AiPD: Autoinhibited Protein Database

Q9NZJ5

Gene name	EIF2AK3 (PEK, PERK)
Protein name	Eukaryotic translation initiation factor 2-alpha kinase 3
Names	PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, HsPEK
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9451
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

524-593 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

524-593 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

954-989 (Activation loop from InterPro)

Target domain	593-1077 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

16 structures for Q9NZJ5

Entry ID	Method	Resolution	Chain	Position	Source
4G31	X-ray	228 A	A	588-1093	PDB
4G34	X-ray	270 A	A	588-1093	PDB
4M7I	X-ray	234 A	A	588-1093	PDB
4X7H	X-ray	200 A	A	575-1094	PDB
4X7J	X-ray	230 A	A	575-1094	PDB
4X7K	X-ray	180 A	A	575-1094	PDB
4X7L	X-ray	190 A	A	575-1094	PDB
4X7N	X-ray	235 A	A	575-1094	PDB
4X7O	X-ray	265 A	A	575-1094	PDB
4YZS	X-ray	314 A	A/B	104-403	PDB
5SV7	X-ray	321 A	A/B/C/D	95-420	PDB
7MF0	X-ray	281 A	AAA	575-1094	PDB
8EQ9	X-ray	286 A	AAA	575-1094	PDB
8EQD	X-ray	292 A	AAA	575-1094	PDB
8EQE	X-ray	256 A	AAA	575-1094	PDB
AF-Q9NZJ5-F1	Predicted				AlphaFoldDB

