ClinGen TOPMed
rs1431411849 CA356582768	224	I>V	No	ClinGen gnomAD
CA2882748 rs768256503	225	V>L	No	ClinGen ExAC gnomAD
rs774125124 CA2882749	227	G>C	No	ClinGen ExAC gnomAD
rs747870723 CA2882750	228	V>A	No	ClinGen ExAC TOPMed gnomAD
rs1293664127 CA356582815	228	V>I	No	ClinGen gnomAD
CA2882751 rs772563282	232	W>L	No	ClinGen ExAC TOPMed gnomAD
rs112506864 CA93711468	232	W>R	No	ClinGen Ensembl
rs201149830 CA2882753	236	T>M	No	ClinGen ExAC TOPMed gnomAD
CA2882754 rs766823545	238	N>S	No	ClinGen ExAC gnomAD
rs1189169289 CA356582978	241	S>A	No	ClinGen gnomAD
rs759508445 CA2882756	244	H>R	No	ClinGen ExAC gnomAD
rs542227268 CA2882757	245	V>I	No	ClinGen 1000Genomes ExAC gnomAD
CA356583055 rs1486841089	247	K>T	No	ClinGen gnomAD
CA356583086 rs1484981361	249	M>V	No	ClinGen Ensembl
CA2882759 rs752911443	250	K>E	No	ClinGen ExAC gnomAD
rs752911443 CA356583103	250	K>Q	No	ClinGen ExAC gnomAD
CA2882760 rs376945466	251	D>E	No	ClinGen ESP ExAC TOPMed gnomAD
rs767240785 CA2882761	252	L>V	No	ClinGen ExAC gnomAD
CA2882762 rs750210211	254	S>T	No	ClinGen ExAC gnomAD
CA93711481 rs1014548714	263	M>V	No	ClinGen TOPMed
rs1374558417 CA356583303	264	D>Y	No	ClinGen gnomAD
rs10028164 CA356583322	266	Q>H	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs10028164 CA356583323	266	Q>H	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA356583330 rs754526763	267	E>D	No	ClinGen ExAC TOPMed gnomAD
CA2882766 rs754526763	267	E>D	No	ClinGen ExAC TOPMed gnomAD
CA2882767 rs778635997	268	R>K	No	ClinGen ExAC gnomAD
CA2882793 rs746314754	272	A>T	No	ClinGen ExAC gnomAD
CA93711581 rs567187564	272	A>V	No	ClinGen TOPMed
rs770306430 CA2882794	273	Q>E	No	ClinGen ExAC gnomAD
rs1419885417 CA356583445	274	E>G	No	ClinGen gnomAD
CA93711584 rs113460656	276	N>D	No	ClinGen Ensembl
CA356583479 rs1214829679	276	N>K	No	ClinGen TOPMed
CA356583503 rs1409026680	278	N>S	No	ClinGen gnomAD
rs762990114 CA2882796	281	V>I	No	ClinGen ExAC TOPMed gnomAD
rs950184397 CA93711588	285	N>I	No	ClinGen TOPMed
rs773097725 CA2882799	288	R>C	No	ClinGen ExAC TOPMed gnomAD
rs138261553 CA356583633	288	R>H	No	ClinGen ESP ExAC TOPMed gnomAD
rs138261553 CA2882800	288	R>L	No	ClinGen ESP ExAC TOPMed gnomAD
CA93711592 rs867051196	289	K>R	No	ClinGen Ensembl
CA2882801 rs753683702	291	M>L	No	ClinGen ExAC TOPMed gnomAD
CA2882802 rs759501224	295	N>S	No	ClinGen ExAC TOPMed gnomAD
rs765233222 CA2882803	296	Y>S	No	ClinGen ExAC gnomAD
CA2882804 rs149592017	298	K>E	No	ClinGen ESP ExAC TOPMed gnomAD
CA2882805 rs757964892	301	A>D	No	ClinGen ExAC TOPMed gnomAD
CA356583808 rs757964892	301	A>V	No	ClinGen ExAC TOPMed gnomAD
CA93711597 rs144272871	302	C>R	No	ClinGen ESP gnomAD
CA93711600 rs973703044	303	R>Q	No	ClinGen TOPMed gnomAD
rs148718801 CA2882806	303	R>W	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA93711601 rs919706738	309	E>K	No	ClinGen gnomAD
rs1168234354 CA356583915	312	E>Q	No	ClinGen gnomAD
CA356583949 rs1350400155	314	E>G	No	ClinGen TOPMed gnomAD
CA356583971 rs1258712023	316	S>C	No	ClinGen TOPMed
