AiPD: Autoinhibited Protein Database

Q9P212

Gene name	PLCE1 (KIAA1516, PLCE, PPLC)
Protein name	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Names	EC 3.1.4.11 , Pancreas-enriched phospholipase C , Phosphoinositide phospholipase C-epsilon-1 , Phospholipase C-epsilon-1 , PLC-epsilon-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51196
EC number	3.1.4.11: Phosphoric diester hydrolases
Protein Class

Descriptions

PLCε is a critical regulator of calcium and DAG-dependent signaling in the cardiovascular system, where changes in its expression and/or aberrant activation result in cardiac hypertrophy and heart failure. PLCε shares four core domains common to most PLCs, including a pleckstrin homology (PH) domain, followed by four tandem EF hand repeats (EF1-4), the catalytic TIM barrel domain (split by an autoregulatory X-Y linker), and a C2 domain. In PLCε, these core domains are flanked by regions that confer responsiveness to different signal transduction pathways. The N-terminal region contains a CDC25 domain that acts as a guanine nucleotide exchange factor (GEF) for the Rap1A GTPase. This domain is essential for sustained PI hydrolysis at the perinuclear and Golgi membranes in cardiomyocytes. The C-terminal region contains two Ras association (RA) domains (RA1 and RA2) that bind activated Rap1A and Ras. PLCε is present predominantly in the cytoplasm, and is maintained in a low-activity state by the autoinhibitory X-Y linker and the C2-RA1 linker. Localization of PLCε to the perinuclear membrane through interactions between the RA1 domain and the scaffolding protein mAKAP increases lipase activity. RA1 binding to mAKAP could alter the conformation of, or displace, the C2-RA1 linker, increasing basal activity. Membrane association would also increase basal activity via interfacial activation, which may be facilitated by interactions between the αx-y helix and the membrane or, alternatively, with other domain in PLCε or proteins at the target membrane, such as activated Rap1A.

Autoinhibitory domains (AIDs)

1541-1662 (X-Y linker) SS

Target domain	1392-1541 (PI-PLC X domain);1728-1846 (PI-PLC Y domain)
Relief mechanism	Ligand binding, Partner binding
Assay

AID

1541-1662 (X-Y linker)

Target domain

1392-1541 (PI-PLC X domain);1728-1846 (PI-PLC Y domain)

Relief mechanism

Ligand binding (Membrane association), Partner binding (G protein binding)

Assay

1993-2010 (C2-RA1 linker) SS

Target domain	1846-1871 (A cleft between TIM barrel and C2 domain)
Relief mechanism	Ligand binding, Partner binding
Assay

AID

1993-2010 (C2-RA1 linker)

Target domain

1846-1871 (A cleft between TIM barrel and C2 domain)

Relief mechanism

Ligand binding (Membrane association), Partner binding (G protein binding)

Assay

Accessory elements

No accessory elements

References

Muralidharan K et al. (2021) "Structure and regulation of phospholipase Cβ and ε at the membrane", Chemistry and physics of lipids, 235, 105050

Rugema NY et al. (2020) "Structure of phospholipase Cε reveals an integrated RA1 domain and previously unidentified regulatory elements", Communications biology, 3, 445

Autoinhibited structure

Activated structure

4 structures for Q9P212

Entry ID	Method	Resolution	Chain	Position	Source
2BYE	NMR	-	A	2006-2114	PDB
2BYF	NMR	-	A	2131-2246	PDB
2C5L	X-ray	190 A	C/D	2131-2246	PDB
AF-Q9P212-F1	Predicted				AlphaFoldDB