813 variants for Q9NZJ5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV001865223 CA10614598 rs886056419 RCV000403647	5	I>V	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
rs1045275032 CA51963765 RCV002556982 RCV001140157	18	L>R	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP
RCV000173359 RCV001521775 rs1805190 RCV000344451	21	L>missing	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinVar dbSNP
RCV000287113 CA10616306 rs886056418	23	L>R	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
RCV001137907 rs1675887917	34	R>H	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinVar dbSNP
rs766276341 RCV001174437 RCV002505754 CA1755009 RCV001873639	50	A>V	Wolcott-Rallison dysplasia Monogenic diabetes [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs201593811 RCV002277335 RCV000379170 CA238804 RCV000894632 RCV000173360 RCV000664082	52	A>T	Connective tissue disorder Wolcott-Rallison dysplasia Monogenic diabetes [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV001856761 rs1675883639 RCV001137906	71	T>I	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinVar dbSNP
CA1754990 rs539891019 RCV001137905 RCV001174436 RCV001417472	79	P>L	Wolcott-Rallison dysplasia Monogenic diabetes [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV000322169 CA152715 VAR_011409 RCV000116969 rs867529 RCV001516846	136	S>C	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA16609248 RCV000445410 rs1057524886	147	V>G	Monogenic diabetes [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
VAR_011410 RCV001521774 CA152717 RCV002277158 rs13045 RCV000116970 RCV000283479	166	Q>R	Connective tissue disorder Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1003629254 CA51498993 RCV000625664 RCV001855320	168	R>H	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
RCV000349841 CA1754900 RCV002502135 rs200991366	186	Y>H	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV001861158 RCV002278523 RCV002523146 RCV000375498 rs147458427 CA1754859	240	R>H	Connective tissue disorder Wolcott-Rallison dysplasia Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001142646 CA1754858 rs775353963	246	R>K	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
CA1754828 rs756231274 RCV001174435	278	F>Y	Monogenic diabetes [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA1754823 rs765112357 RCV002493793 RCV001348553 RCV002547480	282	T>I	Wolcott-Rallison dysplasia Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA1754821 RCV001301631 RCV002499560 rs150474217	286	N>S	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs549674310 RCV002495532 CA1754815 RCV000918179	302	E>D	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC dbSNP gnomAD
rs191277311 RCV001142644 RCV001857094 RCV001174434 RCV000504087 CA1754809	310	I>L	Wolcott-Rallison dysplasia Monogenic diabetes [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs121908570 RCV000006236 CA117826	332	E>*	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs869025178 RCV000006232	346	K>*	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinVar dbSNP
RCV001329322 rs1674857627	362	T>I	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinVar dbSNP
CA10616305 RCV000318510 rs886056417	364	N>K	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar dbSNP gnomAD
CA339733 rs864621972 RCV000204196	398	Q>*	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
rs145427892 RCV001140795 RCV000901896 RCV002279622 CA1754733	422	A>T	Connective tissue disorder Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV002493655 rs947983532 RCV001316623 CA51495185	422	A>V	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
RCV001858920 rs200574679 CA1754717 RCV001140794	437	S>Y	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA1754712 RCV001296864 RCV002504437 rs750810139 COSM1471356 COSM255398	457	D>G	Wolcott-Rallison dysplasia central_nervous_system prostate [ClinVar, Cosmic]	Yes	ClinGen cosmic curated ClinVar ExAC TOPMed dbSNP gnomAD
RCV001140793 RCV001326864 CA1754678 rs141901506	502	D>N	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV001283831 rs1674719462	513	K>missing	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinVar dbSNP
rs797045558 RCV002517071 RCV000193530	522	W>missing	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinVar dbSNP
rs1558652941 RCV000006235	523	K>*	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinVar dbSNP
RCV000368240 rs747376208 CA1754668 RCV001850816	534	I>T	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000311224 RCV001821019 VAR_040477 CA1754624 RCV000664080 RCV000423642 rs55791823 RCV002278521	566	D>V	Connective tissue disorder Wolcott-Rallison dysplasia Monogenic diabetes [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001140038 rs1674645367	576	S>R	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinVar dbSNP
RCV001339493 rs150314450 RCV000764448 CA1754614 RCV000445365 RCV002279228	584	G>E	Connective tissue disorder Wolcott-Rallison dysplasia Monogenic diabetes [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000364989 rs75385605 RCV000116965 CA152708 RCV000664081 RCV000419198	586	I>L	Wolcott-Rallison dysplasia Monogenic diabetes [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000006233 CA117825 rs121908569 VAR_011408	588	R>Q	Wolcott-Rallison dysplasia Variant assessed as Somatic; impact. WRS [ClinVar, NCI-TCGA, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl NCI-TCGA dbSNP
RCV001338593 RCV002486354 CA1754583 rs776579341	628	N>S	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000342457 RCV000432671 rs35226268 CA1754539	672	E>K	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000499424 RCV001303458 rs771612567 RCV000303905 CA1754514	688	S>R	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA1754508 RCV000281735 rs780592115	698	R>H	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs189064501 RCV000339055 RCV002519993 CA1754511	698	R>S	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV002476341 RCV000591252 rs781754103 CA1754505	702	P>A	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000116968 CA152713 RCV001521772 VAR_011411 RCV000374096 rs1805165	704	A>S	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA1754499 rs760433148 RCV000335758	712	I>T	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV001850815 CA1754480 RCV000278324 rs201662849	746	M>T	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV002505321 RCV000906073 CA1754471 rs777171158	762	Q>H	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV002504428 CA1754465 RCV001294549 rs778904290 RCV002538438	772	E>V	Wolcott-Rallison dysplasia Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs374540128 RCV001137797 RCV001348253 CA1754446	823	K>E	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000388427 rs751296708 CA1754441	834	A>T	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000331627 rs200270016 RCV003114497 CA1754439	836	K>I	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1178109063 RCV000995765 CA347589607 RCV002549918	903	R>*	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar dbSNP gnomAD
rs1553407942 CA347589356 RCV000503236	920	Q>*	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
RCV001142557 rs1674406193	934	M>R	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinVar dbSNP
rs759906972 RCV000501577 RCV002496946 CA1754370	975	M>V	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
RCV001142556 rs766524866 CA1754368	979	A>T	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
RCV001329324 rs755369984	1032	T>S	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinVar dbSNP
rs1441763585 CA347583810 RCV001142555	1074	N>K	Wolcott-Rallison dysplasia [ClinVar]	Yes	ClinGen ClinVar dbSNP gnomAD
CA347763649 rs1455129183	3	R>L		No	ClinGen TOPMed gnomAD
rs1439564564 CA347763643	4	A>G		No	ClinGen TOPMed
CA347763637 rs1378858666	5	I>S		No	ClinGen TOPMed
rs1432289766 CA347763630	6	S>I		No	ClinGen gnomAD
CA347763628 rs780496323	6	S>R		No	ClinGen ExAC gnomAD
CA347763624 rs1038519173	7	P>L		No	ClinGen gnomAD
CA51963773 rs1038519173	7	P>R		No	ClinGen gnomAD
rs1486401299 CA347763620	8	G>R		No	ClinGen gnomAD
CA347763616 rs1573432415	9	L>M		No	ClinGen Ensembl
rs1247889487 CA347763613	9	L>P		No	ClinGen gnomAD
CA347763610 rs1462706867	10	L>V		No	ClinGen gnomAD
rs1232776381 CA347763600	12	R>G		No	ClinGen gnomAD
rs756618692 CA1755021	12	R>P		No	ClinGen ExAC TOPMed gnomAD
CA347763594 rs1216036151	13	A>S		No	ClinGen gnomAD
rs1573432370 CA347763586	14	L>P		No	ClinGen Ensembl
rs1182739831 CA347763562	19	L>P		No	ClinGen gnomAD
CA347763553 rs1399462832	21	L>V		No	ClinGen TOPMed
CA347763537 rs1220868165	24	A>P		No	ClinGen TOPMed
rs1205554960 CA347763533	24	A>V		No	ClinGen gnomAD
rs1457762479 CA347763523	26	R>K		No	ClinGen TOPMed
rs1296667678 CA347763520	26	R>S		No	ClinGen gnomAD
rs1200915007 CA347763513	28	V>M		No	ClinGen gnomAD
CA51963750 rs935323305	29	A>P		No	ClinGen TOPMed gnomAD