CA2882807 rs751106460	316	S>N	No	ClinGen ExAC gnomAD
rs756946958 CA2882808	318	R>H	No	ClinGen ExAC TOPMed gnomAD
CA356583997 rs1212042646	318	R>S	No	ClinGen gnomAD
CA356584014 rs1577490960	320	Y>F	No	ClinGen Ensembl
CA2882809 rs781361800	322	E>K	No	ClinGen ExAC gnomAD
CA2882810 rs375152155	325	L>S	No	ClinGen ESP ExAC gnomAD
rs752672938 CA2882830	329	R>C	No	ClinGen ExAC gnomAD
CA93712343 rs748529061	329	R>H	No	ClinGen ExAC gnomAD
rs748529061 CA2882831	329	R>L	No	ClinGen ExAC gnomAD
rs780868761 CA356584092	330	M>K	No	ClinGen ExAC gnomAD
rs751101903 CA2882834	330	M>L	No	ClinGen ExAC TOPMed gnomAD
CA2882835 rs780868761	330	M>T	No	ClinGen ExAC gnomAD
rs751101903 CA2882833	330	M>V	No	ClinGen ExAC TOPMed gnomAD
CA2882836 rs750126977	334	K>M	No	ClinGen ExAC gnomAD
rs780464550 CA2882838	338	E>D	No	ClinGen ExAC gnomAD
rs749732722 CA356584225	344	S>N	No	ClinGen ExAC TOPMed gnomAD
CA2882839 rs749732722	344	S>T	No	ClinGen ExAC TOPMed gnomAD
rs755526664 CA2882840	347	V>F	No	ClinGen ExAC TOPMed gnomAD
rs755526664 CA356584263	347	V>L	No	ClinGen ExAC TOPMed gnomAD
CA2882841 rs778812591	348	P>A	No	ClinGen ExAC gnomAD
CA93712364 rs983470433	348	P>L	No	ClinGen Ensembl
CA356584272 rs778812591	348	P>S	No	ClinGen ExAC gnomAD
CA356584367 rs1399825261	355	L>P	No	ClinGen gnomAD
rs1313575558 CA356584431	364	Q>L	No	ClinGen TOPMed
rs373574051 CA2882846	367	N>S	No	ClinGen ExAC TOPMed gnomAD
rs1218101115 CA356584483	371	Q>R	No	ClinGen TOPMed
rs772994756 CA93712374	375	M>K	No	ClinGen Ensembl
rs764121949 CA2882850	378	A>V	No	ClinGen ExAC gnomAD
CA2882852 rs761365736	379	I>V	No	ClinGen ExAC TOPMed gnomAD
CA356584541 rs1374696249	380	A>T	No	ClinGen gnomAD
CA356584650 rs1197761442	385	E>K	No	ClinGen gnomAD
rs1234681038 CA356584689	390	K>Q	No	ClinGen gnomAD
rs758838287 CA2882878	391	R>S	No	ClinGen ExAC gnomAD
CA2882879 rs777950063	392	S>N	No	ClinGen ExAC gnomAD
rs781540546 CA2882882	394	V>G	No	ClinGen ExAC gnomAD
CA93712572 rs914869530	399	H>R	No	ClinGen Ensembl
rs748063907 CA2882886	400	V>I	No	ClinGen ExAC TOPMed gnomAD
rs751622285 CA93712578	404	S>C	No	ClinGen Ensembl
CA356584790 rs1473423294	405	S>F	No	ClinGen TOPMed
CA93712588 rs927372951	411	H>Y	No	ClinGen TOPMed
rs1185888570 CA356584834	412	K>E	No	ClinGen TOPMed
rs760150725 CA2882889	416	A>T	No	ClinGen ExAC gnomAD
rs1378370698 CA356584884	417	K>N	No	ClinGen gnomAD
CA2882905 rs556465364	418	K>R	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA356584914 rs1413114673	422	E>Q	No	ClinGen TOPMed
CA93712635 rs111334428	423	L>S	No	ClinGen Ensembl
rs777668521 CA2882907	425	T>A	No	ClinGen ExAC gnomAD
CA2882908 rs747013033	428	R>Q	No	ClinGen ExAC TOPMed gnomAD
CA93712641 rs191916227	429	E>A	No	ClinGen 1000Genomes
rs1299400467 CA356584964	430	R>*	No	ClinGen gnomAD
rs1376934772 CA356584965	430	R>Q	No	ClinGen gnomAD
CA2882909 rs770359539	433	R>H	No	ClinGen ExAC gnomAD
CA2882910 rs770359539	433	R>L	No	ClinGen ExAC gnomAD
rs866045652 CA93712647	434	W>*	No	ClinGen Ensembl
rs1018897804 CA93712650	436	Q>L	No	ClinGen gnomAD