2328 variants for Q9P212

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA10636938 RCV000299500 rs61749238	76	A>E	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001105466 RCV000908925 RCV002294185 RCV000246633 CA5612095 rs61749238	76	A>V	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs761055810 RCV000354406 RCV002520645 CA5612107	99	A>V	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000260001 rs886047493 CA10636550	108	N>S	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
rs886047495 CA10629509 RCV000320844	192	E>D	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
RCV002274138 RCV001106613 rs776583769	212	D>N	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
RCV002056158 CA5612159 rs373215088 RCV000344043	222	G>R	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs774497694 RCV001106614	225	K>E	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
RCV001108774 rs1304398531	238	M>T	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar dbSNP gnomAD
RCV000295057 CA10629510 rs886047497	242	K>Q	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP
rs374137235 RCV001330719	245	D>N	Nephrotic syndrome, type 3 Variant assessed as Somatic; MODERATE impact. [ClinVar, NCI-TCGA]	Yes	ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
RCV001108775 rs1193922904	250	Q>K	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar dbSNP gnomAD
RCV001195710 rs781693565	252	Q>H	Glomerulonephritis [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
RCV000398446 CA10632911 rs886047498	317	S>N	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
CA115501 RCV000002443 rs267606954	321	R>*	Nephrotic syndrome, type 3 (nphs3) Nephrotic syndrome, type 3 [Ensembl, ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs564879389 RCV001108777	361	W>R	Nephrotic syndrome, type 3 [ClinVar]	Yes	1000Genomes ExAC TOPMed gnomAD ClinVar dbSNP
rs372621219 RCV000337057 CA5612224	364	I>V	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs876657369 CA10575469 RCV000002435	383	S>missing	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar dbSNP
rs2134504108 RCV002250248	383	S>*	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar Ensembl dbSNP
RCV001103624 rs761213168	394	R>C	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
rs2061573367 RCV001103625	398	A>G	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar Ensembl dbSNP
RCV001103626 rs201401363 RCV000712688	401	Y>H	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs752029771 RCV000786899	408	R>I	Nephrotic syndrome, type 3 (nphs3) Nephrotic syndrome, type 3 [Ensembl, ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
rs145451189 RCV000896139 RCV001103627	410	E>K	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA5612343 rs199689540 RCV003556317 RCV000296944	438	V>A	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs192219615 RCV001105569 RCV000517387 RCV002525063 CA5612364	467	T>I	Nephrotic syndrome, type 3 (nphs3) Nephrotic syndrome, type 3 [Ensembl, ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
VAR_031843 RCV000250368 RCV000710172 RCV002294181 CA5612366 RCV000302907 rs17508082	469	S>T	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10632915 RCV000357669 rs886047499	474	T>I	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar dbSNP gnomAD
RCV001967313 RCV003339835 rs150173742	491	T>N	Inborn genetic diseases [ClinVar]	Yes	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA115490 RCV000002436 RCV002508771 rs121912601	493	R>*	Variant assessed as Somatic; HIGH impact. Nephrotic syndrome, type 3 (nphs3) Nephrotic syndrome, type 3 [NCI-TCGA, Ensembl, ClinVar]	Yes	ClinGen ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
RCV000514699 RCV000327511 rs61751493 CA5612404	499	R>C	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs757336023 COSM1970335 RCV001105570	499	R>H	Nephrotic syndrome, type 3 pancreas [ClinVar, Cosmic]	Yes	cosmic curated ClinVar ExAC TOPMed dbSNP gnomAD
RCV002284196 rs61751494 CA5612418 RCV000948377 RCV000364133	523	I>V	Nephrotic syndrome, type 3 Polycystic kidney disease [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001106712 rs369152754	548	R>C	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000242119 RCV000712689 VAR_031844 rs17417407 CA5612431 RCV000616298 RCV002294182	548	R>L	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001330717 rs377400616	550	V>F	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar ESP TOPMed dbSNP
RCV001849870 rs2136320656	570	S>missing	Nephrotic syndrome [ClinVar]	Yes	ClinVar dbSNP
RCV000246926 rs141639885 RCV002225567 RCV002294183 RCV000388334 CA5612453	577	A>T	Kidney disorder Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001106713 rs554159388 RCV002556091	603	E>K	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs61886330 RCV000516190 RCV000891403 CA5612512 RCV001108876	643	A>S	Nephrotic syndrome, type 3 (nphs3) Nephrotic syndrome, type 3 [Ensembl, ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001106714 rs61886330 RCV001356680	643	A>T	Nephrotic syndrome, type 3 (nphs3) Nephrotic syndrome, type 3 [Ensembl, ClinVar]	Yes	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001108877 RCV001288671 rs201422605	678	M>V	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001108879 rs200013667	722	G>S	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
CA5612615 RCV000375481 rs761776701	775	R>W	Nephrotic syndrome, type 3 Variant assessed as Somatic; MODERATE impact. [ClinVar, NCI-TCGA]	Yes	ClinGen ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
RCV002491905 RCV001931032 rs201965980	781	L>P	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar TOPMed dbSNP gnomAD
RCV000336531 CA5612648 rs78217273 RCV000884580	810	I>V	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs2137512478 RCV001849871	859	Q>missing	Nephrotic syndrome [ClinVar]	Yes	ClinVar dbSNP
CA5612694 rs372756642 RCV000287364	879	R>C	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000959882 RCV000734018 CA5612706 rs61751497 RCV000342370	910	V>I	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000390276 rs758463243 CA5612708	924	G>S	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
rs773857638 RCV001103722	943	A>S	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar ExAC dbSNP gnomAD
rs757606247 RCV001103723	948	H>Y	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
rs780213480 RCV001105669	955	T>S	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
RCV003420208 rs762245091 RCV000681907	987	H>R	PLCE1-related condition [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
rs61751498 RCV002294420 RCV001105670 RCV002284208 RCV000948378	1000	S>N	Nephrotic syndrome, type 3 Polycystic kidney disease [ClinVar]	Yes	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs895782232 RCV000985026	1020	Q>*	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar Ensembl dbSNP
VAR_087600	1020	Q>del	NPHS3 [UniProt]	Yes	UniProt
RCV000790391 rs1589413498	1022	W>*	Nephrotic syndrome, type 3 (nphs3) Nephrotic syndrome, type 3 [Ensembl, ClinVar]	Yes	ClinVar Ensembl dbSNP
rs2050907070 RCV001105671	1033	E>A	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar TOPMed dbSNP gnomAD
rs200419008 CA5612785 RCV003546507 RCV000366664	1045	A>S	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs773093424 RCV001105672	1062	G>R	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
rs764019766 RCV001105673	1072	N>S	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
RCV001571057 CA5612837 rs61732523 RCV000275815	1094	G>A	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs61732523 RCV002556092 RCV001106795 RCV002284211	1094	G>V	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV002556093 rs775231257 RCV003293881 RCV001106796	1112	H>R	Nephrotic syndrome, type 3 Inborn genetic diseases [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
rs918508213 RCV002244205	1113	K>missing	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar dbSNP
RCV000002437 rs121912602 CA115492	1116	R>*	Nephrotic syndrome, type 3 (nphs3) Nephrotic syndrome, type 3 [Ensembl, ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs2132855762 RCV001849873	1126	I>*	Nephrotic syndrome [ClinVar]	Yes	ClinVar dbSNP
rs778868001 RCV001106797	1150	H>R	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar ExAC dbSNP gnomAD
RCV001756696 rs540730568 RCV002477924	1164	T>M	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar 1000Genomes ExAC dbSNP gnomAD
RCV002485793 RCV002532936 rs180753337 RCV000712693	1173	S>F	Nephrotic syndrome, type 3 Inborn genetic diseases [ClinVar]	Yes	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
COSM1262370 rs747635422 RCV001106798	1195	R>W	Nephrotic syndrome, type 3 oesophagus stomach [ClinVar, Cosmic]	Yes	cosmic curated ClinVar ExAC TOPMed dbSNP gnomAD
RCV002284221 RCV002294473 RCV001580291 rs199781223 RCV002072296	1199	G>S	Kidney disorder [ClinVar]	Yes	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1589433172 RCV000988437	1233	L>P	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar Ensembl dbSNP
RCV001107433 rs975453016	1240	Y>C	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar TOPMed dbSNP gnomAD
CA115503 RCV002514120 rs267606955 RCV000002444	1246	R>*	Nephrotic syndrome, type 3 (nphs3) Nephrotic syndrome, type 3 [Ensembl, ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV002225052 rs754487813	1278	V>L	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar ExAC dbSNP gnomAD
CA10575470 rs876657370 RCV000002438	1283	L>missing	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar dbSNP
rs1345048932 RCV001107436	1327	L>R	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar dbSNP gnomAD
rs2051493957 RCV001103812	1376	D>V	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar Ensembl dbSNP
rs886047502 CA10632918 RCV000372815	1389	E>K	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
rs2051495579 RCV001328253	1401	Y>missing	Nephrotic syndrome [ClinVar]	Yes	ClinVar dbSNP
rs2051499855 RCV001330718	1423	E>D	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar Ensembl dbSNP
RCV000380300 RCV000323390 rs766196444 CA5613111 CA5613112	1447	M>I	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV001535848 rs2133104138	1455	T>missing	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar dbSNP
RCV000283512 rs199793703 CA5613137	1471	R>H	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs886047503 CA10629515 COSM1349953 COSM5136227 COSM1349955 RCV000340765 COSM1349954	1483	I>V	Nephrotic syndrome, type 3 Variant assessed as Somatic; MODERATE impact. large_intestine [ClinVar, NCI-TCGA, Cosmic]	Yes	ClinGen NCI-TCGA Cosmic cosmic curated ClinVar NCI-TCGA dbSNP gnomAD
COSM1585217 VAR_029883 RCV000002441 COSM921664 COSM1585216 rs121912605 CA115498	1484	S>L	Nephrotic syndrome, type 3 (nphs3) Nephrotic syndrome, type 3 Variant assessed as Somatic; MODERATE impact. endometrium NPHS3; gives rise to focal segmental glomerulosclerosis rather than diffuse mesangial sclerosis [Ensembl, ClinVar, NCI-TCGA, Cosmic, UniProt]	Yes	ClinGen NCI-TCGA Cosmic cosmic curated ClinVar UniProt ExAC NCI-TCGA dbSNP gnomAD
rs2051691492 RCV002244206	1493	Q>*	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar Ensembl dbSNP
rs548655036 RCV001885363 RCV001823445	1495	R>*	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar 1000Genomes ExAC dbSNP gnomAD
CA5613212 RCV001725149 VAR_031845 RCV000254331 rs2274224 RCV000605019 RCV002294188	1575	R>P	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000594173 CA5613213 rs2274224 RCV001105758	1575	R>Q	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000291719 CA5613220 rs61732525	1578	N>I	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs61732525 RCV001105759 RCV000947271 RCV002294419	1578	N>S	Kidney disorder Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5613236 rs765634224 RCV000344250	1604	D>Y	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000002439 CA115494 rs121912603	1616	Q>*	Nephrotic syndrome, type 3 (nphs3) Nephrotic syndrome, type 3 [Ensembl, ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
RCV001849875 rs747229979	1630	A>missing	Nephrotic syndrome [ClinVar]	Yes	ClinVar dbSNP
rs886047504 CA10632924 RCV000400675	1642	D>N	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
RCV000785963 rs1589475328 RCV002508255 RCV001849443 RCV001849442	1660	Q>missing	Nephrotic syndrome, type 3 Nephrotic syndrome [ClinVar]	Yes	ClinVar dbSNP
RCV000401505 CA10632925 rs886047505 RCV003480587	1700	I>T	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
RCV000297333 CA5613336 rs781690094	1771	R>S	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
RCV000616997 rs3765524 CA5613337 RCV000245651 RCV001610692 VAR_031846 RCV002294190	1777	T>I	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs2133537931 RCV002250848	1788	Y>*	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar Ensembl dbSNP
rs2053139766 RCV002244207	1837	G>D	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar Ensembl dbSNP
RCV002221406 rs2133612518	1840	L>V	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar Ensembl dbSNP
rs2133612592 RCV001849876	1841	K>E	Nephrotic syndrome [ClinVar]	Yes	ClinVar Ensembl dbSNP
rs776276690 RCV000256376 CA5613382	1850	C>Y	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1589509476 RCV000991397	1853	Y>*	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar Ensembl dbSNP
CA115496 RCV000002440 rs121912604	1854	Q>*	Variant assessed as Somatic; HIGH impact. Nephrotic syndrome, type 3 (nphs3) Nephrotic syndrome, type 3 [NCI-TCGA, Ensembl, ClinVar]	Yes	ClinGen ClinVar Ensembl NCI-TCGA dbSNP
RCV002484403 RCV002555357 RCV001927691 rs762506926	1871	Y>C	Nephrotic syndrome, type 3 Inborn genetic diseases [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
CA5613405 rs58539480 RCV000968188 RCV002294191 RCV000253540 RCV000323870	1890	P>L	Kidney disorder Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
VAR_031847 RCV000250112 RCV000605587 RCV002294192 rs2274223 CA5613420 RCV001683082	1927	H>R	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5613423 RCV000712695 rs202171627 RCV000265307	1928	V>I	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5613430 RCV002520650 rs763348713 RCV000327449	1947	A>V	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV001849877 rs2133673643	1984	N>missing	Nephrotic syndrome [ClinVar]	Yes	ClinVar dbSNP
rs2053582229 RCV001103929	2052	I>N	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar Ensembl dbSNP
RCV001103930 rs760229823	2104	M>L	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
CA5613571 rs528942664 RCV000351419	2122	V>I	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV003768422 rs773902333 RCV000778294	2126	K>missing	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar dbSNP
rs192586920 RCV001104206 RCV003727857	2149	P>L	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV000002442 CA115499 COSM3738795 COSM3738796 rs267606953 COSM3738797	2150	R>*	Variant assessed as Somatic; HIGH impact. Nephrotic syndrome, type 3 (nphs3) Nephrotic syndrome, type 3 liver [NCI-TCGA, Ensembl, ClinVar, Cosmic]	Yes	ClinGen NCI-TCGA Cosmic cosmic curated ClinVar NCI-TCGA dbSNP gnomAD
RCV000490198 VAR_087601 CA5613605 RCV001104207 rs111929795	2173	K>R	Nephrotic syndrome, type 3 (nphs3) Nephrotic syndrome, type 3 [Ensembl, ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs376129110 RCV001104208	2231	F>L	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs180876175 RCV000984912	2253	A>T	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA645372502 RCV000256386 rs886039892 RCV002518786 RCV002470831	2267	R>Q	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
RCV001328219 rs375606039	2274	Q>R	Nephrotic syndrome [ClinVar]	Yes	ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV002490887 CA5613674 rs771798085 RCV003565432 RCV000517610	2286	E>missing	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinGen ClinVar dbSNP
RCV002171780 RCV002500368 rs571727623	2288	P>T	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV001782650 rs1193230553	2301	R>*	Nephrotic syndrome, type 3 [ClinVar]	Yes	ClinVar dbSNP gnomAD
rs773702940	2	T>I		No	TOPMed
rs199886888	4	E>K		No	TOPMed gnomAD
rs199886888	4	E>Q		No	TOPMed gnomAD
rs2134488348	6	M>I		No	Ensembl
rs2061547861	6	M>V		No	TOPMed
rs1564634285	8	A>T		No	Ensembl
rs755873612	10	V>I		No	ExAC TOPMed gnomAD
rs900776425	11	L>F		No	TOPMed gnomAD
rs575611837	13	P>A		No	1000Genomes ExAC TOPMed gnomAD
rs770415486	13	P>L		No	ExAC TOPMed gnomAD
rs575611837	13	P>S		No	1000Genomes ExAC TOPMed gnomAD
rs1264873184	15	T>S		No	gnomAD
rs2061548251	16	Q>E		No	TOPMed
rs2061548294	16	Q>L		No	TOPMed
rs2061548294	16	Q>R		No	TOPMed
rs2061548343	17	R>T		No	TOPMed
rs866625982	18	K>E		No	Ensembl
rs773920088	18	K>N		No	ExAC gnomAD
COSM4404032 COSM4404033	20	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs745312368	21	S>C		No	ExAC gnomAD
rs2061548459	21	S>P		No	TOPMed
rs538129490	22	A>V		No	1000Genomes ExAC TOPMed gnomAD
rs775247624 COSM4016780 COSM4016779	24	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs1175295307	25	A>T		No	TOPMed gnomAD
rs1464445750	25	A>V		No	TOPMed
rs996745960	27	D>G		No	TOPMed
COSM3441746 rs577951879 COSM3441747	28	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA gnomAD
rs1424154839	29	S>G		No	gnomAD
rs2061548891	30	S>N		No	TOPMed gnomAD
rs2061548891	30	S>T		No	TOPMed gnomAD
rs1172068516	32	K>N		No	TOPMed gnomAD
rs1051971566	33	V>D		No	TOPMed gnomAD
rs1474301044	34	S>L		No	gnomAD
rs773919510	34	S>P		No	ExAC gnomAD
rs1355346364	35	D>H		No	gnomAD
rs1463688295	36	I>V		No	TOPMed gnomAD
rs763517011	37	N>S		No	ExAC TOPMed gnomAD
rs763517011	37	N>T		No	ExAC TOPMed gnomAD
rs766736677	39	S>*		No	ExAC
rs751680917	40	K>*		No	ExAC
TCGA novel	41	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2061549605	41	A>V		No	gnomAD
rs1396274897	43	T>A		No	gnomAD
rs1415773380	44	V>F		No	TOPMed gnomAD
rs1415773380	44	V>I		No	TOPMed gnomAD
rs1415773380	44	V>L		No	TOPMed gnomAD
COSM1651225 COSM921642	45	R>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs754972798	46	R>*		No	ExAC TOPMed gnomAD
rs754972798	46	R>G		No	ExAC TOPMed gnomAD
COSM1585245 COSM921643 rs767766247	46	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs752895021	47	S>R		No	ExAC TOPMed gnomAD
rs200054827	49	E>D		No	1000Genomes ExAC gnomAD
TCGA novel	49	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1308915483	50	T>I		No	gnomAD
COSM1349897 COSM5163755 COSM1349898	51	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs372251905	52	H>L		No	ESP ExAC gnomAD
rs372251905	52	H>R		No	ESP ExAC gnomAD
rs2061550103	52	H>Y		No	Ensembl
rs1483493650	53	T>A		No	TOPMed gnomAD
rs1212739268	54	I>V		No	TOPMed gnomAD
rs373593384	55	S>L		No	ESP ExAC TOPMed gnomAD
rs2134490508	56	Q>R		No	Ensembl
rs761575973	58	N>K		No	ExAC TOPMed gnomAD
rs2061550559	59	K>*		No	Ensembl
COSM921644 COSM1585244	61	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2061550685	64	P>S		No	TOPMed
rs771457628	65	S>P		No	ExAC TOPMed gnomAD
rs2061550828	67	S>G		No	gnomAD
rs2061550877	67	S>N		No	TOPMed gnomAD
rs746652821	68	N>H		No	ExAC gnomAD
rs983406494	68	N>S		No	TOPMed gnomAD
rs746652821	68	N>Y		No	ExAC gnomAD
rs2061551075	71	K>N		No	Ensembl
rs1374204447	72	I>S		No	gnomAD
rs2061551112	72	I>V		No	gnomAD
rs2061551225	74	S>L		No	Ensembl
rs2134491266	75	I>M		No	Ensembl
rs367762397	75	I>T		No	ESP ExAC TOPMed gnomAD
rs61749238	76	A>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs368296510	77	R>K		No	ESP ExAC TOPMed gnomAD
rs2061551507	78	E>G		No	TOPMed
rs1456154904	81	V>G		No	TOPMed gnomAD
rs372609071	82	S>N		No	ESP ExAC TOPMed gnomAD
rs2061551713	82	S>R		No	TOPMed
rs375835173	83	D>E		No	ESP ExAC TOPMed gnomAD
