AiPD: Autoinhibited Protein Database

Q9NRD5

Gene name	PICK1 (PRKCABP)
Protein name	PRKCA-binding protein
Names	Protein interacting with C kinase 1, Protein kinase C-alpha-binding protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9463
EC number
Protein Class	ARFAPTIN-RELATED (PTHR12141)

Descriptions

PRCKA-binding protein (PICK1) is a modular scaffold protein that regulates the activity and trafficking of several neural proteins. The membrane vesiculation capacity of the BAR domain is autoinhibited by PDZ and an acidic C-terminal tail (ACT). Upon deletion of ACT or PDZ domain, PICK1 clusters on vesicle-like structures that colocalize with the trans-Golgi network marker TGN38, driven by BAR domain. The ACT of one subunit of the PICK1 homodimer interacts with the PDZ and BAR domains of the other subunit. The autoinhibition is released by the binding of PDZ domain to receptor proteins or

Autoinhibitory domains (AIDs)

Target domain	147-355 (BAR domain)
Relief mechanism	Partner binding
Assay	Deletion assay, Structural analysis

AID

15-108 (PDZ domain)

Target domain

147-355 (BAR domain)

Relief mechanism

Partner binding (Binding of PDZ domain to receptors at the membrane)

Assay

Deletion assay, Structural analysis

Target domain	147-355 (BAR domain)
Relief mechanism	Partner binding
Assay	Deletion assay

AID

356-415 (acidic C-terminal tail, ACT)

Target domain

147-355 (BAR domain)

Relief mechanism

Partner binding (Binding of PDZ domain to receptors at the membrane)

Assay

Deletion assay

Accessory elements

No accessory elements

References

Karlsen ML et al. (2015) "Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering", Structure (London, England : 1993), 23, 1258-1270

Madasu Y et al. (2015) "PICK1 is implicated in organelle motility in an Arp2/3 complex-independent manner", Molecular biology of the cell, 26, 1308-22

Autoinhibited structure

Activated structure

5 structures for Q9NRD5

Entry ID	Method	Resolution	Chain	Position	Source
2GZV	X-ray	112 A	A	19-105	PDB
6AR4	X-ray	169 A	A/B	1-105	PDB
6BJN	X-ray	243 A	A/B	1-105	PDB
6BJO	X-ray	175 A	A/B	1-105	PDB
AF-Q9NRD5-F1	Predicted				AlphaFoldDB