rs1350652603 CA356585036	440	I>T	No	ClinGen gnomAD
CA356585059 rs1407601779	443	F>L	No	ClinGen TOPMed
rs763385147 CA356585071	445	I>K	No	ClinGen ExAC gnomAD
rs763385147 CA2882914	445	I>R	No	ClinGen ExAC gnomAD
CA2882913 rs748731448	445	I>V	No	ClinGen ExAC TOPMed gnomAD
CA356585077 rs1241542938	446	A>D	No	ClinGen gnomAD
CA2882915 rs140811417	447	H>R	No	ClinGen ESP ExAC TOPMed gnomAD
rs1457401458 CA356585135	455	T>N	No	ClinGen gnomAD
rs767577020 CA2882918	456	S>F	No	ClinGen ExAC gnomAD
CA2882919 rs149693330	458	L>F	No	ClinGen ESP ExAC TOPMed gnomAD
CA2882920 rs756324326	460	S>C	No	ClinGen ExAC gnomAD
rs374862281 CA2882921	461	D>H	No	ClinGen ESP ExAC TOPMed gnomAD
rs1172038648 CA356585186	463	S>T	No	ClinGen gnomAD
CA2882922 rs754112174	464	W>R	No	ClinGen ExAC TOPMed gnomAD
CA93712669 rs980528029	467	M>I	No	ClinGen TOPMed gnomAD
CA93712667 rs535251864	467	M>R	No	ClinGen 1000Genomes
rs777545959 CA2882924	473	P>A	No	ClinGen ExAC gnomAD
rs369199067 CA2882925	475	Y>C	No	ClinGen ESP ExAC TOPMed gnomAD
CA356585263 rs369199067	475	Y>S	No	ClinGen ESP ExAC TOPMed gnomAD
CA356585272 rs1365878161	476	P>L	No	ClinGen gnomAD
rs1274039178 CA356585277	477	I>N	No	ClinGen gnomAD
CA2882926 rs200776417	477	I>V	No	ClinGen ESP ExAC TOPMed gnomAD
CA356585281 rs1420505485	478	A>S	No	ClinGen TOPMed gnomAD
rs1469774300 CA356585301	481	V>A	No	ClinGen gnomAD
CA356585299 rs1275052726	481	V>F	No	ClinGen TOPMed gnomAD
CA356585297 rs1275052726	481	V>I	No	ClinGen TOPMed gnomAD
CA356585315 rs1245946250	483	D>G	No	ClinGen gnomAD
CA2882930 rs774991626	485	D>G	No	ClinGen ExAC TOPMed gnomAD
rs1435151450 CA356585354	488	T>I	No	ClinGen TOPMed
CA93712689 rs952660796	489	P>L	No	ClinGen TOPMed
CA2882932 rs182507259	491	I>V	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs145490820 CA93712693	492	V>A	No	ClinGen ESP TOPMed
CA93712694 rs112062184	493	S>P	No	ClinGen Ensembl
CA356585382 rs1453660749	494	Q>K	No	ClinGen TOPMed
rs1167923982 CA356585386	494	Q>R	No	ClinGen gnomAD
CA356585403 rs1484799725	496	P>L	No	ClinGen TOPMed
rs778329352 CA2882934	497	G>R	No	ClinGen ExAC TOPMed gnomAD
CA356585421 rs1577500206	498	T>P	No	ClinGen Ensembl
rs1311375416 CA356585431	499	M>T	No	ClinGen TOPMed
rs1434493275 CA356585440	500	A>G	No	ClinGen TOPMed
CA356585448 rs1560242098	501	K>N	No	ClinGen Ensembl
CA356585452 rs1293024276	502	P>S	No	ClinGen gnomAD
CA93714165 rs1032065039	504	G>E	No	ClinGen TOPMed
rs1197872025 CA356585470	505	S>L	No	ClinGen Ensembl
CA2882951 rs113180595	506	L>I	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA356585475 rs1408254584	506	L>S	No	ClinGen TOPMed
CA2882952 rs774818363	507	A>D	No	ClinGen ExAC gnomAD
rs910661162 CA93714170	510	S>G	No	ClinGen TOPMed
rs772541032 CA2882954	510	S>T	No	ClinGen ExAC gnomAD
CA2882955 rs773582601	514	R>C	No	ClinGen ExAC TOPMed gnomAD
rs1049239912 CA93714173	514	R>H	No	ClinGen TOPMed gnomAD
CA2882956 rs761245104	516	R>C	No	ClinGen ExAC TOPMed gnomAD
CA2882957 rs140734561	516	R>H	No	ClinGen ESP ExAC gnomAD