rs1236231628	83	D>Y		No	gnomAD
rs267602624	84	E>D		No	gnomAD
rs1589883073	84	E>K		No	Ensembl
rs1485318519	86	S>N		No	gnomAD
rs2061552015	86	S>R		No	TOPMed gnomAD
rs756966446	88	E>G		No	ExAC TOPMed gnomAD
COSM5543309 COSM5543310 COSM5543311	88	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	89	K>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs750829654	90	C>F		No	ExAC TOPMed gnomAD
rs750829654	90	C>Y		No	ExAC TOPMed gnomAD
rs2134492124	91	W>C		No	Ensembl
rs2134492096	91	W>R		No	Ensembl
rs1486921056	92	E>K		No	gnomAD
TCGA novel	93	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs750310703	94	I>S		No	ExAC gnomAD
rs779712636	95	M>L		No	ExAC TOPMed gnomAD
rs779712636	95	M>V		No	ExAC TOPMed gnomAD
rs1564634630	97	D>H		No	gnomAD
COSM3441750 COSM3441751	97	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs780949804	100	K>Q		No	ExAC gnomAD
rs1024101614	101	N>K		No	TOPMed gnomAD
COSM3441752 COSM3441753	102	L>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1449382962	103	N>T		No	TOPMed gnomAD
COSM921645 COSM1585243	108	N>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs771177637	109	I>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs771177637	109	I>V		No	ExAC gnomAD
rs2061553228	110	L>V		No	TOPMed
COSM5826851 COSM1349902 COSM1349901	111	R>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs774981225	111	R>T		No	ExAC gnomAD
rs2061553336	113	H>N		No	Ensembl
rs2061553393	114	Q>H		No	Ensembl
rs759958187	115	H>P		No	ExAC TOPMed gnomAD
rs759958187	115	H>R		No	ExAC TOPMed gnomAD
COSM6067217 COSM6067218 COSM6067216	119	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1355131868	119	Q>P		No	TOPMed gnomAD
TCGA novel	120	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1240154880	121	Q>K		No	TOPMed gnomAD
rs1442592804	123	Y>*		No	TOPMed gnomAD
COSM5837484 COSM5837483 COSM5837485	124	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1224113478	125	M>I		No	gnomAD
rs2061554049	125	M>L		No	Ensembl
rs967633416	125	M>T		No	TOPMed gnomAD
rs1286274921	126	Y>H		No	gnomAD
rs1213773441	129	V>I		No	TOPMed gnomAD
rs1213773441	129	V>L		No	TOPMed gnomAD
COSM1317414 COSM1317413	130	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs764335423	130	A>T		No	ExAC gnomAD
rs2061554485	131	E>D		No	TOPMed gnomAD
TCGA novel	133	D>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1195774926	133	D>V		No	gnomAD
rs753979956	133	D>Y		No	ExAC TOPMed gnomAD
rs1251371175	134	L>F		No	gnomAD
COSM3868092 COSM3868091 rs2061554785	141	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
COSM5371330 COSM5371331 COSM5371329	141	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1044573434	142	S>P		No	Ensembl
rs1169144353	143	P>L		No	TOPMed
TCGA novel	143	P>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1564634768	144	L>V		No	Ensembl
rs761721376	145	E>G		No	ExAC gnomAD
rs906066688	145	E>K		No	TOPMed gnomAD
rs977110384	146	R>G		No	TOPMed gnomAD
rs758420946	147	K>N		No	ExAC TOPMed gnomAD
RCV002224953 rs573360290	147	K>R		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs182480150	148	V>M		No	1000Genomes ExAC gnomAD
COSM3441754 COSM3441755	149	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs751143974	150	P>L		No	ExAC TOPMed gnomAD
rs867577134	150	P>S		No	TOPMed gnomAD
rs2061555825 COSM3441756 COSM3441757	151	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed gnomAD
rs886047494	153	Q>H		No	TOPMed gnomAD
rs1442664929	153	Q>P		No	gnomAD
COSM3441758 COSM3441759 rs1281031440 COSM5604514	155	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1283949487	156	L>V		No	TOPMed gnomAD
rs754506421	157	D>E		No	ExAC gnomAD
rs2061556622	157	D>N		No	gnomAD
COSM3441760 COSM3441761	158	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1028185313	158	R>S		No	Ensembl
rs1342740388	159	P>L		No	TOPMed gnomAD
rs780946460	159	P>S		No	ExAC TOPMed gnomAD
rs780946460	159	P>T		No	ExAC TOPMed gnomAD
TCGA novel	161	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2061557028	161	M>V		No	TOPMed gnomAD
rs1215621414	164	S>C		No	gnomAD
rs1271524140	164	S>N		No	gnomAD
rs1451187790	164	S>R		No	TOPMed gnomAD
rs373678903	165	P>S		No	ESP ExAC TOPMed gnomAD
rs746187420	166	L>S		No	ExAC TOPMed gnomAD
COSM5592567 COSM3441762 COSM3441763	167	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3441764 COSM3441765 COSM5371335	169	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1589883602	169	Q>R		No	Ensembl
rs2061557538	170	S>T		No	gnomAD
rs2134495095	171	V>A		No	Ensembl
rs1468907560	171	V>M		No	TOPMed gnomAD
rs531313054	173	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs775939596	173	I>V		No	ExAC TOPMed gnomAD
rs768703688	175	T>A		No	ExAC gnomAD
rs2061557938	175	T>R		No	TOPMed
rs1440257014	176	G>S		No	TOPMed gnomAD
rs1410133165	177	R>G		No	gnomAD
rs771355101	179	H>Q		No	ExAC TOPMed gnomAD
rs2061558202	180	P>T		No	Ensembl
rs1018870505	181	D>E		No	TOPMed gnomAD
rs761942331	181	D>G		No	ExAC TOPMed gnomAD
rs1488040207	182	S>N		No	TOPMed
rs2134495528	182	S>R		No	Ensembl
rs765438751	182	S>R		No	ExAC gnomAD
rs1589883724	183	R>T		No	Ensembl
rs772902065	184	R>G		No	ExAC TOPMed gnomAD
rs2061558488	184	R>K		No	TOPMed gnomAD
rs1393379998	185	A>P		No	gnomAD
COSM4715055 COSM4715056 COSM4715054	186	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	186	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1291472151	187	F>Y		No	gnomAD
rs866228865	188	H>N		No	Ensembl
rs1355943464	188	H>R		No	gnomAD
rs866228865	188	H>Y		No	Ensembl
rs2061558820	190	H>L		No	Ensembl
rs762794649	190	H>Y		No	ExAC gnomAD
COSM4552893 COSM4552894	192	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs377113732	193	V>A		No	1000Genomes ExAC TOPMed gnomAD
rs1434221808	193	V>I		No	TOPMed gnomAD
rs2134496222	194	D>G		No	Ensembl
rs1204808932	195	R>G		No	gnomAD
rs751519901	195	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
COSM3397317 rs752185437 COSM3397316	197	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs1185188574	197	M>L		No	TOPMed gnomAD
rs766931943	197	M>T		No	ExAC gnomAD
rs1185188574	197	M>V		No	TOPMed gnomAD
rs755737422	198	S>L		No	ExAC gnomAD
rs977033893	199	D>N		No	Ensembl
RCV000712696 rs777436865	200	T>I		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs746265623	201	F>L		No	ExAC gnomAD
rs1313196238	202	C>Y		No	TOPMed gnomAD
rs1328605372	204	L>V		No	TOPMed gnomAD
rs758734605	205	S>P		No	ExAC gnomAD
rs1228245583	211	D>G		No	gnomAD
rs1339992165	211	D>H		No	gnomAD
rs1228245583	211	D>V		No	gnomAD
rs776583769	212	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1228165244	213	C>Y		No	gnomAD
TCGA novel	214	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs752701924	216	C>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs752701924	216	C>Y		No	ExAC TOPMed gnomAD
rs1209405400	217	V>L		No	TOPMed gnomAD
rs2061560822	220	P>H		No	TOPMed
rs1034390108	220	P>S		No	TOPMed gnomAD
rs1477441868	221	G>R		No	TOPMed
rs1194626059	222	G>D		No	gnomAD
rs373215088	222	G>S		No	1000Genomes ExAC TOPMed gnomAD
rs1194626059	222	G>V		No	gnomAD
COSM6130808 COSM6130809 COSM6130807	223	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2061561153	224	E>V		No	Ensembl
rs1174053364	226	Q>P		No	gnomAD
COSM3415369 COSM5825666 rs894468303 COSM3415370	227	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed
rs1487629775	228	K>*		No	TOPMed gnomAD
rs916881442	229	N>H		No	Ensembl
rs2061561622	229	N>S		No	TOPMed
rs376748611	230	Y>C		No	1000Genomes ESP ExAC TOPMed gnomAD
rs376748611 COSM3441772 COSM3441771	230	Y>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1589884080	230	Y>H		No	Ensembl
rs767432281	232	A>E		No	ExAC gnomAD
rs1171999183	232	A>T		No	gnomAD
rs949698821	234	T>I		No	TOPMed
rs949698821	234	T>N		No	TOPMed
rs1324928667	235	C>S		No	gnomAD
rs1256537854	237	L>R		No	TOPMed
rs755612271	237	L>V		No	ExAC TOPMed gnomAD
rs758824388	239	E>D		No	ExAC gnomAD
TCGA novel	239	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs753470093	239	E>K		No	ExAC gnomAD
rs780397243	240	L>M		No	ExAC gnomAD
rs777822074	241	A>T		No	ExAC TOPMed gnomAD
rs371380798	243	N>D		No	Ensembl
rs1351944452	243	N>S		No	gnomAD
rs1206410558	244	C>F		No	gnomAD
rs1206410558	244	C>Y		No	gnomAD
rs2061563389	245	D>G		No	Ensembl
rs1281464900	246	N>Y		No	gnomAD
rs1295681966	248	N>D		No	TOPMed
rs1464034304	249	E>K		No	TOPMed gnomAD
rs2061563806	249	E>V		No	Ensembl
rs1193922904	250	Q>*		No	gnomAD
rs2061563948	250	Q>R		No	TOPMed gnomAD
TCGA novel	251	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1349904 COSM1349903 rs1589884285 COSM5100917	252	Q>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs1292650860	252	Q>P		No	TOPMed gnomAD
rs200257502	253	C>R		No	Ensembl
rs2061564373	255	H>L		No	TOPMed
rs2061564373	255	H>R		No	TOPMed
RCV001985468 rs61749240	255	H>Y		No	ClinVar TOPMed dbSNP gnomAD
COSM3441774 rs1199755219 COSM3441773	258	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1474556107	259	L>M		No	TOPMed gnomAD
rs1364338965	259	L>W		No	gnomAD
rs769894431	260	N>S		No	ExAC gnomAD
rs374561180	267	E>*		No	ESP ExAC TOPMed gnomAD
rs374561180	267	E>Q		No	ESP ExAC TOPMed gnomAD
rs2061565268	268	G>A		No	gnomAD
rs1431581516	268	G>S		No	TOPMed gnomAD
rs2061565268	268	G>V		No	gnomAD
COSM3441775 COSM3441776 rs1424514797	269	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed
rs187112223	270	C>Y		No	1000Genomes ExAC TOPMed gnomAD
rs774301672	271	E>*		No	ExAC TOPMed gnomAD
rs774301672	271	E>K		No	ExAC TOPMed gnomAD
rs1439165211	272	K>E		No	gnomAD
rs771936307	274	D>E		No	ExAC gnomAD
rs2061565766	274	D>Y		No	TOPMed gnomAD
rs201683279	275	M>L		No	ExAC TOPMed gnomAD
rs201683279	275	M>V		No	ExAC TOPMed gnomAD
rs1278265755	276	V>A		No	gnomAD
TCGA novel	276	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2061565917	276	V>L		No	Ensembl
rs2134500079	278	S>A		No	Ensembl
rs2134500124	279	G>D		No	Ensembl
rs1213761389	280	D>G		No	gnomAD
rs1466826254	281	S>I		No	gnomAD
rs1209041837	281	S>R		No	TOPMed gnomAD
rs764817889	284	R>K		No	ExAC gnomAD
rs751950223	285	K>E		No	ExAC TOPMed gnomAD
rs755337510	285	K>I		No	ExAC gnomAD
COSM3868095 COSM3868096	286	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs781597048	289	D>N		No	ExAC gnomAD
rs370227059	292	A>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs370227059	292	A>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs370227059	292	A>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1309970660	292	A>V		No	TOPMed gnomAD
rs192084195	293	A>S		No	1000Genomes ExAC TOPMed gnomAD
rs749260720	295	T>A		No	ExAC TOPMed gnomAD
rs749324639	295	T>I		No	ExAC gnomAD
rs749324639	295	T>N		No	ExAC gnomAD
rs2061566612	296	F>V		No	Ensembl
COSM3441780 COSM3441779	297	L>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs771301576	297	L>V		No	ExAC gnomAD
rs1397712129	298	S>N		No	gnomAD
rs957152318	299	H>R		No	TOPMed gnomAD
rs1564635702	300	F>S		No	Ensembl
rs745692327	302	D>G		No	ExAC TOPMed gnomAD
rs773458204	302	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs771881470	303	F>L		No	ExAC gnomAD
rs760662146	304	P>H		No	ExAC gnomAD
rs1332419858	305	D>E		No	TOPMed gnomAD
rs577869012	305	D>G		No	1000Genomes ExAC TOPMed gnomAD
rs577869012	305	D>V		No	1000Genomes ExAC TOPMed gnomAD
rs2061567177	306	N>D		No	TOPMed
rs768558197	306	N>K		No	TOPMed gnomAD
COSM5826852 COSM1349912 COSM1349911	306	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM466110 rs773934458	308	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs761269172	309	D>G		No	ExAC TOPMed gnomAD
rs761269172	309	D>V		No	ExAC TOPMed gnomAD
rs1464464324	309	D>Y		No	TOPMed
rs750053159	310	V>A		No	ExAC gnomAD
TCGA novel	312	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1250994151	312	E>G		No	gnomAD
rs534230873	313	D>E		No	1000Genomes ExAC gnomAD
rs1485935185	313	D>G		No	TOPMed gnomAD
COSM4926312 COSM4926310 COSM4926311	313	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1349914 COSM1349913 COSM5129326 rs201003341	314	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
COSM3441783 COSM3441784	314	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs752937283	316	K>E		No	ExAC gnomAD
COSM921646 COSM1585242	316	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs886047498	317	S>I		No	TOPMed gnomAD
rs2061567932	318	K>E		No	TOPMed
rs573916830	319	K>N		No	1000Genomes ExAC TOPMed gnomAD
rs17109674	320	E>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs201512392	321	R>P		No	ExAC TOPMed gnomAD
rs201512392	321	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1394931862	323	T>A		No	gnomAD
rs1295865478	323	T>S		No	gnomAD
rs1308826821	324	L>M		No	gnomAD
rs1225942355	324	L>S		No	gnomAD
rs1273592559	327	R>K		No	gnomAD
TCGA novel	328	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1589884909	329	F>L		No	Ensembl
rs1212988900	330	C>R		No	TOPMed gnomAD
COSM3358920 COSM3358919	335	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1483179479	337	K>E		No	TOPMed
rs2061568832	341	Y>C		No	TOPMed
rs1210892675	342	T>I		No	TOPMed
rs1283509106	345	R>G		No	Ensembl
rs1389986963	345	R>I		No	TOPMed gnomAD
rs1389986963	345	R>K		No	TOPMed gnomAD
rs368340608	345	R>S		No	ESP ExAC gnomAD
rs1389986963	345	R>T		No	TOPMed gnomAD
rs1176141437	347	I>V		No	gnomAD
rs2061569275	349	R>K		No	gnomAD
rs1336181934	350	T>S		No	TOPMed gnomAD
COSM686046 COSM1646369	351	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1056300115	352	P>L		No	TOPMed gnomAD
rs544983455	353	S>T		No	1000Genomes ExAC gnomAD
rs2061569453	354	G>C		No	gnomAD
rs2061569640	356	I>F		No	Ensembl
rs2061569735	356	I>T		No	Ensembl
rs2061569640	356	I>V		No	Ensembl
rs2134502948	357	G>W		No	Ensembl
rs894445177	358	L>P		No	TOPMed
rs2061570006	360	A>T		No	TOPMed
rs1432513098	360	A>V		No	gnomAD
rs201677757	361	W>*		No	TOPMed
rs201677757	361	W>L		No	TOPMed
rs762520036	362	S>N		No	ExAC TOPMed
rs776042399	365	D>E		No	ExAC gnomAD
rs903147027	365	D>V		No	TOPMed gnomAD
rs955777589	366	Q>*		No	TOPMed
rs867011104	367	K>*		No	Ensembl
COSM686045 COSM1646368	367	K>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM6067212 COSM6067210 COSM6067211	367	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs771184962	368	R>S		No	Ensembl
rs2061570821	368	R>T		No	TOPMed gnomAD
rs1185816545	370	G>C		No	TOPMed gnomAD
rs764511730	370	G>D		No	ExAC TOPMed gnomAD
rs764511730	370	G>V		No	ExAC TOPMed gnomAD
rs867723144	371	P>A		No	TOPMed gnomAD
rs371635786	371	P>L		No	ESP ExAC TOPMed gnomAD
rs371635786	371	P>R		No	ESP ExAC TOPMed gnomAD
COSM3441786 COSM3441785	371	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs867723144	371	P>T		No	TOPMed gnomAD
rs199906617 COSM3868097 COSM3868098	374	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs780040765	377	R>K		No	ExAC gnomAD
rs368745117	378	V>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2061571853	379	M>V		No	TOPMed
rs1589885236	380	E>D		No	Ensembl
rs754933489	381	P>A		No	ExAC TOPMed gnomAD
rs780910033	381	P>H		No	ExAC TOPMed gnomAD
rs780910033	381	P>R		No	ExAC TOPMed gnomAD
rs754933489	381	P>S		No	ExAC TOPMed gnomAD
rs772683273	382	P>L		No	ExAC TOPMed gnomAD
rs202112015	383	S>P		No	1000Genomes ExAC gnomAD
rs1394676351	384	T>I		No	TOPMed gnomAD
rs1272805667	385	V>A		No	gnomAD
rs373211588	385	V>L		No	ESP TOPMed
rs1366611890	386	E>*		No	gnomAD
rs1028504203	387	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs748941618	388	R>S		No	ExAC gnomAD
rs770442535	390	D>N		No	ExAC gnomAD
rs2061572910	392	S>T		No	gnomAD
rs2061573033	393	Q>*		No	Ensembl
rs760137530	394	R>H		No	ExAC TOPMed gnomAD
rs529894244	395	L>P		No	1000Genomes ExAC TOPMed gnomAD
rs374964859	396	S>L		No	ESP ExAC TOPMed gnomAD
COSM3441787 COSM3441788	400	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1419025268	402	P>L		No	Ensembl
rs1421936530	403	I>M		No	TOPMed
rs989468480	403	I>V		No	gnomAD
rs2046617013	405	N>D		No	TOPMed
rs2046617097	405	N>K		No	gnomAD
rs531179968	407	V>M		No	1000Genomes ExAC TOPMed gnomAD
rs1270211318	409	R>I		No	TOPMed gnomAD
rs1285859675	409	R>S		No	gnomAD
rs749717429	410	E>V		No	ExAC gnomAD
TCGA novel	411	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs757784218	412	T>I		No	ExAC TOPMed gnomAD
rs757784218	412	T>K		No	ExAC TOPMed gnomAD
rs779188785	414	N>S		No	ExAC TOPMed
rs977349780	415	T>I		No	TOPMed gnomAD
rs746234814	415	T>P		No	ExAC gnomAD
rs2046619145	416	V>A		No	TOPMed gnomAD
rs1483973768	416	V>I		No	gnomAD
rs375770728	417	G>V		No	ESP ExAC TOPMed gnomAD
rs768583952	418	S>A		No	ExAC TOPMed gnomAD
rs2135907716	419	L>V		No	Ensembl
rs776797451	420	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs761601311	420	L>R		No	ExAC gnomAD
rs769861376	423	L>F		No	ExAC TOPMed gnomAD
rs769861376	423	L>I		No	ExAC TOPMed gnomAD
rs1371745054	424	T>A		No	gnomAD
rs757833114	424	T>N		No	ExAC TOPMed gnomAD
TCGA novel	425	K>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1306689063	426	L>F		No	gnomAD
rs762830348	428	A>G		No	ExAC TOPMed gnomAD
rs762830348	428	A>V		No	ExAC TOPMed gnomAD
rs2046620578	429	S>P		No	Ensembl
rs2135908196	430	E>G		No	Ensembl
rs759264866 COSM3981205	430	E>K	ovary [Cosmic]	No	cosmic curated ExAC gnomAD
rs200380935 RCV002244601	432	A>G		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs200380935	432	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2046621411	433	H>Q		No	TOPMed
rs2135908297	433	H>R		No	Ensembl
rs1344014759	436	I>K		No	gnomAD
rs757692426	437	S>N		No	ExAC gnomAD
COSM5461109 COSM5461111 COSM5461110 COSM5461112 rs1482772158	438	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
COSM686044 COSM1646367 COSM1146514	439	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1422242968	439	G>D		No	gnomAD
rs201727715	439	G>R		No	TOPMed gnomAD
rs201727715	439	G>S		No	TOPMed gnomAD
TCGA novel	440	P>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1391218575	441	C>F		No	gnomAD
rs2046622845	441	C>R		No	gnomAD
COSM3441793 COSM3441792 COSM3441794	441	C>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1431996947	443	K>N		No	gnomAD
rs1167331937	444	Q>K		No	gnomAD
rs369517030	444	Q>P		No	ESP ExAC TOPMed gnomAD
rs187314834	446	V>D		No	1000Genomes
RCV001896130 rs781068774	447	R>*		No	ClinVar ExAC dbSNP gnomAD
rs140876132	447	R>L		No	1000Genomes ExAC gnomAD
rs140876132	447	R>P		No	1000Genomes ExAC gnomAD
rs140876132	447	R>Q		No	1000Genomes ExAC gnomAD
rs770058603	448	D>N		No	ExAC TOPMed gnomAD
rs773262919	449	T>I		No	ExAC gnomAD
rs116996657	450	V>A		No	1000Genomes ExAC gnomAD
rs2046624714	451	C>R		No	gnomAD
rs1312653010	452	E>A		No	TOPMed gnomAD
rs1312653010	452	E>G		No	TOPMed gnomAD
rs2046625103	453	Y>H		No	TOPMed gnomAD
rs759052382	454	R>C		No	ExAC TOPMed gnomAD
rs796709138	454	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs752358441	455	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1421030425	456	T>N		No	gnomAD
rs1173503822	459	R>K		No	gnomAD
rs1590089276	460	T>I		No	Ensembl
rs945128964	461	S>L		No	TOPMed
rs760161309	462	I>M		No	ExAC gnomAD
rs1263170493	462	I>T		No	TOPMed gnomAD
rs2046626116	462	I>V		No	TOPMed
rs763640206 COSM1646366 COSM1146515 COSM686043	463	S>L	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs1187018122	463	S>P		No	TOPMed gnomAD
rs1306287584	464	Q>P		No	TOPMed gnomAD
rs569393306	465	Y>S		No	1000Genomes ExAC gnomAD
rs2046627483	466	I>T		No	Ensembl
rs1465104605	466	I>V		No	gnomAD
rs1452138098	468	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs903544158	468	G>S		No	TOPMed gnomAD
rs17508082	469	S>P		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM3441797 COSM3441796 COSM3441795	470	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs980321568	470	L>I		No	Ensembl
rs575908537	471	L>I		No	ExAC TOPMed gnomAD
rs748431259	471	L>Q		No	ExAC gnomAD
rs371884091	473	A>G		No	TOPMed gnomAD
rs1299085187	473	A>T		No	gnomAD
rs371884091	473	A>V		No	TOPMed gnomAD
rs200830976	474	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs886047499	474	T>N		No	gnomAD
rs769965610	475	T>K		No	ExAC TOPMed gnomAD
rs769965610	475	T>M		No	ExAC TOPMed gnomAD