CA1755014 rs529920914	29	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA1755012 rs764363291	30	A>T		No	ClinGen ExAC gnomAD
rs1373301967 CA347763481	33	A>V		No	ClinGen TOPMed
CA1755011 rs759316192	34	R>S		No	ClinGen ExAC gnomAD
rs1370315159 CA347763473	35	G>D		No	ClinGen gnomAD
rs776456569 CA1755010	35	G>R		No	ClinGen ExAC TOPMed gnomAD
CA347763475 rs776456569	35	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1167045257 CA347763470	36	L>F		No	ClinGen gnomAD
CA347763462 rs1317727916	37	P>S		No	ClinGen gnomAD
rs886042833 CA10604741 RCV000302079 RCV001820817	38	A>T		No	ClinGen ClinVar TOPMed dbSNP gnomAD
rs1388434655 CA347763454	38	A>V		No	ClinGen TOPMed
rs1385185104 CA347763448	39	P>L		No	ClinGen TOPMed
RCV001327447 rs1675886949	41	A>G		No	ClinVar dbSNP
TCGA novel	42	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1187474096 CA347763416	44	A>V		No	ClinGen gnomAD
rs1177978428 CA347763386	49	A>E		No	ClinGen TOPMed gnomAD
rs1177978428 CA347763384	49	A>V		No	ClinGen TOPMed gnomAD
rs201593811 CA1755008	52	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1202682565 CA347763366	53	P>A		No	ClinGen gnomAD
rs1361346758 CA347763364	53	P>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs905092644 CA51963736	55	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA1755006 rs761352130	56	A>E		No	ClinGen ExAC TOPMed gnomAD
CA1755005 rs773937986	57	T>M		No	ClinGen ExAC TOPMed gnomAD
CA347763342 rs773937986	57	T>R		No	ClinGen ExAC TOPMed gnomAD
rs768354404 CA1755004	58	R>Q		No	ClinGen ExAC gnomAD
rs1407082315 CA347763336	59	V>L		No	ClinGen gnomAD
CA347763328 rs1456887978	60	P>R		No	ClinGen gnomAD
rs1163180250 CA347763329	60	P>S		No	ClinGen gnomAD
rs1249821556 CA347763308	63	G>D		No	ClinGen gnomAD
rs1453110315 CA347763307	64	A>T		No	ClinGen gnomAD
rs1489098296 CA347763302	64	A>V		No	ClinGen TOPMed
rs1209141506 CA347763299	65	V>L		No	ClinGen gnomAD
rs746375881 CA1755000	66	A>V		No	ClinGen ExAC TOPMed gnomAD
rs781620386 CA1754999	67	A>V		No	ClinGen ExAC TOPMed gnomAD
CA1754998 rs757383379	68	A>T		No	ClinGen ExAC TOPMed gnomAD
rs565172181 CA1754996	70	V>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1036035211 CA51963723	75	A>T		No	ClinGen TOPMed gnomAD
rs1323254419 CA347763224	77	A>E		No	ClinGen gnomAD
rs1001666194 CA51963722	77	A>T		No	ClinGen TOPMed
rs1323254419 CA347763222	77	A>V		No	ClinGen gnomAD
rs539891019 CA1754991	79	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs766230167 CA1754992	79	P>S		No	ClinGen ExAC gnomAD
CA347763202 rs1456764971	81	A>V		No	ClinGen gnomAD
CA347763196 rs1478508112	82	A>E		No	ClinGen TOPMed gnomAD
CA347763197 rs1478508112	82	A>G		No	ClinGen TOPMed gnomAD
CA347763199 rs1178813253	82	A>S		No	ClinGen gnomAD
CA347763198 rs1478508112	82	A>V		No	ClinGen TOPMed gnomAD
rs1197851445 CA347763179	85	Q>*		No	ClinGen gnomAD
rs1422535694 CA347763178	85	Q>P		No	ClinGen gnomAD
CA1754987 rs767999139	89	G>C		No	ClinGen ExAC TOPMed gnomAD
CA1754986 rs767999139	89	G>S		No	ClinGen ExAC TOPMed gnomAD
CA347763146 rs1249747845	90	P>R		No	ClinGen gnomAD
rs770154991 CA1754984	91	E>D		No	ClinGen ExAC gnomAD
rs774936605 CA1754985	91	E>G		No	ClinGen ExAC gnomAD
CA347763127 CA1754983 rs372535313	93	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA51963707 rs896692801	93	D>N		No	ClinGen Ensembl
CA51963703 rs1053103909	94	D>E		No	ClinGen Ensembl
rs1260850302 CA347763125	94	D>H		No	ClinGen TOPMed
rs781713956 CA1754982	95	E>K		No	ClinGen ExAC
rs1386816960 CA347763107	96	T>I		No	ClinGen TOPMed gnomAD
CA51963700 rs13034488	97	E>*		No	ClinGen Ensembl
TCGA novel	97	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1754980 rs747108159	99	R>Q		No	ClinGen ExAC gnomAD
CA1754979 rs777931916	100	P>R		No	ClinGen ExAC gnomAD
CA347763086 rs1231453856	100	P>S		No	ClinGen gnomAD
rs758371991 CA1754978	101	R>H		No	ClinGen ExAC gnomAD
rs1284890385 CA347763072	103	R>G		No	ClinGen TOPMed
rs1204800330 CA347762711	103	R>S		No	ClinGen gnomAD
rs757041625 COSM289681 CA1754955	104	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA347762709 RCV000593171 rs1340497908	104	S>P		No	ClinGen ClinVar TOPMed dbSNP gnomAD
TCGA novel CA1754954 rs751527003	106	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC gnomAD
TCGA novel	108	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1754953 rs763921692	108	I>V		No	ClinGen ExAC TOPMed gnomAD
CA1754952 rs139901728	110	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1411763475 CA347762640	110	T>S		No	ClinGen TOPMed gnomAD
CA347762591 rs1314896894	115	I>V		No	ClinGen TOPMed
rs1338949091 CA347762573	116	A>V		No	ClinGen TOPMed
CA1754951 rs752117328	117	A>V		No	ClinGen ExAC TOPMed gnomAD
CA347762522 rs1269205947	122	N>H		No	ClinGen TOPMed
COSM3783446 rs1331657578 COSM3783445 CA347762518	122	N>S	Variant assessed as Somatic; impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA347762507 rs1307674868	123	H>R		No	ClinGen gnomAD
rs1292907531 CA347762492	125	K>E		No	ClinGen gnomAD
TCGA novel	128	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
RCV001296860 rs144124418 CA1754950	132	V>M		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs776226805 CA1754948	135	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs867529 CA347762356	136	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs867529 CA347762355	136	S>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	140	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347762308 rs1473288789	141	S>R		No	ClinGen gnomAD
CA1754947 rs760891399	143	S>C		No	ClinGen ExAC gnomAD
rs1209761689 CA347596996	148	F>C		No	ClinGen TOPMed gnomAD
TCGA novel	151	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347596970 rs1277977772	152	M>V		No	ClinGen TOPMed gnomAD
rs754542348 CA1754913	157	L>R		No	ClinGen ExAC gnomAD
rs753345227 CA1754912	164	W>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	165	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779799076 CA1754911	165	D>N		No	ClinGen ExAC gnomAD
rs779799076 CA51499019	165	D>Y		No	ClinGen ExAC gnomAD
COSM244223 rs755704498 CA347596875	166	Q>*	prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA1754910 rs755704498	166	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA1754909 rs767773902	166	Q>H		No	ClinGen ExAC gnomAD
CA347596873 rs13045	166	Q>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV001319399 CA1754908 rs762206822	168	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs762206822 CA347596862	168	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1003629254 CA347596861	168	R>P		No	ClinGen TOPMed gnomAD
CA51498991 rs1030746890	170	S>G		No	ClinGen TOPMed
CA51498989 rs752167830	170	S>N		No	ClinGen ExAC gnomAD
CA1754907 rs752167830	170	S>T		No	ClinGen ExAC gnomAD
rs1174380674 CA347596841	171	M>K		No	ClinGen TOPMed
rs1174380674 CA347596843	171	M>R		No	ClinGen TOPMed
rs1425626815 CA347596845	171	M>V		No	ClinGen gnomAD
rs770372979 CA1754906	173	T>R		No	ClinGen ExAC gnomAD
rs1395927778 CA347596824	174	V>I		No	ClinGen TOPMed
rs187776572 CA1754904	177	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1754903 rs769862062	178	V>A		No	ClinGen ExAC TOPMed gnomAD
rs759708667 CA1754902	179	E>K		No	ClinGen ExAC gnomAD
rs1253714888 CA347596747	186	Y>S		No	ClinGen TOPMed
rs145470505 CA1754898	187	K>R		No	ClinGen ESP ExAC gnomAD
TCGA novel	187	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347596726 rs1394978406	189	G>R		No	ClinGen gnomAD
rs1309491307 CA347596702	192	V>D		No	ClinGen TOPMed gnomAD
CA51498920 rs1049632455	192	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1410811524 CA347596698	193	V>F		No	ClinGen gnomAD
rs748849019 CA1754896	195	V>F		No	ClinGen ExAC gnomAD
rs779455657 CA1754895	196	G>R		No	ClinGen ExAC gnomAD
CA51498910 rs932283418	201	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA51498905 rs900837802	202	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs780881069 COSM364505 CA1754891	203	Y>C	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1483244464 CA347596621	206	S>R		No	ClinGen gnomAD
rs894717636 CA51498847	208	Y>C		No	ClinGen TOPMed gnomAD
CA1754888 rs764744831	208	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA1754887 rs758995400	209	S>G		No	ClinGen ExAC gnomAD
CA347596567 rs745376249 CA1754873	212	V>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC gnomAD NCI-TCGA
rs745376249 CA347596568	212	V>M		No	ClinGen ExAC gnomAD
CA347596553 rs1327996297	214	Y>C		No	ClinGen gnomAD
CA1754872 rs780745612	214	Y>H		No	ClinGen ExAC gnomAD
rs1235805014 CA347596548	215	I>V		No	ClinGen gnomAD
CA347596529 rs1227879512	217	S>L		No	ClinGen TOPMed
CA51497729 rs1054960475	218	A>T		No	ClinGen TOPMed
rs1301153218 CA347596521	219	L>P		No	ClinGen gnomAD
TCGA novel	222	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1754869 rs144117387	222	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs753157985 CA1754867	224	W>R		No	ClinGen ExAC TOPMed gnomAD