311 variants for Q9NRD5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1601933264 CA411507155	3	A>V		No	ClinGen Ensembl
CA10228988 rs200693534	7	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	9	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1331717911 CA411507267	10	E>K		No	ClinGen gnomAD
TCGA novel	11	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA324179862 rs757672073	12	D>G		No	ClinGen Ensembl
rs758299374 CA10228990	13	K>R		No	ClinGen ExAC gnomAD
rs777592756 CA10228991	14	L>F		No	ClinGen ExAC gnomAD
rs746762898 CA10228992	14	L>R		No	ClinGen ExAC
CA324180849 COSM3723048 rs889163499	15	G>R	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA411507817 rs1346856836	15	G>V		No	ClinGen TOPMed
CA10229005 rs529594848	17	P>L		No	ClinGen ExAC TOPMed gnomAD
CA411507844 rs529594848	17	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1011662250 CA324180852	17	P>S		No	ClinGen Ensembl
CA411507907 rs1343298477	22	K>R		No	ClinGen TOPMed
rs1330468417 CA411507934	24	T>S		No	ClinGen TOPMed
CA324180868 rs144230832	26	Q>E		No	ClinGen ESP TOPMed gnomAD
CA10229007 rs752748202	28	D>G		No	ClinGen ExAC gnomAD
CA411507985 rs1267916199	28	D>N		No	ClinGen gnomAD
CA10229008 rs758384023	29	A>P		No	ClinGen ExAC TOPMed gnomAD
rs1376915390 CA411507996	29	A>V		No	ClinGen gnomAD
rs5756896 CA10229009	30	Q>H		No	ClinGen ExAC TOPMed gnomAD
COSM3673279	31	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA10229011 rs375001291	33	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA411508020 rs1421037201	33	I>N		No	ClinGen gnomAD
rs1375257084 CA411508026	34	G>E		No	ClinGen gnomAD
rs1200286749 CA411508025	34	G>R		No	ClinGen TOPMed
CA411508044 rs1393471162	36	S>G		No	ClinGen gnomAD
rs914780868 CA324180888	37	I>T		No	ClinGen TOPMed
CA411508081 rs1449682473	38	G>E		No	ClinGen TOPMed gnomAD
TCGA novel	42	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA411508162 rs1323301759	44	C>R		No	ClinGen gnomAD
CA411508166 rs1327458589	44	C>Y		No	ClinGen gnomAD
CA411508257 rs1276478116	50	V>F		No	ClinGen gnomAD
rs1601944373 CA411509044	56	T>P		No	ClinGen Ensembl
rs1277258113 CA411509048	56	T>S		No	ClinGen TOPMed
CA324191387 rs373401475	59	A>V		No	ClinGen ESP TOPMed
rs751472759 CA10229028	62	G>S		No	ClinGen ExAC TOPMed gnomAD
rs780886922 CA10229030	63	T>I		No	ClinGen ExAC gnomAD
rs755889746 CA10229032	66	A>G		No	ClinGen ExAC gnomAD
rs1360359047 CA411509164	68	D>N		No	ClinGen TOPMed gnomAD
rs1450330922 CA411509181	69	E>*		No	ClinGen TOPMed
COSM3842672	69	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3554324	71	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA10229036 rs144498214	72	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs144498214 CA10229037	72	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA10229038 rs771440049	74	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1307843872 CA411509246	76	R>T		No	ClinGen gnomAD
CA10229041 rs770073408	77	S>*		No	ClinGen ExAC gnomAD
CA10229040 rs759886998	77	S>A		No	ClinGen ExAC gnomAD
rs1306797006 CA411509256	78	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
COSM1416214 rs868326767 CA324191416	82	T>N	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA Cosmic
CA411509311 rs1601944546	84	V>G		No	ClinGen Ensembl
CA411509305 rs763111317	84	V>L		No	ClinGen ExAC gnomAD
rs763111317 CA10229043	84	V>M		No	ClinGen ExAC gnomAD
CA324191438 rs908750329	86	V>G		No	ClinGen Ensembl
CA10229044 rs764110971	87	A>V		No	ClinGen ExAC gnomAD
CA324191490 rs767008199	89	M>V		No	ClinGen Ensembl
CA324191497 rs1043621768	93	V>A		No	ClinGen Ensembl
rs768613937 CA10229046	93	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1353828266 CA411509726	95	G>A		No	ClinGen gnomAD
COSM3554326	96	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs774355038 CA411509735	96	E>D		No	ClinGen ExAC gnomAD