rs749189889	476	S>T		No	ExAC gnomAD
rs1412024507	479	A>T		No	TOPMed
rs2046629622	482	G>D		No	TOPMed
rs2046629544	482	G>S		No	TOPMed
rs376905496	483	L>F		No	ESP ExAC TOPMed gnomAD
rs2046629807	484	L>R		No	TOPMed
rs2046629894	485	S>C		No	Ensembl
rs773950474	486	T>I		No	ExAC gnomAD
rs1489004720 COSM1139525	487	F>L	lung [Cosmic]	No	cosmic curated gnomAD
rs940715174	488	G>R		No	Ensembl
rs951540403	489	G>A		No	TOPMed
rs377605811	489	G>R		No	ESP ExAC TOPMed gnomAD
TCGA novel	489	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs760357464	490	S>P		No	ExAC TOPMed gnomAD
rs901826866	492	G>R		No	Ensembl
rs763387612	493	R>Q		No	ExAC gnomAD
rs1249996267	495	M>I		No	gnomAD
rs766906990	495	M>R		No	ExAC gnomAD
rs2046631636	497	K>R		No	TOPMed
rs1404447144	498	E>Q		No	gnomAD
rs61751493	499	R>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1331936652	500	Q>*		No	gnomAD
rs2047963296	500	Q>H		No	TOPMed
rs1237728742	501	P>A		No	gnomAD
rs371545313	501	P>L		No	ESP ExAC gnomAD
rs1237728742	501	P>T		No	gnomAD
rs927084372	502	G>A		No	gnomAD
rs927084372	502	G>D		No	gnomAD
rs200875238	502	G>S		No	1000Genomes ExAC TOPMed gnomAD
rs181228584	503	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs746806934	504	S>F		No	ExAC gnomAD
rs780803829	505	V>L		No	ExAC TOPMed gnomAD
COSM1152213	505	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2047964359	506	A>T		No	gnomAD
rs766326899	507	N>D		No	ExAC gnomAD
rs766326899	507	N>H		No	ExAC gnomAD
rs1590176627	507	N>S		No	Ensembl
rs1590176627	507	N>T		No	Ensembl
rs998892346	508	S>A		No	Ensembl
rs769308791	508	S>Y		No	ExAC gnomAD
rs1159752358	509	N>K		No	TOPMed gnomAD
rs1473457358	510	A>V		No	gnomAD
rs772621903	511	L>F		No	ExAC gnomAD
rs1382585182	512	P>L		No	TOPMed gnomAD
rs2047964962	512	P>T		No	Ensembl
TCGA novel	513	S>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2047965270 TCGA novel	513	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs2047965527	514	S>N		No	Ensembl
rs2047965698	515	S>L		No	Ensembl
rs1300461089	516	A>S		No	gnomAD
rs375109167	519	S>G		No	ESP TOPMed
COSM6067202 COSM6067200 COSM6067199 COSM6067201	520	K>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs945679453	522	L>M		No	TOPMed gnomAD
rs2047966560	523	I>M		No	1000Genomes TOPMed gnomAD
COSM198849 rs761107139 COSM5117632 COSM5117630 COSM5117631	524	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs761107139	524	D>Y		No	ExAC TOPMed gnomAD
rs764601690 COSM6130803 COSM1506413 COSM6130806 COSM6130805 COSM6130804	526	Q>H	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated ExAC gnomAD NCI-TCGA Cosmic
rs377031690	527	P>H		No	ESP ExAC TOPMed gnomAD
rs377031690	527	P>R		No	ESP ExAC TOPMed gnomAD
rs761968908	529	I>T		No	ExAC TOPMed gnomAD
rs1449861664	530	Q>*		No	gnomAD
rs1415198205	530	Q>R		No	Ensembl
rs556484452	532	P>S		No	1000Genomes ExAC TOPMed gnomAD
COSM4573914 rs1426033120 COSM4573913 COSM4573912	536	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs1014453435	537	S>I		No	1000Genomes TOPMed
rs1014453435	537	S>N		No	1000Genomes TOPMed
rs1023103811	538	I>M		No	TOPMed
rs1416236768	538	I>N		No	TOPMed gnomAD
rs754740363	542	Q>H		No	ExAC TOPMed
rs2047968511	543	E>G		No	TOPMed gnomAD
rs1436302444	544	Q>R		No	gnomAD
rs780996293	546	I>V		No	ExAC TOPMed gnomAD
rs17417407	548	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs770620916	550	V>A		No	ExAC TOPMed gnomAD
rs377400616	550	V>I		No	ESP TOPMed
rs559300385	551	L>F		No	1000Genomes ExAC TOPMed gnomAD
TCGA novel	552	P>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs370540250	553	V>I		No	1000Genomes ESP ExAC gnomAD
rs781026952	554	D>N		No	ExAC TOPMed gnomAD
COSM3441802 COSM3441803 COSM5837486 rs541692822 COSM3441801	556	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
COSM1349916 COSM1349918 COSM1349917 COSM5131287	556	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs541692822	556	L>V		No	1000Genomes ExAC TOPMed gnomAD
rs765379329	557	C>F		No	ExAC gnomAD
rs750719125	559	L>F		No	ExAC gnomAD
rs763000355	560	T>A		No	ExAC gnomAD
rs2047970494	560	T>I		No	TOPMed
rs375307339	561	R>Q		No	ESP ExAC TOPMed gnomAD
COSM1349920 rs186743876	561	R>W	large_intestine [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
COSM3441805 COSM3441804 COSM3441806	562	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1381945637	563	L>S		No	gnomAD
COSM6067196 COSM6067197 COSM343911 COSM6067198	564	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs754931497	564	G>V		No	ExAC TOPMed gnomAD
rs557560167	565	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1433716770	565	T>I		No	gnomAD
rs1433716770	565	T>N		No	gnomAD
rs557560167	565	T>S		No	ExAC gnomAD
rs1564753542	566	P>L		No	TOPMed
TCGA novel	569	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs749018318	572	L>F		No	ExAC
rs1590177206	572	L>W		No	TOPMed
rs1323830446	573	P>L		No	Ensembl
rs1291594905	574	C>S		No	TOPMed
rs1225640410	575	L>R		No	TOPMed gnomAD
rs756796071	575	L>V		No	ExAC gnomAD
rs778594716	576	K>E		No	ExAC gnomAD
rs141639885	577	A>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs934381964	578	S>A		No	Ensembl
rs2047972927	579	I>T		No	Ensembl
rs368809484	579	I>V		No	ESP ExAC TOPMed gnomAD
rs895454088	580	S>A		No	Ensembl
rs11596200	581	A>T		No	Ensembl
rs1472959016	581	A>V		No	gnomAD
rs748451084	582	S>L		No	ExAC gnomAD
COSM1317408 COSM1317409 COSM1317410	584	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1292831482	585	T>A		No	Ensembl
rs763196962	585	T>N		No	ExAC gnomAD
rs1393290706	586	T>I		No	gnomAD
rs1393290706	586	T>N		No	gnomAD
rs1423348072	588	N>D		No	gnomAD
rs766398340	588	N>K		No	ExAC TOPMed gnomAD
rs1164122278	589	G>E		No	gnomAD
rs2047974886	590	E>G		No	Ensembl
rs906050136	591	H>Y		No	TOPMed
rs2047975328	592	N>S		No	Ensembl
rs2047975245	592	N>Y		No	Ensembl
rs2047975409	593	A>V		No	Ensembl
rs774429019	594	L>H		No	ExAC gnomAD
rs1350645474	594	L>I		No	gnomAD
rs774429019	594	L>P		No	ExAC gnomAD
rs866437239	595	E>K		No	Ensembl
rs767353083	596	D>E		No	ExAC TOPMed gnomAD
rs755841557	598	V>M		No	ExAC TOPMed gnomAD
rs1296578588	599	M>I		No	gnomAD
rs763989985	599	M>V		No	1000Genomes ExAC TOPMed gnomAD
TCGA novel	600	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2047976698	600	R>W		No	TOPMed
rs2047976871	601	F>L		No	TOPMed
rs61751495	602	N>D		No	ESP ExAC TOPMed gnomAD
rs61751495	602	N>H		No	ESP ExAC TOPMed gnomAD
rs554159388	603	E>*		No	1000Genomes ExAC TOPMed gnomAD
COSM1646365 COSM686042 COSM1146516	603	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs554159388	603	E>Q		No	1000Genomes ExAC TOPMed gnomAD
rs2047977233	603	E>V		No	TOPMed
rs778281055	604	V>M		No	TOPMed gnomAD
rs2049980213	607	W>*		No	TOPMed
rs979353907	607	W>*		No	Ensembl
rs756658359	609	T>I		No	ExAC gnomAD
rs749650847	610	W>*		No	ExAC gnomAD
rs1294764092	610	W>R		No	gnomAD
COSM1585239 COSM921648 COSM1585238	611	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1208771113	613	L>F		No	TOPMed gnomAD
rs1485655194	613	L>P		No	TOPMed gnomAD
rs752386035	614	T>M		No	TOPMed gnomAD
rs2049981312	616	G>R		No	TOPMed
rs2049981711	618	M>I		No	Ensembl
rs200180170	618	M>L		No	ESP ExAC TOPMed gnomAD
rs746126689	618	M>T		No	ExAC gnomAD
rs200180170	618	M>V		No	ESP ExAC TOPMed gnomAD
rs1589381574	619	E>G		No	Ensembl
rs1589381584	620	E>G		No	Ensembl
rs778222582	620	E>K		No	ExAC gnomAD
rs775660349	621	K>E		No	ExAC gnomAD
rs1564806961	622	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs376708637	622	R>Q		No	ESP ExAC TOPMed gnomAD
rs1471710477	623	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1589381624	624	V>G		No	Ensembl
rs768638774	627	Y>H		No	ExAC gnomAD
rs776774194	628	L>F		No	ExAC gnomAD
rs1589381648	628	L>S		No	Ensembl
TCGA novel	630	H>Q	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs761685163	630	H>R		No	ExAC gnomAD
TCGA novel	630	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs765167668	632	A>S		No	ExAC TOPMed gnomAD
rs765167668	632	A>T		No	ExAC TOPMed gnomAD
rs2049983582	633	K>E		No	TOPMed
TCGA novel	633	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs750064042	634	C>Y		No	ExAC gnomAD
rs1288229733	636	W>G		No	gnomAD
rs369780470	638	M>K		No	ESP ExAC TOPMed gnomAD
rs1162562876	639	G>D		No	TOPMed gnomAD
rs765752967	639	G>S		No	ExAC gnomAD
rs1285314783	640	N>D		No	gnomAD
rs1321467584	640	N>S		No	gnomAD
rs1223188527	641	Y>*		No	gnomAD
COSM3441810 COSM3441811 COSM3441812	645	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel rs2049984813	645	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1158028629	646	E>Q		No	TOPMed
rs754390309	647	F>L		No	ExAC gnomAD
rs867638196	647	F>L		No	gnomAD
rs368943095	647	F>S		No	ESP ExAC gnomAD
rs779280589	649	A>S		No	ExAC gnomAD
rs2049985812	651	L>F		No	TOPMed
COSM5212620 COSM1474881 COSM1474879 COSM1474880	652	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2050235161	653	S>P		No	Ensembl
COSM1585235 COSM921651 COSM1585234	654	R>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs771164731	655	K>E		No	Ensembl
rs1049081999	655	K>R		No	TOPMed gnomAD
rs1049081999	655	K>T		No	TOPMed gnomAD
rs1475640405	656	V>F		No	TOPMed gnomAD
rs1475640405	656	V>L		No	TOPMed gnomAD
rs1259909740	657	L>*		No	Ensembl
rs776791387	657	L>F		No	TOPMed gnomAD
TCGA novel	658	K>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2050235876	659	M>I		No	TOPMed gnomAD
rs200246546	662	F>C		No	TOPMed
COSM6067193 COSM6067194 COSM6067195 COSM6067192	662	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs200246546	662	F>S		No	TOPMed
rs755071593	665	Q>*		No	ExAC gnomAD
rs781446502	665	Q>H		No	ExAC TOPMed gnomAD
rs1205637132	665	Q>P		No	TOPMed gnomAD
rs367656255	666	S>F		No	ESP ExAC TOPMed gnomAD
rs1313577956	670	T>I		No	TOPMed gnomAD
rs1313577956	670	T>N		No	TOPMed gnomAD
rs2050236802	670	T>P		No	Ensembl
rs1313577956	670	T>S		No	TOPMed gnomAD
rs1229744391	671	M>I		No	TOPMed gnomAD
rs1359294597	671	M>L		No	gnomAD
rs2050237216	671	M>T		No	TOPMed
rs2050237389	672	R>K		No	TOPMed gnomAD
TCGA novel	672	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs773350820	673	S>I		No	ExAC TOPMed gnomAD
rs773350820	673	S>N		No	ExAC TOPMed gnomAD
rs370241315	673	S>R		No	ESP ExAC TOPMed gnomAD
COSM1585232 COSM1585233 COSM921652	676	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1237624507	677	A>T		No	TOPMed gnomAD
rs2050237912	677	A>V		No	Ensembl
rs1181484025	678	M>I		No	gnomAD
rs201422605	678	M>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1030969242	679	A>T		No	TOPMed
rs2050238409	680	Q>H		No	gnomAD
rs770083822	681	H>R		No	ExAC TOPMed gnomAD
COSM3415371 COSM5079183 COSM3415372 COSM3415373	681	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1216844157	682	E>A		No	gnomAD
rs1216844157	682	E>V		No	gnomAD
rs1170403037	683	S>F		No	TOPMed gnomAD
rs2050238839	683	S>T		No	gnomAD
rs2050239028	684	S>F		No	Ensembl
rs1462050295	685	C>S		No	TOPMed gnomAD
rs2050239326	685	C>W		No	gnomAD
rs1462050295	685	C>Y		No	TOPMed gnomAD
COSM1152215	686	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1297291863	689	K>N		No	Ensembl
rs12768416	690	V>A		No	Ensembl
rs12768416	690	V>G		No	Ensembl
rs1408215263	691	V>A		No	TOPMed gnomAD
rs750947203	692	T>I		No	ExAC TOPMed gnomAD
rs750947203	692	T>R		No	ExAC TOPMed gnomAD
COSM1349923 COSM1349922 COSM5140960 COSM1349924	692	T>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs766687684	693	R>C		No	ExAC TOPMed gnomAD
COSM1349926 rs866040967 COSM352323 COSM1349925 COSM5089719	693	R>H	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs375465343	696	H>L		No	ESP ExAC gnomAD
TCGA novel	698	P>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2050240677	698	P>R		No	TOPMed
TCGA novel	698	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	699	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs755267829	700	C>Y		No	ExAC gnomAD
rs781358365	702	V>A		No	ExAC gnomAD
rs748234743	703	V>F		No	ExAC TOPMed gnomAD
rs2050241334	706	C>R		No	Ensembl
rs574681547	707	G>A		No	1000Genomes ExAC TOPMed gnomAD
rs749225777	708	V>A		No	ExAC TOPMed gnomAD
rs749225777	708	V>E		No	ExAC TOPMed gnomAD
rs1167364270	709	F>L		No	gnomAD
rs953269160	710	L>P		No	TOPMed gnomAD
rs2050242046	711	K>R		No	TOPMed gnomAD
rs2137295429	712	E>G		No	Ensembl
rs774037165	714	C>F		No	ExAC TOPMed gnomAD
rs2137295471	714	C>R		No	Ensembl
rs774037165	714	C>S		No	ExAC TOPMed gnomAD
rs1274580178	715	E>D		No	TOPMed gnomAD
rs764624873	715	E>K		No	TOPMed gnomAD
rs771716896	719	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs532351295 COSM1474883	720	A>T	breast [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
COSM3441814 COSM3441813 COSM3441815	723	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs763394762	724	M>L		No	ExAC TOPMed gnomAD
rs140596357	724	M>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs763394762	724	M>V		No	ExAC TOPMed gnomAD
rs751878309	728	P>L		No	ExAC TOPMed gnomAD
rs767839016	729	R>L		No	ExAC TOPMed gnomAD
rs767839016	729	R>Q		No	ExAC TOPMed gnomAD
rs2050244014	729	R>W		No	TOPMed gnomAD
rs969149092	731	N>D		No	TOPMed gnomAD
COSM3441818 COSM3441816 COSM3441817	732	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs373425084	733	Q>R		No	ESP ExAC TOPMed gnomAD
rs2050244914	735	E>A		No	Ensembl
rs777744481	735	E>D		No	ExAC gnomAD
rs2050245093	736	T>I		No	TOPMed
rs2050245184	737	L>S		No	TOPMed
COSM6067191 COSM6067190 COSM6067188 COSM6067189	738	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1454663268	738	E>D		No	gnomAD
rs1428784948	738	E>K		No	gnomAD
rs944765770	740	V>L		No	TOPMed gnomAD
rs11187829	742	D>Y		No	Ensembl
TCGA novel	743	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2050307344	744	S>I		No	TOPMed
rs1291205175	744	S>R		No	gnomAD
rs1480998769	745	G>E		No	gnomAD
rs1213897479	746	Q>E		No	TOPMed
rs753867049	746	Q>R		No	ExAC gnomAD
rs1248624002	747	D>N		No	gnomAD
rs778698239	748	N>Y		No	ExAC gnomAD
rs1589395609	749	F>L		No	Ensembl
rs1387431754	750	L>S		No	gnomAD
rs750405323 COSM1970368	752	R>*	central_nervous_system [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
COSM5837487 COSM5837490 COSM5837489 COSM5837488	752	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs758156206	752	R>Q		No	ExAC TOPMed gnomAD
rs777426672	753	V>M		No	TOPMed gnomAD
rs2050309437	754	G>A		No	Ensembl
TCGA novel rs746608788	754	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA ExAC gnomAD
rs768199585	756	N>K		No	ExAC gnomAD
rs1293747652	759	K>Q		No	Ensembl
rs1433151711	760	N>K		No	Ensembl
rs376554016	761	S>L		No	ESP ExAC TOPMed gnomAD
rs769399012	762	E>D		No	ExAC gnomAD
rs1395256114	762	E>K		No	gnomAD
rs1170242242	764	E>D		No	TOPMed
rs774971762	764	E>G		No	ExAC gnomAD
rs1380292836	765	S>C		No	gnomAD
rs760154119	766	T>I		No	ExAC TOPMed gnomAD
rs772518223	767	V>A		No	ExAC TOPMed gnomAD
rs2137327219	767	V>I		No	Ensembl
rs760881877	768	N>T		No	ExAC TOPMed gnomAD
rs2137327391	769	S>T		No	Ensembl
rs764214312	770	I>T		No	ExAC gnomAD
rs1245412653	775	R>Q		No	TOPMed gnomAD
rs370127450	778	N>S		No	ESP ExAC TOPMed gnomAD
rs750319129	779	R>P		No	ExAC TOPMed gnomAD
rs750319129	779	R>Q		No	ExAC TOPMed gnomAD
rs1589395804	780	S>I		No	Ensembl
rs758346786	782	E>D		No	ExAC gnomAD
rs766097369	783	T>A		No	ExAC gnomAD
rs1371978421	784	D>G		No	TOPMed gnomAD
rs376994717	785	E>*		No	ESP ExAC TOPMed gnomAD
rs376994717	785	E>K		No	ESP ExAC TOPMed gnomAD
rs1469051094	786	E>D		No	gnomAD
rs1002583376	786	E>K		No	TOPMed gnomAD
rs780690530	787	D>E		No	ExAC gnomAD
rs747879044	788	S>G		No	ExAC TOPMed gnomAD
rs572497944	788	S>R		No	1000Genomes ExAC TOPMed gnomAD
rs201028754	789	P>A		No	1000Genomes gnomAD
rs2050313959	789	P>L		No	gnomAD
rs201028754	789	P>S		No	1000Genomes gnomAD
rs777451047	790	S>G		No	ExAC gnomAD
rs1346509519	792	G>R		No	TOPMed gnomAD
rs2050314589	793	N>K		No	TOPMed
rs2050314484	793	N>S		No	TOPMed
COSM4165588 rs2050314693	794	S>R	kidney [Cosmic]	No	cosmic curated Ensembl
rs2050314792	796	R>G		No	TOPMed
rs541915097	796	R>S		No	Ensembl
rs746317392	797	K>Q		No	ExAC gnomAD
rs772708077	801	K>Q		No	ExAC TOPMed gnomAD
rs776201612	802	D>N		No	ExAC TOPMed gnomAD
rs1261856507	803	K>R		No	gnomAD
rs1564815734	804	S>R		No	Ensembl
rs757088793	805	R>L		No	ExAC TOPMed gnomAD
rs757088793	805	R>P		No	ExAC TOPMed gnomAD
COSM4899007 COSM4899008 rs757088793 COSM4899010 COSM4899009	805	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1297912148	806	W>R		No	TOPMed gnomAD
rs780684028	807	Q>H		No	ExAC gnomAD
rs762125266	807	Q>P		No	ExAC TOPMed gnomAD
TCGA novel	808	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1585230 COSM1585231 COSM921655	809	I>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs368230381	809	I>V		No	ESP ExAC gnomAD
rs1266118189	810	I>T		No	gnomAD
rs539472268	811	G>E		No	1000Genomes ExAC gnomAD
rs2050663681	811	G>R		No	Ensembl
rs770001198	812	D>H		No	ExAC TOPMed gnomAD
rs770001198	812	D>Y		No	ExAC TOPMed gnomAD
rs1289346091	813	L>F		No	TOPMed gnomAD
rs2050664204	815	D>E		No	Ensembl
rs2050664129	815	D>Y		No	Ensembl
rs762998243	817	D>N		No	ExAC TOPMed gnomAD
rs771042502	817	D>V		No	ExAC TOPMed gnomAD
COSM1646363 COSM1146518 COSM686040	818	N>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2050664772	819	D>N		No	Ensembl
rs1293673641	820	I>F		No	TOPMed gnomAD
rs1293673641	820	I>V		No	TOPMed gnomAD
rs2050665049	822	E>K		No	TOPMed
rs1341339587	824	S>A		No	TOPMed gnomAD
rs759542875	827	Y>D		No	ExAC TOPMed gnomAD
rs759542875	827	Y>H		No	ExAC TOPMed gnomAD
rs752538893	828	D>N		No	ExAC TOPMed gnomAD
TCGA novel	830	H>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1322398478	830	H>R		No	TOPMed gnomAD
rs1298895117	830	H>Y		No	TOPMed gnomAD
rs760609959	831	G>R		No	ExAC TOPMed gnomAD
rs760609959	831	G>S		No	ExAC TOPMed gnomAD
rs1222377922	831	G>V		No	gnomAD
rs2050666368	833	E>Q		No	Ensembl
rs2050666527	834	D>H		No	TOPMed
rs2050666622	835	S>L		No	Ensembl
rs376083354	837	K>*		No	ESP TOPMed
rs376083354	837	K>E		No	ESP TOPMed
rs1386978841	837	K>N		No	TOPMed gnomAD
rs2050667027	838	A>S		No	TOPMed
rs756796239	840	D>G		No	ExAC gnomAD
rs200455333	840	D>N		No	ExAC TOPMed gnomAD
rs778596911	841	H>D		No	ExAC gnomAD
rs751960203	841	H>P		No	ExAC TOPMed gnomAD
rs755520745	841	H>Q		No	ExAC TOPMed gnomAD
rs748533923	842	G>E		No	ExAC TOPMed gnomAD
rs770194045	843	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1171042109	846	I>M		No	TOPMed gnomAD
RCV001761136 rs2050668187	847	P>A		No	ClinVar TOPMed dbSNP gnomAD
rs2050668279	848	W>C		No	TOPMed gnomAD
rs201457945	850	V>M		No	ExAC TOPMed gnomAD
rs774506744	852	S>C		No	ExAC gnomAD
rs774506744	852	S>Y		No	ExAC gnomAD
rs200483837	853	I>F		No	1000Genomes ExAC TOPMed gnomAD
COSM3985822 COSM3985820 COSM3985821	853	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs772039022	855	A>T		No	ExAC TOPMed gnomAD
rs775344140	855	A>V		No	ExAC gnomAD
rs1313467465	856	D>E		No	gnomAD
COSM6037354 COSM6037356 COSM6037357 rs764021031 COSM6037355	856	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs764021031	856	D>Y		No	ExAC TOPMed gnomAD
rs764592323	857	V>G		No	ExAC
rs761578986	857	V>M		No	ExAC gnomAD
rs536046544	858	H>Q		No	1000Genomes ExAC gnomAD
rs2050669751	858	H>R		No	Ensembl
rs1589412559	859	Q>E		No	Ensembl
rs1274712375	863	Q>*		No	gnomAD
rs1038818069	863	Q>H		No	Ensembl
rs781709034	864	G>E		No	ExAC gnomAD
rs757905871	864	G>R		No	ExAC gnomAD
rs191731938	865	A>S		No	1000Genomes ExAC gnomAD
rs191731938	865	A>T		No	1000Genomes ExAC gnomAD
rs575911826	865	A>V		No	1000Genomes ExAC gnomAD
rs749456827	866	T>M		No	ExAC TOPMed gnomAD
rs745944178	869	H>Q		No	ExAC gnomAD
COSM1220932 rs772089398	871	D>N	large_intestine [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs950362451	871	D>V		No	TOPMed
rs2050671324	872	Q>R		No	TOPMed
rs1342856003	874	T>R		No	TOPMed gnomAD
rs1273728936	875	H>Y		No	Ensembl
rs2050671762	877	S>F		No	Ensembl
rs746973887	878	A>V		No	ExAC gnomAD
rs374847453	879	R>H		No	ESP ExAC TOPMed gnomAD
rs1346951131	880	C>R		No	TOPMed gnomAD