CA1754865 rs367754154	225	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA1754866 rs367754154	225	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1023611 COSM122801 CA1754863 rs766640012	228	E>K	upper_aerodigestive_tract Variant assessed as Somatic; 0.0 impact. endometrium [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA347596448 rs1433170972	229	M>I		No	ClinGen TOPMed
rs1467388361 CA347596449	229	M>T		No	ClinGen gnomAD
TCGA novel	232	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	234	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	235	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763885273 CA1754860	239	Q>H		No	ClinGen ExAC gnomAD
rs906171568 CA51497699	239	Q>K		No	ClinGen TOPMed
rs773387179 CA1754861	239	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1253063852 CA347596364	242	Q>*		No	ClinGen gnomAD
rs929014046 CA51497692	243	K>N		No	ClinGen TOPMed
TCGA novel	244	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1754857 rs769737215	246	R>S		No	ClinGen ExAC gnomAD
COSM3364850 COSM3364851 CA347596321 rs1255725028	249	G>R	kidney [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1461250090 CA347596311	250	P>L		No	ClinGen TOPMed gnomAD
rs1262034040 CA347596308	251	R>C		No	ClinGen gnomAD
rs558872999 CA1754854	251	R>H		No	ClinGen ExAC gnomAD
CA347596282 rs1225449831	255	E>K		No	ClinGen TOPMed
rs774445301 CA51496677	261	V>I		No	ClinGen Ensembl
CA347596213 rs1214543954	262	G>V		No	ClinGen gnomAD
CA1754836 rs201704351	267	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs773037976 CA1754835	268	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs773037976 CA347596175	268	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs748516671 CA1754833	269	I>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	271	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347596133 rs1034090328	274	T>A		No	ClinGen TOPMed gnomAD
CA347596130 rs1372248590 RCV001308350	274	T>M		No	ClinGen ClinVar TOPMed dbSNP gnomAD
rs1034090328 CA51496640	274	T>S		No	ClinGen TOPMed gnomAD
CA1754831 rs567991599	276	A>P		No	ClinGen 1000Genomes ExAC gnomAD
rs780485346 CA1754829	277	G>R		No	ClinGen ExAC TOPMed gnomAD
CA1754825 rs757517499	281	S>I		No	ClinGen ExAC gnomAD
rs765112357 CA1754824	282	T>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	283	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1463949493 CA347596077	283	F>V		No	ClinGen TOPMed
CA347596029 rs1228905306	289	T>I		No	ClinGen gnomAD
CA347596031 rs1228905306	289	T>K		No	ClinGen gnomAD
CA347596012 rs1230504276	292	S>T		No	ClinGen gnomAD
TCGA novel	293	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1351364166 CA534630083	293	K>V		No	ClinGen gnomAD
TCGA novel	294	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1441214040 CA347595987	295	I>T		No	ClinGen gnomAD
CA347595983 rs1352633666	296	S>P		No	ClinGen gnomAD
rs376125904 CA1754818	297	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs772833023 CA1754817	298	V>M		No	ClinGen ExAC
CA51496544 rs1014263422	300	E>K		No	ClinGen TOPMed
CA1754816 rs771423097	302	E>*		No	ClinGen ExAC gnomAD
rs773831879 CA1754814	303	A>P		No	ClinGen ExAC TOPMed gnomAD
rs773831879 CA347595936	303	A>T		No	ClinGen ExAC TOPMed gnomAD
CA347595927 COSM1690778 rs1473338839 COSM1690779	304	A>V	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA1754813 rs769083965	305	I>V		No	ClinGen ExAC TOPMed gnomAD
rs749626188 CA1754812	306	M>K		No	ClinGen ExAC gnomAD
CA347595916 rs749626188	306	M>R		No	ClinGen ExAC gnomAD
rs1320101113 CA347595899	308	I>M		No	ClinGen TOPMed
CA1754811 rs780609524	308	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1468932809 CA347595903	308	I>V		No	ClinGen gnomAD
CA1754810 rs770275798	309	V>M		No	ClinGen ExAC gnomAD
rs191277311 CA347595892	310	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs781256167 CA1754808	312	V>I		No	ClinGen ExAC gnomAD
CA1754807 rs757246219	313	S>L	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs563686568 CA1754805	314	V>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1222983133 CA347595858	316	D>H		No	ClinGen gnomAD
CA347595857 rs1222983133	316	D>N		No	ClinGen gnomAD
CA1754804 rs754842136	318	K>R		No	ClinGen ExAC gnomAD
CA347595824 rs1276515547	320	M>T		No	ClinGen TOPMed gnomAD
CA51496481 rs993234315	321	A>E		No	ClinGen TOPMed
CA347595802 rs1193957620	323	S>T		No	ClinGen TOPMed
rs753681109 CA1754803	326	G>A		No	ClinGen ExAC gnomAD
TCGA novel	327	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1754800 rs370390181	330	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA347595738 rs1157996080	332	E>D		No	ClinGen gnomAD
CA1754799 rs121908570	332	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1169209411 CA347595722	334	Q>H		No	ClinGen TOPMed
CA347595723 rs1427743527	334	Q>R		No	ClinGen gnomAD
CA51496328 rs779996738	339	I>L		No	ClinGen ExAC TOPMed gnomAD
CA1754782 rs779996738	339	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs755930425 CA1754781	341	S>F		No	ClinGen ExAC gnomAD
CA1754779 rs767330545	345	L>F		No	ClinGen ExAC gnomAD
rs200315616 CA1754778	346	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200315616 CA1754777	346	K>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1754776 rs763604716	349	K>E		No	ClinGen ExAC gnomAD
CA347595611 rs1294172310	350	V>I		No	ClinGen gnomAD
rs1242428960 CA347595601	351	I>S		No	ClinGen TOPMed
CA347595602 rs1242428960	351	I>T		No	ClinGen TOPMed
CA347595593 rs1380818081	352	P>L		No	ClinGen gnomAD
rs901651363 CA51496306	354	S>R		No	ClinGen TOPMed gnomAD
CA347595576 rs1414546855	355	L>F		No	ClinGen gnomAD
rs1374073234 CA347595565	356	F>L		No	ClinGen gnomAD
rs1310368926 CA347595544	359	T>R		No	ClinGen gnomAD
rs765614263 CA1754773	360	S>N		No	ClinGen ExAC gnomAD
TCGA novel	360	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347595520 rs1425646551	363	S>P		No	ClinGen TOPMed gnomAD
CA347595495 rs1417492130	366	D>V		No	ClinGen TOPMed
CA347595491 rs1485204178	367	V>L		No	ClinGen gnomAD
rs771337239 CA1754769	369	E>G		No	ClinGen ExAC gnomAD
CA347595477 rs1480894325	369	E>K		No	ClinGen TOPMed gnomAD
TCGA novel	370	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	370	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1201810520 CA347595464	371	E>K		No	ClinGen gnomAD
CA51496280 rs535701506	372	E>D		No	ClinGen gnomAD
CA1754768 rs760865789	374	I>T		No	ClinGen ExAC TOPMed gnomAD
rs773177236 CA1754767	375	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1007871504 CA51496270	376	E>A		No	ClinGen Ensembl
CA347595423 rs1290556322	377	A>P		No	ClinGen gnomAD
rs1290556322 CA347595422	377	A>T		No	ClinGen gnomAD
CA1754765 rs748410567	378	A>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	379	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1396329078 CA347595400	380	G>V		No	ClinGen gnomAD
rs199822416 CA51496259	382	T>I		No	ClinGen 1000Genomes
rs199822416 CA347595389	382	T>K		No	ClinGen 1000Genomes
rs1054339837 CA51496252	386	V>D		No	ClinGen TOPMed
rs1159411533 CA347595364	386	V>I		No	ClinGen gnomAD
CA1754764 rs779224696	387	Y>N		No	ClinGen ExAC TOPMed gnomAD
rs1459503137 CA347595345	389	G>R		No	ClinGen gnomAD
rs1253554833 CA347595323	390	M>T		No	ClinGen gnomAD
CA1754739 rs146469659	392	R>G		No	ClinGen ESP ExAC gnomAD
rs1674809495 RCV001343812	393	G>D		No	ClinVar dbSNP
rs1558654231 CA347595289	395	L>V		No	ClinGen Ensembl
CA347595282 rs1259281305	396	Y>C		No	ClinGen gnomAD
rs1218098381 CA347595273	397	L>R		No	ClinGen TOPMed
rs1349144870 CA347595266	398	Q>H		No	ClinGen gnomAD
CA347595261 rs1573404121	399	S>*		No	ClinGen Ensembl
rs1438799680 CA347595237	403	I>S		No	ClinGen TOPMed gnomAD
rs1438799680 CA347595235	403	I>T		No	ClinGen TOPMed gnomAD
CA347595221 rs1485843012	405	E>D		No	ClinGen TOPMed
rs1558654210 CA347595209	407	F>L		No	ClinGen Ensembl
TCGA novel	407	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1319205117 CA347595195	409	S>A		No	ClinGen gnomAD
rs777668213 CA1754738	410	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1387484778 CA347595189	410	S>I		No	ClinGen TOPMed
CA1754737 rs757943925	411	P>T		No	ClinGen ExAC gnomAD
rs1395595747 CA347595155	415	E>A		No	ClinGen gnomAD
CA1754734 rs754599917	417	V>A		No	ClinGen ExAC gnomAD
rs1162535354 CA347595122	420	E>A		No	ClinGen TOPMed
rs947983532 CA347595106	422	A>G		No	ClinGen TOPMed gnomAD
rs145427892 CA347595109	422	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1193307627 CA347595104	423	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1446025106 CA347595087	425	P>R		No	ClinGen gnomAD
CA51495183 rs868486408	427	P>L		No	ClinGen gnomAD
CA51495184 rs866665157	427	P>S		No	ClinGen Ensembl
CA1754732 rs766683603	428	T>K		No	ClinGen ExAC gnomAD
rs1486242692 CA347595061	430	K>E		No	ClinGen gnomAD
COSM1023607 rs761048614 CA1754731 COSM1023608	436	H>Y	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA1754716 rs754468668	438	P>R		No	ClinGen ExAC gnomAD
rs990293614 CA51494766	440	R>I		No	ClinGen gnomAD
