AiPD: Autoinhibited Protein Database

Q9NR96

Gene name	TLR9 (UNQ5798/PRO19605)
Protein name	Toll-like receptor 9
Names	CD antigen CD289
Species	Homo sapiens (Human)
KEGG Pathway	hsa:54106
EC number
Protein Class	TOLL-LIKE RECEPTOR 7-RELATED (PTHR47410)

Descriptions

TLR9 (Toll-like receptor 9) plays a key role in the innate immune system in response to unmethylated CpG DNA. After stimulation of cells with CpG DNA, TLR9 redistributes from the endoplasmic reticulum to lysosomes, where a signaling cascade is triggered by recruitment of the MyD88 adaptor molecule. TLR9 is a type I transmembrane protein characterized by an extracellular leucine-rich repeat (LRR) domain, a transmembrane helix, and an intracellular Toll/interleukin-1 receptor (TIR) homology domain. TLR9 undergoes proteolytic cleavage, executed by cysteine proteases, in the endolysosomal compartment, and molecular modeling shows that the cleavage sites are situated between LRR14 and LRR15, as being part of a flexible loop that could render TLR9 susceptible to proteolysis. On a molar basis, the C-terminal cleavage fragment of TLR9 binds CpG DNA more strongly than does full-length TLR9, although full-length TLR9 binds CpG DNA. The broadly specific inhibitor z-FA-fmk is most effective at blocking the cleavage and, accordingly, abrogated TNF production in cells exposed to the TLR9 agonist CpG DNA.

Autoinhibitory domains (AIDs)

Target domain	24-806 (LRR domains)
Relief mechanism	Cleavage
Assay	Deletion assay

AID

441-470 (Z-loop)

Target domain

24-806 (LRR domains)

Relief mechanism

Cleavage (Cleavage by multiple proteases)

Assay

Deletion assay

Accessory elements

No accessory elements

References

Tanji H et al. (2016) "Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8", Proceedings of the National Academy of Sciences of the United States of America, 113, 3012-7

Park B et al. (2008) "Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9", Nature immunology, 9, 1407-14

Autoinhibited structure

Activated structure

2 structures for Q9NR96

Entry ID	Method	Resolution	Chain	Position	Source
8AR3	NMR	-	A	812-860	PDB
AF-Q9NR96-F1	Predicted				AlphaFoldDB