CA2882958 rs760297373	517	R>C	No	ClinGen ExAC TOPMed gnomAD
CA356585542 rs760297373	517	R>G	No	ClinGen ExAC TOPMed gnomAD
CA2882959 rs73251774	517	R>H	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA356585550 rs1366142873	518	S>I	No	ClinGen gnomAD
CA2882961 rs765413572	520	V>L	No	ClinGen ExAC gnomAD
rs765413572 CA356585560	520	V>M	No	ClinGen ExAC gnomAD
rs761253528 CA2882963	521	P>L	No	ClinGen ExAC TOPMed gnomAD
CA2882964 rs761253528	521	P>Q	No	ClinGen ExAC TOPMed gnomAD
rs752964490 CA2882962	521	P>S	No	ClinGen ExAC TOPMed gnomAD
CA356585572 rs1418309193	522	S>C	No	ClinGen gnomAD
CA2882966 rs370564030	523	S>P	No	ClinGen ESP ExAC TOPMed gnomAD
CA2882968 rs753432538	524	P>S	No	ClinGen ExAC TOPMed gnomAD
rs1337563225 CA356585588	525	Q>R	No	ClinGen gnomAD
CA2882970 rs754578090	528	R>*	No	ClinGen ExAC TOPMed gnomAD
CA2882969 rs754578090	528	R>G	No	ClinGen ExAC TOPMed gnomAD
rs141922019 CA2882971	528	R>L	No	ClinGen ESP ExAC gnomAD
rs141922019 CA93714185	528	R>Q	No	ClinGen ESP ExAC gnomAD
CA93714187 rs1020888544	529	A>V	No	ClinGen TOPMed gnomAD
rs1237769649 CA356585616	530	Q>R	No	ClinGen gnomAD
CA356585625 rs1257467789	531	L>P	No	ClinGen gnomAD
rs1345297103 CA356585628	532	A>S	No	ClinGen gnomAD
CA2882973 rs778209965	533	P>L	No	ClinGen ExAC gnomAD
CA2882972 rs559835870	533	P>S	No	ClinGen 1000Genomes ExAC
CA356585639 rs1407185854	534	H>P	No	ClinGen TOPMed
CA2882975 rs150222188	534	H>Q	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA356585640 rs1407185854	534	H>R	No	ClinGen TOPMed
rs1178692719 CA356585645	535	A>D	No	ClinGen TOPMed gnomAD
CA356585646 rs1178692719	535	A>G	No	ClinGen TOPMed gnomAD
CA2882976 rs551838879	535	A>T	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA356585652 rs571663629	536	P>H	No	ClinGen 1000Genomes ExAC gnomAD
CA2882977 rs571663629	536	P>R	No	ClinGen 1000Genomes ExAC gnomAD
CA2882980 rs150975796	537	H>D	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA356585654 rs1577500383	537	H>P	No	ClinGen Ensembl
CA2882979 rs150975796	537	H>Y	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs767160624 CA2882981	538	P>A	No	ClinGen ExAC gnomAD
CA2882982 rs200847867	538	P>L	No	ClinGen ESP ExAC TOPMed gnomAD
rs747029301 CA93714198	540	H>Y	No	ClinGen gnomAD
rs766389217 CA2882984	541	P>L	No	ClinGen ExAC TOPMed gnomAD
CA2882986 rs143107481	542	R>Q	No	ClinGen ESP ExAC TOPMed gnomAD
CA2882985 rs753878084	542	R>W	No	ClinGen ExAC TOPMed gnomAD
CA356585687 rs1560242297	543	H>P	No	ClinGen Ensembl
CA2882988 rs778636017	547	P>L	No	ClinGen ExAC TOPMed gnomAD
rs778636017 CA2882987	547	P>Q	No	ClinGen ExAC TOPMed gnomAD
rs371154629 CA2882990	548	Q>R	No	ClinGen ESP ExAC gnomAD
CA2882992 rs139856611	551	P>L	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA93714205 rs1031951403	551	P>S	No	ClinGen TOPMed
rs781654147 CA2882993	552	H>L	No	ClinGen ExAC TOPMed gnomAD
rs1198800157 CA356585755	553	S>F	No	ClinGen gnomAD
CA2882995 rs144093498	556	S>F	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA93714210 rs764914346	557	P>A	No	ClinGen gnomAD