CA347594981 rs990293614	440	R>K		No	ClinGen gnomAD
rs748913188 CA1754715	442	P>R		No	ClinGen ExAC gnomAD
CA347594967 rs1385654135	443	V>I		No	ClinGen TOPMed
CA347594903 rs1292403664	452	K>E		No	ClinGen gnomAD
rs149737775 CA51494756	452	K>R		No	ClinGen ESP TOPMed gnomAD
rs756471929 CA1754713	454	L>P		No	ClinGen ExAC gnomAD
CA347594866 rs1329525666	457	D>N		No	ClinGen gnomAD
rs1329525666 RCV001338039	457	D>Y		No	ClinVar dbSNP
TCGA novel	458	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	460	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	462	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1387709739 CA347594815	463	E>D		No	ClinGen TOPMed
CA347594812 rs1381033306	464	Y>H		No	ClinGen TOPMed
CA51494738 rs976327992	465	S>G		No	ClinGen TOPMed
CA347594794 rs1383983021	466	N>S		No	ClinGen TOPMed
CA347594787 rs1416724116	467	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1461603249 CA347594790	467	G>S		No	ClinGen gnomAD
CA1754708 rs764107317	471	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	474	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1233965274 CA347594744	474	Y>H		No	ClinGen gnomAD
rs1166606987 CA347594742	474	Y>S		No	ClinGen gnomAD
CA51494737 rs966305598	475	P>T		No	ClinGen Ensembl
CA1754691 rs147874614	478	N>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA1754690 rs745450434	478	N>S		No	ClinGen ExAC
CA51493754 rs921135222	479	G>S		No	ClinGen gnomAD
rs757649885 CA1754688	481	Y>F		No	ClinGen ExAC gnomAD
CA1754689 rs781716922	481	Y>H		No	ClinGen ExAC gnomAD
CA1754686 rs764632909	483	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs1284650063 CA347594668	484	Y>H		No	ClinGen gnomAD
rs1223004994 CA347594660	485	Y>D		No	ClinGen gnomAD
CA347594638 rs1223494806	488	E>K		No	ClinGen gnomAD
rs758476728 CA1754685	489	R>K		No	ClinGen ExAC gnomAD
TCGA novel	492	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA51493742 rs377071401	492	R>Q		No	ClinGen gnomAD
rs965316271 CA51493737	494	T>I		No	ClinGen TOPMed
rs765173142 CA1754683	495	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA347594570 rs1432389199	498	V>I		No	ClinGen TOPMed gnomAD
rs754018614 CA1754681	499	R>S		No	ClinGen ExAC gnomAD
rs564017955 CA1754680	501	L>P		No	ClinGen 1000Genomes ExAC gnomAD
CA1754677 rs768630246	503	N>D		No	ClinGen ExAC gnomAD
TCGA novel	508	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	509	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762424772 CA1754675	509	N>Y		No	ClinGen ExAC gnomAD
rs1188393423 CA347594477	511	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA347594453 rs1278900422	514	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA1754673 rs769150243	516	V>L		No	ClinGen ExAC TOPMed gnomAD
CA347594439 rs1487226765	517	L>I		No	ClinGen gnomAD
TCGA novel	519	L>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
RCV000722900 rs1558652960	519	L>missing		No	ClinVar dbSNP
CA347594426 rs1282347047	519	L>V		No	ClinGen gnomAD
TCGA novel	520	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1754672 rs745540061	520	H>Y		No	ClinGen ExAC gnomAD
rs1414649675 CA347594406	521	W>C		No	ClinGen TOPMed
TCGA novel	522	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780972290 CA1754671	523	K>N		No	ClinGen ExAC gnomAD
CA347594379 rs1223196466	525	I>V		No	ClinGen gnomAD
rs200171164 CA1754669	528	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1398538548 CA347594314	534	I>M		No	ClinGen gnomAD
rs778201509 CA1754667	535	A>T		No	ClinGen ExAC gnomAD
CA347594297 rs1434600602	537	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1558652905 CA347594286	539	I>F		No	ClinGen Ensembl
rs1034289372 CA51493616	541	R>C		No	ClinGen TOPMed gnomAD
CA1754664 rs758957898 COSM1023604 COSM722931	541	R>H	lung Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs758957898 CA347594272	541	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1429259695 CA347594271	542	R>G		No	ClinGen gnomAD
CA347594265 rs1228918071	542	R>S		No	ClinGen TOPMed
CA1754663 rs753078059	543	L>F		No	ClinGen ExAC gnomAD
TCGA novel	544	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	546	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1754662 rs779080859	547	H>Q		No	ClinGen ExAC gnomAD
CA347594234 rs1326776600	547	H>R		No	ClinGen TOPMed
rs894772982 CA51493608	547	H>Y		No	ClinGen TOPMed gnomAD
CA1754661 rs755000762	548	P>L		No	ClinGen ExAC TOPMed gnomAD
CA347594227 rs755000762	548	P>R		No	ClinGen ExAC TOPMed gnomAD
rs766554136 CA1754659	549	H>D		No	ClinGen ExAC TOPMed gnomAD
rs766554136 CA1754660	549	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA1754658 rs761661210	550	R>K		No	ClinGen ExAC gnomAD
CA347594216 rs1254187256	550	R>S		No	ClinGen gnomAD
TCGA novel	552	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1754633 rs758108455	553	K>E		No	ClinGen ExAC gnomAD
CA51492063 rs113253152	553	K>R		No	ClinGen Ensembl
CA347594145 rs1337754799	558	Q>H		No	ClinGen TOPMed
rs1307924363 CA347594148	558	Q>R		No	ClinGen TOPMed
CA1754631 rs765262030	561	T>I		No	ClinGen ExAC gnomAD
rs752723076 CA1754632	561	T>S		No	ClinGen ExAC gnomAD
rs759175402 CA1754630	563	N>D		No	ClinGen ExAC gnomAD
CA1754629 rs776297256	563	N>T		No	ClinGen ExAC gnomAD
CA347594098 rs1176222628	565	Y>C		No	ClinGen gnomAD
rs765922890 CA1754628	565	Y>H		No	ClinGen ExAC gnomAD
rs55791823 CA1754625	566	D>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772689343 CA1754626	566	D>N		No	ClinGen ExAC
CA347594077 rs1348772635	569	S>R		No	ClinGen TOPMed
rs1573399708 CA347594070	569	S>R		No	ClinGen Ensembl
rs1353851715 CA347594063	571	E>K		No	ClinGen gnomAD
CA1754622 rs139037041	572	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA1754621 rs749734822	573	N>H		No	ClinGen ExAC TOPMed gnomAD
CA347594043 rs756141427	574	D>H		No	ClinGen ExAC TOPMed gnomAD
rs756141427 CA1754619	574	D>N		No	ClinGen ExAC TOPMed gnomAD
CA1754617 rs781244752	577	W>*		No	ClinGen ExAC gnomAD
CA1754618 rs746152711	577	W>R		No	ClinGen ExAC gnomAD
CA347594007 rs1373832495	578	N>K		No	ClinGen Ensembl
CA347594005 rs1456164712	579	D>N		No	ClinGen TOPMed
COSM1023603 COSM1023602 CA347593984 rs1573399636	581	K>N	endometrium [Cosmic]	No	ClinGen cosmic curated Ensembl
TCGA novel	582	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776056726	582	N>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1031732785 CA51491996	585	Y>S		No	ClinGen TOPMed gnomAD
CA1754613 rs754973185	588	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA347593922 rs371389672	589	Y>*		No	ClinGen ESP ExAC gnomAD
CA347593867 rs1805164	597	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs761374228 CA1754590	601	R>C		No	ClinGen ExAC TOPMed gnomAD
rs367551388 CA1754589	601	R>H		No	ClinGen ESP ExAC gnomAD
CA347593843 rs367551388	601	R>L		No	ClinGen ESP ExAC gnomAD
CA347593833 rs1558650314	603	G>D		No	ClinGen Ensembl
TCGA novel	612	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1263885546 CA347593758	614	V>I		No	ClinGen TOPMed
rs1025951513 CA51489981	618	N>S		No	ClinGen TOPMed
CA1754587 rs763275495	620	A>V		No	ClinGen ExAC gnomAD
TCGA novel	623	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1754585 rs770192517	625	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1754586 rs770192517	625	R>G		No	ClinGen ExAC TOPMed gnomAD
rs374308160 CA1754584	625	R>H		No	ClinGen ExAC gnomAD
CA1754581 rs747258023	628	N>K		No	ClinGen ExAC gnomAD
CA1754557 rs540704378	631	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA347593388 rs1233975926	632	A>V		No	ClinGen gnomAD
rs1283246923 CA347593386	633	R>Q		No	ClinGen TOPMed
COSM1409912 rs748318874 CA1754556 COSM1409913	633	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1255091514 CA347593374	635	K>E		No	ClinGen TOPMed gnomAD
CA347593355 rs1212032502	637	M>I		No	ClinGen TOPMed
rs1288833379 CA347593349	638	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs180939276 CA1754552	639	E>K		No	ClinGen 1000Genomes ExAC
CA1754549 rs777211078	641	K>*		No	ClinGen ExAC gnomAD
rs1474386390 CA347593311	644	A>D		No	ClinGen TOPMed
rs752306602 CA1754547	649	P>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	649	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA51487548 rs1031139865	657	A>S		No	ClinGen Ensembl
CA51487541 rs1041632555	659	L>I		No	ClinGen TOPMed
rs1415375926 CA347593204	660	E>K		No	ClinGen TOPMed
rs142325107 CA1754543	661	A>T		No	ClinGen ESP ExAC
CA1754542 rs760895791	662	P>Q		No	ClinGen ExAC gnomAD
rs773438842 CA1754541	664	E>Q		No	ClinGen ExAC gnomAD
CA347593164 rs1409352536	666	W>R		No	ClinGen gnomAD
CA347593155 rs1336637096	667	Q>E		No	ClinGen TOPMed
CA51487499 rs999686631	670	M>L		No	ClinGen TOPMed gnomAD
CA1754540 rs767634201	670	M>T		No	ClinGen ExAC gnomAD
CA1754538 rs774582330	673	I>T		No	ClinGen ExAC TOPMed gnomAD
CA347593093 rs1312383245	675	L>R		No	ClinGen Ensembl
rs769523936 CA1754537	677	D>G		No	ClinGen ExAC gnomAD
rs1245216593 CA347593081	677	D>H		No	ClinGen gnomAD