825 variants for Q9NR96

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA353105861 rs1240996318	2	G>D		No	ClinGen gnomAD
CA353105858 rs1273048547	3	F>L		No	ClinGen gnomAD
VAR_024668 RCV000971495 CA2430897 rs5743842	5	R>C		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2430896 rs199759037 COSM1424364	5	R>H	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA2430895 rs56172276	6	S>R		No	ClinGen ExAC TOPMed gnomAD
CA353105732 rs1362089750	7	A>D		No	ClinGen gnomAD
CA2430893 COSM1046839 rs150459369	7	A>T	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs202195635 CA74732836	9	H>Y		No	ClinGen TOPMed gnomAD
rs370157255 CA2430892	10	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1270141629 CA353105641	11	L>M		No	ClinGen gnomAD
rs1288470860 CA353105588	13	L>F		No	ClinGen gnomAD
rs1394861605 CA353105537	15	V>M		No	ClinGen TOPMed
rs1577981421 CA353105507	16	Q>K		No	ClinGen Ensembl
CA2430888 rs139242193	18	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA353105393 rs1186360916	18	I>V		No	ClinGen gnomAD
CA2430887 rs746563907	19	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1241708543 CA2430885	22	M>I		No	ClinGen TOPMed
rs1312227021 CA353105155	23	T>A		No	ClinGen TOPMed
rs1277429812 CA353105116	23	T>I		No	ClinGen gnomAD
CA74732820 rs918728499	25	A>V		No	ClinGen Ensembl
CA2430882 rs754311214	26	L>P		No	ClinGen ExAC gnomAD
rs1356994585 CA353105013	27	G>D		No	ClinGen gnomAD
CA74732815 rs866728864	28	T>I		No	ClinGen Ensembl
CA353104941 rs1245349119	29	L>F		No	ClinGen TOPMed
rs1354121442 CA353104893	31	A>D		No	ClinGen TOPMed gnomAD
rs1354121442 CA353104888	31	A>V		No	ClinGen TOPMed gnomAD
CA2430881 rs367677799	32	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs974271351 CA74732806	35	C>F		No	ClinGen Ensembl
CA353104801 rs1239041600	35	C>R		No	ClinGen TOPMed
rs892160452 CA74732803	38	Q>L		No	ClinGen Ensembl
rs750628960 CA2430879	39	P>A		No	ClinGen ExAC gnomAD
rs1229630759 CA353104652	40	H>Y		No	ClinGen gnomAD
rs200055519 CA2430877	41	G>S		No	ClinGen ExAC gnomAD
CA74732795 rs952850329	44	N>K		No	ClinGen gnomAD
rs201958063 CA74732793	45	C>Y		No	ClinGen gnomAD
TCGA novel	47	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
CA74732790 rs180715569	49	F>V		No	ClinGen Ensembl
CA2430873 rs775461893	52	S>F		No	ClinGen ExAC gnomAD
CA353104311 rs1257387558	54	P>H		No	ClinGen gnomAD
CA2430872 rs764964193	55	H>L		No	ClinGen ExAC gnomAD
CA2430871 rs55979550	58	M>R		No	ClinGen ExAC gnomAD
rs750403100 CA74732781	58	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA2430869 rs374677585	60	A>T		No	ClinGen ESP ExAC gnomAD
rs770637836 CA2430868	61	P>S		No	ClinGen ExAC TOPMed gnomAD
rs770637836 CA353104131	61	P>T		No	ClinGen ExAC TOPMed gnomAD
CA2430867 rs200596305	62	R>C		No	ClinGen ExAC TOPMed gnomAD
rs997645449 CA74732772	62	R>H		No	ClinGen gnomAD
rs772719609 CA2430866	63	G>D		No	ClinGen ExAC gnomAD
CA353104068 rs1464508419	64	N>D		No	ClinGen gnomAD
CA353104044 rs1171569842	65	V>I		No	ClinGen gnomAD
rs189941642 CA74732765	66	T>I		No	ClinGen 1000Genomes TOPMed
CA353104024 rs1577981311	66	T>P		No	ClinGen Ensembl
rs780558008 CA2430863	67	S>R		No	ClinGen ExAC gnomAD
rs1183785127 CA353103942	69	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs756551977 CA2430862	70	L>*		No	ClinGen ExAC gnomAD
CA353103924 rs756551977	70	L>S		No	ClinGen ExAC gnomAD
CA2430861 rs746281362	74	R>C		No	ClinGen ExAC TOPMed gnomAD
CA2430860 rs781684117	74	R>H		No	ClinGen ExAC TOPMed gnomAD
CA353103729 rs1319660926	77	H>Q		No	ClinGen gnomAD
CA2430858 rs5743843 VAR_052364	79	H>Q		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs1246235772 CA353103702	79	H>Y		No	ClinGen gnomAD
rs1020495230 CA74732752	83	F>L		No	ClinGen Ensembl
CA2430857 rs751767849	83	F>S		No	ClinGen ExAC gnomAD
rs1226463372 CA353103578	84	A>V		No	ClinGen TOPMed
COSM3595893	85	H>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1299201604 CA353103568	85	H>P		No	ClinGen gnomAD
CA2430855 rs201646083	85	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs776469312 CA2430851	88	S>R		No	ClinGen ExAC gnomAD
rs759389903 CA2430852	88	S>R		No	ClinGen ExAC gnomAD
rs766103514 CA2430850	90	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA353103487 rs1441565360	90	R>W		No	ClinGen gnomAD
CA2430849 rs201572271	91	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1577981247 CA353103457	91	H>Y		No	ClinGen Ensembl
rs200206317 CA2430848	93	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1166311703 CA353103366	94	L>R		No	ClinGen gnomAD
rs747740029 CA2430846	96	W>*		No	ClinGen ExAC TOPMed gnomAD
CA2430845 rs773699082	98	C>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2430844 rs5743844	99	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2430842 COSM3781847 rs781694864	100	P>L	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1389105161 CA353103180	101	V>A		No	ClinGen gnomAD
TCGA novel	104	S>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1577981210 CA353103059	106	M>R		No	ClinGen Ensembl
CA353103046 rs1577981209	107	H>P		No	ClinGen Ensembl
rs1577981207 CA353103009	108	F>S		No	ClinGen Ensembl
CA353102991 rs1295652148	109	P>R		No	ClinGen gnomAD
CA2430840 rs747260036	111	H>Q		No	ClinGen ExAC gnomAD
CA353102893 rs1157043280	114	I>V		No	ClinGen gnomAD
CA2430836 rs184563116	115	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs184563116 CA2430837	115	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA74732717 rs1026141784	116	P>S		No	ClinGen Ensembl
rs1431366387 CA353102831	117	S>N		No	ClinGen gnomAD
COSM3595892	118	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs149110022 CA2430834	121	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs149110022 CA2430835	121	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs148085174 CA2430833	122	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs56287816 CA2430832	123	P>S		No	ClinGen ExAC TOPMed gnomAD
CA2430831 rs201783734	124	T>A		No	ClinGen ExAC gnomAD
rs974162456 CA74732702	124	T>N		No	ClinGen gnomAD
rs201783734 CA74732705	124	T>S		No	ClinGen ExAC gnomAD
CA353102627 rs1350834332	126	E>G		No	ClinGen gnomAD
rs1262811850 CA353102553	129	N>K		No	ClinGen TOPMed
rs761364189 CA2430829	135	I>V		No	ClinGen ExAC gnomAD
CA2430828 rs200978876	136	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2430827 rs767987176	136	M>T		No	ClinGen ExAC TOPMed gnomAD
CA74732695 rs200978876	136	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
COSM273352	139	P>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA353102276 rs1402656322	139	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA2430826 rs200627901	140	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1379324294 CA353102228	142	P>A		No	ClinGen gnomAD
rs1379324294 CA353102226	142	P>S		No	ClinGen gnomAD
CA353102190 rs1577981122	144	S>P		No	ClinGen Ensembl
COSM1046837	146	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA2430823 rs747419130	147	S>C		No	ClinGen ExAC gnomAD
COSM3595891	147	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA353102136 rs1577981119	147	S>P		No	ClinGen Ensembl
CA353102131 rs1424057961	148	L>M		No	ClinGen TOPMed
rs1577981105 CA353102117	149	S>P		No	ClinGen Ensembl
rs376087748 CA2430821	149	S>Y		No	ClinGen ESP ExAC gnomAD
CA2430819 rs779052425	150	L>P		No	ClinGen ExAC
CA74732683 rs919277696	150	L>V		No	ClinGen TOPMed
rs1342987320 CA353102034	152	H>R		No	ClinGen TOPMed
CA353101977 rs1577981096	153	T>P		No	ClinGen Ensembl
rs1224643512 CA353101840	156	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1298778487 CA353101700	161	A>T		No	ClinGen TOPMed
rs201201841 CA2430813	163	L>I		No	ClinGen ExAC TOPMed gnomAD
CA2430810 rs763686449	164	A>D		No	ClinGen ExAC gnomAD
TCGA novel	164	A>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1046836 CA2430811 rs200062660	164	A>T	oesophagus endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs201740851 COSM6165006 COSM1538106 CA2430807	165	G>S	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed
rs771634375 CA2430806	166	L>P		No	ClinGen ExAC gnomAD
COSM4118968	167	H>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1421307312 CA353101497	167	H>Q		No	ClinGen gnomAD
rs1172566806 CA353101489	168	A>S		No	ClinGen gnomAD
CA2430805 rs201098493	168	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA74732656 rs1011356526	170	R>C		No	ClinGen TOPMed gnomAD
rs199767102 CA2430803	170	R>H		No	ClinGen ExAC TOPMed gnomAD
COSM1046835	176	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1479202525 CA353101300	176	G>S		No	ClinGen TOPMed
CA353101236 rs1405309670	177	N>S		No	ClinGen TOPMed
CA353101256 rs1192636526	177	N>Y		No	ClinGen TOPMed
rs768844402 CA2430800	180	Y>H		No	ClinGen ExAC gnomAD
