AiPD: Autoinhibited Protein Database

Q9NR20

Gene name	DYRK4
Protein name	Dual specificity tyrosine-phosphorylation-regulated kinase 4
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8798
EC number	2.7.12.1: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-71 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-71 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

249-269 (Activation loop from InterPro)

Target domain	104-400 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9NR20

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9NR20-F1	Predicted				AlphaFoldDB

476 variants for Q9NR20

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA6396896 rs138016131	2	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	3	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs111557443 CA231811869	6	L>V		No	ClinGen Ensembl
rs148232276 CA6396898	12	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA383428809 rs148232276	12	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	13	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1176595000 CA383428816	13	F>V		No	ClinGen TOPMed gnomAD
rs967736764 CA231811888	15	P>H		No	ClinGen Ensembl
TCGA novel	16	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383428863 rs1408605523	19	T>I		No	ClinGen gnomAD
CA231811893 rs267603477	20	Q>*		No	ClinGen Ensembl
rs762336784 CA6396899	20	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs765959517 CA6396900	23	K>E		No	ClinGen ExAC TOPMed gnomAD
CA231811922 rs765959517	23	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs1591797443 CA383428885	23	K>T		No	ClinGen Ensembl
TCGA novel	26	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6396901 rs751155960	26	E>G		No	ClinGen ExAC gnomAD
rs1591797454 CA383428913	27	K>E		No	ClinGen Ensembl
CA231811940 rs959843048	27	K>R		No	ClinGen Ensembl
CA383428918 rs1377392991	28	S>T		No	ClinGen gnomAD
CA383428925 rs1389341569	29	P>A		No	ClinGen TOPMed
rs866936547 CA231811962	30	K>N		No	ClinGen Ensembl
rs1402081240 CA383428954	33	K>*		No	ClinGen TOPMed
CA6396903 rs535704578	34	V>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1331570834 CA383428968	35	T>A		No	ClinGen TOPMed
CA6396904 rs141198151	37	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs150726529 CA6396905	38	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA383429357 rs1211783562	40	E>D		No	ClinGen gnomAD
TCGA novel	41	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1468794645 CA383429371	42	L>Q		No	ClinGen gnomAD
CA383429368 rs2240763	42	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1255131704 CA383429386	43	K>N		No	ClinGen gnomAD
rs370590188 CA6396925	43	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA231813776 rs200597785	47	N>D		No	ClinGen Ensembl
rs750893511 CA6396926	47	N>K		No	ClinGen ExAC TOPMed gnomAD
rs201436897 CA231813779	47	N>T		No	ClinGen Ensembl
CA6396929 rs374489268	48	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6396928 rs780443245	48	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA383429459 rs1163489988	50	S>T		No	ClinGen gnomAD
rs55825154 CA6396932	54	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs911033284 CA231813857	55	S>N		No	ClinGen gnomAD
rs1270379910 CA383429523	59	G>C		No	ClinGen gnomAD
rs12306130 CA383429535	61	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs12306130 VAR_033900 CA6396936	61	A>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA6396937 rs774187466	61	A>V		No	ClinGen ExAC gnomAD
CA6396940 rs775111536	64	W>*		No	ClinGen ExAC TOPMed gnomAD
rs775111536 CA383429558	64	W>C		No	ClinGen ExAC TOPMed gnomAD
rs1242914379 CA383429574	67	G>R		No	ClinGen gnomAD
rs554288890 CA6396941	67	G>V		No	ClinGen 1000Genomes ExAC gnomAD
CA6396942 rs377694754	68	L>P		No	ClinGen ESP ExAC TOPMed
CA383429588 rs1356699258	69	E>A		No	ClinGen TOPMed
VAR_040465	70	A>S		No	UniProt
CA6396943 rs71579238	71	K>R		No	ClinGen ExAC TOPMed gnomAD
CA231813937 rs903523440	72	K>N		No	ClinGen gnomAD
rs766865898 CA6396945	74	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6396947 rs567542352	75	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA6396948 rs767760845	75	T>M		No	ClinGen ExAC TOPMed gnomAD