rs1601948536 CA411509741	97	V>G		No	ClinGen Ensembl
rs767430648 CA10229064	98	T>P		No	ClinGen ExAC gnomAD
CA10229066 rs760644693	100	H>R		No	ClinGen ExAC TOPMed gnomAD
CA411509756 rs1278380187	100	H>Y		No	ClinGen gnomAD
CA411509767 rs1256921063	101	Y>*		No	ClinGen gnomAD
CA10229068 rs374422539	102	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs749368799 CA324193551	103	K>E		No	ClinGen Ensembl
rs1224509124 CA411509790	105	Q>E		No	ClinGen TOPMed gnomAD
rs1361186118 CA411509795	105	Q>H		No	ClinGen TOPMed
CA411509800 rs1245485885	106	A>V		No	ClinGen gnomAD
CA10229069 rs754638692	107	D>H		No	ClinGen ExAC TOPMed gnomAD
rs1476989308 CA411509810	108	P>A		No	ClinGen gnomAD
rs200039533 CA324193578	112	M>I		No	ClinGen Ensembl
rs1414699852 CA411509854	114	L>P		No	ClinGen gnomAD
rs1197812788 CA411510213	118	L>M		No	ClinGen TOPMed
COSM6162288	123	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA324194730 rs1011013513	124	R>Q		No	ClinGen TOPMed
rs1489069613 CA411510334	124	R>W		No	ClinGen TOPMed gnomAD
CA411510364 rs773477637	126	V>A		No	ClinGen ExAC gnomAD
CA10229103 rs773477637	126	V>G		No	ClinGen ExAC gnomAD
COSM5749697	126	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs771064347 CA10229105	127	E>G		No	ClinGen ExAC gnomAD
rs776641391 CA10229106	128	N>D		No	ClinGen ExAC
rs769660774 CA10229108	129	M>L		No	ClinGen ExAC
CA411510446 rs1172240986	130	S>T		No	ClinGen gnomAD
CA411510477 rs1194766363	132	G>R		No	ClinGen gnomAD
rs763721808 CA10229111	134	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs751138380 CA411510525	135	D>H		No	ClinGen ExAC TOPMed gnomAD
CA10229112 rs751138380	135	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs766956739 CA10229114	136	A>S		No	ClinGen ExAC gnomAD
TCGA novel	139	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs755404092 CA10229116	140	S>G		No	ClinGen ExAC gnomAD
rs779380103 CA10229117	141	R>Q		No	ClinGen ExAC gnomAD
rs529753389 CA324194839	141	R>W		No	ClinGen 1000Genomes gnomAD
CA10229118 rs752984261	143	I>L		No	ClinGen ExAC gnomAD
CA411510683 rs1477970983	146	N>S		No	ClinGen gnomAD
rs1415020764 CA411511525	151	K>N		No	ClinGen TOPMed
COSM6162287	152	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	154	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	157	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
CA10229142 rs141358050	158	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs781381422 CA10229141	158	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1460371188 CA411511642	160	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA411511653 rs1183452291	161	E>*		No	ClinGen gnomAD
rs974202812 CA324197375	165	G>A		No	ClinGen TOPMed
CA411511845 rs1222342185	166	M>L		No	ClinGen gnomAD
CA411511843 rs1222342185	166	M>V		No	ClinGen gnomAD
CA10229173 rs766756193	167	T>M		No	ClinGen ExAC TOPMed gnomAD
CA411511884 rs1251254966	168	E>D		No	ClinGen gnomAD
CA411511870 rs1202954419	168	E>K		No	ClinGen gnomAD
rs1301431475 CA411511891	169	H>Y		No	ClinGen TOPMed
CA411511925 rs1455635289	171	K>N		No	ClinGen TOPMed
CA10229176 rs762087441	174	L>R		No	ClinGen ExAC gnomAD
rs919508841 CA324197403	175	R>Q		No	ClinGen TOPMed gnomAD
CA10229177 rs369159661	175	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA324197406 rs985113091	176	A>V		No	ClinGen TOPMed
CA411511993 rs1408284648	179	E>K		No	ClinGen gnomAD
CA411512011 rs1353885580	181	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs753896605 CA10229181 COSM3363639	182	Q>L	kidney [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA411512024 rs1343231969	183	T>I		No	ClinGen gnomAD
CA10229182 rs754970431	184	H>D		No	ClinGen ExAC gnomAD
COSM1130434	184	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs140773654 CA10229186	185	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1416215 CA10229185 rs199868329	185	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA10229208 rs745458781	189	D>Y		No	ClinGen ExAC gnomAD