TCGA novel	181	K>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1438595607 CA353101101	181	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs749405730 CA2430799	182	N>K		No	ClinGen ExAC gnomAD
CA2430798 rs780099835	183	P>L		No	ClinGen ExAC gnomAD
rs780099835 RCV001172304	183	P>R		No	ClinVar dbSNP
rs777760744 CA74732648	183	P>T		No	ClinGen TOPMed gnomAD
CA2430797 CA353101020 rs756098803	185	R>S		No	ClinGen ExAC TOPMed gnomAD
CA2430796 rs750300739	187	A>E		No	ClinGen ExAC gnomAD
CA353100919 rs1577981012	190	V>G		No	ClinGen Ensembl
CA353100932 rs1339785578	190	V>M		No	ClinGen Ensembl
rs1330761016 CA353100897 COSM3696180	191	A>V	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
CA2430793 rs751351212	192	P>L		No	ClinGen ExAC gnomAD
CA74732629 rs199542217	193	G>D		No	ClinGen TOPMed
TCGA novel	193	G>V	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
CA353100858 rs1161158331	194	A>T		No	ClinGen gnomAD
CA2430791 rs201050931	195	L>F		No	ClinGen ExAC TOPMed gnomAD
CA353100819 rs1385403961	196	L>P		No	ClinGen gnomAD
rs764783650 CA2430789	197	G>A		No	ClinGen ExAC gnomAD
rs764783650 CA353100798	197	G>D		No	ClinGen ExAC gnomAD
CA2430790 rs200383943	197	G>S		No	ClinGen ExAC gnomAD
CA353100764 rs1438812490	199	G>D		No	ClinGen gnomAD
CA353100746 rs1577980971	200	N>T		No	ClinGen Ensembl
CA353100707 rs1376410257	202	T>N		No	ClinGen TOPMed
rs1577980966 CA353100715	202	T>P		No	ClinGen Ensembl
CA353100691 rs1361879205	203	H>L		No	ClinGen gnomAD
CA353100695 rs1361879205	203	H>P		No	ClinGen gnomAD
rs1007724971 CA74732617	206	L>F		No	ClinGen TOPMed gnomAD
CA353100568 rs1321350883	209	N>D		No	ClinGen gnomAD
TCGA novel	210	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs759945507 CA74732610	211	L>F		No	ClinGen gnomAD
rs774746148 CA2430784	213	V>A		No	ClinGen ExAC TOPMed gnomAD
CA353100442 rs1228312597	215	P>L		No	ClinGen TOPMed
rs147453407 CA2430783	216	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA2430782 rs749495421 COSM285758	216	R>H	Variant assessed as Somatic; MODERATE impact. oesophagus large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs140994532 CA2430781	217	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs929984846 CA74732602	217	N>S		No	ClinGen TOPMed
CA353100283 rs1490930435	221	S>R		No	ClinGen TOPMed gnomAD
rs769795689 CA2430780	221	S>R		No	ClinGen ExAC gnomAD
CA2430778 rs781043967	223	E>D		No	ClinGen ExAC gnomAD
CA2430779 rs201564821	223	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2430776 rs746846564	230	N>D		No	ClinGen ExAC gnomAD
CA353100097 COSM4118967 rs1366842587	231	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA gnomAD
rs147300053 CA2430775	231	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs147300053 CA2430774	231	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2430772 rs137890561	233	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA353100016 rs1297252503	234	K>T		No	ClinGen gnomAD
CA2430770 rs753365019	236	A>T		No	ClinGen ExAC gnomAD
CA2430769 rs201482702	236	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1174860358 CA353099943	238	E>K		No	ClinGen gnomAD
rs978782016 CA74732575	240	L>P		No	ClinGen Ensembl
CA2430767 rs774632252	242	N>I		No	ClinGen ExAC gnomAD
CA353099818 rs774632252	242	N>S		No	ClinGen ExAC gnomAD
CA74732571 rs200364422	243	L>Q		No	ClinGen TOPMed gnomAD
CA74732569 rs200364422	243	L>R		No	ClinGen TOPMed gnomAD
rs763164177 CA2430765	245	A>T		No	ClinGen ExAC gnomAD
rs1559437996 CA353099715	246	L>P		No	ClinGen Ensembl
CA2430763 COSM1229413 rs769984937	247	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA74732562 COSM290543 rs749742285	247	R>H	Variant assessed as Somatic; MODERATE impact. large_intestine breast [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
CA353099672 rs1225248290	248	V>L		No	ClinGen gnomAD
rs776772605 CA2430761	250	D>N		No	ClinGen ExAC gnomAD
rs1287019916 CA353099586	251	V>M		No	ClinGen gnomAD
CA2430759 rs746908600 COSM1734823	253	G>R	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA74732554 rs992576380	256	R>C		No	ClinGen TOPMed gnomAD
rs202089021 CA2430758	256	R>H		No	ClinGen ExAC gnomAD
rs202089021 CA353099424	256	R>L		No	ClinGen ExAC gnomAD
CA74732550 rs201149475	257	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA353099410 COSM1424363 rs1430528863	257	R>H	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
CA353099353 rs1421960438	259	D>N		No	ClinGen gnomAD
COSM1424362 CA353099277 rs1482996940	261	A>T	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs1034146592 CA74732543	263	N>K		No	ClinGen Ensembl
CA74732545 rs200870101	263	N>S		No	ClinGen TOPMed
CA2430755 rs778756316	265	C>S		No	ClinGen ExAC gnomAD
rs1461720605 CA353099106	266	M>T		No	ClinGen gnomAD
rs754627415 CA2430754	266	M>V		No	ClinGen ExAC gnomAD
rs1577980835 CA353099074	267	E>G		No	ClinGen Ensembl
CA74732538 rs1001378722	268	C>R		No	ClinGen Ensembl
CA353099041 rs1225003881	268	C>Y		No	ClinGen gnomAD
rs372334880 CA2430753	270	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs147338328 CA2430752	270	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA74732533 rs200060595	271	H>R		No	ClinGen TOPMed gnomAD
CA353098866 rs1452816146	273	P>T		No	ClinGen gnomAD
CA74732529 rs968406997	274	Q>*		No	ClinGen TOPMed
COSM3595889	277	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs199797502 COSM4118964 CA2430749	278	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs1189982304 CA353098569	280	F>S		No	ClinGen gnomAD
TCGA novel	282	H>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA2430747 rs753032218	285	R>C		No	ClinGen ExAC TOPMed gnomAD
CA353098375 rs897140854 COSM1617836	285	R>H	liver Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs897140854 CA74732522	285	R>P		No	ClinGen TOPMed gnomAD
rs1423460421 CA353098331	287	E>*		No	ClinGen gnomAD
rs759791507 CA2430745	289	L>P		No	ClinGen ExAC gnomAD
CA353098081 rs1559437926	293	D>E		No	ClinGen Ensembl
rs1445268865 CA353098094	293	D>G		No	ClinGen gnomAD
COSM731140	294	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1193981814 CA353098032	297	S>P		No	ClinGen TOPMed gnomAD
TCGA novel	297	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA353097979 rs1342379548	298	W>C		No	ClinGen TOPMed
CA353097929 rs1476223719	301	A>T		No	ClinGen TOPMed gnomAD
TCGA novel	301	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs770978006 CA2430743	302	S>I		No	ClinGen ExAC gnomAD
rs200788196 CA74732511	303	W>*		No	ClinGen Ensembl
CA2430742 rs760563131	303	W>S		No	ClinGen ExAC gnomAD
CA2430741 rs773233756	305	R>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	306	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs747995692 COSM1670242 CA2430739	311	R>*	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs141692865 CA2430738	311	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1005568000 CA74732502	312	V>A		No	ClinGen Ensembl
rs1559437904 CA353097649	312	V>M		No	ClinGen Ensembl
CA353097591 rs1195512596	313	L>P		No	ClinGen TOPMed
rs1477781976 CA353097350	320	L>F		No	ClinGen TOPMed
CA353097344 rs1299111372	320	L>P		No	ClinGen gnomAD
CA353097237 rs1577980747	323	C>Y		No	ClinGen Ensembl
CA353097156 rs1165668310	326	K>Q		No	ClinGen gnomAD
CA353097003 rs1179656671	331	Q>*		No	ClinGen gnomAD
rs202131815 CA2430731 COSM4734022	337	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1489779545 CA353096842	337	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
COSM6097955	340	N>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA2430729 rs765584183	342	S>F		No	ClinGen ExAC gnomAD
rs201312874 CA74732481	344	N>S		No	ClinGen TOPMed
CA353096585 rs1275070203	348	R>T		No	ClinGen TOPMed
rs1319273627 CA353096573	349	V>M		No	ClinGen TOPMed gnomAD
CA353096483 rs1577980699	353	H>P		No	ClinGen Ensembl
rs1488551983 CA353096426	358	P>A		No	ClinGen TOPMed
rs200074687 CA2430724	361	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs772198850 CA2430723	362	S>N		No	ClinGen ExAC gnomAD
CA2430717 rs373946909	365	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA2430716 rs373946909	365	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs924347558 CA74732456 COSM1229419	371	M>I	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1327780209 CA353096245	371	M>T		No	ClinGen gnomAD
rs780667225 CA2430714	371	M>V		No	ClinGen ExAC gnomAD
CA353096229 rs1259167420	372	H>D		No	ClinGen gnomAD
CA74732454 rs978547295	372	H>P		No	ClinGen TOPMed
CA74732452 rs143200897	372	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM4118963 CA353096227 rs1259167420	372	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA gnomAD
COSM1424361	373	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs927023070 CA74732450	373	G>S		No	ClinGen Ensembl
CA353096166 rs1559437844	376	F>L		No	ClinGen Ensembl