CA2882997 rs763036602	558	D>H	No	ClinGen ExAC gnomAD
CA356585786 rs768955451	559	P>S	No	ClinGen ExAC TOPMed gnomAD
rs768955451 CA2882998	559	P>T	No	ClinGen ExAC TOPMed gnomAD
rs1370209711 CA356585792	560	D>H	No	ClinGen gnomAD
rs774478254 CA2882999	561	I>T	No	ClinGen ExAC gnomAD
rs758210883 CA93714215	563	S>L	No	ClinGen Ensembl
CA356585816 rs1170070824	564	V>M	No	ClinGen gnomAD
CA2883001 rs766337823	565	S>*	No	ClinGen ExAC gnomAD
CA2883002 rs776710635	566	S>R	No	ClinGen ExAC gnomAD
CA2883004 rs764787780	569	A>V	No	ClinGen ExAC TOPMed gnomAD
rs757883766 CA2883006	571	Y>F	No	ClinGen ExAC TOPMed gnomAD
rs763776616 CA2883007	572	R>L	No	ClinGen ExAC TOPMed gnomAD
rs763776616 CA356585868	572	R>Q	No	ClinGen ExAC TOPMed gnomAD
rs751227260 CA2883008	573	N>S	No	ClinGen ExAC gnomAD
CA356585877 rs1223091860	574	E>K	No	ClinGen gnomAD
CA356585889 rs1212538915	575	E>G	No	ClinGen TOPMed
rs943520700 CA93714223	577	E>K	No	ClinGen Ensembl
CA356585908 rs1488436619	578	E>K	No	ClinGen gnomAD
rs1553855805 CA356585919	579	A>D	No	ClinGen Ensembl
rs1265717828 CA356585917	579	A>P	No	ClinGen TOPMed gnomAD
rs1265717828 CA356585916	579	A>T	No	ClinGen TOPMed gnomAD
rs1396016056 CA356585939	582	F>L	No	ClinGen gnomAD
rs756638003 CA2883012	583	S>F	No	ClinGen ExAC TOPMed gnomAD
CA356585959 rs1193166572	585	E>A	No	ClinGen gnomAD
CA2883052 rs761015663	589	E>G	No	ClinGen ExAC gnomAD
CA93714963 rs895651219	589	E>K	No	ClinGen Ensembl
CA2883054 rs754307203	593	T>R	No	ClinGen ExAC gnomAD
rs755457280 CA2883055	596	E>K	No	ClinGen ExAC gnomAD
rs779007168 CA2883056	596	E>V	No	ClinGen ExAC gnomAD
CA93714969 rs554839491	597	C>R	No	ClinGen 1000Genomes
rs752789594 CA2883057	598	D>G	No	ClinGen ExAC gnomAD
rs138416647 CA2883058	599	S>F	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs778125021 CA2883059	600	L>F	No	ClinGen ExAC
CA93714974 rs898850102	602	S>Y	No	ClinGen Ensembl
rs151194488 CA2883062	603	S>P	No	ClinGen ESP ExAC TOPMed gnomAD
rs200782524 CA2883063	605	G>R	No	ClinGen ESP ExAC TOPMed gnomAD
CA356586726 rs1319279915	605	G>V	No	ClinGen gnomAD
CA2883065 rs774312925	606	R>K	No	ClinGen ExAC gnomAD
rs1380502880 CA356586735	607	K>Q	No	ClinGen gnomAD
CA93714980 rs1028588423	607	K>R	No	ClinGen TOPMed gnomAD
CA2883067 rs771630845	609	S>Y	No	ClinGen ExAC gnomAD
CA2883068 rs772850099	611	P>S	No	ClinGen ExAC gnomAD
rs1315085662 CA356586764	612	L>I	No	ClinGen TOPMed
rs766712491 CA2883071	615	E>G	No	ClinGen ExAC TOPMed gnomAD
CA93714985 rs750543457	615	E>K	No	ClinGen TOPMed gnomAD
rs759981562 CA2883073	617	Y>H	No	ClinGen ExAC TOPMed gnomAD
CA356586798 rs759981562	617	Y>N	No	ClinGen ExAC TOPMed gnomAD
rs1417757108 CA356586818	619	T>I	No	ClinGen gnomAD
rs777285458 CA2883077	621	S>F	No	ClinGen ExAC gnomAD
rs758545658 CA2883076	621	S>P	No	ClinGen ExAC TOPMed gnomAD
rs758545658 CA356586826	621	S>T	No	ClinGen ExAC TOPMed gnomAD
rs368630622 CA2883078	622	P>L	No	ClinGen ExAC TOPMed gnomAD
rs1366485319 CA356586832	622	P>S	No	ClinGen gnomAD
