Q9NRW1

PR
Gene name
RAB6B
Protein name
Ras-related protein Rab-6B
Names
Species
Homo sapiens (Human)
KEGG Pathway
hsa:51560
EC number
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

144-208 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q9NRW1

Entry ID Method Resolution Chain Position Source
2E9S X-ray 178 A A/B/C 13-174 PDB
2FE4 X-ray 230 A A 13-174 PDB
2FFQ X-ray 178 A A 13-174 PDB
AF-Q9NRW1-F1 Predicted AlphaFoldDB

102 variants for Q9NRW1

Variant ID(s) Position Change Description Diseaes Association Provenance
CA2626107
rs199656580
 3 A>T No ClinGen
ExAC
TOPMed
gnomAD
rs939693796
CA83707342
 3 A>V No ClinGen
TOPMed
gnomAD
rs1576414129
CA354612848
 8 G>V No ClinGen
Ensembl
CA354612849
rs1576414133
 8 G>W No ClinGen
Ensembl
CA354612807
rs1359106322
 14 F>S No ClinGen
gnomAD
CA354612759
rs1226875280
 21 E>K No ClinGen
gnomAD
TCGA novel 23 S>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs373466732 24 V>= Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
CA354610291
rs1349102496
 24 V>A No ClinGen
TOPMed
CA83686171
rs1008529663
 25 G>R No ClinGen
gnomAD
TCGA novel 27 T>A Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1229890593
CA354610195
 32 R>K Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA354610167
rs1376652326
 34 M>T No ClinGen
gnomAD
TCGA novel 35 Y>C Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA354610137
rs1410074939
 36 D>N Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA354610079
rs1305643893
 40 N>H No ClinGen
gnomAD
rs1408626485
CA354610073
 40 N>S No ClinGen
gnomAD
TCGA novel 42 Y>F Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs775065498
CA83686136
 43 Q>* Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
Ensembl
NCI-TCGA
TCGA novel 49 D>Y Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA354613846
rs1437630973
 55 M>I No ClinGen
TOPMed
CA2626040
rs777877260
 59 D>N No ClinGen
ExAC
gnomAD
CA83689547
rs769336149
 60 R>C No ClinGen
gnomAD
CA2626039
COSM1038585
rs770015097
 60 R>H Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
gnomAD
rs748177345
CA2626038
 61 T>M No ClinGen
ExAC
TOPMed
gnomAD
rs778758018
CA2626012
 62 V>M No ClinGen
ExAC
gnomAD
CA354613784
rs1179735181
 63 R>Q Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
gnomAD
rs534416766
CA2626007
 76 R>H Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
TCGA novel 77 S>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA83689172
rs1024396218
 83 I>L No ClinGen
Ensembl
rs78439152
CA354613591
 92 V>A No ClinGen
gnomAD
CA83689130
rs78439152
 92 V>G No ClinGen
gnomAD
rs542416427
CA83689110
 93 Y>* No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs776861578
CA2626001
 94 D>N No ClinGen
ExAC
gnomAD
CA83689093
rs768772585
 97 N>H No ClinGen
Ensembl
CA2625978
rs772157331
 97 N>T No ClinGen
ExAC
TOPMed
gnomAD
CA354613521
rs1453849035
 101 F>S No ClinGen
gnomAD
rs1576394530
CA354613488
 106 K>E No ClinGen
Ensembl
CA354613478
rs1344216638
 107 W>* No ClinGen
TOPMed
rs769627212
CA2625972
 109 D>N Variant assessed as Somatic; 0.0001848 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
CA354613461
rs1559901029
 109 D>V No ClinGen
Ensembl
TCGA novel 110 D>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
COSM1222953
rs1222618592
CA354613450
 111 V>I large_intestine [Cosmic] No ClinGen
cosmic curated
TOPMed
TCGA novel 115 R>M Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA2625969
rs368174948
 117 S>T No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA354613395
rs1301150657
 119 V>I No ClinGen
gnomAD
TCGA novel 121 I>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1188262606
CA354613355
 125 G>S No ClinGen
TOPMed