rs980298299 CA74732447	377	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA353096150 rs1321938830	377	R>H		No	ClinGen gnomAD
CA353096131 rs1285586024	379	L>F		No	ClinGen gnomAD
CA2430708 rs754127798	380	D>E		No	ClinGen ExAC gnomAD
rs201499670 CA2430710	380	D>N		No	ClinGen ExAC TOPMed gnomAD
rs201499670 CA2430709	380	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs971236893 CA74732440	381	E>D		No	ClinGen Ensembl
rs766661466 CA2430707	381	E>K		No	ClinGen ExAC gnomAD
rs1577980628 CA353096062	382	T>P		No	ClinGen Ensembl
rs200533822 CA2430705	383	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs774303186 CA2430702	385	R>Q		No	ClinGen ExAC gnomAD
rs144717805 CA2430703	385	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs769544318 CA2430698	389	R>C		No	ClinGen ExAC TOPMed gnomAD
CA2430697 rs142357270	389	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142357270 CA2430696	389	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1204748301 CA353095955	390	L>M		No	ClinGen gnomAD
CA353095929 rs1339105704	392	M>V		No	ClinGen gnomAD
CA353095909 rs1268690823	393	L>F		No	ClinGen gnomAD
rs748679440 CA2430694	395	T>I		No	ClinGen ExAC gnomAD
rs199736549 CA74732424	397	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs199736549 CA74732426	397	R>G		No	ClinGen Ensembl
CA2430693 rs779526214	397	R>H		No	ClinGen ExAC TOPMed gnomAD
CA74732421 rs1006284456	398	L>V		No	ClinGen TOPMed
COSM4819269	399	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA353095799 CA74732417 rs41308230	400	M>I		No	ClinGen TOPMed
CA353095811 rs1163341375	400	M>V		No	ClinGen TOPMed
CA353095784 rs1458754306	401	N>S		No	ClinGen TOPMed
COSM1328132	404	N>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA2430692 rs755406172	404	N>S		No	ClinGen ExAC gnomAD
rs755406172 CA353095734	404	N>T		No	ClinGen ExAC gnomAD
rs866716615 CA74732414	406	A>T		No	ClinGen Ensembl
rs749725833 CA2430691	406	A>V		No	ClinGen ExAC gnomAD
rs745639056 CA2430690	408	L>I		No	ClinGen ExAC gnomAD
CA2430688 rs200495784	409	G>C		No	ClinGen ExAC TOPMed gnomAD
CA74732408 rs200495784	409	G>S		No	ClinGen ExAC TOPMed gnomAD
CA353095648 rs1243994424	410	I>V		No	ClinGen TOPMed gnomAD
rs1475539937 CA353095637	411	F>L		No	ClinGen gnomAD
rs550218164 CA353095597	413	A>G		No	ClinGen 1000Genomes ExAC gnomAD
rs550218164 CA2430687	413	A>V		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	414	F>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA74732402 rs901314272	415	P>L		No	ClinGen Ensembl
rs1181237457 CA353095574	415	P>T		No	ClinGen gnomAD
rs751568161 CA2430684	418	R>C		No	ClinGen ExAC gnomAD
rs550092930 CA74732398	418	R>H		No	ClinGen Ensembl
CA2430682 rs762788064	419	Y>C		No	ClinGen ExAC gnomAD
rs201417455 CA2430681	420	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA2430680 RCV000959560 rs764944818	421	D>V		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2430676 rs148578023	423	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA353095454 rs148578023	423	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1410273857 COSM4118962 CA353095402	426	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA gnomAD
CA2430674 rs199611737	426	R>H		No	ClinGen ExAC TOPMed gnomAD
COSM6097956	429	G>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA2430672 rs561203848 COSM731141	429	G>R	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs368350972 CA2430670	431	S>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs368350972 CA2430669	431	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA353095200 rs1231615025	434	T>I		No	ClinGen gnomAD
CA353095190 rs1184457201	435	A>T		No	ClinGen gnomAD
CA74732376 rs935650288	436	T>I		No	ClinGen TOPMed
CA353095125 CA74732372 rs201448668	437	M>I		No	ClinGen TOPMed gnomAD
CA353095150 rs751720030	437	M>L		No	ClinGen ExAC gnomAD
rs1268506008 CA353095143	437	M>T		No	ClinGen gnomAD
CA2430667 rs751720030	437	M>V		No	ClinGen ExAC gnomAD
rs200559631 CA353095109	438	G>A		No	ClinGen gnomAD
rs200559631 CA74732370	438	G>E		No	ClinGen gnomAD
CA353095115 rs1361760252	438	G>R		No	ClinGen gnomAD
COSM5216819 rs1223235663	439	E>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
rs202223797 CA2430666	441	D>G		No	ClinGen ExAC gnomAD
rs202223797 CA74732367	441	D>V		No	ClinGen ExAC gnomAD
CA74732363 rs200813049	443	G>R		No	ClinGen Ensembl
CA353095004 rs1300972125	444	E>K		No	ClinGen gnomAD
rs758360470 CA2430664	445	K>N		No	ClinGen ExAC gnomAD
rs200190729 CA2430663	446	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs200190729 CA2430662	446	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs200190729 CA353094970	446	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA353094936 rs1157756109	447	W>*		No	ClinGen gnomAD
rs373748615 CA2430659	449	Q>*		No	ClinGen ESP ExAC gnomAD
rs1473155380 CA353094837	451	G>E		No	ClinGen gnomAD
CA2430658 rs760228106	452	D>E		No	ClinGen ExAC gnomAD
COSM1267931 CA2430657 rs146228125	455	P>L	oesophagus [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA2430656 rs146228125	455	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA353094776 rs1197626645	455	P>S		No	ClinGen gnomAD
CA74732350 rs200091521	456	A>P		No	ClinGen gnomAD
CA353094770 rs200091521	456	A>T		No	ClinGen gnomAD
CA353094752 rs1286320128	457	P>L		No	ClinGen gnomAD
CA353094742 rs1258972633	458	V>A		No	ClinGen TOPMed
rs1258972633 CA353094740	458	V>G		No	ClinGen TOPMed
rs746272802 CA2430653	459	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2430652 rs746272802	459	D>Y		No	ClinGen ExAC gnomAD
rs200543932 CA2430651	461	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1322632187 CA353094710	461	P>S		No	ClinGen gnomAD
CA2430650 rs201133673	462	S>R		No	ClinGen ExAC TOPMed gnomAD
CA353094629 rs1287887590	467	R>S		No	ClinGen gnomAD
rs747134694 CA2430649	468	P>A		No	ClinGen ExAC
TCGA novel	469	N>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs777940338 CA2430648	470	C>F		No	ClinGen ExAC gnomAD
CA353094599 rs777940338	470	C>S		No	ClinGen ExAC gnomAD
TCGA novel	472	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs374117701 CA2430647	472	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs374117701 CA2430646	472	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA74732336 rs200116400	473	L>F		No	ClinGen Ensembl
rs1458231824 CA353094531	474	N>H		No	ClinGen gnomAD
rs961242459 CA74732334	474	N>S		No	ClinGen Ensembl
CA74732329 rs201773500	481	R>G		No	ClinGen TOPMed gnomAD
COSM2852651 rs200601173 CA2430643	481	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
CA353094384 rs201773500	481	R>W		No	ClinGen TOPMed gnomAD
TCGA novel	484	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs766101387 CA2430642	485	V>L		No	ClinGen ExAC TOPMed gnomAD
rs750002586 CA2430640	486	T>A		No	ClinGen ExAC TOPMed gnomAD
rs767076265 CA353094271	486	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs767076265 CA2430639	486	T>S		No	ClinGen ExAC gnomAD
CA2430641 rs750002586	486	T>S		No	ClinGen ExAC TOPMed gnomAD
CA2430637 rs773966360	487	V>M		No	ClinGen ExAC TOPMed gnomAD
CA2430636 rs770483581	489	P>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs199540271 CA74732315	491	M>T		No	ClinGen Ensembl
rs201649020 CA353094091	493	A>D		No	ClinGen gnomAD
CA74732313 rs201649020	493	A>V		No	ClinGen gnomAD
CA2430634 rs777140542	496	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1013997109 CA74732306	499	Q>*		No	ClinGen TOPMed gnomAD
CA2430633 rs771161329	499	Q>R		No	ClinGen ExAC gnomAD
rs747281323 CA2430632	500	C>F		No	ClinGen ExAC TOPMed gnomAD
rs199734250 CA2430631 COSM4734018	502	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
CA2430630 rs201440225	502	R>H		No	ClinGen ExAC gnomAD
CA2430629 rs200224404	504	S>R		No	ClinGen ExAC gnomAD
TCGA novel	505	H>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1444049124 CA353093716	506	N>S		No	ClinGen gnomAD
rs754919914 CA2430627	509	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1488228492 CA353093577	513	N>D		No	ClinGen TOPMed
rs1250552274 CA353093559	513	N>S		No	ClinGen gnomAD
CA74732289 rs267599888 COSM36649	514	G>S	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
CA353093527 rs1217818548	514	G>V		No	ClinGen TOPMed
rs1577980355 CA353093449	517	F>S		No	ClinGen Ensembl
rs1021090913 CA74732287	519	P>L		No	ClinGen TOPMed gnomAD
rs755815220 CA2430624	519	P>S		No	ClinGen ExAC gnomAD
rs1313628899 CA353093300	522	G>S		No	ClinGen gnomAD
rs1455049195 CA353093234	524	Q>*		No	ClinGen gnomAD
CA353093186 rs1577980341	525	V>G		No	ClinGen Ensembl
rs756928475 CA2430621	530	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA353092996 rs1174928876	532	K>E		No	ClinGen TOPMed
rs1356528648 CA353092932	535	L>F		No	ClinGen gnomAD
CA353092855 rs1383453062 COSM3916361	538	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA gnomAD