CA6396951 rs777871159	76	A>G		No	ClinGen ExAC gnomAD
CA383429629 rs756336354	76	A>P		No	ClinGen ExAC TOPMed gnomAD
CA6396950 rs756336354	76	A>T		No	ClinGen ExAC TOPMed gnomAD
rs555679721 CA6396952	83	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757042179 CA6396953	84	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs150048576 CA383429695	85	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs778888694 CA6396954	85	F>S		No	ClinGen ExAC gnomAD
rs1451950652 CA383429700	86	D>A		No	ClinGen gnomAD
rs771567729 CA6396956	87	D>G		No	ClinGen ExAC gnomAD
rs1002099396 CA231814065	89	H>R		No	ClinGen TOPMed
rs774917137 CA6396957	89	H>Y		No	ClinGen ExAC gnomAD
TCGA novel	90	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA231814072 rs371271508	90	G>S		No	ClinGen ESP TOPMed
CA6396958 rs746539217	93	L>M		No	ClinGen ExAC TOPMed gnomAD
CA383429750 rs1224321089	93	L>Q		No	ClinGen TOPMed
rs746486416 CA6396975 VAR_010721	95	V>I		No	ClinGen UniProt ExAC dbSNP gnomAD
CA6396977 rs776320698	97	H>P		No	ClinGen ExAC TOPMed gnomAD
rs776320698 CA6396978	97	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1165607611 CA383429783	97	H>Y		No	ClinGen gnomAD
CA383429804 rs1391941177	100	I>V		No	ClinGen gnomAD
CA6396979 rs375867790	103	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1368597301 CA383429826	103	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs981907009 CA231816585	104	Y>D		No	ClinGen Ensembl
CA6396980 rs774788027	105	E>G		No	ClinGen ExAC TOPMed gnomAD
rs772657205 CA6396982	106	V>F		No	ClinGen ExAC TOPMed gnomAD
rs772657205 CA6396983	106	V>I		No	ClinGen ExAC TOPMed gnomAD
CA383429847 rs1184397958	107	L>M		No	ClinGen TOPMed
rs1289223890 CA383429858	108	E>D		No	ClinGen gnomAD
CA231816633 rs867633350	108	E>K		No	ClinGen gnomAD
rs867633350 CA383429852	108	E>Q		No	ClinGen gnomAD
CA231816638 rs757177268	109	T>A		No	ClinGen Ensembl
rs1338802648 CA383429865	110	I>V		No	ClinGen TOPMed gnomAD
rs1240571226 CA383429871 CA383429872	111	G>R		No	ClinGen TOPMed gnomAD
rs1467464171 CA383429887	113	G>W		No	ClinGen gnomAD
CA383429908 rs1193317518	116	G>E		No	ClinGen TOPMed gnomAD
CA231816645 rs1018197341	117	Q>R		No	ClinGen TOPMed
rs1253249924 CA383429923	118	V>A		No	ClinGen gnomAD
CA383429929 rs1327677517	119	A>V		No	ClinGen TOPMed
CA383429931 rs1434508428	120	K>E		No	ClinGen gnomAD
TCGA novel	123	D>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6396987 rs761876793	123	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1372051549 CA383429974	125	K>N		No	ClinGen gnomAD
rs765460759 CA6396988	126	N>K		No	ClinGen ExAC TOPMed gnomAD
rs563856942 CA6396989	127	N>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	128	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA231816664 rs147920780	128	E>K		No	ClinGen Ensembl
rs1460742202 CA383430005	130	V>G		No	ClinGen gnomAD
rs142320223 CA6396990	130	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142320223 CA6396991	130	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6396992 rs751496925	131	A>T		No	ClinGen ExAC gnomAD
CA383430018 rs1372039331	133	K>*		No	ClinGen gnomAD
TCGA novel	133	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1388783788 CA383430025	134	I>V		No	ClinGen gnomAD
rs1293671112 CA383430031	135	I>L		No	ClinGen gnomAD
rs1228236428 CA383430068	139	K>N		No	ClinGen gnomAD
rs780631150 CA6396995	140	R>K		No	ClinGen ExAC gnomAD
rs780631150 CA6396994	140	R>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs772561161 CA6397016 CA6397017	140	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1392469916 CA383430093	142	H>Y		No	ClinGen TOPMed
rs747416114 CA383430108	144	Q>*		No	ClinGen ExAC gnomAD
rs747416114 CA6397018	144	Q>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA6397019 rs768998640	145	A>G		No	ClinGen ExAC gnomAD
CA383430115 rs1565539355	145	A>S		No	ClinGen Ensembl
rs1420589537 CA383430122	146	L>P		No	ClinGen gnomAD
TCGA novel	146	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs868709118 CA231817006	147	M>V		No	ClinGen Ensembl
CA231817016 rs267603479	148	E>K		No	ClinGen Ensembl