rs745674404 CA1754536	679	S>N		No	ClinGen ExAC gnomAD
TCGA novel	682	W>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770672534 CA1754517	684	L>F		No	ClinGen ExAC gnomAD
rs746972131 CA1754516	685	S>R		No	ClinGen ExAC TOPMed gnomAD
rs773112872 CA1754515	686	S>F		No	ClinGen ExAC gnomAD
CA51486711 rs867113140	690	M>I		No	ClinGen Ensembl
rs1465588512 CA347592972	691	D>G		No	ClinGen gnomAD
rs62157769 CA51486682	692	A>V		No	ClinGen gnomAD
rs1466276004 CA347592962	693	P>T		No	ClinGen gnomAD
rs974345812 CA51486670	695	V>I		No	ClinGen TOPMed gnomAD
CA51486661 rs895611424	697	I>V		No	ClinGen Ensembl
rs189064501 CA1754510	698	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs780592115 CA1754509	698	R>L		No	ClinGen ExAC TOPMed gnomAD
CA51486642 rs780592115	698	R>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	699	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347592921 rs751013573	700	M>K		No	ClinGen ExAC gnomAD
CA1754506 rs751013573	700	M>T		No	ClinGen ExAC gnomAD
CA1754507 rs756493851	700	M>V		No	ClinGen ExAC gnomAD
CA347592914 rs1233958215	701	D>V		No	ClinGen TOPMed
CA347592881 rs1805165 COSM1205103	704	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs542707362 CA51486635	705	T>S		No	ClinGen gnomAD
CA1754503 rs764017694	706	K>E		No	ClinGen ExAC gnomAD
rs570127757 CA1754502	707	E>G		No	ClinGen 1000Genomes ExAC gnomAD
CA1754501 rs374554600	709	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA51486621 rs764085183	709	I>V		No	ClinGen Ensembl
CA1754500 RCV001345768 rs766212381	712	I>V		No	ClinGen ClinVar ExAC dbSNP gnomAD
TCGA novel	713	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773198802 CA1754498	713	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	714	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs55861585 CA1754495 VAR_040478	716	P>L		No	ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD
CA51486572 rs574976232	716	P>S		No	ClinGen ExAC gnomAD
rs574976232 CA1754496	716	P>T		No	ClinGen ExAC gnomAD
CA1754494 rs768007461	717	Q>R		No	ClinGen ExAC gnomAD
CA51486556 rs201096232	718	R>G		No	ClinGen TOPMed
CA347592681 rs779827181 CA1754493	718	R>S		No	ClinGen ExAC TOPMed gnomAD
CA1754490 rs746223755	719	S>N		No	ClinGen ExAC gnomAD
CA1754491 rs770320288	719	S>R		No	ClinGen ExAC gnomAD
TCGA novel	721	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs947040918 CA51486528	721	S>Y		No	ClinGen TOPMed gnomAD
rs781644116 CA1754489	722	F>S		No	ClinGen ExAC gnomAD
rs1236281507 CA347592600	724	V>G		No	ClinGen TOPMed
CA1754486 rs777932006	726	I>F		No	ClinGen ExAC gnomAD
CA1754487 rs777932006	726	I>V		No	ClinGen ExAC gnomAD
rs1140819 CA51486508	727	S>P		No	ClinGen Ensembl
rs758386944 CA1754485	728	C>R		No	ClinGen ExAC gnomAD
CA1754484 rs752958536	731	T>K		No	ClinGen ExAC TOPMed gnomAD
CA347592510 rs752958536	731	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1346069423 CA347592433	737	Q>E		No	ClinGen TOPMed
CA347592370 rs1309864268	742	E>A		No	ClinGen gnomAD
CA347592359 rs1558648202	743	F>L		No	ClinGen Ensembl
rs1573393261 CA347592313	746	M>I		No	ClinGen Ensembl
CA347592299 rs1443330902	747	D>G		No	ClinGen gnomAD
CA347592305 rs1329425023	747	D>H		No	ClinGen TOPMed gnomAD
rs1329425023 CA347592307	747	D>N		No	ClinGen TOPMed gnomAD
TCGA novel	749	E>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774103568 CA1754478	751	I>T		No	ClinGen ExAC
rs376905155 CA1754476	752	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA1754475 rs762335106	754	S>*		No	ClinGen ExAC gnomAD
TCGA novel	754	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	755	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	756	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347592161 rs1558648168	756	D>H		No	ClinGen Ensembl
CA347592132 rs1160426248	758	A>P		No	ClinGen gnomAD
rs769586514 CA1754473	759	Y>*		No	ClinGen ExAC
CA1754472 rs745450377	760	N>D		No	ClinGen ExAC gnomAD
CA347592084 rs1379109787	761	L>F		No	ClinGen gnomAD
CA1754470 rs771151381	764	S>N		No	ClinGen ExAC gnomAD
rs747601591 CA1754469	764	S>R		No	ClinGen ExAC gnomAD
CA1754468 rs778113344	766	L>F		No	ClinGen ExAC gnomAD
CA1754467 rs758572014	767	T>K		No	ClinGen ExAC gnomAD
rs758572014 CA347592000	767	T>R		No	ClinGen ExAC gnomAD
TCGA novel	768	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1754466 rs566226789	770	D>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs933101367 CA51486374	774	G>R		No	ClinGen Ensembl
CA347591893 rs1430430675	775	T>N		No	ClinGen Ensembl
CA1754463 rs754018522	776	M>I		No	ClinGen ExAC TOPMed gnomAD
rs755197043 CA1754464	776	M>K		No	ClinGen ExAC gnomAD
TCGA novel	778	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347591868 rs1331889033	779	N>D		No	ClinGen gnomAD
CA1754460 rs751553557	779	N>K		No	ClinGen ExAC gnomAD
rs752973018 CA1754461	779	N>S		No	ClinGen ExAC gnomAD
TCGA novel	780	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347591850 COSM1023592 rs1365163126 COSM1023593	780	D>Y	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA347591812 rs1420157803	782	G>E		No	ClinGen gnomAD
CA51486342 rs866676281	784	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs762928284 CA1754458	786	E>D		No	ClinGen ExAC gnomAD
CA347591744 rs1467191584	787	L>F		No	ClinGen gnomAD
CA347591733 rs1197779008	788	C>G		No	ClinGen gnomAD
CA347591730 rs1431121237	788	C>Y		No	ClinGen gnomAD
rs976895681 CA51486334	791	E>K		No	ClinGen gnomAD
rs1488218683 CA347591672	792	A>V		No	ClinGen gnomAD
TCGA novel	795	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764803957 CA1754456	796	V>I		No	ClinGen ExAC TOPMed gnomAD
rs764803957 CA347591627	796	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1345857138 CA534630098	797	R>T*		No	ClinGen gnomAD
CA347591593 rs1255608073	798	S>L		No	ClinGen gnomAD
rs759288815 CA1754455	799	R>K		No	ClinGen ExAC gnomAD
rs908796009 CA51486306	800	E>D		No	ClinGen Ensembl
CA347591549 rs1573393050	802	T>P		No	ClinGen Ensembl
CA347591542 rs1328430364	802	T>S		No	ClinGen TOPMed gnomAD
CA347591502 rs1301049321	805	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA347591479 rs1558648052	807	V>E		No	ClinGen Ensembl
TCGA novel	807	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1647359 CA347591457 rs1279792355 COSM722934	809	E>K	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA347591427 rs1558648042	810	D>E		No	ClinGen Ensembl
CA1754454 rs776126535	811	S>C		No	ClinGen ExAC gnomAD
rs1244497174 CA347591398	813	C>G		No	ClinGen TOPMed gnomAD
rs1270797792 CA347591373	814	D>E		No	ClinGen TOPMed
CA347591378 rs1232810293	814	D>G		No	ClinGen TOPMed
CA1754452 rs569324630	816	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA347591337 rs1194194745	817	S>F		No	ClinGen TOPMed
CA347591332 rs1397242777	818	S>G		No	ClinGen gnomAD
rs1469352010 CA347591273	821	E>D		No	ClinGen TOPMed
rs767541817 RCV001320118	821	E>missing		No	ClinVar dbSNP
rs551274166 CA1754448	822	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs551274166 CA347591260	822	P>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA1754449 rs551274166	822	P>R		No	ClinGen 1000Genomes ExAC gnomAD
CA347591232 rs1432196367	825	N>I		No	ClinGen TOPMed
CA1754445 rs755001234	826	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA347591223 COSM1023590 COSM1023591 rs1171816937	826	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs369837691 CA1754443	828	H>L		No	ClinGen ESP ExAC gnomAD
CA1754444 rs369837691	828	H>P		No	ClinGen ESP ExAC gnomAD
TCGA novel	830	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347591113 rs1261615597	830	G>D		No	ClinGen gnomAD
CA347591051 rs1190282186	832	H>R		No	ClinGen gnomAD
rs1474123036 CA347591005	833	C>W		No	ClinGen TOPMed
rs1395104505 CA347590962	834	A>V		No	ClinGen TOPMed
rs763883904 CA1754440	835	N>S		No	ClinGen ExAC gnomAD
rs1198813637 CA347590947	835	N>Y		No	ClinGen gnomAD
rs137868793 CA51486230	837	L>I		No	ClinGen ESP TOPMed gnomAD
CA347590869 rs1317118350	837	L>P		No	ClinGen gnomAD
rs1382624185 CA347590758	841	K>N		No	ClinGen TOPMed
rs759089652 CA1754436	841	K>Q		No	ClinGen ExAC gnomAD
rs776415401 CA1754435	842	P>A		No	ClinGen ExAC gnomAD
CA347590690 rs1393852682	844	S>G		No	ClinGen gnomAD
CA1754434 rs765936619	844	S>N		No	ClinGen ExAC TOPMed gnomAD
CA51486152 rs369602164	845	S>T		No	ClinGen ESP TOPMed gnomAD
CA347590608 rs1573392867	846	K>R		No	ClinGen Ensembl
rs1558647914 CA347590586	847	S>F		No	ClinGen Ensembl
TCGA novel	848	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1421873804 CA347590530	849	S>F		No	ClinGen gnomAD
CA347590523 rs1558647902	850	E>Q		No	ClinGen Ensembl
CA1754431 rs773451477	851	A>V		No	ClinGen ExAC gnomAD
CA1754429 rs150135027	852	T>I		No	ClinGen ESP ExAC gnomAD
CA347590395 rs1459173233	854	S>C		No	ClinGen gnomAD
CA347590373 rs1356220658	855	I>T		No	ClinGen Ensembl
rs1238993770 CA347590380	855	I>V		No	ClinGen TOPMed gnomAD
rs768762794 CA1754427	857	P>L		No	ClinGen ExAC gnomAD
rs1263404377 CA347590335	858	P>A		No	ClinGen TOPMed