rs141799890 CA2430617	539	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA74732273 rs200585692	542	T>M		No	ClinGen gnomAD
rs760989847 CA2430615	545	P>L		No	ClinGen ExAC gnomAD
rs760989847 CA353092658	545	P>R		No	ClinGen ExAC gnomAD
CA74732270 rs905498105	545	P>S		No	ClinGen Ensembl
CA74732264 rs947083609	546	R>*		No	ClinGen TOPMed gnomAD
CA2430612 rs17846009	546	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs17846009 CA2430613 COSM1617835	546	R>Q	liver [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1577980271 CA353092497	551	D>A		No	ClinGen Ensembl
COSM4926082	551	D>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs774414920 CA2430611	553	S>N		No	ClinGen ExAC gnomAD
rs768678941 CA353092399	555	N>S		No	ClinGen ExAC gnomAD
CA2430610 rs768678941	555	N>T		No	ClinGen ExAC gnomAD
rs749244791 CA2430609	556	S>N		No	ClinGen ExAC gnomAD
rs199885824 CA2430608	557	Q>*		No	ClinGen ExAC gnomAD
CA2430607 rs756045938	558	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs745714862 CA2430606	559	F>L		No	ClinGen ExAC gnomAD
rs201896507 CA74732250	560	G>S		No	ClinGen Ensembl
CA353092157 rs200059070	564	V>L		No	ClinGen TOPMed gnomAD
CA74732247 rs200059070 COSM1424360	564	V>M	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
COSM3775220	566	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs374460076 CA2430603	568	F>V		No	ClinGen ESP ExAC gnomAD
CA2430602 rs751217567	569	S>N		No	ClinGen ExAC gnomAD
rs115440379 RCV000884426 CA2430600	571	V>M		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1577980226 CA353091944	573	H>P		No	ClinGen Ensembl
CA74732241 rs909740582	573	H>Q		No	ClinGen TOPMed
rs752229105 CA2430599	575	R>C		No	ClinGen ExAC gnomAD
CA2430597 rs192701551	575	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs192701551 CA2430598	575	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773459682 CA2430596	576	T>N		No	ClinGen ExAC gnomAD
rs1577980212 CA353091868	576	T>P		No	ClinGen Ensembl
rs1438533732 CA353091836	577	L>P		No	ClinGen TOPMed
rs767853618 CA2430595	578	R>C		No	ClinGen ExAC gnomAD
rs200751137 CA74732230	578	R>H		No	ClinGen TOPMed
rs1577980202 CA353091793	579	H>P		No	ClinGen Ensembl
CA353091701 rs1410036819	581	S>I		No	ClinGen TOPMed
CA353091669 rs1403421962	583	A>T		No	ClinGen TOPMed
rs762049685 CA2430594	584	H>L		No	ClinGen ExAC gnomAD
rs199719397 CA74732228	584	H>Y		No	ClinGen TOPMed gnomAD
COSM1046833	585	N>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA74732223 rs200663962	588	H>N		No	ClinGen gnomAD
rs774587357 CA74732219	595	L>R		No	ClinGen Ensembl
CA2430589 rs572658072	596	C>R		No	ClinGen 1000Genomes ExAC gnomAD
CA2430588 rs149970781	598	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs770800745 CA2430586	599	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1431030598 CA353091051	600	L>P		No	ClinGen gnomAD
CA2430583 rs199788447	601	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs200714733 CA2430584	601	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1215245832 CA353091012	602	A>S		No	ClinGen TOPMed
rs1206320256 CA353090991	603	L>V		No	ClinGen gnomAD
rs778432728 CA2430581	607	G>S		No	ClinGen ExAC gnomAD
rs1203475069 CA353090796	609	A>V		No	ClinGen TOPMed gnomAD
CA353090774 rs1258046481	611	G>S		No	ClinGen gnomAD
CA74732201 rs909361016	613	M>I		No	ClinGen TOPMed
rs202141288 CA74732195	616	E>A		No	ClinGen Ensembl
rs767792206 CA2430578	616	E>K		No	ClinGen ExAC TOPMed gnomAD
COSM3595887	617	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA353090535 rs1293541461	619	L>F		No	ClinGen TOPMed gnomAD
rs762213729 CA2430577	620	Y>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	621	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs539192498 CA2430575	622	H>R		No	ClinGen 1000Genomes ExAC gnomAD
CA353090369 rs1404073219	624	F>L		No	ClinGen gnomAD
rs1481791404 CA353090347	625	Q>R		No	ClinGen gnomAD
rs1461180978 CA353090314	626	G>D		No	ClinGen gnomAD
rs201860133 CA74732190	626	G>S		No	ClinGen 1000Genomes gnomAD
CA2430572 rs202065055	628	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs200907891 CA353090269	628	S>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	629	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs34399053 CA2430570 COSM241915	629	G>S	prostate [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1217155929 CA353090211	632	W>C		No	ClinGen TOPMed
rs1577980076 CA353090142	638	N>T		No	ClinGen Ensembl
CA2430567 rs777700511	639	R>C		No	ClinGen ExAC TOPMed gnomAD
CA353090131 rs777700511	639	R>G		No	ClinGen ExAC TOPMed gnomAD
CA2430566 rs771867596	639	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs747766747 CA2430565	642	T>I		No	ClinGen ExAC gnomAD
rs1577980069 CA353090097	642	T>P		No	ClinGen Ensembl
CA353090070 rs1249798745	644	L>P		No	ClinGen gnomAD
CA353090036 rs1209417305	647	T>I		No	ClinGen TOPMed
rs1577980050 CA353090042	647	T>P		No	ClinGen Ensembl
CA2430563 rs754458236	648	L>V		No	ClinGen ExAC gnomAD
CA353090019 rs1314371566	649	R>C		No	ClinGen TOPMed gnomAD
CA353090021 rs1314371566	649	R>G		No	ClinGen TOPMed gnomAD
CA2430562 rs202082899 COSM175135	649	R>H	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	649	R>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1314371566 CA353090022	649	R>S		No	ClinGen TOPMed gnomAD
CA74732169 CA353090001 rs201034065	650	N>K		No	ClinGen TOPMed
rs1577980034 CA353090007	650	N>T		No	ClinGen Ensembl
rs1577980026 CA353089992	651	L>P		No	ClinGen Ensembl
rs992280381 CA74732165	653	K>Q		No	ClinGen TOPMed
rs150805215 CA2430559	653	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	655	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1046832	656	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs758580734 CA2430557	656	Q>R		No	ClinGen ExAC gnomAD
rs1384070157 CA353089950	657	V>M		No	ClinGen gnomAD
CA2430556 rs201883862	659	R>C		No	ClinGen ExAC TOPMed gnomAD
CA2430555 rs765355058	659	R>H		No	ClinGen ExAC TOPMed gnomAD
CA2430554 rs759702310	661	R>C		No	ClinGen ExAC TOPMed gnomAD
CA353086408 rs759702310	661	R>G		No	ClinGen ExAC TOPMed gnomAD
rs939800947 CA74732158	661	R>H		No	ClinGen TOPMed gnomAD
rs1577979989 CA353086332	664	Y>S		No	ClinGen Ensembl
rs766486365 CA2430552	665	L>P		No	ClinGen ExAC TOPMed gnomAD
CA2430551 rs760634405	666	A>T		No	ClinGen ExAC gnomAD
CA2430550 rs773148312	667	F>L		No	ClinGen ExAC TOPMed gnomAD
rs200974209 CA2430549	667	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA353086256 rs1358414938	670	W>R		No	ClinGen gnomAD
rs1559437280 CA353086251	670	W>S		No	ClinGen Ensembl
rs1284674932 CA353086209	672	S>T		No	ClinGen gnomAD
rs144698131 CA2430547	673	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2430546 rs768160968	674	H>P		No	ClinGen ExAC gnomAD
CA353086171 rs201492068	674	H>Q		No	ClinGen ExAC gnomAD
rs145919121 CA2430544	678	K>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA353086078 rs1577979946	681	V>A		No	ClinGen Ensembl
CA353086085 rs1466784711	681	V>F		No	ClinGen gnomAD
rs757774232 CA2430543	682	L>F		No	ClinGen ExAC gnomAD
CA353086058 rs1470002044	683	D>N		No	ClinGen TOPMed gnomAD
CA353086016 rs1486589254	685	A>T		No	ClinGen TOPMed
rs1577979930 CA353085965	687	N>T		No	ClinGen Ensembl
rs752974071 CA2430539	690	K>E		No	ClinGen ExAC gnomAD
rs765565816 CA2430538	692	L>P		No	ClinGen ExAC gnomAD
CA353085812 rs1559880670	693	T>I		No	ClinGen Ensembl
rs1262275709 CA353085810	694	N>D		No	ClinGen TOPMed
CA353085794 rs965741284	694	N>K		No	ClinGen TOPMed gnomAD
TCGA novel	694	N>K	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs200668101 CA2430537	694	N>S		No	ClinGen ExAC gnomAD
CA2430536 rs753984605	695	G>S		No	ClinGen ExAC gnomAD
rs1195653141 CA353085754	696	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA353085727 rs1577979894	697	L>P		No	ClinGen Ensembl
CA353085706 rs1376106057	698	P>L		No	ClinGen TOPMed
CA2430535 rs766504452	700	G>D		No	ClinGen ExAC gnomAD
CA74732125 rs868746147	701	T>N		No	ClinGen Ensembl
CA74732121 rs1050578753	702	R>Q		No	ClinGen TOPMed gnomAD
CA2430534 rs199773918	702	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA353085621 rs1397431776	703	L>F		No	ClinGen TOPMed
rs761704908 CA2430531	704	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2430532 COSM2852629 rs145698725	704	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs1349946976 CA353085597	705	R>K		No	ClinGen gnomAD
CA74732115 rs202130322	705	R>S		No	ClinGen ExAC TOPMed gnomAD
CA353085580 rs1387020386	707	D>N		No	ClinGen gnomAD
CA2430528 rs748833451	708	V>I		No	ClinGen ExAC gnomAD
CA2430527 rs774984770	712	S>G		No	ClinGen ExAC gnomAD
rs1159164136 CA353085462	712	S>N		No	ClinGen gnomAD
CA74732111 rs201308500	714	S>T		No	ClinGen Ensembl
rs1384245534 CA353085323	715	F>C		No	ClinGen TOPMed
CA353085305 rs1479085302	716	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