CA10229210 rs370494530	190	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA324197843 rs950072445	191	F>L		No	ClinGen Ensembl
rs201758961 CA411512092	193	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10229212 rs201758961	193	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA411512102 rs761099651	194	I>M		No	ClinGen ExAC TOPMed gnomAD
CA10229213 rs773510787	194	I>T		No	ClinGen ExAC gnomAD
TCGA novel	196	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA10229218 rs138517790	197	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs776855622 CA10229217	197	R>W		No	ClinGen ExAC TOPMed gnomAD
CA411512125 rs1447947465	198	E>D		No	ClinGen gnomAD
CA10229220 rs373829961	200	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA411512135 rs1223501775	200	Q>R		No	ClinGen gnomAD
CA411512143 rs1388700038	201	P>R		No	ClinGen TOPMed
rs1279616473 CA411512156	203	A>V		No	ClinGen TOPMed gnomAD
CA10229222 rs141463477	204	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA411512161 rs141463477	204	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
COSM580036 rs200906170 CA324197905	205	E>K	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated 1000Genomes NCI-TCGA TOPMed gnomAD
rs1025987976 CA324197911	206	A>T		No	ClinGen Ensembl
COSM3554327	209	K>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs767370449 CA10229224	209	K>E		No	ClinGen ExAC gnomAD
COSM3554328	210	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs755797154 CA10229226	211	A>T		No	ClinGen ExAC gnomAD
rs748819803 CA10229228	212	D>N		No	ClinGen ExAC TOPMed gnomAD
CA10229229 rs758898232	215	R>C		No	ClinGen ExAC TOPMed gnomAD
rs778351060 CA10229230	215	R>H		No	ClinGen ExAC gnomAD
CA411512249 rs151027653	217	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10229232 rs149406206 COSM388727	218	E>K	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA10229233 rs149406206	218	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA411512272 rs373937870	220	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA324197963 rs974961347	221	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA10229237 COSM1220527 rs763096477	223	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs368390981 CA10229236	223	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA411512318 rs761803705	228	I>M		No	ClinGen ExAC TOPMed gnomAD
rs774366608 CA10229239	228	I>T		No	ClinGen ExAC gnomAD
rs767460364 CA10229241	229	K>E		No	ClinGen ExAC
CA10229242 rs750223551	229	K>R		No	ClinGen ExAC TOPMed gnomAD
rs755889770 CA10229243	230	P>L		No	ClinGen ExAC TOPMed gnomAD
rs755889770 CA411512328	230	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA411512327 rs1359113183	230	P>S		No	ClinGen TOPMed
rs1361263875 CA411512360	233	T>M		No	ClinGen gnomAD
rs878967259 CA324198269	233	T>P		No	ClinGen Ensembl
CA10229269 rs752849719	234	D>A		No	ClinGen ExAC TOPMed gnomAD
CA10229268 rs550929865	234	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs756522592 CA10229270	237	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1356135658 CA411512403	240	N>S		No	ClinGen gnomAD
CA10229271 rs780240972	243	I>N		No	ClinGen ExAC gnomAD
CA10229272 rs749565487	244	P>L		No	ClinGen ExAC gnomAD
CA10229275 rs748234997	247	R>C		No	ClinGen ExAC gnomAD
CA10229276 rs376594572	247	R>H		No	ClinGen ESP ExAC gnomAD
CA10229279 rs770795862	250	I>M		No	ClinGen ExAC gnomAD
rs1301712577 CA411512472	251	K>R		No	ClinGen gnomAD
rs1601958645 CA411512480	252	K>R		No	ClinGen Ensembl
rs999854781 CA324198327	255	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs199605777 CA10229282 COSM4939840	256	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