CA347590313 rs1444977556	859	R>K		No	ClinGen TOPMed
rs1456637620 CA347590271	861	T>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs200955126 CA1754426	862	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	863	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	867	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1356952939 CA347590095	870	N>T		No	ClinGen gnomAD
CA347590022 rs1573392756	874	K>E		No	ClinGen Ensembl
CA347590003 rs1162677725	875	L>F		No	ClinGen TOPMed
rs1378539318 CA347589999	875	L>R		No	ClinGen gnomAD
rs746064190 CA1754423	878	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1397688884 CA347589906	882	V>L		No	ClinGen TOPMed gnomAD
rs1325927822 CA347589819	888	M>I		No	ClinGen gnomAD
CA347589802 rs1387341784	889	Q>H		No	ClinGen TOPMed
rs758246673 CA1754421	897	K>E		No	ClinGen ExAC gnomAD
rs1380949636 CA347589640	900	M>I		No	ClinGen gnomAD
rs1442109327 CA347589651	900	M>V		No	ClinGen gnomAD
CA347589602 rs1438002291 COSM1752716 COSM1752717	903	R>Q	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA347589595 rs752726105	904	C>G		No	ClinGen ExAC TOPMed gnomAD
CA1754420 rs752726105	904	C>R		No	ClinGen ExAC TOPMed gnomAD
rs1452006499 CA347589562	906	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1311165257 CA347589548	907	E>G		No	ClinGen TOPMed
rs1289032685 CA347589541	908	E>K		No	ClinGen gnomAD
rs754596362 CA1754418	909	R>I		No	ClinGen ExAC gnomAD
CA347589476 rs1355808997	912	S>N		No	ClinGen gnomAD
CA1754416 rs761829897	913	V>M	Variant assessed as Somatic; 0.0001386 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA347589407 rs1437599611	917	I>F		No	ClinGen gnomAD
rs1437599611 CA347589409	917	I>V		No	ClinGen gnomAD
CA1754411 rs774904859	922	A>S		No	ClinGen ExAC TOPMed gnomAD
CA347589311 rs774904859	922	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs769136888 CA1754410	922	A>V		No	ClinGen ExAC gnomAD
rs781534136 CA1754405	935	H>D		No	ClinGen ExAC gnomAD
CA347588986 rs1488731167	936	R>G		No	ClinGen gnomAD
CA347587449 rs1238631613	943	I>V		No	ClinGen gnomAD
rs577767738 CA1754380	947	M>I		No	ClinGen 1000Genomes ExAC gnomAD
CA347587368 rs1045936070	947	M>R		No	ClinGen TOPMed gnomAD
CA51483554 rs1045936070	947	M>T		No	ClinGen TOPMed gnomAD
rs781425137 CA51483538	949	D>H		No	ClinGen Ensembl
rs745368997 CA1754378	950	V>A		No	ClinGen ExAC gnomAD
CA1754379 rs755647253	950	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1558646384 CA347587207	956	F>L		No	ClinGen Ensembl
CA347587169 rs1262362715	960	T>A		No	ClinGen TOPMed
CA1754376 rs756905625	962	M>T		No	ClinGen ExAC TOPMed gnomAD
COSM1159223 rs1213285607 CA347587158	962	M>V	pancreas [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1256624277 CA347587109	968	E>K		No	ClinGen TOPMed
CA347587101 rs1462526886	969	Q>E		No	ClinGen TOPMed
rs1447475016 CA347587097	969	Q>L		No	ClinGen gnomAD
CA1754375 rs751166753	970	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA347587077 rs1466354178	973	T>A		No	ClinGen gnomAD
CA1754373 rs758759825	973	T>I		No	ClinGen ExAC TOPMed gnomAD
CA347587065 rs1558646340	975	M>K		No	ClinGen Ensembl
CA1754369 rs372331748	976	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA51483443 rs764214778	980	R>K		No	ClinGen Ensembl
rs1573389692 CA347587027	981	H>Y		No	ClinGen Ensembl
CA51483416 rs918476097	982	T>I		No	ClinGen TOPMed
rs918476097 CA347587018	982	T>K		No	ClinGen TOPMed
TCGA novel	984	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1240864656 CA347587004	984	Q>H		No	ClinGen gnomAD
rs1158541478 CA347586998	985	V>A		No	ClinGen TOPMed
rs368610114 CA1754367	987	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs200538775 CA1754366	991	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1573389652 CA347586942	991	M>T		No	ClinGen Ensembl
CA347586927 rs1257752880	992	S>T		No	ClinGen gnomAD
TCGA novel	995	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs148953825 CA1754356	996	I>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs148953825 CA51473740	996	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs758752139 CA1754355	997	H>Q		No	ClinGen ExAC gnomAD
CA51473726 rs986571206	998	G>E		No	ClinGen Ensembl
CA347585377 rs1216835629	1000	S>N		No	ClinGen TOPMed
CA347585369 rs1271254368	1001	Y>C		No	ClinGen TOPMed
CA1754352 rs779084189	1003	H>Q		No	ClinGen ExAC gnomAD
CA347585350 rs755543117	1004	K>*		No	ClinGen ExAC TOPMed gnomAD
rs755543117 CA1754351	1004	K>E		No	ClinGen ExAC TOPMed gnomAD
rs754710304 CA51473714	1007	I>V		No	ClinGen gnomAD
CA1754350 rs754345067	1010	L>S		No	ClinGen ExAC TOPMed gnomAD
rs1398272432 CA347585281	1015	F>V		No	ClinGen TOPMed gnomAD
TCGA novel	1019	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1020	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1242197456 CA347585213	1024	Q>R		No	ClinGen TOPMed
rs767767088 CA1754346	1026	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1184728974 CA347585193	1027	R>G		No	ClinGen TOPMed
CA347585191 rs1369407813	1027	R>K		No	ClinGen gnomAD
CA347585190 rs1369407813	1027	R>T		No	ClinGen gnomAD
rs1199995541 CA347584461	1030	T>S		No	ClinGen gnomAD
CA1754324 rs755369984	1032	T>I		No	ClinGen ExAC gnomAD
CA51470973 rs995615422	1033	D>Y		No	ClinGen gnomAD
COSM1637915 CA1754323 COSM1637914 rs374423016	1034	V>I	bone [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
CA51470957 rs146129461	1035	R>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
RCV000502635 rs750529763 CA347584352	1038	K>N		No	ClinGen ClinVar ExAC dbSNP gnomAD
rs1194974239 CA347584359	1038	K>R		No	ClinGen gnomAD
CA347584269 rs1433555672	1045	Q>E		No	ClinGen TOPMed
rs1168679739 CA347584237	1047	Y>C		No	ClinGen TOPMed
CA51470941 rs767840632	1047	Y>H		No	ClinGen Ensembl
rs746319005 CA1754299	1052	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1378636412 CA347584084	1053	M>T		No	ClinGen TOPMed gnomAD
rs141166027 CA1754298	1053	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA347584064 rs1268382711	1055	Q>E		No	ClinGen gnomAD
CA1754297 rs757254462	1056	D>V		No	ClinGen ExAC TOPMed gnomAD
CA1754296 rs751877330	1062	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	1063	M>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1754295 rs764288224	1063	M>T		No	ClinGen ExAC gnomAD
rs1449935403 CA347583987	1064	E>V		No	ClinGen gnomAD
rs866814797 CA51470182 COSM79355 COSM1205102	1065	R>*	ovary large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
TCGA novel	1065	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347583971 rs1332444284	1065	R>Q		No	ClinGen gnomAD
rs1283080966 CA347583944	1067	E>A		No	ClinGen TOPMed
rs1283080966 CA347583940	1067	E>V		No	ClinGen TOPMed
CA347583905 rs1165452910	1069	I>M		No	ClinGen gnomAD
CA347583911 rs1394933147	1069	I>T		No	ClinGen gnomAD
TCGA novel	1072	I>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1458891483 CA347583856	1072	I>T		No	ClinGen gnomAD
rs1209823230 CA347583793	1075	A>V		No	ClinGen TOPMed
CA347583690 rs1182218596	1081	D>G		No	ClinGen gnomAD
rs1270652878 CA347583658	1083	P>A		No	ClinGen TOPMed gnomAD
TCGA novel	1083	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347583638 rs1454332345	1084	G>E		No	ClinGen TOPMed
rs773099851 CA1754292	1086	T>R		No	ClinGen ExAC TOPMed gnomAD
rs766126107 CA1754291	1087	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1558640744 CA347583602	1087	V>M		No	ClinGen Ensembl
CA1754290 rs143931342	1088	L>R		No	ClinGen ESP ExAC
rs1413880878 CA347583572	1089	R>K		No	ClinGen TOPMed
rs1329497693 CA347583561	1090	Q>R		No	ClinGen TOPMed
rs773003685 CA1754289	1091	R>K		No	ClinGen ExAC
CA347583546 rs1279814645	1092	S>F		No	ClinGen gnomAD
rs765299033 CA51470133	1093	R>C		No	ClinGen TOPMed gnomAD
COSM1409905 CA1754286 rs765878566 COSM1409904	1093	R>H	large_intestine Variant assessed as Somatic; 9.239e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs376257254 CA1754285	1094	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs768435755 CA1754284	1095	L>M		No	ClinGen ExAC gnomAD
CA51470090 rs762080456	1096	S>N		No	ClinGen TOPMed gnomAD
rs770232594 CA1754281	1098	S>*		No	ClinGen ExAC gnomAD
rs770232594 CA1754282	1098	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1200751163 CA347583421	1104	R>I		No	ClinGen gnomAD
rs1490490578 CA347583408	1105	Q>*		No	ClinGen gnomAD
CA1754277 rs747073375	1106	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs1439859735 CA347583358	1108	N>D		No	ClinGen TOPMed
CA51470041 rs1032902320	1109	S>C		No	ClinGen TOPMed
CA1754275 rs145982613 RCV001297358	1110	H>Q		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1558640665 CA347583316	1110	H>R		No	ClinGen Ensembl
rs1468683841 CA347583269	1112	P>L		No	ClinGen TOPMed
TCGA novel	1113	L>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA51470032 rs776812138	1114	P>L		No	ClinGen TOPMed
rs1040042580 CA51470030	1115	S>T		No	ClinGen Ensembl
CA894312208 rs1477421865	1117	N>A		No	ClinGen TOPMed
rs752870446 CA1754274	1117	N>S		No	ClinGen ExAC TOPMed gnomAD