rs199588346	881	F>C		No	ExAC TOPMed gnomAD
rs199588346	881	F>S		No	ExAC TOPMed gnomAD
rs1271479389	884	L>F		No	gnomAD
TCGA novel	885	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs199780413	886	P>S		No	Ensembl
rs772791356	887	D>N		No	ExAC TOPMed gnomAD
rs1263314743	888	N>D		No	TOPMed gnomAD
rs1263314743	888	N>H		No	TOPMed gnomAD
rs1162021268	888	N>S		No	gnomAD
rs2050673265	889	S>N		No	TOPMed
COSM3967236 COSM3967234 COSM3967235	891	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1201497545	893	W>*		No	gnomAD
rs756631887	895	K>N		No	ExAC TOPMed gnomAD
rs753156935	895	K>R		No	ExAC
rs2050673844	896	P>T		No	TOPMed
rs2050673933	897	T>K		No	TOPMed gnomAD
rs1447566018	898	T>A		No	gnomAD
rs764378302	899	A>S		No	ExAC gnomAD
rs754200278	899	A>V		No	ExAC TOPMed gnomAD
rs1193228304	900	S>F		No	gnomAD
COSM1152217	902	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1481470094	903	S>N		No	TOPMed
rs2050674801	903	S>R		No	gnomAD
rs757617776	903	S>R		No	ExAC TOPMed gnomAD
COSM6130796 COSM6130795 COSM1506407 COSM6130797 COSM6130798 rs749091097	906	A>E	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs749091097	906	A>V		No	TOPMed gnomAD
rs2050675191	908	L>F		No	Ensembl
TCGA novel	908	L>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1181732024	909	G>D		No	TOPMed
rs1023013888	911	L>F		No	TOPMed gnomAD
rs2050675809	911	L>P		No	TOPMed
rs1023013888	911	L>V		No	TOPMed gnomAD
COSM72213	912	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2050675908	913	N>D		No	Ensembl
rs2137515728	913	N>S		No	Ensembl
rs970162626	914	T>R		No	Ensembl
rs1320844399	923	L>V		No	gnomAD
rs879061152	924	G>V		No	gnomAD
rs973537952	926	A>V		No	TOPMed gnomAD
rs1283564915	927	G>R		No	gnomAD
rs780303607	928	L>F		No	ExAC gnomAD
rs61732521 RCV000712691	929	S>T		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1274092765	930	S>I		No	gnomAD
rs768717488	930	S>R		No	ExAC gnomAD
rs776768312	932	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1487360805	934	G>V		No	gnomAD
TCGA novel	935	V>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2050677555	935	V>I		No	gnomAD
COSM686039 COSM1146519 COSM1646362	937	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs772882305	938	L>F		No	ExAC TOPMed gnomAD
rs772882305	938	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs772882305	938	L>V		No	ExAC TOPMed gnomAD
rs765860462	942	K>N		No	ExAC gnomAD
COSM4840166 COSM4840167 COSM4840165 COSM4840164	942	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2050678561	944	V>I		No	TOPMed
rs764568518	945	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs759116659	945	Y>H		No	ExAC TOPMed gnomAD
rs754390172	946	M>I		No	ExAC gnomAD
rs1419597023	946	M>K		No	gnomAD
rs1564824750	946	M>L		No	Ensembl
rs1419597023	946	M>T		No	gnomAD
rs2050679175	947	G>C		No	TOPMed
rs2050679175	947	G>S		No	TOPMed
rs1589413093	949	P>A		No	Ensembl
TCGA novel	949	P>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1589413093	949	P>S		No	Ensembl
rs911535516	950	G>R		No	gnomAD
rs911535516	950	G>S		No	gnomAD
rs1355716225	951	I>V		No	gnomAD
rs750609293	953	I>M		No	ExAC gnomAD
COSM4940134 COSM4940135 COSM4940137 COSM4940136	953	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs369531579	953	I>V		No	ESP ExAC TOPMed gnomAD
rs373257538	955	T>A		No	ESP ExAC TOPMed gnomAD
rs780213480	955	T>I		No	ExAC TOPMed gnomAD
rs2137518055	956	V>M		No	Ensembl
rs2050680729	957	C>Y		No	gnomAD
rs955386857	958	V>A		No	TOPMed gnomAD
TCGA novel rs2050681205	960	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs2050681336	961	K>E		No	TOPMed
rs755159339	963	G>R		No	ExAC gnomAD
rs1266883654	964	S>G		No	gnomAD
rs781246375	964	S>I		No	ExAC gnomAD
rs1178702807	965	M>I		No	TOPMed gnomAD
rs1015462195	965	M>V		No	TOPMed
rs1184475250	966	F>L		No	gnomAD
rs2050683027	968	S>T		No	Ensembl
rs769583065	969	E>D		No	ExAC gnomAD
rs748066952	969	E>K		No	ExAC gnomAD
rs748066952	969	E>Q		No	ExAC gnomAD
rs921680781	971	G>A		No	TOPMed gnomAD
rs1386567169	976	Y>C		No	TOPMed gnomAD
COSM3441819 COSM3441821 COSM3441820	977	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs777446204	978	L>F		No	ExAC gnomAD
rs369699653	979	Q>E		No	ESP ExAC TOPMed gnomAD
TCGA novel	979	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs770488694	980	T>A		No	ExAC gnomAD
rs2050684856	981	T>I		No	gnomAD
rs1375857629	982	D>E		No	gnomAD
COSM3441824 COSM3441822 COSM3441823 rs759022354	982	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
TCGA novel rs2050685801	987	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs763441024	989	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2050686506	990	A>V		No	TOPMed
rs2050686578	991	P>A		No	TOPMed gnomAD
rs2050686578	991	P>T		No	TOPMed gnomAD
rs2050686970	993	H>R		No	Ensembl
rs2050686872	993	H>Y		No	Ensembl
rs1378903754	994	T>A		No	TOPMed gnomAD
rs949014384	997	M>I		No	TOPMed
rs751871890 RCV000992631	999	F>L		No	ClinVar ExAC TOPMed dbSNP gnomAD
COSM368000	1001	G>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4016804 rs376113551 COSM4016806 COSM4016805	1001	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs2137520716	1003	L>W		No	Ensembl
rs756013871	1004	E>D		No	ExAC gnomAD
rs1816047274	1004	E>K		No	TOPMed gnomAD
rs2050687979	1005	L>F		No	gnomAD
COSM6130794 COSM6130792 COSM6130791 COSM6130793	1005	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1168087143	1008	A>T		No	gnomAD
rs770758387	1009	V>A		No	ExAC gnomAD
rs749025597	1009	V>L		No	ExAC TOPMed gnomAD
rs749025597	1009	V>M		No	ExAC TOPMed gnomAD
TCGA novel	1011	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs199673510	1011	K>R		No	gnomAD
rs1395362832	1015	F>S		No	gnomAD
rs1327100233	1016	P>A		No	gnomAD
rs1220705180	1017	D>N		No	gnomAD
rs1276478450	1019	R>K		No	gnomAD
COSM1287207 COSM1287208 COSM1287206	1021	Q>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs776237015	1024	R>G		No	ExAC gnomAD
COSM1659515 rs762313611	1024	R>Q	kidney [Cosmic]	No	cosmic curated ExAC gnomAD
rs776237015	1024	R>W		No	ExAC gnomAD
rs770196468	1026	Q>*		No	ExAC gnomAD
rs770196468	1026	Q>E		No	ExAC gnomAD
rs2137522174	1026	Q>H		No	Ensembl
rs201933093	1028	V>I		No	ESP ExAC TOPMed gnomAD
rs2050690720	1031	Y>C		No	gnomAD
rs766883789	1032	Q>*		No	ExAC TOPMed gnomAD
rs768254310 RCV001580285	1034	D>G		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs746486644	1034	D>N		No	ExAC gnomAD
rs773553954	1036	R>P		No	ExAC TOPMed gnomAD
rs773553954	1036	R>Q		No	ExAC TOPMed gnomAD
rs1031828990	1036	R>W		No	TOPMed gnomAD
rs771364821	1037	Y>C		No	ExAC TOPMed gnomAD
rs771364821	1037	Y>F		No	ExAC TOPMed gnomAD
rs1245539376	1037	Y>H		No	gnomAD
TCGA novel	1039	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs767622781	1042	L>V		No	ExAC gnomAD
rs775833869	1044	H>Y		No	ExAC TOPMed
rs200419008	1045	A>T		No	ExAC TOPMed gnomAD
rs2137624990	1046	V>M		No	Ensembl
rs750212847	1051	G>D		No	ExAC gnomAD
rs764944510	1051	G>S		No	ExAC gnomAD
rs375633926 COSM1220930	1053	R>Q	large_intestine [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs779549576	1053	R>W		No	ExAC TOPMed gnomAD
TCGA novel	1054	W>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1252384003	1055	S>G		No	gnomAD
rs1437816828	1057	R>*		No	gnomAD
COSM1970401 COSM1970400 rs754397478 COSM1970402	1057	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
COSM3791044 COSM3791045 rs780768832 COSM3791043	1059	P>R	Variant assessed as Somatic; MODERATE impact. urinary_tract [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs1589422307	1060	S>R		No	Ensembl
rs1183631930	1061	P>T		No	gnomAD
rs775057970	1064	S>L		No	ExAC TOPMed gnomAD
rs1299156613	1065	A>G		No	gnomAD
rs746217285	1066	K>E		No	ExAC TOPMed gnomAD
rs201554414	1066	K>R		No	ESP ExAC TOPMed gnomAD
rs530440610	1071	P>A		No	1000Genomes ExAC TOPMed gnomAD
rs1233760819	1071	P>L		No	Ensembl
rs530440610	1071	P>S		No	1000Genomes ExAC TOPMed gnomAD
rs199555701	1072	N>D		No	1000Genomes ExAC TOPMed gnomAD
rs564249217	1072	N>K		No	1000Genomes ExAC TOPMed gnomAD
rs761945688	1073	M>V		No	ExAC gnomAD
rs1259830097	1075	R>K		No	gnomAD
rs2050912107	1077	N>D		No	Ensembl
rs533132260	1077	N>S		No	1000Genomes ExAC TOPMed gnomAD
rs1014273898	1078	T>A		No	TOPMed gnomAD
rs762697292	1078	T>N		No	ExAC gnomAD
rs1024281662	1080	G>A		No	TOPMed gnomAD
rs1024281662	1080	G>D		No	TOPMed gnomAD
rs1423525893	1081	I>K		No	gnomAD
rs751116995	1081	I>V		No	ExAC gnomAD
rs1402922181	1084	T>I		No	gnomAD
TCGA novel	1085	K>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1464344672	1086	K>R		No	gnomAD
rs754664492	1087	K>N		No	ExAC TOPMed gnomAD
rs2050913614	1087	K>R		No	Ensembl
rs780778339	1088	K>E		No	ExAC gnomAD
rs752243865	1088	K>R		No	ExAC
rs1394137090	1089	K>E		No	TOPMed gnomAD
rs755738108	1089	K>N		No	ExAC gnomAD
rs929071659	1090	I>L		No	Ensembl
rs929071659	1090	I>V		No	Ensembl
rs1281983846	1091	L>F		No	gnomAD
rs2050914456	1091	L>P		No	TOPMed
rs374934241	1092	M>I		No	ESP ExAC TOPMed gnomAD
rs746405415	1093	R>K		No	ExAC gnomAD
rs746405415	1093	R>T		No	ExAC gnomAD
rs956275597	1094	G>C		No	TOPMed gnomAD
TCGA novel	1095	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1564832268	1096	S>N		No	Ensembl
rs577187940	1098	E>A		No	1000Genomes ExAC gnomAD
rs769807716	1099	V>E		No	ExAC TOPMed gnomAD
rs769807716	1099	V>G		No	ExAC TOPMed gnomAD
rs2050983118	1099	V>L		No	TOPMed
rs954154818	1100	T>I		No	TOPMed gnomAD
COSM4016809 COSM4016808 COSM4016807 rs763011760	1102	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs763011760	1102	D>Y		No	ExAC TOPMed gnomAD
rs770891858	1104	M>T		No	ExAC TOPMed gnomAD
rs2132854636	1105	A>E		No	Ensembl
rs2050984292	1106	T>A		No	TOPMed
rs774206142	1107	R>Q		No	ExAC TOPMed gnomAD
rs759348587	1109	A>S		No	ExAC TOPMed gnomAD
rs759348587	1109	A>T		No	ExAC TOPMed gnomAD
rs767455902	1111	M>T		No	ExAC TOPMed gnomAD
rs2050985080	1112	H>Q		No	Ensembl
COSM1474886 COSM5200026 rs1440919623 COSM1474885 COSM428166	1114	E>D	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs533569760	1114	E>K		No	1000Genomes ExAC TOPMed gnomAD
rs533569760	1114	E>Q		No	1000Genomes ExAC TOPMed gnomAD
rs2132855108	1115	C>F		No	Ensembl
rs121912602	1116	R>G	Nephrotic syndrome, type 3 (nphs3) [Ensembl]	No	ExAC TOPMed gnomAD
rs201350449	1116	R>L		No	ESP ExAC TOPMed gnomAD
rs201350449	1116	R>Q		No	ESP ExAC TOPMed gnomAD
rs772363295	1118	R>Q		No	ExAC TOPMed gnomAD
rs756774063	1118	R>W		No	ExAC TOPMed gnomAD
rs752045984	1119	S>N		No	ExAC gnomAD
rs372493357	1120	G>D		No	ExAC TOPMed gnomAD
rs372493357	1120	G>V		No	ExAC TOPMed gnomAD
rs781551456	1122	D>G		No	ExAC TOPMed gnomAD
rs1331510718	1123	P>H		No	Ensembl
rs748303342	1124	Q>P		No	ExAC TOPMed gnomAD
rs748303342	1124	Q>R		No	ExAC TOPMed gnomAD
rs867256208	1125	D>N		No	TOPMed gnomAD
rs867256208	1125	D>Y		No	TOPMed gnomAD
rs377402718	1126	I>V		No	ESP ExAC TOPMed gnomAD
TCGA novel	1130	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1173569661	1130	E>G		No	TOPMed gnomAD
rs2050987713	1130	E>Q		No	TOPMed
rs752056387	1133	E>A		No	ExAC TOPMed gnomAD
rs752056387	1133	E>G		No	ExAC TOPMed gnomAD
rs1440143492	1134	V>G		No	gnomAD
rs755481126	1134	V>M		No	ExAC TOPMed gnomAD
rs2132865347	1136	A>T		No	Ensembl
rs2051011476	1136	A>V		No	Ensembl
rs2051011643	1137	I>V		No	gnomAD
rs753048370 COSM1585228 COSM1585229 COSM921657	1138	A>T	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1367424901	1139	N>K		No	TOPMed gnomAD
rs2051012507	1140	P>L		No	TOPMed
rs745848489	1140	P>S		No	TOPMed gnomAD
rs745848489	1140	P>T		No	TOPMed gnomAD
rs756521986	1142	N>K		No	ExAC TOPMed gnomAD
rs2051012911	1143	P>L		No	TOPMed
rs1317856330	1144	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs757315158	1147	R>G		No	1000Genomes ExAC TOPMed gnomAD
rs1304457385	1147	R>K		No	gnomAD
rs2051013866	1148	R>G		No	TOPMed
rs1372617995	1151	S>C		No	TOPMed
rs1394322207	1151	S>P		No	gnomAD
TCGA novel	1151	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM4016810 COSM4016811 COSM4016812	1152	L>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs745747725	1153	T>I		No	ExAC TOPMed gnomAD
rs745747725	1153	T>N		No	ExAC TOPMed gnomAD
rs371294665	1155	A>P		No	ESP ExAC TOPMed gnomAD
rs371294665	1155	A>T		No	ESP ExAC TOPMed gnomAD
rs539061909	1156	G>A		No	TOPMed gnomAD
rs539061909	1156	G>V		No	TOPMed gnomAD
rs768610934	1157	S>F		No	ExAC gnomAD
rs1234627666	1158	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs776306167	1159	N>S		No	ExAC TOPMed gnomAD
TCGA novel	1161	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs761394585	1162	A>S		No	ExAC gnomAD
COSM1349934 COSM1349932 COSM5140961 COSM1349933	1162	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs578176464	1163	G>R		No	1000Genomes ExAC TOPMed gnomAD
COSM3441826 COSM3441825 COSM3441827	1167	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1178176115	1168	I>F		No	gnomAD
rs753244923	1169	R>S		No	ExAC TOPMed gnomAD
rs760990876	1170	P>L		No	ExAC gnomAD
rs757421093	1171	V>A		No	ExAC TOPMed gnomAD
rs1296521084	1172	S>F		No	gnomAD
rs2051018900	1172	S>T		No	gnomAD
rs746745562	1172	S>V		No	ExAC
rs1387669948	1174	P>A		No	TOPMed gnomAD
rs2051019940	1174	P>L		No	TOPMed
rs1387669948	1174	P>S		No	TOPMed gnomAD
rs750514109	1175	V>G		No	1000Genomes ExAC TOPMed gnomAD
rs2051020492	1177	S>A		No	TOPMed
rs2051020849	1179	S>L		No	TOPMed
rs758597789	1180	N>K		No	ExAC gnomAD
rs367778209	1184	S>C		No	ESP ExAC TOPMed gnomAD
rs1167101726	1186	A>S		No	gnomAD
rs1348516267	1186	A>V		No	gnomAD
rs200141684	1189	S>G		No	1000Genomes ExAC TOPMed gnomAD
rs769027296	1190	S>G		No	ExAC TOPMed gnomAD
COSM269898	1192	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs762050661	1194	G>R		No	ExAC TOPMed gnomAD
rs763280408	1195	R>Q		No	ExAC gnomAD
rs370773518	1199	G>D		No	ESP ExAC TOPMed gnomAD
rs767328344	1200	M>L		No	ExAC TOPMed gnomAD
rs767328344	1200	M>V		No	ExAC TOPMed gnomAD
rs752714644	1202	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs777562042	1207	M>V		No	ExAC gnomAD
rs2051195027	1208	V>A		No	TOPMed
rs2051194926 TCGA novel	1208	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
COSM1133919 COSM5201794 COSM5201795 COSM428167	1210	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs756895101	1210	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
COSM6067180 COSM6067181 COSM6067183 COSM6067182	1211	S>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1201260365	1212	N>S		No	gnomAD
rs778591304	1215	F>Y		No	ExAC TOPMed gnomAD
rs745345130	1216	V>F		No	ExAC gnomAD
rs745345130	1216	V>I		No	ExAC gnomAD
TCGA novel	1217	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1218	F>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1220	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1224	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs866394425	1226	S>G		No	gnomAD
rs1338175454	1230	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
COSM1474889 COSM5226868 COSM1474890 rs2051200242 COSM1474891	1230	R>H	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs2051200242	1230	R>L		No	Ensembl
rs2051200428	1231	K>N		No	gnomAD
rs778503393	1231	K>R		No	ExAC gnomAD
rs757795778	1235	D>E		No	ExAC TOPMed gnomAD
rs2051200874	1235	D>V		No	gnomAD
rs1564837390	1238	D>G		No	Ensembl
TCGA novel	1238	D>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1238	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs779628620	1239	V>I		No	ExAC TOPMed gnomAD
rs935673723	1240	Y>H		No	TOPMed gnomAD
TCGA novel	1241	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs770420406	1242	V>A		No	ExAC TOPMed gnomAD
rs1226061657	1243	P>A		No	TOPMed
rs267606955	1246	R>G	Nephrotic syndrome, type 3 (nphs3) [Ensembl]	No	ExAC TOPMed gnomAD
rs374570009	1246	R>L		No	ESP ExAC TOPMed gnomAD
rs374570009	1246	R>P		No	ESP ExAC TOPMed gnomAD
rs374570009 COSM921660 COSM4651062 COSM1585222 COSM1585223	1246	R>Q	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs759820322	1247	S>C		No	ExAC TOPMed gnomAD
rs759820322	1247	S>F		No	ExAC TOPMed gnomAD
rs866284212	1249	S>F		No	Ensembl
COSM5469460 COSM5469463 COSM5469461 rs775639600 COSM5469462	1250	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs2051203070	1253	P>A		No	Ensembl
rs760720254	1256	T>A		No	ExAC TOPMed gnomAD
COSM3441830 COSM3441828 COSM3441829	1256	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs760720254	1256	T>P		No	ExAC TOPMed gnomAD
rs1296627391	1257	N>S		No	TOPMed gnomAD
rs2051203902	1258	L>P		No	TOPMed
rs1351334345	1260	I>T		No	TOPMed gnomAD
rs1434225252	1261	D>E		No	gnomAD
rs753816984	1262	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1241012234	1264	T>N		No	gnomAD
rs1432013966	1265	S>T		No	gnomAD
rs2051205002	1266	D>G		No	Ensembl
COSM3441833 rs2051204883 COSM3441831 COSM3441832	1266	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed gnomAD
COSM1349943 COSM1349945 COSM1349944 COSM5131288	1266	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1476945487	1269	P>T		No	TOPMed
rs1348884857	1270	D>N		No	TOPMed gnomAD
rs749988048	1271	L>V		No	ExAC gnomAD
rs766023332	1273	L>P		No	ExAC gnomAD
rs751200886	1277	N>S		No	ExAC gnomAD
rs1340734586	1278	V>A		No	TOPMed gnomAD
TCGA novel	1278	V>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs754487813	1278	V>I		No	ExAC gnomAD
rs575762810	1279	S>L		No	1000Genomes ExAC TOPMed gnomAD
rs757831852	1280	D>N		No	ExAC gnomAD
rs757831852	1280	D>Y		No	ExAC gnomAD
rs746226079	1281	L>F		No	ExAC TOPMed gnomAD
rs779342517	1281	L>S		No	ExAC gnomAD
rs1564840438	1282	G>R		No	Ensembl
rs780286250	1285	I>F		No	ExAC TOPMed gnomAD
rs780286250	1285	I>L		No	ExAC TOPMed gnomAD
COSM5192321 COSM5192322 COSM1133920	1285	I>S	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs747256450	1286	K>E		No	ExAC gnomAD
rs2051338373	1286	K>N		No	Ensembl
rs200409656	1286	K>R		No	TOPMed
rs2051338473	1287	S>R		No	TOPMed
rs1318965929	1288	K>T		No	gnomAD
rs776697711	1290	Q>H		No	ExAC TOPMed gnomAD
rs768666755	1290	Q>L		No	ExAC gnomAD
rs1407013393	1292	S>*		No	TOPMed
rs1407013393 COSM1220936	1292	S>L	large_intestine [Cosmic]	No	cosmic curated TOPMed
rs1283124862	1292	S>P		No	Ensembl
rs201423664	1293	D>G		No	ESP ExAC TOPMed gnomAD
TCGA novel	1294	N>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1391588139	1294	N>Y		No	TOPMed
rs1186700450	1295	Q>R		No	gnomAD
rs773062926	1296	R>K		No	ExAC gnomAD
rs2051340221	1298	I>M		No	TOPMed
rs762769053	1298	I>V		No	ExAC TOPMed gnomAD
rs267602625	1299	S>F		No	Ensembl
rs2051340438	1303	A>G		No	Ensembl
rs942852147	1304	A>V		No	TOPMed
rs2051340631	1307	I>V		No	Ensembl
rs2051340779	1309	T>R		No	TOPMed
rs766108640	1312	T>S		No	ExAC
rs774088194	1314	I>M		No	ExAC TOPMed gnomAD
rs1372474008	1314	I>V		No	TOPMed gnomAD
rs767341790	1315	E>D		No	ExAC TOPMed gnomAD
rs759264327	1315	E>K		No	ExAC gnomAD
rs752237635	1317	T>I		No	ExAC TOPMed gnomAD
rs1344374749	1318	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs765748194	1319	L>P		No	ExAC gnomAD
TCGA novel	1319	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1299346018	1322	F>L		No	TOPMed gnomAD
rs1384312021	1322	F>Y		No	gnomAD
rs1368657323	1323	G>E		No	TOPMed
rs758743699	1324	V>A		No	ExAC gnomAD
rs867372355 COSM1133326	1325	G>D	kidney [Cosmic]	No	cosmic curated Ensembl
rs1438360400	1325	G>S		No	TOPMed gnomAD
rs780298176	1326	I>K		No	ExAC gnomAD
rs2051343281	1326	I>V		No	Ensembl
rs747170266	1327	L>F		No	ExAC gnomAD
rs1209743554	1328	Q>E		No	gnomAD
rs887784910	1328	Q>R		No	Ensembl
rs755190924	1330	N>D		No	ExAC gnomAD
COSM921661 COSM1585220 COSM1585221	1331	D>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs372685240	1331	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs773151394	1333	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1200839708	1333	L>P		No	gnomAD
rs61886335	1334	V>L		No	ExAC TOPMed gnomAD
rs61886335	1334	V>M		No	ExAC TOPMed gnomAD
rs1748430092	1335	N>I		No	1000Genomes
rs997620952	1336	C>Y		No	TOPMed
rs759458474	1341	C>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs759458474	1341	C>Y		No	ExAC gnomAD