TCGA novel	258	F>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs752277834 CA10229283	258	F>S		No	ClinGen ExAC gnomAD
CA411512585 rs1373714380	266	K>Q		No	ClinGen gnomAD
rs1280502953 CA411512599	268	K>E		No	ClinGen gnomAD
rs914333902 CA324198810	271	D>N		No	ClinGen Ensembl
COSM4104043 CA324198831 rs945697657	273	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic Ensembl NCI-TCGA
TCGA novel	276	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs747734248 CA10229305	277	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs376840369 CA10229306	278	I>T		No	ClinGen ESP ExAC gnomAD
CA411512704 rs1436116403	281	G>S		No	ClinGen gnomAD
rs1289821026 CA411512715	282	E>D		No	ClinGen gnomAD
rs749077696 CA10229341	282	E>K		No	ClinGen ExAC gnomAD
rs756192771 CA324199261	283	P>H		No	ClinGen Ensembl
rs201690115 CA324199263	284	L>F		No	ClinGen TOPMed gnomAD
CA324199270 rs779309005	285	Y>*		No	ClinGen Ensembl
CA411512728 rs1216575475	285	Y>H		No	ClinGen gnomAD
CA411512738 rs1312964485	286	R>L		No	ClinGen TOPMed gnomAD
CA411512737 rs1312964485	286	R>P		No	ClinGen TOPMed gnomAD
rs768374079 CA10229342	286	R>W		No	ClinGen ExAC gnomAD
rs1601961139 CA411512743	287	V>G		No	ClinGen Ensembl
rs748514389 CA324199278	287	V>L		No	ClinGen Ensembl
CA10229345 rs771516897	288	S>G		No	ClinGen ExAC gnomAD
CA411512747 rs1247371829	288	S>I		No	ClinGen gnomAD
CA324199291 rs771516897	288	S>R		No	ClinGen ExAC gnomAD
rs1165286735 CA411512754	289	T>I		No	ClinGen gnomAD
CA411512750 rs772751539	289	T>P		No	ClinGen ExAC gnomAD
rs772751539 CA10229346	289	T>S		No	ClinGen ExAC gnomAD
CA324199324 rs1004271976	290	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1404463657 CA411512760	291	N>H		No	ClinGen gnomAD
CA411512766 rs1346394372	291	N>K		No	ClinGen gnomAD
CA411512764 rs1159382697	291	N>S		No	ClinGen gnomAD
CA411512772 rs1320421578	292	Y>C		No	ClinGen TOPMed gnomAD
CA411512771 rs1320421578	292	Y>F		No	ClinGen TOPMed gnomAD
rs770416253 CA10229348	292	Y>H		No	ClinGen ExAC gnomAD
COSM4104044	299	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM392957	301	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA10229351 rs111975858	303	E>A		No	ClinGen ExAC gnomAD
rs111975858 CA324199346	303	E>V		No	ClinGen ExAC gnomAD
TCGA novel	304	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	304	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	305	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	306	A>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM1220526 CA10229352 rs373780505	306	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA411512864 rs1224480074	306	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1286627775 CA411512898	311	M>R		No	ClinGen gnomAD
CA411512907 rs1386481151	312	R>H		No	ClinGen TOPMed
CA10229353 rs762062613	313	K>N		No	ClinGen ExAC TOPMed
CA411512929 rs1249313746	316	L>M		No	ClinGen TOPMed
CA10229354 rs767542796	316	L>R		No	ClinGen ExAC gnomAD
CA411512937 rs1215836539	317	E>G		No	ClinGen TOPMed
CA411512953 rs1267397284	319	M>T		No	ClinGen gnomAD
CA10229357 rs779971688	320	E>Q		No	ClinGen ExAC gnomAD
rs754791623 CA10229359	323	D>E		No	ClinGen ExAC TOPMed gnomAD
rs7511294 CA324199379	323	D>V		No	ClinGen Ensembl
rs778731511 CA10229360	324	Q>E		No	ClinGen ExAC gnomAD
rs376883577 CA324199397	326	H>R		No	ClinGen ESP TOPMed gnomAD
rs1215524681 CA411513023	328	Q>E		No	ClinGen TOPMed
CA324199838 rs915606766	328	Q>H		No	ClinGen Ensembl
rs771625974 CA411513041	330	I>M		No	ClinGen ExAC gnomAD
rs745323732 CA10229386	330	I>V		No	ClinGen ExAC gnomAD
TCGA novel	331	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA10229388 rs774938827	332	F>C		No	ClinGen ExAC gnomAD
rs746669587 CA10229389 COSM1034092	336	R>C	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1269183909 CA411513078	336	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