CA356586836 rs1308963533	623	R>*	No	ClinGen gnomAD
rs371582371 CA2883080	623	R>Q	No	ClinGen ESP ExAC TOPMed gnomAD
rs1332011711 CA356586853	625	I>M	No	ClinGen gnomAD
CA356586864 rs1395664752	627	R>K	No	ClinGen gnomAD
CA2883081 rs749005161	628	D>V	No	ClinGen ExAC gnomAD
rs768546472 CA2883082	629	E>K	No	ClinGen ExAC gnomAD
rs772725492 CA2883086	637	R>Q	No	ClinGen ExAC TOPMed gnomAD
rs1479943043 CA356586932	638	G>R	No	ClinGen gnomAD
rs1478271481 CA356586940	639	D>G	No	ClinGen TOPMed
CA356586936 rs1212010982	639	D>N	No	ClinGen gnomAD
CA356586937 rs1212010982	639	D>Y	No	ClinGen gnomAD
CA2883088 rs377370453	640	S>L	No	ClinGen ESP ExAC TOPMed gnomAD
CA356586968 rs1241485177	644	V>L	No	ClinGen TOPMed
rs763567286 CA2883093	645	D>N	No	ClinGen ExAC gnomAD
CA356586980 rs1169816763	646	V>M	No	ClinGen gnomAD
rs1372434428 CA356587001	649	G>S	No	ClinGen gnomAD
rs764219641 CA2883094	650	S>P	No	ClinGen ExAC gnomAD
CA356587021 rs1222451461	652	D>G	No	ClinGen TOPMed
rs757398904 CA2883096	652	D>N	No	ClinGen ExAC TOPMed gnomAD
rs186274200 CA93715015	653	C>W	No	ClinGen 1000Genomes
CA93715017 rs930028329	654	V>A	No	ClinGen TOPMed
CA356587034 rs1410686511	654	V>L	No	ClinGen gnomAD
CA356587039 rs1300962620	655	G>C	No	ClinGen gnomAD
CA356587038 rs1300962620	655	G>R	No	ClinGen gnomAD
CA93715018 rs969346727	655	G>V	No	ClinGen Ensembl
rs146426799 CA2883097	657	T>I	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2883098 rs531937020	659	T>S	No	ClinGen 1000Genomes ExAC
rs1294157011 CA356587071	660	K>N	No	ClinGen gnomAD
rs758597494 CA93715022	663	I>S	No	ClinGen Ensembl
CA356587091 rs1212345112	663	I>V	No	ClinGen TOPMed
CA2883099 rs754726697	664	F>V	No	ClinGen ExAC gnomAD
CA93715025 rs927241762	665	S>G	No	ClinGen TOPMed gnomAD
CA356587120 rs1159026783	667	A>G	No	ClinGen gnomAD
CA356587124 rs1220698308	668	S>C	No	ClinGen gnomAD
CA2883101 rs748023356	668	S>N	No	ClinGen ExAC gnomAD
CA2883102 rs770321321	672	N>D	No	ClinGen ExAC TOPMed gnomAD
rs199899002 CA2883103	672	N>S	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA356587178 rs1426693734	676	E>Q	No	ClinGen gnomAD
rs140768028 CA93715031	678	S>T	No	ClinGen ESP TOPMed
rs746474550 CA2883104	679	C>R	No	ClinGen ExAC TOPMed gnomAD
rs182543204 CA2883105	680	S>C	No	ClinGen 1000Genomes ExAC gnomAD
rs745537137 CA2883107	681	M>T	No	ClinGen ExAC gnomAD
CA356587224 rs1462640773	682	N>S	No	ClinGen TOPMed
rs1362070320 CA356587232	683	Q>R	No	ClinGen TOPMed gnomAD
CA93715034 rs917116568	688	I>L	No	ClinGen Ensembl
rs1419872267 CA356587267	688	I>M	No	ClinGen gnomAD
CA2883109 rs776018804	689	P>L	No	ClinGen ExAC TOPMed gnomAD
CA356587271 rs776018804	689	P>R	No	ClinGen ExAC TOPMed gnomAD
CA2883108 rs370990239	689	P>S	No	ClinGen ESP ExAC TOPMed gnomAD
CA93715038 rs186602217	691	P>A	No	ClinGen 1000Genomes ExAC gnomAD
rs186602217 CA2883110	691	P>S	No	ClinGen 1000Genomes ExAC gnomAD
rs142749005 CA2883112	694	R>C	No	ClinGen 1000Genomes ExAC gnomAD
CA2883113 rs150484445	694	R>H	No	ClinGen ESP ExAC TOPMed gnomAD