TCGA novel 126 N>K Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA2625967
rs201627683
 128 T>M Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
1000Genomes
ExAC
NCI-TCGA
TOPMed
gnomAD
CA354613304
rs1172716308
 132 D>V No ClinGen
gnomAD
rs767779820
CA2625941
 136 I>V No ClinGen
ExAC
TOPMed
gnomAD
CA83686514
rs1036387197
 140 E>D No ClinGen
TOPMed
CA354613226
COSM1222952
rs1199263239
 142 E>K large_intestine [Cosmic] No ClinGen
cosmic curated
TOPMed
CA354613208
rs1311764888
 144 R>C Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
COSM1038583
CA2625937
rs749807184
 144 R>H Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
CA354613207
rs749807184
 144 R>L No ClinGen
ExAC
TOPMed
gnomAD
rs901474058
CA83686498
 147 E>V No ClinGen
Ensembl
rs1409804092
CA354613175
 149 S>N No ClinGen
gnomAD
rs144269069
CA2625933
 150 V>I No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs144269069
CA354613171
 150 V>L No ClinGen
ESP
ExAC
TOPMed
gnomAD
TCGA novel 152 F>L Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1559900654
CA354613153
 152 F>S No ClinGen
Ensembl
CA2625931
rs746640270
 153 I>T No ClinGen
ExAC
gnomAD
CA354613148
COSM1536374
rs1417399223
 153 I>V lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] No ClinGen
cosmic curated
NCI-TCGA
gnomAD
CA83686468
rs999252754
 156 S>N No ClinGen
TOPMed
gnomAD
TCGA novel 160 G>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA2625928
rs745330518
 162 N>S No ClinGen
ExAC
TOPMed
gnomAD
rs969928306
CA83683946
 166 L>P No ClinGen
Ensembl
COSM1222954
CA2625879
rs147187493
 168 R>* Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
CA354613031
rs1396071031
 168 R>Q No ClinGen
gnomAD
CA2625878
rs767167270
 169 R>C No ClinGen
ExAC
gnomAD
CA2625877
rs759175694
 169 R>H Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
rs141807334
CA83683930
 170 V>A No ClinGen
ESP
gnomAD
CA83683932
rs1032614289
 170 V>L No ClinGen
TOPMed
rs773916908
CA2625876
 171 A>V No ClinGen
ExAC
gnomAD
CA2625874
rs762430079
 172 S>L Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
CA2625871
rs559212190
 176 G>R No ClinGen
1000Genomes
ExAC
gnomAD
rs780553261
CA2625870
 179 N>K No ClinGen
ExAC
gnomAD
TCGA novel 182 E>A Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA2625869
rs761263159
 182 E>D No ClinGen
ExAC
TOPMed
gnomAD
rs1360993853
CA354612924
 185 K>N No ClinGen
TOPMed
gnomAD
rs773423094
CA2625867
 185 K>R No ClinGen
ExAC
TOPMed
gnomAD
rs1468545531
CA354612911
 187 G>E No ClinGen
gnomAD
CA2625846
rs749338361
 190 D>E No ClinGen
ExAC
TOPMed
gnomAD
rs771114953
CA2625847
 190 D>N Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
rs777891226
CA2625845
 192 K>N No ClinGen
ExAC
gnomAD
rs1293603104
CA354612682
 194 D>N No ClinGen
TOPMed
CA354612670
rs1576390360
 195 K>N No ClinGen
Ensembl
rs1576390356
CA354612655
 197 Q>H No ClinGen
Ensembl
CA354612658
rs1185244984
 197 Q>R No ClinGen
gnomAD
CA2625843
rs748045973
 199 P>T No ClinGen
ExAC
gnomAD
rs756660568
CA83681305
 200 P>A No ClinGen
Ensembl
CA83681302
rs1020325020
 200 P>L No ClinGen
TOPMed
gnomAD
CA354612638
rs1020325020
 200 P>Q Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
gnomAD
CA354612639
rs1020325020
 200 P>R No ClinGen
TOPMed
gnomAD
rs1251112776
CA354612637
 201 A>T No ClinGen
TOPMed
gnomAD
CA2625838
rs373337169
 203 E>K No ClinGen
ESP
ExAC
TOPMed
gnomAD
COSM728337
CA2625839
rs373337169
 203 E>Q lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] No ClinGen
cosmic curated
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
CA2625836
rs761317503
 205 G>R No ClinGen
ExAC
TOPMed
gnomAD
CA2625835
rs761317503
 205 G>S No ClinGen
ExAC
TOPMed
gnomAD
CA2625834
rs149351332
 207 S>F No ClinGen
ESP
ExAC
TOPMed
gnomAD