COSM6095376	338	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs895122027 CA411513097	339	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs895122027 CA324199861	339	S>Y		No	ClinGen TOPMed gnomAD
rs200682835 CA10229391	340	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1476062469 CA411513109	341	M>I		No	ClinGen gnomAD
rs952399927 CA324199864	345	Y>C		No	ClinGen TOPMed
rs773151921 CA10229394	347	D>E		No	ClinGen ExAC TOPMed gnomAD
rs765117173 CA10229393	347	D>N		No	ClinGen ExAC gnomAD
rs766481418 CA10229396	350	A>S		No	ClinGen ExAC gnomAD
CA411513172 rs766481418	350	A>T		No	ClinGen ExAC gnomAD
COSM4104045	351	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs767894272 CA411513189	353	R>P		No	ClinGen ExAC TOPMed gnomAD
rs767894272 CA10229399	353	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1227984224 CA411513188	353	R>W		No	ClinGen TOPMed gnomAD
CA411513193 rs1339750116	354	D>Y		No	ClinGen gnomAD
rs868820760 CA324199900	355	A>V		No	ClinGen Ensembl
CA10229400 rs753073612	356	D>N		No	ClinGen ExAC gnomAD
rs756571367 CA10229401	357	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	358	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	361	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1447089053 CA411513238	361	E>K		No	ClinGen gnomAD
CA411513239 rs1447089053	361	E>Q		No	ClinGen gnomAD
rs749818794 CA10229404	362	V>I		No	ClinGen ExAC TOPMed gnomAD
rs749818794 CA411513246	362	V>L		No	ClinGen ExAC TOPMed gnomAD
rs779602161 CA10229406	365	A>V		No	ClinGen ExAC gnomAD
rs1387296537 CA411513281	367	T>I		No	ClinGen gnomAD
CA411513279 rs1387296537	367	T>N		No	ClinGen gnomAD
CA411513288 rs371575593	369	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs776294355 CA10229409	371	Y>C		No	ClinGen ExAC gnomAD
CA411513314 rs1285300109	373	L>F		No	ClinGen TOPMed gnomAD
rs1320163856 CA411513326	374	N>K		No	ClinGen gnomAD
CA411513329 rs1569205925	375	Q>E		No	ClinGen Ensembl
CA411513331 rs769587321	375	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs769587321 CA10229412	375	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA324199981 rs1005944442	376	E>K		No	ClinGen TOPMed
CA411513368 rs1434064454	380	D>G		No	ClinGen gnomAD
CA411513364 rs1321355978	380	D>N		No	ClinGen gnomAD
rs1220485612 CA411513374	381	G>R		No	ClinGen TOPMed gnomAD
CA411513383 rs762939296	382	E>D		No	ClinGen ExAC TOPMed
CA10229416 rs773063627	382	E>G		No	ClinGen ExAC TOPMed gnomAD
CA411513396 rs1242082785	384	E>A		No	ClinGen gnomAD
CA10229419 rs774462263	386	E>D		No	ClinGen ExAC gnomAD
rs923555440 CA324200028	386	E>Q		No	ClinGen TOPMed gnomAD
CA411513419 rs1206416140	387	E>G		No	ClinGen gnomAD
CA10229420 rs547766954	389	D>H		No	ClinGen 1000Genomes ExAC
rs767801528 CA10229421	390	T>K		No	ClinGen ExAC gnomAD
rs767801528 CA10229422	390	T>M		No	ClinGen ExAC gnomAD
rs767801528 CA411513441	390	T>R		No	ClinGen ExAC gnomAD
TCGA novel	391	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA411513448 rs1422449148	392	A>T		No	ClinGen gnomAD
CA10229423 rs187753076	393	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10229425 rs754213542	395	P>R		No	ClinGen ExAC TOPMed gnomAD
CA411513475 rs1386348153	396	S>F		No	ClinGen gnomAD
rs1456707221 CA411513487	398	D>H		No	ClinGen gnomAD
rs1337321149 CA411513498	399	T>I		No	ClinGen gnomAD
CA324200079 rs766115790	400	R>*		No	ClinGen gnomAD
CA411513501 rs1394100412	400	R>P		No	ClinGen gnomAD
rs1049850068 CA324200081	401	G>E		No	ClinGen TOPMed
CA411513503 rs1311527496	401	G>R		No	ClinGen gnomAD
COSM3554330	404	G>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1327869119 CA411513545	407	D>E		No	ClinGen gnomAD
CA411513561 rs1265567981	410	G>R		No	ClinGen gnomAD
CA411513583 rs1482458962	412	W>*		No	ClinGen gnomAD
CA411513578 rs1224548222	412	W>*		No	ClinGen TOPMed
CA411513596 rs1200282713	414	D>G		No	ClinGen gnomAD

