AiPD: Autoinhibited Protein Database

Q9NSA1

Gene name	FGF21 (UNQ3115/PRO10196)
Protein name	Fibroblast growth factor 21
Names	FGF-21
Species	Homo sapiens (Human)
KEGG Pathway	hsa:26291
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

117-209 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

117-209 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q9NSA1

Entry ID	Method	Resolution	Chain	Position	Source
5VAQ	X-ray	261 A	C	186-209	PDB
6M6E	NMR	-	A	42-169	PDB
6M6F	NMR	-	A	42-164	PDB
AF-Q9NSA1-F1	Predicted				AlphaFoldDB

214 variants for Q9NSA1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA9557867 rs762567273	2	D>V		No	ClinGen ExAC gnomAD
rs770606924 CA9557868	3	S>L		No	ClinGen ExAC TOPMed gnomAD
CA406706505 rs1432613460	5	E>D		No	ClinGen gnomAD
CA9557871 rs574758901	5	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9557872 rs752583273	6	T>I		No	ClinGen ExAC gnomAD
rs143082272 CA9557875 CA9557876	7	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs373747907 CA9557878	8	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA9557880 rs781395923 COSM94310	9	E>K	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1224993400 CA406706558	10	H>R		No	ClinGen TOPMed gnomAD
CA406706591 rs1199960284	13	L>P		No	ClinGen TOPMed
CA309363242 rs976979026	18	L>M		No	ClinGen TOPMed
rs1291526000 CA406706661	19	A>V		No	ClinGen TOPMed
CA406706664 rs1219499744	20	G>C		No	ClinGen gnomAD
rs368542265 CA9557883	23	L>P		No	ClinGen ESP ExAC TOPMed
CA406706706 COSM1712567 rs1240408972	24	G>E	skin [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA9557886 rs773891074	25	A>S		No	ClinGen ExAC gnomAD
CA309363258 rs924185822	26	C>Y		No	ClinGen TOPMed
CA9557887 rs745319885	27	Q>H		No	ClinGen ExAC gnomAD
rs771480087 CA9557888	28	A>S		No	ClinGen ExAC gnomAD
rs1599769671 CA406706734	28	A>V		No	ClinGen Ensembl
CA9557889 rs775124219	29	H>Y		No	ClinGen ExAC gnomAD
rs760498049 CA9557890	30	P>S		No	ClinGen ExAC gnomAD
rs776517157 CA9557892	31	I>N		No	ClinGen ExAC gnomAD
TCGA novel	32	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA406706787 rs1599769702	36	P>L		No	ClinGen Ensembl
CA406706784 rs1378753078	36	P>S		No	ClinGen gnomAD
CA406706789 rs1166694162	37	L>F		No	ClinGen gnomAD
CA406706802 rs1457360424	39	Q>*		No	ClinGen gnomAD
rs766639565 CA9557894	40	F>L		No	ClinGen ExAC TOPMed gnomAD
CA309363291 rs915340719	41	G>R		No	ClinGen TOPMed gnomAD
rs755282525 CA9557896	42	G>V		No	ClinGen ExAC gnomAD
CA406706869 rs1370762359	44	V>A		No	ClinGen gnomAD
rs200208273 CA9557900	45	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs551483904 CA9557899	45	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406706889 rs1173702665	46	Q>L		No	ClinGen TOPMed
CA9557902 rs36123953	47	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs531768367 CA9557901	47	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	48	Y>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1599769767 CA406706910	48	Y>S		No	ClinGen Ensembl
CA406706922 rs1231357114	49	L>I		No	ClinGen gnomAD
CA309363352 rs779402704	50	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA406706939 rs1473901387	50	Y>C		No	ClinGen TOPMed gnomAD
rs374756853 CA9557904	51	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA309363362 rs1057111019	51	T>I		No	ClinGen TOPMed
rs771805912 CA9557905	53	D>N		No	ClinGen ExAC TOPMed gnomAD
rs774822193 CA9557906	54	A>T		No	ClinGen ExAC TOPMed gnomAD
CA9557907 rs746538552	54	A>V		No	ClinGen ExAC TOPMed gnomAD
CA406707054 rs1465649236	59	A>V		No	ClinGen gnomAD