rs767251854	1342	T>A		No	ExAC gnomAD
rs1425436432	1342	T>I		No	TOPMed
TCGA novel	1342	T>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs763537813	1343	Y>*		No	ExAC TOPMed gnomAD
rs775326157	1343	Y>C		No	ExAC TOPMed gnomAD
rs775326157 COSM1187996	1343	Y>F	lung [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
COSM4901808 COSM4901807 COSM4901806 COSM4901805	1345	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2051345948	1348	S>N		No	TOPMed gnomAD
rs1232980375	1350	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
TCGA novel	1351	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2133063867	1352	K>E		No	Ensembl
rs2133063900	1352	K>N		No	Ensembl
rs61751499	1353	F>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2051487896	1353	F>L		No	Ensembl
rs2133063965	1353	F>S		No	Ensembl
COSM1152218	1354	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1564843295 COSM1474892	1354	E>K	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA gnomAD
rs1243745506	1355	P>T		No	TOPMed gnomAD
rs2051488992	1356	S>I		No	TOPMed
rs1318388132	1357	I>F		No	Ensembl
rs1221670185	1357	I>M		No	Ensembl
rs1279990462	1357	I>T		No	Ensembl
rs1589442441	1359	M>K		No	Ensembl
rs1366282160	1362	Q>E		No	TOPMed gnomAD
rs2051489731	1363	G>E		No	Ensembl
rs761445364	1366	S>P		No	ExAC TOPMed gnomAD
rs752101948	1367	F>I		No	ExAC gnomAD
rs2051490160	1367	F>L		No	TOPMed
rs532167723	1368	E>D		No	1000Genomes ExAC gnomAD
rs1424595212	1368	E>K		No	gnomAD
rs1424595212	1368	E>Q		No	gnomAD
rs369676435	1371	A>S		No	ESP ExAC TOPMed gnomAD
TCGA novel	1380	F>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1255871441	1381	A>P		No	gnomAD
rs2051494450	1383	K>E		No	Ensembl
COSM4715081 COSM4715080 COSM4715082 rs1564843502 COSM4715079	1384	N>M	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
rs771937306	1385	D>G		No	ExAC TOPMed gnomAD
rs1193007439	1385	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs373593323	1386	E>A		No	ESP ExAC TOPMed gnomAD
rs373593323	1386	E>V		No	ESP ExAC TOPMed gnomAD
rs1232485824	1391	I>V		No	TOPMed
rs2051495488	1393	E>D		No	TOPMed
rs2133066319	1393	E>K		No	Ensembl
rs1359169206	1397	P>S		No	gnomAD
RCV001385982 rs750815297	1398	L>missing		No	ClinVar dbSNP
rs765106847	1400	Y>C		No	TOPMed gnomAD
rs765106847	1400	Y>F		No	TOPMed gnomAD
rs1400427421	1401	Y>C		No	gnomAD
rs2051496689	1401	Y>H		No	Ensembl
rs1020324868	1403	I>V		No	Ensembl
rs1213917729	1404	E>G		No	TOPMed gnomAD
rs575613361	1404	E>K		No	TOPMed gnomAD
rs1294951284	1406	S>L		No	gnomAD
rs761198488	1407	H>D		No	ExAC TOPMed gnomAD
rs2051497777	1407	H>P		No	Ensembl
rs761198488	1407	H>Y		No	ExAC TOPMed gnomAD
rs769314870	1411	L>R		No	ExAC gnomAD
rs376243775 COSM1220942	1412	T>M	large_intestine [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs1013956708	1413	G>A		No	TOPMed gnomAD
rs1395184523	1414	H>Y		No	gnomAD
COSM1349948 COSM5156116 COSM1349947 COSM1349946	1416	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs768077598	1417	K>Q		No	ExAC gnomAD
COSM3868104 rs370622297 COSM3868103 COSM3868102	1418	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs1408950534	1419	E>G		No	TOPMed gnomAD
COSM4830038 COSM4830037 COSM4830039 COSM4830036	1419	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1585218 COSM1585219 rs761148662 COSM921663	1421	S>L	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1564843738	1424	L>F		No	Ensembl
rs754117196	1427	Q>P		No	ExAC TOPMed gnomAD
rs754117196	1427	Q>R		No	ExAC TOPMed gnomAD
rs776101909	1429	L>V		No	ExAC gnomAD
rs760903665	1430	L>*		No	ExAC TOPMed gnomAD
rs760903665	1430	L>S		No	ExAC TOPMed gnomAD
rs764545119	1433	C>R		No	ExAC gnomAD
rs776663468	1433	C>S		No	ExAC TOPMed gnomAD
rs776663468	1433	C>Y		No	ExAC TOPMed gnomAD
rs1274185689	1434	R>*		No	gnomAD
COSM1220943 COSM1349949 COSM5826853 COSM1220944	1434	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs765625216	1436	V>I		No	ExAC gnomAD
rs2051614417	1437	E>A		No	TOPMed
TCGA novel	1440	C>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1251852335	1441	W>*		No	gnomAD
rs1183306182	1443	G>R		No	TOPMed gnomAD
rs2133103739	1443	G>V		No	Ensembl
rs1423447994	1445	D>G		No	TOPMed gnomAD
COSM1349951 COSM1349952 COSM1349950 COSM5100918	1445	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs368429183	1445	D>Y		No	ESP TOPMed
TCGA novel	1447	M>C	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1469293582	1447	M>K		No	gnomAD
TCGA novel	1447	M>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs754671370	1449	I>V		No	ExAC gnomAD
rs2051616208	1452	H>Y		No	gnomAD
rs983730547	1453	G>E		No	TOPMed gnomAD
rs1164068178	1455	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1164068178	1455	T>R		No	TOPMed gnomAD
rs1589446823	1456	L>R		No	Ensembl
rs866629033	1457	T>I		No	Ensembl
rs866629033	1457	T>K		No	Ensembl
rs1392078248	1458	T>A		No	gnomAD
rs1330951857	1458	T>N		No	gnomAD
COSM3441841 COSM3441840 COSM3441842	1461	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2051617972	1463	K>E		No	Ensembl
rs2051687357	1464	E>A		No	Ensembl
rs767410318	1466	V>F		No	ExAC gnomAD
rs767410318	1466	V>I		No	ExAC gnomAD
rs767410318	1466	V>L		No	ExAC gnomAD
rs1589449171	1467	E>K		No	Ensembl
rs2051688064	1468	A>D		No	Ensembl
rs752465893	1469	I>T		No	ExAC TOPMed gnomAD
rs1009208215	1469	I>V		No	TOPMed gnomAD
rs1589449189	1470	D>Y		No	TOPMed
rs778433836	1471	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs199793703	1471	R>L		No	1000Genomes ExAC TOPMed gnomAD
TCGA novel	1472	S>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2051688967	1473	A>*		No	TOPMed
rs2051689215	1473	A>D		No	TOPMed gnomAD
rs1589449211	1473	A>P		No	Ensembl
rs1190870060	1475	I>M		No	TOPMed gnomAD
rs1430243872	1475	I>V		No	gnomAD
rs560712395	1476	N>I		No	1000Genomes ExAC TOPMed gnomAD
rs560712395	1476	N>S		No	1000Genomes ExAC TOPMed gnomAD
rs560712395	1476	N>T		No	1000Genomes ExAC TOPMed gnomAD
rs2051689915	1477	S>C		No	TOPMed
rs745439074	1478	D>A		No	ExAC gnomAD
rs769196439	1478	D>E		No	ExAC TOPMed gnomAD
rs991464575	1480	P>Q		No	Ensembl
rs529475564	1481	I>V		No	1000Genomes TOPMed gnomAD
TCGA novel	1482	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1393795942	1485	I>V		No	TOPMed
TCGA novel	1487	N>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs770314103	1489	C>R		No	ExAC gnomAD
COSM1585215 COSM921665 COSM1585214	1490	S>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2051691492	1493	Q>E		No	Ensembl
COSM5371362 COSM139850 COSM1722506 rs771124727 COSM222187	1495	R>Q	NS Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs759582192	1497	M>I		No	ExAC gnomAD
rs774474634	1497	M>V		No	ExAC gnomAD
TCGA novel	1497	M>W	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM1585212 COSM1585213 COSM921666	1499	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1345378487	1500	I>M		No	gnomAD
rs1233025723	1501	F>C		No	gnomAD
COSM5228116 COSM1474895 COSM1474894 COSM428171	1502	K>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1159598158	1514	L>I		No	TOPMed
rs2051830475	1516	E>G		No	TOPMed gnomAD
TCGA novel	1518	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1585210 COSM1585211 COSM921667	1519	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs931524881	1519	F>Y		No	TOPMed gnomAD
rs772160156	1520	S>A		No	ExAC gnomAD
rs775344945	1520	S>L		No	ExAC gnomAD
rs772160156	1520	S>P		No	ExAC gnomAD
rs760606863	1521	D>G		No	ExAC gnomAD
rs1182368388	1522	D>N		No	TOPMed gnomAD
rs865837779	1523	P>L		No	Ensembl
rs2051831551	1523	P>S		No	Ensembl
rs764087748	1524	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
COSM5158843 COSM1349956 COSM1349958 COSM1349957	1526	P>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs776401726	1526	P>S		No	ExAC gnomAD
rs761566268	1527	S>P		No	ExAC TOPMed gnomAD
COSM1152219 rs2051832384	1528	P>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed
rs2051832384	1528	P>R		No	TOPMed
rs1389250936	1528	P>S		No	TOPMed gnomAD
rs1355796898	1529	D>E		No	TOPMed gnomAD
RCV000519966 CA5613173 rs182314619	1529	D>V		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1235091819	1531	L>V		No	gnomAD
TCGA novel	1533	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1485358230	1536	L>I		No	TOPMed gnomAD
rs750075391	1536	L>P		No	ExAC gnomAD
TCGA novel	1536	L>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2051833352	1537	L>F		No	Ensembl
TCGA novel	1540	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs757878108	1540	K>R		No	ExAC TOPMed gnomAD
rs1331277852	1541	K>N		No	Ensembl
rs766002774	1542	L>I		No	ExAC TOPMed gnomAD
rs766002774	1542	L>V		No	ExAC TOPMed gnomAD
rs1261632735	1545	H>L		No	TOPMed gnomAD
rs751180713	1546	Q>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs2051834185	1546	Q>H		No	TOPMed
rs768854393	1547	T>M		No	ExAC TOPMed gnomAD
rs1475718709	1549	V>E		No	gnomAD
rs2051834619	1549	V>M		No	gnomAD
rs376222459	1550	D>Y		No	ESP ExAC TOPMed gnomAD
rs757589468	1554	Q>K		No	ExAC gnomAD
rs2133172714	1555	K>N		No	Ensembl
rs757579659	1556	A>P		No	ExAC gnomAD
rs757579659	1556	A>S		No	ExAC gnomAD
rs757579659	1556	A>T		No	ExAC gnomAD
rs1358302667	1556	A>V		No	gnomAD
COSM686035 COSM1146523 COSM1646358	1558	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs758609545	1560	A>V		No	ExAC gnomAD
COSM3415374 COSM3415375 COSM3415376 COSM5078857	1561	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1391076246	1562	M>T		No	TOPMed
rs2133254310	1564	V>A		No	Ensembl
rs780305452	1564	V>M		No	ExAC TOPMed gnomAD
TCGA novel rs768754811	1565	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA ExAC gnomAD
rs1265008421	1566	A>S		No	TOPMed
rs2052128193	1567	Y>*		No	TOPMed
rs1348871494	1569	G>C		No	gnomAD
rs897492037	1569	G>D		No	TOPMed
rs748050550	1570	G>R		No	ExAC gnomAD
TCGA novel rs1589464286	1571	N>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs769566656	1572	A>P		No	ExAC gnomAD
rs865781686	1572	A>V		No	Ensembl
rs762889107	1573	N>K		No	ExAC TOPMed gnomAD
rs772868962	1573	N>T		No	ExAC gnomAD
rs1187459288	1574	P>A		No	TOPMed gnomAD
rs1187459288	1574	P>S		No	TOPMed gnomAD
rs2274224	1575	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs765834047	1576	P>S		No	ExAC gnomAD
rs2052131388	1577	A>D		No	Ensembl
rs1216357274	1577	A>T		No	Ensembl
TCGA novel	1580	E>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1023411023	1582	E>D		No	Ensembl
COSM6130785 COSM6130783 COSM6130784 COSM6130786	1586	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4016823 COSM4016824 rs1282534937 COSM4016822	1588	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
TCGA novel	1588	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1024165268	1593	Y>C		No	TOPMed
rs1319983314	1596	L>P		No	gnomAD
rs1443119002	1599	D>E		No	TOPMed gnomAD
rs1281653799	1600	N>D		No	gnomAD
rs2052337127	1600	N>K		No	TOPMed
rs1228355324	1603	E>A		No	gnomAD
rs750964111	1604	D>E		No	ExAC gnomAD
rs765634224 COSM1603870	1604	D>H	liver [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs1207616254	1605	R>G		No	gnomAD
rs1443540342	1608	N>S		No	gnomAD
rs1288527473	1609	K>N		No	TOPMed gnomAD
COSM4715085 COSM4715084 COSM4715083 COSM4715086	1610	S>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1014863355	1611	C>*		No	TOPMed gnomAD
rs1438056519	1611	C>R		No	gnomAD
rs1564860133	1611	C>Y		No	gnomAD
rs371524257	1615	L>F		No	ESP TOPMed gnomAD
rs371524257	1615	L>I		No	ESP TOPMed gnomAD
rs763255266	1616	Q>H		No	ExAC TOPMed gnomAD
rs766744123	1617	F>L		No	ExAC gnomAD
rs1188868783	1618	E>D		No	TOPMed
rs2052339052	1619	Y>C		No	gnomAD
rs1420005853	1623	I>V		No	gnomAD
rs1471766120	1626	R>K		No	TOPMed gnomAD
rs1471766120	1626	R>M		No	TOPMed gnomAD
rs972762217	1627	I>V		No	Ensembl
COSM921671 COSM1585207 rs988525181 COSM1585206	1628	K>N	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed
rs755152638	1630	A>E		No	ExAC gnomAD
rs539090556 RCV000980308	1630	A>T		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1294281128	1631	D>G		No	gnomAD
COSM4844269 COSM4844266 COSM4844268 COSM4844267	1631	D>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1357989560	1633	S>P		No	gnomAD
rs2052340787	1636	N>H		No	TOPMed gnomAD
rs2052340882	1636	N>S		No	TOPMed
rs1243172719	1637	K>E		No	gnomAD
rs2052341081	1638	G>V		No	Ensembl
rs1589475254	1640	V>A		No	Ensembl
rs371691449	1640	V>I		No	ESP ExAC TOPMed gnomAD
rs371691449	1640	V>L		No	ESP ExAC TOPMed gnomAD
rs2052379194	1641	Y>C		No	Ensembl
TCGA novel	1644	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1341022209	1645	L>P		No	TOPMed gnomAD
rs375092651	1645	L>V		No	ESP ExAC TOPMed gnomAD
rs759983858	1647	E>D		No	ExAC TOPMed gnomAD
COSM3415377 COSM5825667 COSM3415378 COSM3415379	1648	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1238732808	1650	Y>F		No	TOPMed gnomAD
rs2133337317	1650	Y>H		No	Ensembl
rs1238732808	1650	Y>S		No	TOPMed gnomAD
rs2052379881	1653	Q>R		No	Ensembl
rs373844518	1654	N>S		No	ESP ExAC gnomAD
COSM1970500 COSM1970501 rs2052380259 COSM1970502	1657	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
rs2052380526	1660	Q>*		No	Ensembl
rs1448650125	1661	I>V		No	gnomAD
rs1487080758	1662	A>V		No	gnomAD
rs41291138	1663	P>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs41291138	1663	P>T		No	1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	1664	E>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs756088601	1665	L>F		No	ExAC gnomAD
rs1234317631	1667	D>N		No	TOPMed gnomAD
COSM3441847 COSM329537 COSM3441846	1668	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2052381416	1669	V>L		No	Ensembl
rs754034304	1672	C>F		No	ExAC gnomAD
rs1172343524	1674	A>P		No	gnomAD
rs2052381808	1676	K>N		No	gnomAD
COSM1585205 COSM921672 COSM1585204	1676	K>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1386394599	1677	F>I		No	gnomAD
TCGA novel	1677	F>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1243136941	1678	P>S		No	TOPMed gnomAD
rs1243136941	1678	P>T		No	TOPMed gnomAD
rs2052708471	1679	G>E		No	TOPMed gnomAD
rs200570410	1679	G>R		No	ExAC gnomAD
rs757455360	1680	L>R		No	ExAC gnomAD
rs753944067	1680	L>V		No	ExAC
rs1479758750	1682	T>I		No	TOPMed gnomAD
rs937542975	1685	A>V		No	TOPMed
rs2052709328	1686	S>F		No	TOPMed
rs2052709215	1686	S>T		No	TOPMed
rs765229262	1688	S>C		No	ExAC gnomAD
rs1335336022	1690	R>K		No	gnomAD
rs1335336022	1690	R>T		No	gnomAD
rs2052709838 TCGA novel	1691	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs2133454288	1694	R>K		No	Ensembl
rs1055957017	1697	R>K		No	TOPMed
rs1267301603	1701	F>L		No	TOPMed gnomAD
RCV001908295 rs2133454427	1701	F>S		No	ClinVar Ensembl dbSNP
rs201633028 RCV002096149	1704	N>S		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1251741271	1705	P>A		No	TOPMed gnomAD
rs539813481	1705	P>L		No	1000Genomes ExAC TOPMed gnomAD
rs539813481	1705	P>Q		No	1000Genomes ExAC TOPMed gnomAD
rs754613559	1707	R>G		No	ExAC TOPMed gnomAD
rs780873471	1707	R>K		No	ExAC TOPMed gnomAD
rs2052711356	1708	M>R		No	Ensembl
rs1378053673	1711	G>E		No	TOPMed
rs1405270558	1711	G>W		No	gnomAD
TCGA novel	1712	E>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1333813518	1713	T>I		No	TOPMed gnomAD
rs2052711841	1714	A>T		No	TOPMed
TCGA novel	1720	S>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs929600820	1722	K>Q		No	Ensembl
COSM4405486 COSM4405485 COSM4405484	1723	S>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1038433250	1723	S>N		No	TOPMed gnomAD
COSM921673 COSM1585202 COSM1585203	1723	S>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	1723	S>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
RCV000722362 rs1564873908	1725	C>missing		No	ClinVar dbSNP
rs780773220	1725	C>F		No	ExAC TOPMed gnomAD
rs752359550	1725	C>W		No	ExAC TOPMed gnomAD
COSM3868107 COSM3868106 COSM3868105	1727	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2052916640 TCGA novel	1727	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2052916537	1727	G>S		No	Ensembl
rs777329061	1729	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
COSM921674 COSM1585201 rs368531853 COSM1585200	1729	R>Q	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1051743395	1730	Q>E		No	Ensembl
rs1226440254	1731	T>I		No	gnomAD
rs772606467	1732	W>R		No	ExAC TOPMed gnomAD
rs2052917485	1733	E>G		No	Ensembl
rs2052917389	1733	E>K		No	TOPMed
rs267602626	1734	E>*		No	gnomAD
rs267602626	1734	E>K		No	gnomAD
rs1236250466	1734	E>V		No	gnomAD
COSM1474897 COSM428172 COSM1474896 COSM5227757	1735	S>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs769168756	1736	S>A		No	ExAC gnomAD
rs1249334030	1736	S>F		No	gnomAD
RCV000912809 rs762135003	1737	S>F		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs891372245	1738	P>A		No	TOPMed gnomAD
rs770207968	1738	P>R		No	ExAC gnomAD
COSM3441853 COSM3441852 COSM3441851	1738	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1173624921	1739	L>F		No	gnomAD
rs112359735	1742	T>A		No	Ensembl
rs1179835431	1742	T>I		No	TOPMed
rs117545428	1743	T>M		No	1000Genomes ExAC TOPMed gnomAD
rs1367411406	1744	S>Y		No	gnomAD
rs1433215737	1745	L>F		No	gnomAD
rs1185378074	1747	A>G		No	TOPMed gnomAD
rs1185378074	1747	A>V		No	TOPMed gnomAD
rs1297178595	1748	I>S		No	gnomAD
rs2052920557	1751	T>I		No	Ensembl
rs2052920754 COSM1220938	1753	K>R	large_intestine [Cosmic]	No	cosmic curated Ensembl
rs2052920838	1754	C>Y		No	Ensembl
COSM3808049 COSM1220945 COSM1220946 COSM5831617	1756	H>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs371506038	1756	H>R		No	ESP ExAC TOPMed gnomAD
rs759267806	1759	S>L		No	ExAC gnomAD
rs1228062735	1763	N>I		No	TOPMed gnomAD
rs544095097	1764	A>S		No	1000Genomes ExAC gnomAD
rs563882342	1765	A>T		No	1000Genomes ExAC gnomAD
rs2133536861	1767	R>C		No	1000Genomes
rs373607060	1767	R>H		No	ESP ExAC TOPMed gnomAD
COSM3738793 rs747535637	1770	R>C	liver [Cosmic]	No	cosmic curated ExAC gnomAD
rs755331165	1770	R>H		No	ExAC TOPMed gnomAD
TCGA novel	1771	R>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2052922661	1771	R>T		No	TOPMed
rs1386309138	1774	Q>*		No	gnomAD
rs3765524	1777	T>N		No	1000Genomes ESP ExAC TOPMed gnomAD
rs773347686	1778	Q>H		No	ExAC gnomAD
TCGA novel	1778	Q>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1780	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs749337785	1780	T>I		No	ExAC TOPMed gnomAD
rs749337785	1780	T>N		No	ExAC TOPMed gnomAD
rs184878324	1781	A>S		No	1000Genomes ExAC TOPMed gnomAD
rs184878324	1781	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1229352883	1781	A>V		No	gnomAD
rs375009518	1783	Q>R		No	ESP ExAC gnomAD
rs1327628714	1786	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs368327192	1786	R>S		No	ESP ExAC gnomAD
rs763759972	1789	P>S		No	ExAC gnomAD
rs1245949386	1793	R>C		No	gnomAD
COSM1585198 COSM1585199 COSM921675 rs1472812094	1793	R>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs2052925451	1795	D>E		No	TOPMed
rs2052925360	1795	D>N		No	TOPMed
rs2052925557	1797	S>A		No	Ensembl
rs764661960	1797	S>C		No	ExAC gnomAD
COSM3383113 COSM3383112 COSM3383114	1798	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1472223808	1799	P>A		No	gnomAD
rs1158131470	1799	P>L		No	TOPMed gnomAD
rs755528503	1803	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs2052926302	1804	F>I		No	Ensembl
rs1002696684	1805	W>R		No	TOPMed gnomAD
rs981294689	1806	L>F		No	TOPMed gnomAD
rs781777103	1806	L>P		No	ExAC gnomAD
rs981294689	1806	L>V		No	TOPMed gnomAD
rs1310169027	1807	H>Y		No	gnomAD
rs1349255578	1808	G>W		No	gnomAD
TCGA novel	1809	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1811	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1220428835	1816	Y>C		No	TOPMed gnomAD
COSM6130776 COSM6130777 COSM6130778 COSM6130775	1816	Y>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs749474276	1818	T>S		No	ExAC TOPMed gnomAD
rs771250044	1820	D>Y		No	ExAC gnomAD
rs1317035766	1821	L>F		No	gnomAD
rs1375813217	1821	L>P		No	gnomAD
rs2053138612	1824	H>Y		No	Ensembl
rs1258200464	1827	A>P		No	gnomAD
rs1386718843	1827	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