CA356587299 rs150484445	694	R>L	No	ClinGen ESP ExAC TOPMed gnomAD
CA356587300 rs1215280672	695	H>N	No	ClinGen gnomAD
rs773930630 CA93715042	695	H>R	No	ClinGen Ensembl
CA356587336 rs1182508753	700	S>L	No	ClinGen gnomAD
rs373113749 CA93715045	703	N>K	No	ClinGen ESP ExAC TOPMed gnomAD
CA356587356 rs1443861055	703	N>T	No	ClinGen gnomAD
CA2883117 rs764965234	704	D>N	No	ClinGen ExAC TOPMed gnomAD
rs764965234 CA356587359	704	D>Y	No	ClinGen ExAC TOPMed gnomAD
CA356587369 rs1400968113	705	S>T	No	ClinGen gnomAD
rs758234102 CA2883119	713	S>G	No	ClinGen ExAC TOPMed gnomAD
rs758234102 CA356587421	713	S>R	No	ClinGen ExAC TOPMed gnomAD
CA356587433 rs1467191514	714	V>A	No	ClinGen gnomAD
CA2883120 rs147362228	716	R>K	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA356587442 rs147362228	716	R>T	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA356587464 rs1406006983	719	S>N	No	ClinGen gnomAD
rs1451033166 CA356587471	720	I>V	No	ClinGen gnomAD
CA356587480 rs1311958564	721	P>L	No	ClinGen gnomAD
CA93715052 rs1008630038	721	P>S	No	ClinGen Ensembl
rs549938218 CA2883121	722	H>R	No	ClinGen 1000Genomes ExAC gnomAD
rs756653388 CA2883122	724	L>F	No	ClinGen ExAC gnomAD
CA356587513 rs1314161288	726	H>L	No	ClinGen gnomAD
rs1314161288 CA356587512	726	H>R	No	ClinGen gnomAD
rs892184465 CA93715055	726	H>Y	No	ClinGen gnomAD
rs1381251605 CA356587525	728	G>R	No	ClinGen TOPMed
rs772003238 CA93715057	730	K>R	No	ClinGen TOPMed gnomAD
CA356587549 rs1262528004	731	S>I	No	ClinGen TOPMed gnomAD
CA356587550 rs1262528004	731	S>N	No	ClinGen TOPMed gnomAD
rs570017447 CA2883125	733	K>N	No	ClinGen 1000Genomes ExAC gnomAD
CA356587572 rs1470420787	734	P>L	No	ClinGen gnomAD
CA2883126 rs369045286	734	P>S	No	ClinGen ESP ExAC TOPMed gnomAD
rs1176403943 CA356587588	737	I>V	No	ClinGen TOPMed gnomAD
rs1405347502 CA356587594	738	K>E	No	ClinGen TOPMed gnomAD
CA2883127 rs749649077	739	S>I	No	ClinGen ExAC gnomAD
rs769201706 CA356587607	739	S>R	No	ClinGen ExAC TOPMed gnomAD
rs769201706 CA2883128	739	S>R	No	ClinGen ExAC TOPMed gnomAD
rs774717896 CA2883129	743	K>R	No	ClinGen ExAC gnomAD
CA2883131 rs143367720	745	S>C	No	ClinGen ESP ExAC TOPMed gnomAD
rs143367720 CA356587660	745	S>F	No	ClinGen ESP ExAC TOPMed gnomAD

No associated diseases with Q9P246

3 regional properties for Q9P246

Type	Name	Position	InterPro Accession
domain	Sterile alpha motif domain	133 - 201	IPR001660
domain	Stromal interaction molecule, Orai1-activating region	345 - 445	IPR032393
domain	Stromal interaction molecule 2, SAM domain	132 - 205	IPR037610

Functions

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum membrane ; Single-pass type I membrane protein	Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration
PANTHER Family	PTHR15136	STROMAL INTERACTION MOLECULE HOMOLOG
PANTHER Subfamily	PTHR15136:SF2	STROMAL INTERACTION MOLECULE 2
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name	Definition
calcium channel regulator activity	Modulates the activity of a calcium channel.