rs368331867 CA9557909	62	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs368331867 CA9557910	62	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1403049682 CA406707092	63	I>V		No	ClinGen TOPMed gnomAD
rs1352344962 CA406707110	64	R>K		No	ClinGen gnomAD
TCGA novel	64	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs961083362 CA309363404	65	E>K		No	ClinGen TOPMed
CA9557912 rs773104317	66	D>N		No	ClinGen ExAC TOPMed gnomAD
CA309363406 rs993930473	67	G>R		No	ClinGen TOPMed gnomAD
rs372098035 CA406707161	68	T>K		No	ClinGen ESP
rs372098035 CA9557914	68	T>M		No	ClinGen ESP
rs1599769841 CA406707174	69	V>A		No	ClinGen Ensembl
CA9557917 rs767816365	70	G>R		No	ClinGen ExAC TOPMed gnomAD
CA9557919 TCGA novel rs756202748	71	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC gnomAD
rs756202748 CA406707193	71	G>D		No	ClinGen ExAC gnomAD
CA309363436 rs1006645843	71	G>S		No	ClinGen TOPMed gnomAD
rs202109871 CA9557920	72	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1425597803 CA406707223	74	D>G		No	ClinGen gnomAD
CA9557923 rs779125265	74	D>H		No	ClinGen ExAC TOPMed gnomAD
CA406707217 rs779125265	74	D>N		No	ClinGen ExAC TOPMed gnomAD
CA309363472 rs916828684	75	Q>K		No	ClinGen gnomAD
rs1180149376 CA406707235	75	Q>R		No	ClinGen TOPMed
CA406707246 rs1231853565	76	S>N		No	ClinGen TOPMed
CA406707250 rs370864523	76	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs965607160 CA309363476	76	S>R		No	ClinGen TOPMed
CA9557928 rs746450614	78	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs768906027 CA9557961	79	S>N		No	ClinGen ExAC gnomAD
rs1335622870 CA406707430	84	K>E		No	ClinGen TOPMed
CA9557963 rs761964608	85	A>G		No	ClinGen ExAC TOPMed gnomAD
rs141977654 CA9557965	88	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1449169164 CA406707482	88	P>S		No	ClinGen gnomAD
CA9557966 rs763425401	90	V>I		No	ClinGen ExAC TOPMed gnomAD
rs188734926 CA9557968	91	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs570444710 CA309364244	91	I>T		No	ClinGen Ensembl
CA406707543 rs1272539725	93	I>N		No	ClinGen gnomAD
TCGA novel	95	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369717276 CA9557969	96	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA406707582 rs1568493573	97	K>Q		No	ClinGen Ensembl
CA9557970 rs767304819	99	S>F		No	ClinGen ExAC gnomAD
TCGA novel	99	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1329137779 CA406707619	100	R>G		No	ClinGen gnomAD
CA406707624 rs1468183124	100	R>M		No	ClinGen TOPMed
COSM567142 CA9557971 rs752200625	100	R>S	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA9557972 rs150697022	101	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406707655 rs1453031464	103	C>G		No	ClinGen gnomAD
rs201244921 CA309364287	105	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA309364293 rs139679302	105	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA9557974 rs139679302	105	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9557973 rs201244921	105	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs373169857 CA9557975	106	P>S		No	ClinGen ESP ExAC TOPMed
CA9557976 rs778648482	108	G>E		No	ClinGen ExAC gnomAD
CA406707717 rs1222108430	108	G>R		No	ClinGen TOPMed
CA9557980 rs3745711	109	A>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs3745712 CA9557978	109	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA9557979 rs3745711	109	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406707759 rs1395979918	112	G>R		No	ClinGen gnomAD