No associated diseases with Q9NRW1

1 regional properties for Q9NRW1

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 13 - 169 IPR005225

Functions

Description
EC Number 3.6.5.2 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
  • Golgi apparatus membrane ; Lipid-anchor
  • Endoplasmic reticulum-Golgi intermediate compartment
  • Cytoplasmic vesicle
  • Colocalizes with BICD1 at vesicular structures that align along microtubules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum-Golgi intermediate compartment A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
presynapse The part of a synapse that is part of the presynaptic cell.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
myosin V binding Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport.

7 GO annotations of biological process

Name Definition
Golgi organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
intra-Golgi vesicle-mediated transport The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
neuron projection development The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
protein localization to Golgi membrane A process in which a protein is transported to, or maintained in, a location within a Golgi membrane.
retrograde transport, endosome to Golgi The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.

21 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QR46 RAB6B Ras-related protein Rab-6B Bos taurus (Bovine) PR
Q1KME6 RAB6A Ras-related protein Rab-6A Gallus gallus (Chicken) PR
O18334 Rab6 Ras-related protein Rab6 Drosophila melanogaster (Fruit fly) PR
O95755 RAB36 Ras-related protein Rab-36 Homo sapiens (Human) PR
Q9BZG1 RAB34 Ras-related protein Rab-34 Homo sapiens (Human) PR
Q5JT25 RAB41 Ras-related protein Rab-41 Homo sapiens (Human) PR
P20340 RAB6A Ras-related protein Rab-6A Homo sapiens (Human) PR
Q9NP72 RAB18 Ras-related protein Rab-18 Homo sapiens (Human) PR
A4D1S5 RAB19 Ras-related protein Rab-19 Homo sapiens (Human) PR
Q9ULC3 RAB23 Ras-related protein Rab-23 Homo sapiens (Human) PR
P20339 RAB5A Ras-related protein Rab-5A Homo sapiens (Human) PR
Q8CAM5 Rab36 Ras-related protein Rab-36 Mus musculus (Mouse) PR
P35279 Rab6a Ras-related protein Rab-6A Mus musculus (Mouse) PR
P61294 Rab6b Ras-related protein Rab-6B Mus musculus (Mouse) PR
Q9WVB1 Rab6a Ras-related protein Rab-6A Rattus norvegicus (Rat) PR
P34213 rab-6.1 Ras-related protein rab-6.1 Caenorhabditis elegans PR
Q22782 rab-6.2 Ras-related protein rab-6.2 Caenorhabditis elegans PR
Q9LFT9 RABH1E Ras-related protein RABH1e Arabidopsis thaliana (Mouse-ear cress) PR
O80501 RABH1B Ras-related protein RABH1b Arabidopsis thaliana (Mouse-ear cress) PR
Q9SMR4 RABH1C Ras-related protein RABH1c Arabidopsis thaliana (Mouse-ear cress) PR
Q9LV79 RABH1A Ras-related protein RABH1a Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSAGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF LSKTMYLEDR
70 80 90 100 110 120
TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNLNS FQQTSKWIDD VRTERGSDVI
130 140 150 160 170 180
IMLVGNKTDL ADKRQITIEE GEQRAKELSV MFIETSAKTG YNVKQLFRRV ASALPGMENV
190 200
QEKSKEGMID IKLDKPQEPP ASEGGCSC