No associated diseases with Q9NRD5

No regional properties for Q9NRD5

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9NRD5

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, perinuclear region Membrane ; Peripheral membrane protein Membrane ; Lipid-anchor Postsynaptic density Synapse, synaptosome Cytoplasm, cytoskeleton	Also membrane-associated, present at excitatory synapses
PANTHER Family	PTHR12141	ARFAPTIN-RELATED
PANTHER Subfamily	PTHR12141:SF1	PRKCA-BINDING PROTEIN
PANTHER Protein Class	vesicle coat protein
PANTHER Pathway Category	Ionotropic glutamate receptor pathway PICK

14 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endocytic vesicle membrane	The lipid bilayer surrounding an endocytic vesicle.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
postsynaptic early endosome	An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling.
presynaptic membrane	A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
synaptic vesicle	A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
trans-Golgi network membrane	The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.

10 GO annotations of molecular function

Name	Definition
actin filament binding	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
Arp2/3 complex binding	Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5).
G protein-coupled receptor binding	Binding to a G protein-coupled receptor.
identical protein binding	Binding to an identical protein or proteins.
membrane curvature sensor activity	Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins.
metal ion binding	Binding to a metal ion.
phospholipid binding	Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.
protein domain specific binding	Binding to a specific domain of a protein.
protein kinase C binding	Binding to protein kinase C.
signaling receptor binding	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

19 GO annotations of biological process

Name	Definition
cellular response to decreased oxygen levels	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.
cellular response to glucose starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
dendritic spine maintenance	The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
dendritic spine organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
epigenetic regulation of embryonic gene expression	The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression.
establishment of genomic imprinting	The establishment of epigenetic modifications (imprints) during gametogenesis, leading to an asymmetry between the maternal and paternal alleles, leading to differential expression of the corresponding alleles. This can happen through heterochromatin formation or through differential chromatin loop formation.
glial cell development	The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
long-term synaptic depression	A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse.
monoamine transport	The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of Arp2/3 complex-mediated actin nucleation	Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins.
neuronal ion channel clustering	The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation.
positive regulation of receptor internalization	Any process that activates or increases the frequency, rate or extent of receptor internalization.
protein kinase C-activating G protein-coupled receptor signaling pathway	The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
receptor clustering	The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
regulation of Arp2/3 complex-mediated actin nucleation	Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins.
regulation of insulin secretion	Any process that modulates the frequency, rate or extent of the regulated release of insulin.
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2T9M1	PICK1	PRKCA-binding protein	Bos taurus (Bovine)	SS
Q62083	Pick1	PRKCA-binding protein	Mus musculus (Mouse)	SS
Q9EP80	Pick1	PRKCA-binding protein	Rattus norvegicus (Rat)	SS

10	20	30	40	50	60
MFADLDYDIE	EDKLGIPTVP	GKVTLQKDAQ	NLIGISIGGG	AQYCPCLYIV	QVFDNTPAAL
70	80	90	100	110	120
DGTVAAGDEI	TGVNGRSIKG	KTKVEVAKMI	QEVKGEVTIH	YNKLQADPKQ	GMSLDIVLKK
130	140	150	160	170	180
VKHRLVENMS	SGTADALGLS	RAILCNDGLV	KRLEELERTA	ELYKGMTEHT	KNLLRAFYEL
190	200	210	220	230	240
SQTHRAFGDV	FSVIGVREPQ	PAASEAFVKF	ADAHRSIEKF	GIRLLKTIKP	MLTDLNTYLN
250	260	270	280	290	300
KAIPDTRLTI	KKYLDVKFEY	LSYCLKVKEM	DDEEYSCIAL	GEPLYRVSTG	NYEYRLILRC
310	320	330	340	350	360
RQEARARFSQ	MRKDVLEKME	LLDQKHVQDI	VFQLQRLVST	MSKYYNDCYA	VLRDADVFPI
370	380	390	400	410
EVDLAHTTLA	YGLNQEEFTD	GEEEEEEEDT	AAGEPSRDTR	GAAGPLDKGG	SWCDS