rs769914275 CA6397022	149	L>P		No	ClinGen ExAC gnomAD
CA383430140 rs748148722	149	L>V		No	ClinGen ExAC TOPMed gnomAD
CA383430166 rs1265866397	153	E>A		No	ClinGen TOPMed
TCGA novel	153	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs140472890 CA6397023	154	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1489137993 CA383430175	154	A>V		No	ClinGen TOPMed
rs1246958972 CA383430182	156	R>G		No	ClinGen TOPMed
rs766590751 CA6397026	158	K>R		No	ClinGen ExAC gnomAD
CA6397028 rs759395765	162	N>S		No	ClinGen ExAC gnomAD
CA6397029 rs370245586	163	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA383430244 rs1485096254	164	Y>C		No	ClinGen gnomAD
TCGA novel	167	V>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1210890054 CA383430273	168	H>R		No	ClinGen gnomAD
rs752719124 CA6397030	169	M>T		No	ClinGen ExAC TOPMed gnomAD
CA383430292 rs755664062	171	D>H		No	ClinGen ExAC TOPMed gnomAD
CA6397031 rs755664062	171	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1243893467 CA383430299	172	F>I		No	ClinGen gnomAD
rs1176436175 CA383430312	173	F>C		No	ClinGen gnomAD
rs1228866525 CA383430325	175	F>V		No	ClinGen TOPMed
CA6397032 rs763765045	176	R>C	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs763765045 CA383430332	176	R>G		No	ClinGen ExAC TOPMed gnomAD
rs753404187 CA6397033	176	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs753404187 CA383430333	176	R>L		No	ClinGen ExAC TOPMed gnomAD
CA6397034 rs756914513	177	N>H		No	ClinGen ExAC TOPMed gnomAD
CA383430338 rs1393433469	177	N>S		No	ClinGen gnomAD
rs756914513 CA383430335	177	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs778651816 CA6397035	178	H>R		No	ClinGen ExAC
rs747298388 CA6397036	180	C>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	181	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6397037 rs755413598	181	I>V		No	ClinGen ExAC gnomAD
CA6397038 rs56178846	182	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA6397039 rs56178846	182	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6397040 rs769863193	183	F>L		No	ClinGen ExAC gnomAD
rs1169688181 CA383430380	183	F>L		No	ClinGen TOPMed
CA6397041 rs773213017	184	E>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	185	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA231817203 rs916775083	187	G>A		No	ClinGen TOPMed gnomAD
CA6397065 rs778982049	189	N>D		No	ClinGen ExAC TOPMed gnomAD
VAR_010722 rs3741927 CA6397066	189	N>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs775366755 CA383430461	194	M>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs775366755 CA6397069	194	M>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	195	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6397070 rs760566947	198	N>S		No	ClinGen ExAC gnomAD
CA383430501 rs1406320822	199	F>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1406320822 CA383430500	199	F>S		No	ClinGen gnomAD
TCGA novel	199	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768672305 CA6397071	205	S>F		No	ClinGen ExAC gnomAD
rs1278236874 CA383430547	206	I>T		No	ClinGen gnomAD
rs377433879 CA6397072	206	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6397074 rs764856147	207	V>A		No	ClinGen ExAC TOPMed gnomAD
CA6397073 rs761381002	207	V>I		No	ClinGen ExAC gnomAD
rs750043434 CA6397075	208	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6397078 rs765964908	208	R>L		No	ClinGen ExAC TOPMed gnomAD
CA6397077 rs765964908	208	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs750043434 CA6397076	208	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs141110512 CA6397079	209	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs200170020 CA6397080	209	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1171923810 CA383430572	211	T>I		No	ClinGen TOPMed
CA383430569 rs1565540126	211	T>S		No	ClinGen Ensembl
CA383430580 rs1264041901	213	S>P		No	ClinGen gnomAD
CA383430589 rs1186515069	214	V>A		No	ClinGen gnomAD
CA6397084 rs757271050	217	C>R		No	ClinGen ExAC gnomAD
CA383430622 rs1473339254	219	Q>*		No	ClinGen gnomAD
rs1428204249 CA383430624	219	Q>R		No	ClinGen TOPMed
CA383430639 rs1165317100	221	L>F		No	ClinGen gnomAD