TCGA novel	1831	E>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs757398673	1831	E>G		No	ExAC gnomAD
COSM415403 COSM1645601 COSM1133327	1831	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2053139148	1832	A>E		No	TOPMed
rs199653498	1834	G>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2053139572	1835	G>S		No	TOPMed gnomAD
rs75409041	1840	L>F		No	Ensembl
rs779910403	1842	P>A		No	ExAC TOPMed gnomAD
rs2053140300 COSM262983	1845	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs746926247	1846	W>R		No	ExAC gnomAD
COSM4847920 COSM4847919 COSM4847918 COSM4847921	1847	D>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1404986261	1848	K>R		No	gnomAD
rs768706217	1849	N>K		No	ExAC gnomAD
rs2053140884	1851	P>S		No	gnomAD
rs2053140986	1852	M>V		No	gnomAD
rs1589509469	1853	Y>C		No	Ensembl
rs1436598076	1855	K>Q		No	gnomAD
rs1294978179	1855	K>R		No	gnomAD
rs1325431415	1856	F>L		No	gnomAD
rs1233710771	1858	P>A		No	gnomAD
rs1233710771	1858	P>S		No	gnomAD
rs2053142089	1860	E>Q		No	TOPMed gnomAD
rs2053142181	1861	R>K		No	Ensembl
rs1342857627	1865	S>N		No	TOPMed gnomAD
rs1199784194	1865	S>R		No	TOPMed gnomAD
rs1262632814	1868	P>S		No	TOPMed gnomAD
rs1273582281	1869	A>E		No	TOPMed gnomAD
rs184591536	1869	A>S		No	1000Genomes ExAC gnomAD
rs184591536	1869	A>T		No	1000Genomes ExAC gnomAD
rs2053143079	1870	V>D		No	TOPMed gnomAD
rs1246436636	1870	V>I		No	TOPMed gnomAD
rs1234999458	1871	Y>H		No	TOPMed
rs933902901	1872	S>F		No	TOPMed gnomAD
COSM262984	1872	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs772943934	1875	I>F		No	ExAC gnomAD
rs762686660	1875	I>M		No	ExAC gnomAD
COSM3441860 COSM3441861 COSM3441862	1877	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1427932815	1881	V>M		No	TOPMed gnomAD
rs1171255447	1884	S>G		No	TOPMed gnomAD
COSM267190	1886	S>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1294956402	1887	M>I		No	TOPMed gnomAD
rs2053209579	1887	M>T		No	TOPMed
rs2053209419	1887	M>V		No	Ensembl
rs2053209807	1888	G>*		No	Ensembl
rs759125453	1891	C>S		No	ExAC gnomAD
rs2053210252	1891	C>S		No	Ensembl
rs759125453	1891	C>Y		No	ExAC gnomAD
rs2053210462	1892	I>F		No	TOPMed gnomAD
rs2053210597	1892	I>T		No	Ensembl
rs2053210462	1892	I>V		No	TOPMed gnomAD
COSM1646357 COSM686033 COSM1146525	1893	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2053210766	1893	E>G		No	Ensembl
rs764467728	1895	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs374201007	1896	V>I		No	ESP TOPMed gnomAD
rs2053211204	1897	L>V		No	Ensembl
COSM5192515 COSM1474900 COSM1474899 COSM1474898	1898	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1388477579	1899	M>T		No	TOPMed
rs1302831861	1902	D>N		No	gnomAD
rs777216538	1903	S>N		No	ExAC TOPMed gnomAD
rs777216538	1903	S>T		No	ExAC TOPMed gnomAD
rs1589512494	1905	H>R		No	Ensembl
rs974611612	1907	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs762105530	1907	R>H		No	ExAC TOPMed gnomAD
rs2133639890	1908	T>I		No	Ensembl
rs765592069	1910	P>L		No	ExAC gnomAD
rs1366569206	1912	H>L		No	gnomAD
rs1357470118	1912	H>Y		No	gnomAD
TCGA novel	1913	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1589512569	1915	T>A		No	Ensembl
rs918778336	1915	T>N		No	Ensembl
rs766637825	1918	P>L		No	ExAC gnomAD
rs184071036	1919	M>T		No	1000Genomes ExAC TOPMed gnomAD
COSM5765885 rs755120877 COSM5765887 COSM5765884 COSM5765886	1920	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC TOPMed gnomAD
rs1589512617	1920	W>R		No	Ensembl
rs1564881408 RCV000722696	1922	E>missing		No	ClinVar dbSNP
rs780945870	1922	E>K		No	ExAC gnomAD
rs748133025	1923	Q>E		No	ExAC gnomAD
rs2053214256	1923	Q>P		No	TOPMed
rs377288149	1927	H>Q		No	ESP ExAC TOPMed gnomAD
rs2053214462	1927	H>Y		No	Ensembl
rs1004119938	1929	H>R		No	TOPMed
rs745313987	1931	E>K		No	ExAC TOPMed gnomAD
rs866123283	1932	D>N		No	gnomAD
rs866123283	1932	D>Y		No	gnomAD
rs2053215702	1933	L>P		No	Ensembl
rs2053215801	1934	V>A		No	Ensembl
rs1219781383	1935	F>C		No	gnomAD
COSM4016825 rs1314937548 COSM4016826 COSM4016827	1937	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs1343115907	1938	F>C		No	TOPMed gnomAD
rs1300173316	1940	V>I		No	TOPMed
rs1245492536	1943	N>D		No	gnomAD
rs776933870	1943	N>S		No	ExAC gnomAD
rs1344794553	1944	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs376573095	1945	S>T		No	ESP ExAC TOPMed
rs1251254953	1946	S>A		No	gnomAD
rs1443679422	1949	T>I		No	gnomAD
rs1305616570	1950	A>S		No	TOPMed gnomAD
COSM4853514 COSM4853515 COSM4853513 COSM4853512	1952	R>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2053218042	1958	A>V		No	TOPMed
COSM4016830 COSM4016828 COSM4016829 rs774196868	1961	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl NCI-TCGA
rs369203569	1961	R>Q		No	ESP ExAC TOPMed gnomAD
rs267602627	1962	G>E		No	Ensembl
COSM1585195 COSM1585194 COSM921678	1963	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1970567 RCV000592054 CA5613444 rs775052849 COSM1970566 COSM1970568	1964	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs746572025	1964	R>Q		No	ExAC TOPMed gnomAD
rs868033486	1967	Q>*		No	gnomAD
rs1221249322	1967	Q>R		No	gnomAD
rs770255322	1969	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1323373118	1969	R>Q		No	TOPMed gnomAD
rs1228545577	1971	L>I		No	gnomAD
rs763259071	1971	L>P		No	ExAC gnomAD
rs1009072565	1974	E>*		No	TOPMed
rs771343639	1975	V>I		No	ExAC gnomAD
rs1214596384	1976	L>*		No	gnomAD
TCGA novel	1977	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs764292204	1977	E>G		No	TOPMed gnomAD
rs1246888142	1977	E>Q		No	gnomAD
rs1196943350	1979	S>A		No	gnomAD
rs774371738	1980	S>G		No	ExAC TOPMed gnomAD
rs1163170205	1980	S>N		No	gnomAD
rs774371738	1980	S>R		No	ExAC TOPMed gnomAD
COSM1349966 TCGA novel rs775907880	1982	F>L	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA cosmic curated gnomAD
rs1285299068	1983	I>V		No	TOPMed
COSM1585192 COSM1585193 COSM921679	1984	N>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1160067877	1984	N>Y		No	TOPMed gnomAD
rs1399213126	1986	R>G		No	gnomAD
TCGA novel	1986	R>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1386100747	1987	R>K		No	TOPMed gnomAD
rs1317936686	1988	M>I		No	TOPMed gnomAD
rs1299023922	1988	M>V		No	TOPMed gnomAD
rs868319587	1990	E>K		No	TOPMed gnomAD
COSM1744114 rs1350630025 COSM1744115 COSM1744116	1992	S>F	biliary_tract Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs1345503411	1994	G>S		No	gnomAD
rs199968141	1995	N>S		No	1000Genomes ExAC gnomAD
rs1564883514	1996	T>A		No	Ensembl
rs1347962803	1997	M>T		No	TOPMed gnomAD
rs1222657238	1999	A>P		No	TOPMed gnomAD
rs764074119	2001	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs750201745	2002	M>V		No	ExAC gnomAD
rs200908827	2003	F>L		No	ExAC TOPMed
rs2053446778	2005	T>I		No	TOPMed
rs779637729	2007	E>Q		No	ExAC gnomAD
RCV000722980 rs1564887427	2007	E>missing		No	ClinVar dbSNP
rs1461617727	2008	R>G		No	TOPMed gnomAD
rs1169941611	2010	C>R		No	TOPMed gnomAD
rs1169941611	2010	C>S		No	TOPMed gnomAD
TCGA novel	2012	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2053447551	2012	Q>L		No	Ensembl
rs2053447735 TCGA novel	2015	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs751230422	2017	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1449777749	2019	H>D		No	gnomAD
rs1313950181	2019	H>R		No	gnomAD
rs1365390945	2020	G>A		No	TOPMed gnomAD
rs1365390945	2020	G>E		No	TOPMed gnomAD
rs552752024	2021	V>I		No	1000Genomes ExAC TOPMed gnomAD
COSM3441865 COSM3441863 COSM3441864	2022	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1338726854	2024	P>L		No	gnomAD
rs2053448525	2024	P>S		No	gnomAD
rs371057938	2025	E>K		No	ESP ExAC TOPMed gnomAD
rs371057938	2025	E>Q		No	ESP ExAC TOPMed gnomAD
rs2053448918	2026	P>R		No	TOPMed
rs2053449093	2027	F>L		No	Ensembl
rs2053449249	2028	T>A		No	gnomAD
rs1564887576 RCV000722964	2028	T>A		No	ClinVar Ensembl dbSNP
rs2053449340	2028	T>N		No	gnomAD
rs779315815	2029	V>I		No	ExAC TOPMed gnomAD
rs1242763794	2031	T>N		No	gnomAD
rs1242763794	2031	T>S		No	gnomAD
rs2053450020	2032	I>V		No	Ensembl
rs377038783	2034	G>A		No	ESP ExAC TOPMed gnomAD
COSM218286 COSM1159215 COSM3441869	2034	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs373598655	2034	G>R		No	ESP TOPMed gnomAD
rs2053450278	2035	G>D		No	Ensembl
rs370404700	2036	T>I		No	ESP ExAC TOPMed gnomAD
rs370404700	2036	T>S		No	ESP ExAC TOPMed gnomAD
rs769056474	2037	K>T		No	ExAC gnomAD
rs2053450729	2038	A>E		No	Ensembl
rs977054750	2040	Q>H		No	TOPMed
COSM284074	2042	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs761840349	2043	Q>H		No	ExAC TOPMed gnomAD
rs2053581498	2045	I>T		No	Ensembl
rs1310705738	2047	T>A		No	TOPMed gnomAD
rs1165287995	2047	T>I		No	gnomAD
rs769780692	2048	N>H		No	ExAC TOPMed gnomAD
rs1278154640	2048	N>S		No	TOPMed
rs2053582001	2050	Q>H		No	Ensembl
rs773139035	2052	I>V		No	ExAC gnomAD
rs1393217745	2053	K>E		No	gnomAD
rs1304944660	2053	K>N		No	gnomAD
rs202230448	2055	V>A		No	1000Genomes ExAC TOPMed gnomAD
rs2053582524	2055	V>L		No	gnomAD
rs755150417	2056	T>I		No	ExAC TOPMed gnomAD
rs755150417	2056	T>S		No	ExAC TOPMed gnomAD
rs374921875	2057	T>P		No	ESP ExAC TOPMed gnomAD
rs190025280	2058	D>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs190025280	2058	D>N		No	1000Genomes ESP ExAC TOPMed gnomAD
rs372611082	2058	D>V		No	ESP ExAC TOPMed gnomAD
rs199907181	2059	Y>C		No	TOPMed
rs199907181	2059	Y>F		No	TOPMed
COSM1585191 COSM1585190 COSM921681	2060	F>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	2061	L>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2053583521	2061	L>F		No	TOPMed
COSM1585188 COSM921682 COSM1585189	2061	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1249180417	2062	M>I		No	gnomAD
rs373329178	2062	M>K		No	ExAC gnomAD
rs373329178	2062	M>T		No	ExAC gnomAD
rs1589530536	2062	M>V		No	Ensembl
rs763507258	2063	E>A		No	ExAC gnomAD
rs758950503	2065	K>I		No	ExAC gnomAD
TCGA novel	2067	F>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1356269652	2068	I>T		No	gnomAD
rs780749041	2068	I>V		No	ExAC TOPMed gnomAD
rs751934950	2069	S>C		No	ExAC TOPMed gnomAD
rs755416836	2071	E>G		No	ExAC gnomAD
rs748326515	2075	C>G		No	ExAC gnomAD
rs748326515	2075	C>R		No	ExAC gnomAD
rs1317450115	2075	C>Y		No	gnomAD
rs2053585135	2076	R>K		No	TOPMed
rs777703876	2078	Q>H		No	ExAC gnomAD
rs1380776200	2078	Q>P		No	TOPMed gnomAD
COSM1474903 COSM1474901 COSM1474902 rs1431829778 COSM5192801	2079	P>T	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs2053585792	2083	A>T		No	Ensembl
COSM1970594 rs774292214 COSM4626704 COSM1970593 COSM1970595	2083	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs1472589178	2084	I>T		No	TOPMed
rs1157378517	2084	I>V		No	TOPMed gnomAD
TCGA novel	2085	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs771764501	2085	G>D		No	ExAC gnomAD
rs759265610	2085	G>R		No	ExAC gnomAD
rs2053586288	2088	E>K		No	Ensembl
rs1194855624	2089	E>D		No	Ensembl
TCGA novel	2089	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM921683 COSM1585187 COSM1585186	2090	I>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2053586671	2091	M>I		No	gnomAD
rs1000159715	2091	M>V		No	TOPMed gnomAD
rs1204953857	2093	I>T		No	gnomAD
rs1460594357	2096	S>G		No	gnomAD
rs1054881333	2097	W>R		No	Ensembl
rs2053587274	2100	E>K		No	TOPMed
rs538437231	2104	M>I		No	1000Genomes ExAC TOPMed gnomAD
COSM4016833 COSM4016832 COSM4016831	2104	M>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs760229823	2104	M>V		No	ExAC TOPMed gnomAD
rs1349683566	2105	G>A		No	TOPMed gnomAD
rs1426476262	2105	G>R		No	gnomAD
rs753257897	2106	R>K		No	ExAC gnomAD
rs375684891	2107	I>T		No	ESP ExAC gnomAD
TCGA novel	2111	T>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs755331102	2111	T>P		No	ExAC gnomAD
rs781410807	2113	Q>H		No	ExAC TOPMed gnomAD
rs2053588328	2113	Q>R		No	Ensembl
rs1269879141	2114	E>K		No	TOPMed gnomAD
rs2053820935	2116	L>R		No	Ensembl
COSM1585185 COSM1585184 COSM921684	2118	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs908769656	2120	N>S		No	TOPMed gnomAD
rs1410521926	2121	I>T		No	gnomAD
rs1326370481	2123	Q>K		No	gnomAD
rs1589542824	2124	D>G		No	Ensembl
TCGA novel	2125	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1366618328	2126	K>E		No	TOPMed gnomAD
COSM4016836 COSM4016835 COSM4016834	2127	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1301849938	2134	E>A		No	gnomAD
rs758237098	2135	E>G		No	ExAC TOPMed gnomAD
rs758237098	2135	E>V		No	ExAC TOPMed gnomAD
rs1589542917 COSM1585182 COSM921685 COSM1585183	2137	F>L	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs763852846	2137	F>S		No	Ensembl
rs1041719230	2139	V>I		No	Ensembl
rs2053824617	2140	Q>E		No	gnomAD
rs1361352223	2143	D>N		No	gnomAD
rs768511827	2146	P>L		No	ExAC
rs2053825056	2146	P>S		No	Ensembl
rs769631306	2150	R>L		No	ExAC TOPMed gnomAD
COSM1585181 rs769631306 COSM1585180 COSM921686	2150	R>Q	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs568921619	2155	A>P		No	1000Genomes ExAC gnomAD
TCGA novel	2156	P>K	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1589543032	2156	P>L		No	Ensembl
rs1386031367	2156	P>T		No	TOPMed gnomAD
rs762568769	2157	R>C		No	ExAC TOPMed gnomAD
rs767860128	2157	R>H		No	ExAC TOPMed gnomAD
rs767860128	2157	R>L		No	ExAC TOPMed gnomAD
rs767860128	2157	R>P		No	ExAC TOPMed gnomAD
rs1330358397	2158	V>D		No	gnomAD
rs200549010 COSM1970621 COSM1970620 COSM1970622	2158	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1373181398	2160	T>N		No	TOPMed gnomAD
rs1040807562	2161	A>P		No	TOPMed
RCV000516839 rs1040807562 CA377648579	2161	A>T		No	ClinGen ClinVar TOPMed dbSNP
rs896930151	2161	A>V		No	TOPMed gnomAD
rs773108869	2162	Q>*		No	Ensembl
rs751179270	2164	V>I		No	Ensembl
rs1352289869	2165	I>T		No	TOPMed gnomAD
rs748007890	2168	T>N		No	ExAC gnomAD
rs2053932415	2169	L>S		No	Ensembl
rs769544936	2170	C>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs769544936	2170	C>R		No	ExAC TOPMed gnomAD
rs1268350123	2171	K>N		No	gnomAD
rs1379889812	2171	K>T		No	gnomAD
TCGA novel	2172	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2053932804	2172	A>V		No	gnomAD
TCGA novel	2174	Y>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1014600774	2174	Y>S		No	Ensembl
rs373010369	2177	S>C		No	ESP
rs2053933434	2177	S>T		No	Ensembl
rs1165674143	2180	S>G		No	TOPMed gnomAD
rs1202047514	2180	S>N		No	TOPMed gnomAD
rs773797305	2180	S>R		No	ExAC TOPMed gnomAD
rs1202047514	2180	S>T		No	TOPMed gnomAD
rs2053933951	2181	N>D		No	Ensembl
rs776947470	2182	P>L		No	ExAC gnomAD
TCGA novel	2182	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs200439178	2185	S>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs765395358	2186	D>N		No	ExAC TOPMed gnomAD
rs750672164	2187	Y>C		No	ExAC gnomAD
rs1176586432	2187	Y>H		No	gnomAD
rs750672164	2187	Y>S		No	ExAC gnomAD
TCGA novel	2189	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2053934798	2190	L>F		No	TOPMed gnomAD
COSM3441872 COSM3441871 COSM3441870	2191	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs754922973 COSM1187998	2191	E>V	lung [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
COSM4016838 COSM4016839 rs1315950279 COSM4016837	2192	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed gnomAD
rs2053935078	2194	V>L		No	Ensembl
rs976045617	2195	K>R		No	TOPMed
rs2053935425	2197	T>A		No	TOPMed
rs1405452061	2198	T>N		No	TOPMed gnomAD
TCGA novel	2199	N>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1030145372	2203	T>I		No	Ensembl
rs1030145372	2203	T>N		No	Ensembl
rs2053936122	2204	T>I		No	TOPMed
rs2133907640	2205	P>L		No	Ensembl
rs748963046	2205	P>S		No	1000Genomes ExAC TOPMed gnomAD
rs748963046	2205	P>T		No	1000Genomes ExAC TOPMed gnomAD
rs778463347	2207	S>C		No	ExAC TOPMed gnomAD
rs369756376	2207	S>T		No	ESP
rs2053936556	2209	Q>R		No	gnomAD
rs953372406	2210	R>L		No	TOPMed gnomAD
rs953372406	2210	R>P		No	TOPMed gnomAD
rs953372406	2210	R>Q		No	TOPMed gnomAD
COSM1349968 COSM1349969 COSM1349970 rs1363480647 COSM5166243	2210	R>W	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs1271611192	2211	V>I		No	TOPMed gnomAD
rs1271611192	2211	V>L		No	TOPMed gnomAD
rs950728556	2213	L>P		No	TOPMed
rs950728556	2213	L>R		No	TOPMed
rs373489516	2214	D>H		No	1000Genomes ESP ExAC TOPMed gnomAD
RCV001580282 rs373489516	2214	D>N		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1032268249	2216	E>K		No	TOPMed gnomAD
rs762109366	2219	F>I		No	ExAC gnomAD
rs762109366	2219	F>L		No	ExAC gnomAD
rs542110825	2227	G>S		No	Ensembl
COSM4914338 COSM4914339 COSM4914337 COSM4914340	2228	A>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2053937937	2228	A>T		No	Ensembl
COSM686030 COSM1646355 rs1156639637 COSM1146528	2229	G>E	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
COSM1646356 COSM1146526 COSM686032	2229	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1363563143	2232	I>M		No	gnomAD
rs766562737	2232	I>T		No	ExAC gnomAD
rs751630029	2233	L>V		No	ExAC TOPMed gnomAD
rs1338607117	2234	K>*		No	TOPMed gnomAD
rs1336628562	2236	K>E		No	gnomAD
rs2053938809	2236	K>R		No	TOPMed
rs2053938900	2237	E>K		No	TOPMed
rs913291323	2238	Q>R		No	Ensembl
rs770345226	2241	A>P		No	ExAC gnomAD
rs770345226	2241	A>S		No	ExAC gnomAD
rs1317588208	2243	R>*		No	gnomAD
rs1317588208	2243	R>G		No	gnomAD
rs771149406	2243	R>Q		No	ExAC gnomAD
rs1554919219	2246	K>R		No	Ensembl
rs981543530	2247	K>N		No	Ensembl
RCV001383386 rs747833630	2248	K>missing		No	ClinVar dbSNP
rs774462183	2248	K>R		No	ExAC gnomAD
rs2053953964	2249	G>S		No	Ensembl
rs2053954074	2249	G>V		No	Ensembl
TCGA novel	2250	I>F	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs767697356	2251	S>Y		No	ExAC TOPMed gnomAD
rs180876175	2253	A>P		No	1000Genomes ExAC TOPMed gnomAD
rs180876175	2253	A>S		No	1000Genomes ExAC TOPMed gnomAD
rs202032657	2254	S>N		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2053955066	2256	L>V		No	TOPMed
rs1589550076	2258	K>N		No	Ensembl
rs375539976	2258	K>Q		No	ESP
rs2053955629	2261	K>Q		No	TOPMed
rs2053955734	2261	K>T		No	gnomAD
rs2053955838	2263	T>A		No	gnomAD
rs909411688	2263	T>I		No	TOPMed gnomAD
rs1564899669	2264	K>Q		No	Ensembl
rs1422983924	2266	P>H		No	TOPMed gnomAD
rs368314080	2266	P>S		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM921689 COSM1585176 rs201288761 COSM1585177	2267	R>*	Variant assessed as Somatic; HIGH impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes NCI-TCGA
rs867054095	2268	G>R		No	Ensembl
rs1383013974	2268	G>V		No	gnomAD
rs758113749	2270	T>I		No	ExAC gnomAD
rs1453614580	2273	S>P		No	TOPMed gnomAD
rs375606039	2274	Q>P		No	ESP ExAC TOPMed gnomAD
rs1181728731	2275	L>F		No	TOPMed gnomAD
rs778177096	2277	T>I		No	ExAC gnomAD
rs570419090	2278	S>P		No	gnomAD
rs1216315721	2279	E>G		No	gnomAD
rs1256842157	2280	S>C		No	gnomAD
rs1256842157	2280	S>G		No	gnomAD
rs1197510732	2280	S>N		No	TOPMed gnomAD
rs2053958362	2280	S>R		No	Ensembl
rs1323861374	2281	I>T		No	gnomAD
rs749619246	2282	Q>K		No	ExAC gnomAD
rs771218413	2284	K>E		No	ExAC
rs2053958900	2284	K>N		No	TOPMed
rs771540823	2285	E>G		No	ExAC TOPMed gnomAD
rs1235337295	2285	E>K		No	gnomAD
rs1051484226	2286	E>G		No	Ensembl
TCGA novel	2286	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs571727623	2288	P>S		No	1000Genomes ExAC TOPMed gnomAD
rs2053959551	2290	G>S		No	TOPMed
rs772739339	2290	G>V		No	TOPMed gnomAD
rs772469423	2291	G>A		No	ExAC TOPMed gnomAD
rs760867173	2292	L>M		No	ExAC gnomAD
rs2053960028	2293	S>C		No	TOPMed gnomAD
rs1309552948	2295	S>N		No	TOPMed gnomAD
rs1309552948	2295	S>T		No	TOPMed gnomAD
rs1178874455	2296	D>N		No	gnomAD
rs2053960235	2297	T>A		No	TOPMed
TCGA novel	2297	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs764042919	2297	T>K		No	ExAC gnomAD
TCGA novel	2299	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2133916064	2300	Y>D		No	Ensembl
rs776445270	2301	R>L		No	ExAC TOPMed gnomAD
rs776445270	2301	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2133916226	2303	Q>W		No	Ensembl