COSM1424359	719	G>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs375556098 CA353085232	719	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs375556098 CA2430524	719	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	724	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA2430521 rs142377483	725	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1013859585 CA74732095 COSM4998904	728	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic Ensembl NCI-TCGA
CA2430518 rs754077069	729	E>D		No	ClinGen ExAC gnomAD
CA74732093 COSM106782 rs144658278	729	E>K	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1182054900 CA353084870	730	L>F		No	ClinGen TOPMed gnomAD
COSM3775219	731	N>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA2430516 rs200579725	734	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM4118959 rs200579725 CA2430515	734	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1367791908 CA353084789	735	N>S		No	ClinGen TOPMed gnomAD
rs895456647 COSM1229418 CA74732085	736	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA353084773 rs1158620699	736	A>V		No	ClinGen TOPMed
rs761641797 CA2430513	737	L>H		No	ClinGen ExAC TOPMed gnomAD
rs751383938 CA2430512	738	K>R		No	ClinGen ExAC gnomAD
TCGA novel	739	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	740	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1403448146 CA353084725	742	H>N		No	ClinGen gnomAD
COSM3595886	743	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1174999668 CA353084704	744	W>C		No	ClinGen gnomAD
rs1414813774 CA353084683	747	P>L		No	ClinGen gnomAD
rs1184675036 CA353084677	749	A>T		No	ClinGen gnomAD
rs762617367 CA2430509	749	A>V		No	ClinGen ExAC gnomAD
CA2430507 rs148411655	750	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs759114677 CA2430506	751	A>D		No	ClinGen ExAC gnomAD
CA2430505 rs776109297	752	L>V		No	ClinGen ExAC gnomAD
CA353084654 rs1559880570	753	Q>K		No	ClinGen Ensembl
rs1308470038 CA353084634	756	D>N		No	ClinGen TOPMed
TCGA novel	757	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1240920814 CA908071133	759	A>*		No	ClinGen TOPMed
rs748541025 CA2430503	759	A>T		No	ClinGen ExAC gnomAD
rs1214449391 CA353084608	759	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs768851453 CA2430501	763	H>Q		No	ClinGen ExAC gnomAD
rs200101208 CA353084573	765	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA2430499 rs200101208	765	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA2430498 rs756397525	765	A>V		No	ClinGen ExAC gnomAD
CA2430496 rs781072961	766	C>G		No	ClinGen ExAC gnomAD
rs757223362 CA2430495	766	C>Y		No	ClinGen ExAC TOPMed
CA2430493 rs200548286	768	A>E		No	ClinGen ExAC TOPMed gnomAD
CA353084556 rs1428963616	768	A>P		No	ClinGen gnomAD
rs200548286 CA74732056	768	A>V		No	ClinGen ExAC TOPMed gnomAD
CA353084544 rs1413222625	769	A>D		No	ClinGen gnomAD
CA353084552 rs1442838860	769	A>T		No	ClinGen gnomAD
COSM3595884	772	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	773	F>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA2430491 rs752486549	775	L>R		No	ClinGen ExAC gnomAD
rs759134825 CA2430489	779	A>P		No	ClinGen ExAC gnomAD
rs759134825 CA2430490	779	A>T		No	ClinGen ExAC gnomAD
rs199915646 CA74732048	780	A>V		No	ClinGen Ensembl
rs762409250 CA2430486	781	V>M		No	ClinGen ExAC TOPMed gnomAD
CA353084266 rs1389913879	783	G>D		No	ClinGen TOPMed gnomAD
COSM1229414 CA2430484 rs769171891	783	G>S	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1311427036 CA353084197	785	P>R		No	ClinGen gnomAD
CA74732038 rs988141890 COSM3696179	787	R>Q	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs780551078 CA2430482	787	R>W		No	ClinGen ExAC TOPMed gnomAD
CA2430481 rs770152532	788	V>M		No	ClinGen ExAC gnomAD
rs1370997293 CA353084088	789	K>M		No	ClinGen gnomAD
CA2430480 rs746020265	790	C>Y		No	ClinGen ExAC gnomAD
CA353083998 rs1456153842	792	S>G		No	ClinGen gnomAD
CA353083959 rs1339703035	793	P>L		No	ClinGen TOPMed
rs1339703035 CA353083958	793	P>Q		No	ClinGen TOPMed
CA2430478 rs371712112	794	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA2430477 rs747080983	796	L>V		No	ClinGen ExAC gnomAD
rs199709414 CA74732030	797	Q>H		No	ClinGen ExAC gnomAD
rs752504915 CA2430474	799	L>F		No	ClinGen ExAC gnomAD
rs1254469127 CA353083733	801	I>L		No	ClinGen gnomAD
CA74732027 rs925350595	803	A>T		No	ClinGen Ensembl
CA2430473 rs201970730	804	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA2430471 rs199768722	807	R>C		No	ClinGen ExAC TOPMed gnomAD
rs201411213 CA2430469	811	D>N		No	ClinGen ExAC gnomAD
rs772772031 CA2430468	812	E>K		No	ClinGen ExAC gnomAD
CA74732018 rs1014224247	813	A>V		No	ClinGen Ensembl
rs1481655033 CA353083296	816	W>*		No	ClinGen TOPMed
TCGA novel	817	D>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA2430467 rs779293320	818	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs200268875 CA2430466	820	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA2430465 rs200268875	820	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA2430464 rs770242862	822	S>L		No	ClinGen ExAC gnomAD
rs1301069896 CA353083177	825	A>T		No	ClinGen TOPMed
CA2430462 rs776759341	825	A>V		No	ClinGen ExAC gnomAD
rs1457994824 CA353083168	826	V>M		No	ClinGen gnomAD
rs1374720655 CA353083155	827	A>P		No	ClinGen TOPMed
rs1374720655 CA353083156	827	A>T		No	ClinGen TOPMed
rs939400923 CA74732004	831	G>A		No	ClinGen TOPMed gnomAD
rs939400923 CA353083100	831	G>V		No	ClinGen TOPMed gnomAD
rs777853295 CA2430459	832	V>L		No	ClinGen ExAC TOPMed gnomAD
CA353083080 rs1231099314	833	P>T		No	ClinGen TOPMed
rs758340283 CA2430458	836	H>Y		No	ClinGen ExAC gnomAD
rs202058288 CA74731996	837	H>Q		No	ClinGen Ensembl
TCGA novel	837	H>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA2430457 rs200635689	837	H>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	845	Y>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA2430455 rs754820202	846	C>W		No	ClinGen ExAC gnomAD
COSM4118957	846	C>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4818083	848	H>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1269717227 CA353082778	853	W>R		No	ClinGen gnomAD
rs201883321 CA2430454	857	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs200200453 CA74731986	857	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs766010083 CA2430453	858	G>R		No	ClinGen ExAC gnomAD
CA353082675 rs1429803971	858	G>V		No	ClinGen TOPMed
rs763585272 CA2430450	859	R>L		No	ClinGen ExAC TOPMed gnomAD
rs763585272 COSM1566700 CA2430449	859	R>Q	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA2430451 rs749912438	859	R>W		No	ClinGen ExAC TOPMed gnomAD
CA2430448 rs201014855	861	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs201014855 CA2430447	861	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA2430444 rs148303873	862	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs148303873 CA2430443	862	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141461033 CA2430446 CA2430445	862	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
COSM3427733 CA353082535 rs772094857	863	R>*	Variant assessed as Somatic; HIGH impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
RCV000956636 VAR_034555 rs5743845 CA2430440	863	R>Q		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA353082510 rs778857260	864	D>H		No	ClinGen ExAC TOPMed gnomAD
rs778857260 CA2430439	864	D>N		No	ClinGen ExAC TOPMed gnomAD
CA2430438 rs768630458	865	E>K		No	ClinGen ExAC TOPMed gnomAD
CA353082461 rs779837834	866	D>H		No	ClinGen ExAC gnomAD
rs779837834 CA2430436	866	D>N		No	ClinGen ExAC gnomAD
CA353082380 rs1198423186	869	P>A		No	ClinGen gnomAD
CA2430434 rs755749895	869	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1235260637 CA353082309	871	D>N		No	ClinGen gnomAD
rs756875974 CA2430432	872	A>D		No	ClinGen ExAC gnomAD
rs756875974 CA353082271	872	A>G		No	ClinGen ExAC gnomAD
rs201627440 CA2430430	874	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1395708601 CA353082147	877	D>N		No	ClinGen gnomAD
rs1403302593 CA353082114	878	K>R		No	ClinGen gnomAD
CA353082087 rs148993494	879	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs148993494 CA2430426	879	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs148993494 CA2430427	879	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA353082025 rs200817942	881	S>R		No	ClinGen ExAC TOPMed gnomAD
rs5743846 VAR_052365 CA2430423	882	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen UniProt 1000Genomes ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs1184911795 CA353081947	885	D>E		No	ClinGen gnomAD
CA353081954 rs1391526951	885	D>G		No	ClinGen gnomAD
COSM6097957	886	W>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1559880393 CA353081901	887	V>M		No	ClinGen Ensembl