CA406707774 rs763483884	113	S>*		No	ClinGen ExAC TOPMed gnomAD
CA9557984 rs763483884	113	S>L		No	ClinGen ExAC TOPMed gnomAD
CA9557983 rs763483884	113	S>W		No	ClinGen ExAC TOPMed gnomAD
rs758378232 CA9558014	115	H>R		No	ClinGen ExAC gnomAD
CA9558013 rs750345629	115	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA9558015 rs779864316	118	P>A		No	ClinGen ExAC gnomAD
CA309365415 rs779864316	118	P>S		No	ClinGen ExAC gnomAD
CA406707999 rs1426749771	119	E>Q		No	ClinGen gnomAD
rs751339714 CA9558016	120	A>T		No	ClinGen ExAC gnomAD
rs926393101 CA309365434	121	C>*		No	ClinGen TOPMed gnomAD
CA406708044 rs1434357357	121	C>Y		No	ClinGen gnomAD
rs142980324 CA406708106	124	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA9558018 rs142980324	124	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs756306204 CA9558017	124	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1289320708 CA406708115	125	E>*		No	ClinGen gnomAD
rs147466868 CA406708132	126	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA406708165 rs1296592074	128	L>F		No	ClinGen TOPMed
rs1379988301 CA406708184	129	E>G		No	ClinGen gnomAD
COSM3735555 rs929425489 CA309365468	131	G>R	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1320476025 CA406708245	133	N>D		No	ClinGen TOPMed
rs779194038 CA9558021	133	N>S		No	ClinGen ExAC gnomAD
CA9558024 rs775884928	137	S>P		No	ClinGen ExAC gnomAD
rs1453934850 CA406708296	138	E>G		No	ClinGen gnomAD
rs375892369 CA9558026	138	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs375892369 CA9558027	138	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	140	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs41308776 CA9558029 VAR_055375	141	G>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA9558030 rs144978172	142	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs762834260 CA9558031	143	P>L		No	ClinGen ExAC TOPMed gnomAD
CA406708360 rs1599772317	145	H>P		No	ClinGen Ensembl
rs1371086194 CA406708367	145	H>Q		No	ClinGen gnomAD
rs751306574 CA9558033	145	H>Y		No	ClinGen ExAC gnomAD
CA9558034 rs754736990	147	P>T		No	ClinGen ExAC gnomAD
rs1378656774 CA406708416	150	K>N		No	ClinGen gnomAD
rs754101733 CA9558036	152	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1315553668 CA406708455	153	H>P		No	ClinGen gnomAD
rs779105985 CA9558038	154	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9558037 rs112120725	154	R>W		No	ClinGen ExAC TOPMed gnomAD
rs371046094 CA309365563	155	D>V		No	ClinGen ESP TOPMed gnomAD
CA309365574 rs1009354409	156	P>S		No	ClinGen TOPMed gnomAD
rs745977503 CA9558039	157	A>E		No	ClinGen ExAC gnomAD
TCGA novel	157	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745977503 CA406708508	157	A>V		No	ClinGen ExAC gnomAD
rs780439354 CA9558042	158	P>A		No	ClinGen ExAC TOPMed gnomAD
rs780439354 CA9558041	158	P>S		No	ClinGen ExAC TOPMed gnomAD
CA9558044 rs777100377	159	R>*		No	ClinGen ExAC TOPMed gnomAD
COSM1661852 CA9558046 rs371068639	159	R>Q	kidney [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA9558047 rs772658085	160	G>E		No	ClinGen ExAC gnomAD
rs1395141382 CA406709174	160	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9558048 rs540715300	162	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9558049 rs540715300	162	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1401959279 CA406709218	163	R>C		No	ClinGen TOPMed gnomAD
CA9558050 COSM269170 rs374501551	163	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA gnomAD
rs759579781 CA9558051	164	F>S		No	ClinGen ExAC gnomAD