calcium ion binding	Binding to a calcium ion (Ca2+).
store-operated calcium channel activity	A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.

4 GO annotations of biological process

Name	Definition
activation of store-operated calcium channel activity	A process that initiates the activity of an inactive store-operated calcium channel.
cellular calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
positive regulation of calcium ion transport	Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
store-operated calcium entry	A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P83094	Stim	Stromal interaction molecule homolog	Drosophila melanogaster (Fruit fly)	SS
Q13586	STIM1	Stromal interaction molecule 1	Homo sapiens (Human)	EV
P83093	Stim2	Stromal interaction molecule 2	Mus musculus (Mouse)	SS
G5EF60	stim-1	Stromal interaction molecule 1	Caenorhabditis elegans	SS

10	20	30	40	50	60
MLVLGLLVAG	AADGCELVPR	HLRGRRATGS	AATAASSPAA	AAGDSPALMT	DPCMSLSPPC
70	80	90	100	110	120
FTEEDRFSLE	ALQTIHKQMD	DDKDGGIEVE	ESDEFIREDM	KYKDATNKHS	HLHREDKHIT
130	140	150	160	170	180
IEDLWKRWKT	SEVHNWTLED	TLQWLIEFVE	LPQYEKNFRD	NNVKGTTLPR	IAVHEPSFMI
190	200	210	220	230	240
SQLKISDRSH	RQKLQLKALD	VVLFGPLTRP	PHNWMKDFIL	TVSIVIGVGG	CWFAYTQNKT
250	260	270	280	290	300
SKEHVAKMMK	DLESLQTAEQ	SLMDLQERLE	KAQEENRNVA	VEKQNLERKM	MDEINYAKEE
310	320	330	340	350	360
ACRLRELREG	AECELSRRQY	AEQELEQVRM	ALKKAEKEFE	LRSSWSVPDA	LQKWLQLTHE
370	380	390	400	410	420
VEVQYYNIKR	QNAEMQLAIA	KDEAEKIKKK	RSTVFGTLHV	AHSSSLDEVD	HKILEAKKAL
430	440	450	460	470	480
SELTTCLRER	LFRWQQIEKI	CGFQIAHNSG	LPSLTSSLYS	DHSWVVMPRV	SIPPYPIAGG
490	500	510	520	530	540
VDDLDEDTPP	IVSQFPGTMA	KPPGSLARSS	SLCRSRRSIV	PSSPQPQRAQ	LAPHAPHPSH
550	560	570	580	590	600
PRHPHHPQHT	PHSLPSPDPD	ILSVSSCPAL	YRNEEEEEAI	YFSAEKQWEV	PDTASECDSL
610	620	630	640	650	660
NSSIGRKQSP	PLSLEIYQTL	SPRKISRDEV	SLEDSSRGDS	PVTVDVSWGS	PDCVGLTETK
670	680	690	700	710	720
SMIFSPASKV	YNGILEKSCS	MNQLSSGIPV	PKPRHTSCSS	AGNDSKPVQE	APSVARISSI
730	740
PHDLCHNGEK	SKKPSKIKSL	FKKKSK