1 associated diseases with Q9NZJ5

[MIM: 226980]: Wolcott-Rallison syndrome (WRS)

A rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, intellectual disability and cardiovascular abnormalities. {ECO:0000269|PubMed:10932183}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

A rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, intellectual disability and cardiovascular abnormalities. {ECO:0000269|PubMed:10932183}. Note=The disease is caused by variants affecting the gene represented in this entry.

3 regional properties for Q9NZJ5

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	593 - 1077	IPR000719
active_site	Serine/threonine-protein kinase, active site	933 - 945	IPR008271
binding_site	Protein kinase, ATP binding site	599 - 622	IPR017441

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Endoplasmic reticulum membrane; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of endoplasmic reticulum membrane	The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.

9 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
eukaryotic translation initiation factor 2alpha kinase activity	Catalysis of the reaction: ATP
Hsp90 protein binding	+Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.
identical protein binding	Binding to an identical protein or proteins.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein phosphatase binding	Binding to a protein phosphatase.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

33 GO annotations of biological process

Name	Definition
activation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
angiogenesis	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
bone mineralization	The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
calcium-mediated signaling	Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
cellular response to amino acid starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
cellular response to cold	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
cellular response to glucose starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
chondrocyte development	The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.
eiF2alpha phosphorylation in response to endoplasmic reticulum stress	The addition of a phosphate group on to the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress.
endocrine pancreas development	The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
endoplasmic reticulum organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.
endoplasmic reticulum unfolded protein response	The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
ER overload response	The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB.
insulin-like growth factor receptor signaling pathway	The series of molecular signals initiated by a ligand binding to an insulin-like growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
negative regulation of myelination	Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
negative regulation of translation	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
negative regulation of translation in response to stress	Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress.
negative regulation of translational initiation in response to stress	Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress.
ossification	The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
PERK-mediated unfolded protein response	The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of protein localization to nucleus	Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
positive regulation of transcription by RNA polymerase I	Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.
positive regulation of vascular endothelial growth factor production	Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to endoplasmic reticulum stress.
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.
regulation of translational initiation by eIF2 alpha phosphorylation	Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha.
response to endoplasmic reticulum stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
response to manganese-induced endoplasmic reticulum stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of endoplasmic reticulum stress caused by a manganese stimulus.
skeletal system development	The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P30291	WEE1	Wee1-like protein kinase	Homo sapiens (Human)	PR
Q9P2K8	EIF2AK4	eIF-2-alpha kinase GCN2	Homo sapiens (Human)	EV
Q99640	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (Human)	PR
P19525	EIF2AK2	Interferon-induced, double-stranded RNA-activated protein kinase	Homo sapiens (Human)	PR
Q9T014	SPA2	Protein SPA1-RELATED 2	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MERAISPGLL	VRALLLLLLL	LGLAARTVAA	GRARGLPAPT	AEAAFGLGAA	AAPTSATRVP
70	80	90	100	110	120
AAGAVAAAEV	TVEDAEALPA	AAGEQEPRGP	EPDDETELRP	RGRSLVIIST	LDGRIAALDP
130	140	150	160	170	180
ENHGKKQWDL	DVGSGSLVSS	SLSKPEVFGN	KMIIPSLDGA	LFQWDQDRES	METVPFTVES
190	200	210	220	230	240
LLESSYKFGD	DVVLVGGKSL	TTYGLSAYSG	KVRYICSALG	CRQWDSDEME	QEEDILLLQR
250	260	270	280	290	300
TQKTVRAVGP	RSGNEKWNFS	VGHFELRYIP	DMETRAGFIE	STFKPNENTE	ESKIISDVEE
310	320	330	340	350	360
QEAAIMDIVI	KVSVADWKVM	AFSKKGGHLE	WEYQFCTPIA	SAWLLKDGKV	IPISLFDDTS
370	380	390	400	410	420
YTSNDDVLED	EEDIVEAARG	ATENSVYLGM	YRGQLYLQSS	VRISEKFPSS	PKALESVTNE
430	440	450	460	470	480
NAIIPLPTIK	WKPLIHSPSR	TPVLVGSDEF	DKCLSNDKFS	HEEYSNGALS	ILQYPYDNGY
490	500	510	520	530	540
YLPYYKRERN	KRSTQITVRF	LDNPHYNKNI	RKKDPVLLLH	WWKEIVATIL	FCIIATTFIV
550	560	570	580	590	600
RRLFHPHPHR	QRKESETQCQ	TENKYDSVSG	EANDSSWNDI	KNSGYISRYL	TDFEPIQCLG
610	620	630	640	650	660
RGGFGVVFEA	KNKVDDCNYA	IKRIRLPNRE	LAREKVMREV	KALAKLEHPG	IVRYFNAWLE
670	680	690	700	710	720
APPEKWQEKM	DEIWLKDEST	DWPLSSPSPM	DAPSVKIRRM	DPFATKEHIE	IIAPSPQRSR
730	740	750	760	770	780
SFSVGISCDQ	TSSSESQFSP	LEFSGMDHED	ISESVDAAYN	LQDSCLTDCD	VEDGTMDGND
790	800	810	820	830	840
EGHSFELCPS	EASPYVRSRE	RTSSSIVFED	SGCDNASSKE	EPKTNRLHIG	NHCANKLTAF
850	860	870	880	890	900
KPTSSKSSSE	ATLSISPPRP	TTLSLDLTKN	TTEKLQPSSP	KVYLYIQMQL	CRKENLKDWM
910	920	930	940	950	960
NGRCTIEERE	RSVCLHIFLQ	IAEAVEFLHS	KGLMHRDLKP	SNIFFTMDDV	VKVGDFGLVT
970	980	990	1000	1010	1020
AMDQDEEEQT	VLTPMPAYAR	HTGQVGTKLY	MSPEQIHGNS	YSHKVDIFSL	GLILFELLYP
1030	1040	1050	1060	1070	1080
FSTQMERVRT	LTDVRNLKFP	PLFTQKYPCE	YVMVQDMLSP	SPMERPEAIN	IIENAVFEDL
1090	1100	1110
DFPGKTVLRQ	RSRSLSSSGT	KHSRQSNNSH	SPLPSN