CA309365704 rs1023366244	165	L>P		No	ClinGen gnomAD
CA406709253 rs1230403999	166	P>A		No	ClinGen gnomAD
CA406709439 rs1386529931	167	L>P		No	ClinGen TOPMed
rs1294375928 CA406709467	169	G>D		No	ClinGen gnomAD
rs559156552 CA9558052	170	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9558056 rs752583057	171	P>H		No	ClinGen ExAC TOPMed gnomAD
rs752583057 CA9558055	171	P>L		No	ClinGen ExAC TOPMed gnomAD
CA9558059 rs758403141	172	P>L		No	ClinGen ExAC TOPMed gnomAD
CA9558058 rs765579156	172	P>S		No	ClinGen ExAC gnomAD
CA9558057 rs765579156	172	P>T		No	ClinGen ExAC gnomAD
CA406709502 rs376996120	173	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs376996120 CA9558062	173	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1231451873 CA406709513	173	A>V		No	ClinGen gnomAD
CA9558064 rs739320	174	L>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9558063 VAR_049064 rs739320	174	L>P		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs374311260 CA9558066	175	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs374311260 CA9558067 COSM365740	175	P>Q	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs374311260 CA406709545	175	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs769374090 CA9558065	175	P>S		No	ClinGen ExAC gnomAD
rs1301136713 CA406709546	176	E>K		No	ClinGen TOPMed gnomAD
CA309365797 rs3745708	178	P>L		No	ClinGen Ensembl
rs200685930 CA9558070	179	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9558072 rs775377031	182	A>V		No	ClinGen ExAC gnomAD
rs1313895716 CA406709657	183	P>L		No	ClinGen TOPMed gnomAD
rs868452579 CA309365835	183	P>S		No	ClinGen Ensembl
CA406709684 rs750659131	185	P>A		No	ClinGen ExAC gnomAD
CA9558075 rs750659131	185	P>S		No	ClinGen ExAC gnomAD
rs983618958 CA406709704	186	P>L		No	ClinGen TOPMed gnomAD
rs983618958 CA309365843	186	P>R		No	ClinGen TOPMed gnomAD
CA9558076 rs758694383	186	P>S		No	ClinGen ExAC TOPMed gnomAD
CA9558078 rs375785872	187	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs755387755 CA9558079	189	G>D		No	ClinGen ExAC gnomAD
rs781670890 CA9558080	191	S>L		No	ClinGen ExAC TOPMed gnomAD
rs778172084 CA9558083	194	L>P		No	ClinGen ExAC gnomAD
rs933317607 CA309365859	195	S>N		No	ClinGen TOPMed
rs1475419704 CA406709848	195	S>R		No	ClinGen gnomAD
CA9558086 rs773698761	196	M>I		No	ClinGen ExAC gnomAD
CA9558084 rs748872169	196	M>R		No	ClinGen ExAC gnomAD
CA9558085 rs748872169	196	M>T		No	ClinGen ExAC gnomAD
CA406709888 rs1436175854	197	V>A		No	ClinGen gnomAD
rs1051839058 CA309365884	198	G>E		No	ClinGen TOPMed
CA406709896 rs1173924254	198	G>R		No	ClinGen gnomAD
CA9558087 rs745406911	199	P>L		No	ClinGen ExAC gnomAD
CA406709905 rs1375217582	199	P>T		No	ClinGen gnomAD
CA9558088 rs778495177	200	S>F		No	ClinGen ExAC gnomAD
CA406709921 rs1208748417	200	S>P		No	ClinGen gnomAD
CA309365891 rs964395738	201	Q>H		No	ClinGen Ensembl
rs775575253 CA9558089	202	G>C		No	ClinGen ExAC gnomAD
CA9558090 rs760751014	203	R>*		No	ClinGen ExAC TOPMed gnomAD
rs202104197 CA9558091	203	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406709977 rs1369877615	204	S>N		No	ClinGen gnomAD
CA406709983 rs1235254222	204	S>R		No	ClinGen gnomAD
CA9558093 rs571891800	206	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA9558092 rs776608911	206	S>R		No	ClinGen ExAC TOPMed gnomAD
rs759663403 CA9558096	208	A>D		No	ClinGen ExAC TOPMed gnomAD
rs201833005 CA406710047	208	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201833005 CA9558095	208	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD

No associated diseases with Q9NSA1

No regional properties for Q9NSA1

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9NSA1

Functions

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

2 GO annotations of molecular function

Name	Definition
fibroblast growth factor receptor binding	Binding to a fibroblast growth factor receptor (FGFR).
growth factor activity	The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

27 GO annotations of biological process

Name	Definition
animal organ morphogenesis	Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cell-cell signaling	Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
cellular response to glucagon stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.
cellular response to glucose stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
cellular response to low-density lipoprotein particle stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.
cellular response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
endoplasmic reticulum unfolded protein response	The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
endothelial cell apoptotic process	Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal.
fibroblast growth factor receptor signaling pathway	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
negative regulation of endothelial cell apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.
negative regulation of neuron death	Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of cold-induced thermogenesis	Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
positive regulation of ERK1 and ERK2 cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of glucose import	Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
positive regulation of low-density lipoprotein receptor activity	Any process that activates or increases the frequency, rate or extent of low-density lipoprotein receptor activity.
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade.
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
positive regulation of triglyceride catabolic process	Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.
regulation of cell migration	Any process that modulates the frequency, rate or extent of cell migration.
regulation of low-density lipoprotein particle clearance	Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
response to activity	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
response to methionine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus.
response to nutrient levels	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

28 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P48801	FGF3	Fibroblast growth factor 3	Gallus gallus (Chicken)	SS
O15520	FGF10	Fibroblast growth factor 10	Homo sapiens (Human)	SS
O43320	FGF16	Fibroblast growth factor 16	Homo sapiens (Human)	EV SS
P10767	FGF6	Fibroblast growth factor 6	Homo sapiens (Human)	SS
P11487	FGF3	Fibroblast growth factor 3	Homo sapiens (Human)	SS
P31371	FGF9	Fibroblast growth factor 9	Homo sapiens (Human)	EV
Q92914	FGF11	Fibroblast growth factor 11	Homo sapiens (Human)	SS
Q9HCT0	FGF22	Fibroblast growth factor 22	Homo sapiens (Human)	SS
Q9NP95	FGF20	Fibroblast growth factor 20	Homo sapiens (Human)	SS
P08620	FGF4	Fibroblast growth factor 4	Homo sapiens (Human)	PR
P21658	Fgf6	Fibroblast growth factor 6	Mus musculus (Mouse)	SS
Q9ESS2	Fgf22	Fibroblast growth factor 22	Mus musculus (Mouse)	SS
O35565	Fgf10	Fibroblast growth factor 10	Mus musculus (Mouse)	SS
P54130	Fgf9	Fibroblast growth factor 9	Mus musculus (Mouse)	SS
Q9ESL8	Fgf16	Fibroblast growth factor 16	Mus musculus (Mouse)	SS
Q9ESL9	Fgf20	Fibroblast growth factor 20	Mus musculus (Mouse)	SS
P11403	Fgf4	Fibroblast growth factor 4	Mus musculus (Mouse)	PR
P61329	Fgf12	Fibroblast growth factor 12	Mus musculus (Mouse)	PR
P05524	Fgf3	Fibroblast growth factor 3	Mus musculus (Mouse)	SS
Q9JJN1	Fgf21	Fibroblast growth factor 21	Mus musculus (Mouse)	PR
Q95L12	FGF9	Fibroblast growth factor 9	Sus scrofa (Pig)	SS
Q9EST9	Fgf20	Fibroblast growth factor 20	Rattus norvegicus (Rat)	SS
O54769	Fgf16	Fibroblast growth factor 16	Rattus norvegicus (Rat)	SS
P36364	Fgf9	Fibroblast growth factor 9	Rattus norvegicus (Rat)	SS
P70492	Fgf10	Fibroblast growth factor 10	Rattus norvegicus (Rat)	SS
Q6PBT8	fgf1	Putative fibroblast growth factor 1	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q2HXK8	fgf16	Fibroblast growth factor 16	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
P48802	fgf3	Fibroblast growth factor 3	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MDSDETGFEH	SGLWVSVLAG	LLLGACQAHP	IPDSSPLLQF	GGQVRQRYLY	TDDAQQTEAH
70	80	90	100	110	120
LEIREDGTVG	GAADQSPESL	LQLKALKPGV	IQILGVKTSR	FLCQRPDGAL	YGSLHFDPEA
130	140	150	160	170	180
CSFRELLLED	GYNVYQSEAH	GLPLHLPGNK	SPHRDPAPRG	PARFLPLPGL	PPALPEPPGI
190	200
LAPQPPDVGS	SDPLSMVGPS	QGRSPSYAS