No associated diseases with Q9P212

4 regional properties for Q9P212

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	30 - 281	IPR000719
domain	SARAH domain	433 - 480	IPR011524
binding_site	Protein kinase, ATP binding site	36 - 59	IPR017441
domain	Mst1 SARAH domain	433 - 480	IPR024205

Functions

		Description
EC Number	3.1.4.11	Phosphoric diester hydrolases
Subcellular Localization	Cytoplasm, cytosol Cell membrane Golgi apparatus membrane Cell projection, lamellipodium	Recruited to plasma membrane by activated HRAS and RAP2 Recruited to perinuclear membrane by activated RAP1A Isoform 1 and isoform 2 associates with Golgi membranes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
lamellipodium	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name	Definition
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
metal ion binding	Binding to a metal ion.
phosphatidylinositol phospholipase C activity	Catalysis of the reaction
phospholipase C activity	Catalysis of the reaction
small GTPase binding	Binding to a small monomeric GTPase.

13 GO annotations of biological process

Name	Definition
calcium-mediated signaling	Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
diacylglycerol biosynthetic process	The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.
epidermal growth factor receptor signaling pathway	The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
G protein-coupled receptor signaling pathway	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
glomerulus development	The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
lipid catabolic process	The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
phosphatidylinositol metabolic process	The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
phosphatidylinositol-mediated signaling	The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phospholipase C-activating G protein-coupled receptor signaling pathway	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
positive regulation of lamellipodium assembly	Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
Ras protein signal transduction	The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
release of sequestered calcium ion into cytosol	The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.

31 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P32383	PLC1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q1RML2	PLCZ1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	Bos taurus (Bovine)	PR
P10895	PLCD1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	Bos taurus (Bovine)	SS
Q2VRL0	PLCZ1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	Gallus gallus (Chicken)	PR
Q15111	PLCL1	Inactive phospholipase C-like protein 1	Homo sapiens (Human)	PR
Q9UPR0	PLCL2	Inactive phospholipase C-like protein 2	Homo sapiens (Human)	PR
Q86YW0	PLCZ1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	Homo sapiens (Human)	PR
Q8N3E9	PLCD3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	Homo sapiens (Human)	SS
Q9BRC7	PLCD4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	Homo sapiens (Human)	SS
P16885	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	Homo sapiens (Human)	SS
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	Homo sapiens (Human)	EV
Q00722	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	Homo sapiens (Human)	EV
Q01970	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	Homo sapiens (Human)	EV
Q9NQ66	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	Homo sapiens (Human)	EV
P51178	PLCD1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	Homo sapiens (Human)	EV
Q15147	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	Homo sapiens (Human)	PR
Q8R3B1	Plcd1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	Mus musculus (Mouse)	SS
Q8K394	Plcl2	Inactive phospholipase C-like protein 2	Mus musculus (Mouse)	PR
Q8K2J0	Plcd3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	Mus musculus (Mouse)	PR
Q8K4S1	Plce1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	Mus musculus (Mouse)	SS
Q7YRU3	PLCZ	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	Sus scrofa (Pig)	PR
P10688	Plcd1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	Rattus norvegicus (Rat)	SS
Q99P84	Plce1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	Rattus norvegicus (Rat)	EV
Q8GV43	PLC6	Phosphoinositide phospholipase C 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q944C2	PLC5	Phosphoinositide phospholipase C 5	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6NMA7	PLC9	Phosphoinositide phospholipase C 9	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9STZ3	PLC8	Phosphoinositide phospholipase C 8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q56W08	PLC3	Phosphoinositide phospholipase C 3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q39032	PLC1	Phosphoinositide phospholipase C 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q944C1	PLC4	Phosphoinositide phospholipase C 4	Arabidopsis thaliana (Mouse-ear cress)	PR
A5D6R3	plcd3a	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MTSEEMTASV	LIPVTQRKVV	SAQSAADESS	EKVSDINISK	AHTVRRSGET	SHTISQLNKL
70	80	90	100	110	120
KEEPSGSNLP	KILSIAREKI	VSDENSNEKC	WEKIMPDSAK	NLNINCNNIL	RNHQHGLPQR
130	140	150	160	170	180
QFYEMYNSVA	EEDLCLETGI	PSPLERKVFP	GIQLELDRPS	MGISPLGNQS	VIIETGRAHP
190	200	210	220	230	240
DSRRAVFHFH	YEVDRRMSDT	FCTLSENLIL	DDCGNCVPLP	GGEEKQKKNY	VAYTCKLMEL
250	260	270	280	290	300
AKNCDNKNEQ	LQCDHCDTLN	DKYFCFEGSC	EKVDMVYSGD	SFCRKDFTDS	QAAKTFLSHF
310	320	330	340	350	360
EDFPDNCDDV	EEDAFKSKKE	RSTLLVRRFC	KNDREVKKSV	YTGTRAIVRT	LPSGHIGLTA
370	380	390	400	410	420
WSYIDQKRNG	PLLPCGRVME	PPSTVEIRQD	GSQRLSEAQW	YPIYNAVRRE	ETENTVGSLL
430	440	450	460	470	480
HFLTKLPASE	TAHGRISVGP	CLKQCVRDTV	CEYRATLQRT	SISQYITGSL	LEATTSLGAR
490	500	510	520	530	540
SGLLSTFGGS	TGRMMLKERQ	PGPSVANSNA	LPSSSAGISK	ELIDLQPLIQ	FPEEVASILM
550	560	570	580	590	600
EQEQTIYRRV	LPVDYLCFLT	RDLGTPECQS	SLPCLKASIS	ASILTTQNGE	HNALEDLVMR
610	620	630	640	650	660
FNEVSSWVTW	LILTAGSMEE	KREVFSYLVH	VAKCCWNMGN	YNAVMEFLAG	LRSRKVLKMW
670	680	690	700	710	720
QFMDQSDIET	MRSLKDAMAQ	HESSCEYRKV	VTRALHIPGC	KVVPFCGVFL	KELCEVLDGA
730	740	750	760	770	780
SGLMKLCPRY	NSQEETLEFV	ADYSGQDNFL	QRVGQNGLKN	SEKESTVNSI	FQVIRSCNRS
790	800	810	820	830	840
LETDEEDSPS	EGNSSRKSSL	KDKSRWQFII	GDLLDSDNDI	FEQSKEYDSH	GSEDSQKAFD
850	860	870	880	890	900
HGTELIPWYV	LSIQADVHQF	LLQGATVIHY	DQDTHLSARC	FLQLQPDNST	LTWVKPTTAS
910	920	930	940	950	960
PASSKAKLGV	LNNTAEPGKF	PLLGNAGLSS	LTEGVLDLFA	VKAVYMGHPG	IDIHTVCVQN
970	980	990	1000	1010	1020
KLGSMFLSET	GVTLLYGLQT	TDNRLLHFVA	PKHTAKMLFS	GLLELTRAVR	KMRKFPDQRQ
1030	1040	1050	1060	1070	1080
QWLRKQYVSL	YQEDGRYEGP	TLAHAVELFG	GRRWSARNPS	PGTSAKNAEK	PNMQRNNTLG
1090	1100	1110	1120	1130	1140
ISTTKKKKKI	LMRGESGEVT	DDEMATRKAK	MHKECRSRSG	SDPQDINEQE	ESEVNAIANP
1150	1160	1170	1180	1190	1200
PNPLPSRRAH	SLTTAGSPNL	AAGTSSPIRP	VSSPVLSSSN	KSPSSAWSSS	SWHGRIKGGM
1210	1220	1230	1240	1250	1260
KGFQSFMVSD	SNMSFVEFVE	LFKSFSVRSR	KDLKDLFDVY	AVPCNRSGSE	SAPLYTNLTI
1270	1280	1290	1300	1310	1320
DENTSDLQPD	LDLLTRNVSD	LGLFIKSKQQ	LSDNQRQISD	AIAAASIVTN	GTGIESTSLG
1330	1340	1350	1360	1370	1380
IFGVGILQLN	DFLVNCQGEH	CTYDEILSII	QKFEPSISMC	HQGLMSFEGF	ARFLMDKENF
1390	1400	1410	1420	1430	1440
ASKNDESQEN	IKELQLPLSY	YYIESSHNTY	LTGHQLKGES	SVELYSQVLL	QGCRSVELDC
1450	1460	1470	1480	1490	1500
WDGDDGMPII	YHGHTLTTKI	PFKEVVEAID	RSAFINSDLP	IIISIENHCS	LPQQRKMAEI
1510	1520	1530	1540	1550	1560
FKTVFGEKLV	TKFLFETDFS	DDPMLPSPDQ	LRKKVLLKNK	KLKAHQTPVD	ILKQKAHQLA
1570	1580	1590	1600	1610	1620
SMQVQAYNGG	NANPRPANNE	EEEDEEDEYD	YDYESLSDDN	ILEDRPENKS	CNDKLQFEYN
1630	1640	1650	1660	1670	1680
EEIPKRIKKA	DNSACNKGKV	YDMELGEEFY	LDQNKKESRQ	IAPELSDLVI	YCQAVKFPGL
1690	1700	1710	1720	1730	1740
STLNASGSSR	GKERKSRKSI	FGNNPGRMSP	GETASFNKTS	GKSSCEGIRQ	TWEESSSPLN
1750	1760	1770	1780	1790	1800
PTTSLSAIIR	TPKCYHISSL	NENAAKRLCR	RYSQKLTQHT	ACQLLRTYPA	ATRIDSSNPN
1810	1820	1830	1840	1850	1860
PLMFWLHGIQ	LVALNYQTDD	LPLHLNAAMF	EANGGCGYVL	KPPVLWDKNC	PMYQKFSPLE
1870	1880	1890	1900	1910	1920
RDLDSMDPAV	YSLTIVSGQN	VCPSNSMGSP	CIEVDVLGMP	LDSCHFRTKP	IHRNTLNPMW
1930	1940	1950	1960	1970	1980
NEQFLFHVHF	EDLVFLRFAV	VENNSSAVTA	QRIIPLKALK	RGYRHLQLRN	LHNEVLEISS
1990	2000	2010	2020	2030	2040
LFINSRRMEE	NSSGNTMSAS	SMFNTEERKC	LQTHRVTVHG	VPGPEPFTVF	TINGGTKAKQ
2050	2060	2070	2080	2090	2100
LLQQILTNEQ	DIKPVTTDYF	LMEEKYFISK	EKNECRKQPF	QRAIGPEEEI	MQILSSWFPE
2110	2120	2130	2140	2150	2160
EGYMGRIVLK	TQQENLEEKN	IVQDDKEVIL	SSEEESFFVQ	VHDVSPEQPR	TVIKAPRVST
2170	2180	2190	2200	2210	2220
AQDVIQQTLC	KAKYSYSILS	NPNPSDYVLL	EEVVKDTTNK	KTTTPKSSQR	VLLDQECVFQ
2230	2240	2250	2260	2270	2280
AQSKWKGAGK	FILKLKEQVQ	ASREDKKKGI	SFASELKKLT	KSTKQPRGLT	SPSQLLTSES
2290	2300
IQTKEEKPVG	GLSSSDTMDY	RQ