CA2430420 rs749180201	890	E>K		No	ClinGen ExAC TOPMed gnomAD
rs779742290 CA2430419	891	L>F		No	ClinGen ExAC gnomAD
COSM3696178	892	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1325467536 COSM264065 CA353081758	892	R>W	Variant assessed as Somatic; MODERATE impact. pancreas large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed
rs1371871166 CA353081711	893	G>A		No	ClinGen TOPMed
CA353081730 CA2430418 rs769582714	893	G>R		No	ClinGen ExAC gnomAD
rs1015130073 CA74731758	898	C>S		No	ClinGen Ensembl
rs781058107 CA2430416	899	R>C		No	ClinGen ExAC gnomAD
CA2430415 COSM1670241 rs756957650	899	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
COSM1229417 CA2430414 rs751129636	901	R>C	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
VAR_036077 COSM33465 rs755472700 CA2430412	901	R>H	large_intestine a colorectal cancer sample; somatic mutation [Cosmic, UniProt]	No	ClinGen cosmic curated UniProt ExAC TOPMed dbSNP gnomAD
rs755472700 CA2430413	901	R>L		No	ClinGen ExAC TOPMed gnomAD
CA353081467 rs751129636	901	R>S		No	ClinGen ExAC TOPMed gnomAD
rs200216998 CA74731737	902	W>*		No	ClinGen gnomAD
TCGA novel	903	A>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA353081424 rs1370388414	903	A>T		No	ClinGen gnomAD
CA2430411 COSM5822156 rs199785727	905	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
CA2430410 COSM271704 rs376675219	905	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	906	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1397950607 CA353081329	907	C>R		No	ClinGen gnomAD
CA2430409 rs761146594	911	R>C		No	ClinGen ExAC TOPMed gnomAD
COSM1424356	911	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs996977969 COSM1046829 CA74731730	912	D>N	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs201790525 CA74731724	916	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs369271245 CA74731713	917	K>R		No	ClinGen ESP TOPMed
CA74731709 rs1019831022	918	T>I		No	ClinGen TOPMed
rs762819270 CA2430404	919	L>F		No	ClinGen ExAC gnomAD
CA2430403 rs762819270	919	L>V		No	ClinGen ExAC gnomAD
CA353080953 rs200791761	925	A>G		No	ClinGen TOPMed gnomAD
CA74731698 rs200791761	925	A>V		No	ClinGen TOPMed gnomAD
rs775545937 CA2430402	926	S>L		No	ClinGen ExAC gnomAD
rs202055087 CA74731689	927	V>I		No	ClinGen gnomAD
rs776511982 CA2430399	930	S>G		No	ClinGen ExAC gnomAD
rs1350213511 CA353080797	930	S>N		No	ClinGen gnomAD
rs201146442 COSM2852616 CA74731675	931	R>C	pancreas [Cosmic]	No	ClinGen cosmic curated Ensembl
rs201071010 CA2430398	931	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2430397 rs746622200 COSM33147 VAR_036078	933	T>M	large_intestine a colorectal cancer sample; somatic mutation [Cosmic, UniProt]	No	ClinGen cosmic curated UniProt ExAC TOPMed dbSNP gnomAD
CA2430394 rs747584295	935	F>L		No	ClinGen ExAC gnomAD
rs780682624 CA2430393	936	V>M		No	ClinGen ExAC gnomAD
CA74731658 rs202053090	938	A>D		No	ClinGen Ensembl
rs1410887458 CA353080534	939	H>Q		No	ClinGen gnomAD
CA2430391 rs201197940	940	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs751729676 CA2430388	942	R>Q		No	ClinGen ExAC gnomAD
CA2430389 rs544128726	942	R>W		No	ClinGen ExAC TOPMed gnomAD
CA353080473 rs1292157790	943	V>I		No	ClinGen gnomAD
rs936600036 CA74731644	944	S>G		No	ClinGen Ensembl
CA74731641 rs1019590992	945	G>C		No	ClinGen Ensembl
CA353080432 rs1328769300	945	G>D		No	ClinGen gnomAD
COSM4933341	945	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA2430386 rs763133045	946	L>F		No	ClinGen ExAC TOPMed gnomAD
CA353080415 rs1343384382	946	L>P		No	ClinGen gnomAD
CA74731622 COSM3783735 rs369679861	948	R>C	prostate [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs369679861 CA353080391	948	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs201739665 CA2430384	948	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2430385 rs369679861	948	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA2430382 rs776600993	949	A>T		No	ClinGen ExAC gnomAD
CA353080363 rs1387454897	949	A>V		No	ClinGen gnomAD
rs1422851190 CA353080278	954	A>G		No	ClinGen gnomAD
rs1577979350 CA353080284	954	A>S		No	ClinGen Ensembl
rs771623304 CA2430378	960	E>D		No	ClinGen ExAC gnomAD
COSM3595882	960	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs55881257 CA2430377	962	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201773280 CA2430375	962	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201773280 CA2430376	962	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	963	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM3595881	964	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA2430373 rs183735837	965	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1304904381 CA353080012	969	V>A		No	ClinGen gnomAD
CA2430371 rs751838801	969	V>M		No	ClinGen ExAC gnomAD
CA353079973 rs1418858521	972	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1559880264 CA353079954	973	P>L		No	ClinGen Ensembl
rs55846319 CA2430367	975	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs55846319 CA2430368	975	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2430366 rs201076939	976	R>C		No	ClinGen ExAC TOPMed gnomAD
rs776761731 CA2430365 COSM1734822	976	R>H	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA353079913 rs201076939	976	R>S		No	ClinGen ExAC TOPMed gnomAD
CA2430364 rs375003304	977	R>C		No	ClinGen ESP ExAC gnomAD
CA353079864 rs1396810210	977	R>H		No	ClinGen gnomAD
CA2430363 rs760617877	979	R>C		No	ClinGen ExAC gnomAD
rs200209731 CA2430362	979	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1414552763 CA353079796	981	V>M		No	ClinGen TOPMed
rs773946672 CA2430359	982	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs142806370 COSM4118955 CA2430360	982	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs140585419 CA2430358	984	R>C		No	ClinGen ESP ExAC gnomAD
CA2430357 rs748775653	984	R>H		No	ClinGen ExAC gnomAD
COSM3974485	984	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3595880	985	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA2430356 rs781694343	986	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1019357651 CA74731541	986	R>H		No	ClinGen TOPMed
CA353079660 rs1340800121	987	L>F		No	ClinGen gnomAD
COSM4118953 CA2430355 rs747414072	989	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs201478487 CA2430353	989	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA353079599 rs201478487	989	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM2152900 rs747414072 CA2430354	989	R>S	Variant assessed as Somatic; MODERATE impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1283307998 CA353079577	990	Q>*		No	ClinGen gnomAD
CA2430351 rs752812185	990	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA74731529 rs200488254	990	Q>R		No	ClinGen Ensembl
CA2430350 rs779252979	991	S>I		No	ClinGen ExAC gnomAD
rs1486529388 CA353079526	991	S>R		No	ClinGen TOPMed
CA353079520 rs1306072174	992	V>L		No	ClinGen gnomAD
rs1371188266 CA353079395	996	P>T		No	ClinGen gnomAD
CA353079360 rs1577979246	997	H>Y		No	ClinGen Ensembl
rs1422209553 CA353079327	998	Q>*		No	ClinGen gnomAD
rs892288735 CA74731514	999	P>S		No	ClinGen gnomAD
rs202060477 CA74731508	1000	S>G		No	ClinGen Ensembl
CA353079269 rs1290763697	1000	S>N		No	ClinGen gnomAD
CA2430345 rs376972467	1001	G>A		No	ClinGen ESP ExAC gnomAD
TCGA novel	1002	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs200911364 CA74731503	1003	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs200136984 CA2430344	1003	R>H		No	ClinGen ExAC TOPMed gnomAD
CA353079161 rs1206004314	1004	S>R		No	ClinGen gnomAD
rs1251316202 CA353079169	1004	S>T		No	ClinGen gnomAD
CA74731492 rs946743122	1007	A>S		No	ClinGen TOPMed
rs200965458 CA2430342	1008	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA353078975 rs1398517138	1011	M>T		No	ClinGen TOPMed
rs199839624 CA74731485	1011	M>V		No	ClinGen TOPMed
rs201853430 CA2430340	1015	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs555536034 CA74731481	1015	R>S		No	ClinGen Ensembl
CA353078874 rs201853430	1015	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA74731478 rs533787193	1016	D>E		No	ClinGen gnomAD
rs1351034672 CA353078769	1018	H>N		No	ClinGen gnomAD
rs762518214 CA2430338	1023	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2430339 rs200896211	1023	R>W		No	ClinGen ExAC TOPMed gnomAD
rs774968315 CA2430337	1026	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA2430336 rs771432576	1029	P>L		No	ClinGen ExAC gnomAD
rs148852303 CA2430334	1030	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA2430335 rs148852303	1030	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA2430330 rs144798707	1032	E>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2430331 rs144798707	1032	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD

No associated diseases with Q9NR96

No regional properties for Q9NR96

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9NR96

Functions

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum membrane ; Single-pass type I membrane protein Early endosome membrane Lysosome Cytoplasmic vesicle, phagosome Golgi apparatus membrane	Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist Exit from the ER requires UNC93B1 Endolysosomal localization is required for proteolytic cleavage and subsequent activation Intracellular localization of the active receptor may prevent from responding to self nucleic acid
PANTHER Family	PTHR47410	TOLL-LIKE RECEPTOR 7-RELATED
PANTHER Subfamily	PTHR47410:SF3	TOLL-LIKE RECEPTOR 9
PANTHER Protein Class	transmembrane signal receptor
PANTHER Pathway Category	Toll receptor signaling pathway TLR

14 GO annotations of cellular component

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
basolateral plasma membrane	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
early phagosome	A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.
endolysosome	An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place.
endolysosome membrane	The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
endosome	A vacuole to which materials ingested by endocytosis are delivered.
endosome membrane	The lipid bilayer surrounding an endosome.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
lysosome	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name	Definition
interleukin-1 receptor binding	Binding to an interleukin-1 receptor.
pattern recognition receptor activity	Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
siRNA binding	Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
unmethylated CpG binding	Binding to uan nmethylated CpG motif. Unmethylated CpG dinucleotides are often associated with gene promoters.

46 GO annotations of biological process

Name	Definition
cellular response to chloroquine	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus.
cellular response to lipopolysaccharide	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
cellular response to metal ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
defense response to bacterium	Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
defense response to Gram-negative bacterium	Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
defense response to virus	Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
detection of molecule of bacterial origin	The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal.
I-kappaB kinase/NF-kappaB signaling	The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
maintenance of gastrointestinal epithelium	Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents.
male gonad development	The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
microglial cell activation	The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
MyD88-dependent toll-like receptor signaling pathway	A toll-like receptor signaling pathway in which the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.
negative regulation of ATPase-coupled calcium transmembrane transporter activity	Any process that stops, prevents or reduces the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity.
negative regulation of ERK1 and ERK2 cascade	Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of autophagy	Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
positive regulation of B cell activation	Any process that activates or increases the frequency, rate or extent of B cell activation.
positive regulation of B cell proliferation	Any process that activates or increases the rate or extent of B cell proliferation.
positive regulation of chemokine production	Any process that activates or increases the frequency, rate, or extent of chemokine production.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of granulocyte macrophage colony-stimulating factor production	Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.
positive regulation of I-kappaB kinase/NF-kappaB signaling	Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
positive regulation of immunoglobulin production	Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.
positive regulation of inflammatory response	Any process that activates or increases the frequency, rate or extent of the inflammatory response.
positive regulation of interferon-alpha production	Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
positive regulation of interferon-beta production	Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
positive regulation of interleukin-10 production	Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
positive regulation of interleukin-12 production	Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
positive regulation of interleukin-18 production	Any process that activates or increases the frequency, rate, or extent of interleukin-18 production.
positive regulation of interleukin-6 production	Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
positive regulation of interleukin-8 production	Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
positive regulation of intestinal epithelial cell development	Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development.
positive regulation of JNK cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
positive regulation of MAPK cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
positive regulation of NF-kappaB transcription factor activity	Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
positive regulation of NIK/NF-kappaB signaling	Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
positive regulation of toll-like receptor 9 signaling pathway	Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of tumor necrosis factor production	Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.
positive regulation of type II interferon production	Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
regulation of B cell differentiation	Any process that modulates the frequency, rate or extent of B cell differentiation.
regulation of dendritic cell cytokine production	Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production.
regulation of protein phosphorylation	Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
regulation of toll-like receptor 9 signaling pathway	Any process that modulates the frequency, rate, or extent of toll-like receptor 9 signaling pathway.
toll-like receptor 9 signaling pathway	The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 9.
toll-like receptor signaling pathway	The series of molecular signals initiated by a ligand binding to a toll-like receptor of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.

11 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5I2M5	TLR9	Toll-like receptor 9	Bos taurus (Bovine)	SS
Q5I2M7	TLR9	Toll-like receptor 9	Felis catus (Cat) (Felis silvestris catus)	SS
Q5I2M8	TLR9	Toll-like receptor 9	Canis lupus familiaris (Dog) (Canis familiaris)	SS
P08953	Tl	Protein toll	Drosophila melanogaster (Fruit fly)	PR
Q2EEY0	TLR9	Toll-like receptor 9	Equus caballus (Horse)	SS
Q9NR97	TLR8	Toll-like receptor 8	Homo sapiens (Human)	EV
Q9NYK1	TLR7	Toll-like receptor 7	Homo sapiens (Human)	EV
P58681	Tlr7	Toll-like receptor 7	Mus musculus (Mouse)	SS
Q9EQU3	Tlr9	Toll-like receptor 9	Mus musculus (Mouse)	SS
Q5I2M3	TLR9	Toll-like receptor 9	Sus scrofa (Pig)	SS
A5H2Z9	Tlr7	Toll-like receptor 7	Rattus norvegicus (Rat)	SS

10	20	30	40	50	60
MGFCRSALHP	LSLLVQAIML	AMTLALGTLP	AFLPCELQPH	GLVNCNWLFL	KSVPHFSMAA
70	80	90	100	110	120
PRGNVTSLSL	SSNRIHHLHD	SDFAHLPSLR	HLNLKWNCPP	VGLSPMHFPC	HMTIEPSTFL
130	140	150	160	170	180
AVPTLEELNL	SYNNIMTVPA	LPKSLISLSL	SHTNILMLDS	ASLAGLHALR	FLFMDGNCYY
190	200	210	220	230	240
KNPCRQALEV	APGALLGLGN	LTHLSLKYNN	LTVVPRNLPS	SLEYLLLSYN	RIVKLAPEDL
250	260	270	280	290	300
ANLTALRVLD	VGGNCRRCDH	APNPCMECPR	HFPQLHPDTF	SHLSRLEGLV	LKDSSLSWLN
310	320	330	340	350	360
ASWFRGLGNL	RVLDLSENFL	YKCITKTKAF	QGLTQLRKLN	LSFNYQKRVS	FAHLSLAPSF
370	380	390	400	410	420
GSLVALKELD	MHGIFFRSLD	ETTLRPLARL	PMLQTLRLQM	NFINQAQLGI	FRAFPGLRYV
430	440	450	460	470	480
DLSDNRISGA	SELTATMGEA	DGGEKVWLQP	GDLAPAPVDT	PSSEDFRPNC	STLNFTLDLS
490	500	510	520	530	540
RNNLVTVQPE	MFAQLSHLQC	LRLSHNCISQ	AVNGSQFLPL	TGLQVLDLSH	NKLDLYHEHS
550	560	570	580	590	600
FTELPRLEAL	DLSYNSQPFG	MQGVGHNFSF	VAHLRTLRHL	SLAHNNIHSQ	VSQQLCSTSL
610	620	630	640	650	660
RALDFSGNAL	GHMWAEGDLY	LHFFQGLSGL	IWLDLSQNRL	HTLLPQTLRN	LPKSLQVLRL
670	680	690	700	710	720
RDNYLAFFKW	WSLHFLPKLE	VLDLAGNQLK	ALTNGSLPAG	TRLRRLDVSC	NSISFVAPGF
730	740	750	760	770	780
FSKAKELREL	NLSANALKTV	DHSWFGPLAS	ALQILDVSAN	PLHCACGAAF	MDFLLEVQAA
790	800	810	820	830	840
VPGLPSRVKC	GSPGQLQGLS	IFAQDLRLCL	DEALSWDCFA	LSLLAVALGL	GVPMLHHLCG
850	860	870	880	890	900
WDLWYCFHLC	LAWLPWRGRQ	SGRDEDALPY	DAFVVFDKTQ	SAVADWVYNE	LRGQLEECRG
910	920	930	940	950	960
RWALRLCLEE	RDWLPGKTLF	ENLWASVYGS	RKTLFVLAHT	DRVSGLLRAS	FLLAQQRLLE
970	980	990	1000	1010	1020
DRKDVVVLVI	LSPDGRRSRY	VRLRQRLCRQ	SVLLWPHQPS	GQRSFWAQLG	MALTRDNHHF
1030
YNRNFCQGPT	AE