rs1405384430 CA383430640	221	L>H		No	ClinGen gnomAD
CA6397085 rs371159844	222	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA231819156 rs866568899	223	V>I		No	ClinGen Ensembl
TCGA novel	224	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	225	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6397087 rs772286301	230	D>N		No	ClinGen ExAC gnomAD
rs149277354 CA6397089	233	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs149277354 CA6397090	233	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA6397113 rs143480249	234	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA383430750 rs770478238	236	I>L		No	ClinGen ExAC gnomAD
CA383430753 rs1457603376	236	I>R		No	ClinGen TOPMed gnomAD
CA383430752 rs1457603376	236	I>T		No	ClinGen TOPMed gnomAD
CA6397114 rs770478238	236	I>V		No	ClinGen ExAC gnomAD
CA231819738 rs910864161	239	Y>C		No	ClinGen TOPMed gnomAD
CA6397116 rs563226547	240	Q>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6397117 rs563226547	240	Q>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6397118 rs777004256	240	Q>L		No	ClinGen ExAC gnomAD
TCGA novel	241	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1591803206 CA383430788	242	G>C		No	ClinGen Ensembl
CA383430789 rs1467116333	242	G>D		No	ClinGen gnomAD
rs1395619023 CA383430792	243	Q>K		No	ClinGen gnomAD
CA6397120 rs765742184	243	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	245	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750939044 CA6397121	245	S>T		No	ClinGen ExAC TOPMed gnomAD
CA383430810 rs1448123807	246	V>I		No	ClinGen gnomAD
CA6397125 rs147140039	254	S>G		No	ClinGen ESP ExAC gnomAD
CA6397126 rs781591353	255	C>R		No	ClinGen ExAC gnomAD
TCGA novel	258	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383430916 rs1406316200	258	H>R		No	ClinGen TOPMed
CA383430910 rs1400318361	258	H>Y		No	ClinGen TOPMed
CA6397129 rs777746913	259	Q>*		No	ClinGen ExAC gnomAD
rs777746913 CA383430925	259	Q>E		No	ClinGen ExAC gnomAD
rs1261902133	261	V>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs749243941 CA6397130	261	V>L		No	ClinGen ExAC TOPMed gnomAD
rs553202084 CA6397153	262	Y>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs778852958 CA6397152	262	Y>F		No	ClinGen ExAC gnomAD
rs866008182 CA231823610	262	Y>H		No	ClinGen TOPMed
rs866008182 CA383431880	262	Y>N		No	ClinGen TOPMed
CA6397154 rs573116023	263	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs370360080 CA383431892	263	T>K		No	ClinGen ESP ExAC gnomAD
rs370360080 CA383431894	263	T>M		No	ClinGen ESP ExAC gnomAD
rs370360080 CA6397155	263	T>R		No	ClinGen ESP ExAC gnomAD
CA383431902 rs1193329710	264	Y>S		No	ClinGen TOPMed gnomAD
rs201060830 CA6397156	265	I>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773388116 CA6397158	265	I>T		No	ClinGen ExAC gnomAD
CA6397157 rs201060830	265	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs920336107 CA231823668	266	Q>H		No	ClinGen Ensembl
CA383431926 rs1167510678	266	Q>R		No	ClinGen TOPMed
rs763436728 CA6397159	267	S>C		No	ClinGen ExAC TOPMed gnomAD
CA6397160 rs771528443	268	R>L		No	ClinGen ExAC TOPMed gnomAD
rs771528443 CA383431948	268	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA383431947 rs1413797034	268	R>W		No	ClinGen TOPMed
CA6397162 rs759669084	270	Y>S		No	ClinGen ExAC gnomAD
rs752961920 CA6397165	271	R>*		No	ClinGen ExAC TOPMed gnomAD
rs752961920 CA6397164	271	R>G		No	ClinGen ExAC TOPMed gnomAD
CA6397166 rs764391501	271	R>Q		No	ClinGen ExAC gnomAD
rs1197045321 CA383431987	272	S>P		No	ClinGen gnomAD
rs561851186 CA6397168	272	S>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA383432002 rs1263675812	273	P>S		No	ClinGen TOPMed
rs757083454 CA6397169	275	V>M		No	ClinGen ExAC gnomAD
TCGA novel	276	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6397172 rs757896950	277	L>R		No	ClinGen ExAC TOPMed gnomAD
rs746538872 CA383432069	279	H>D		No	ClinGen ExAC TOPMed gnomAD
rs746538872 CA383432067	279	H>N		No	ClinGen ExAC TOPMed gnomAD
CA6397175 rs370279595	279	H>Q		No	ClinGen ExAC gnomAD
CA6397174 rs746538872	279	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA383432082 rs1258067852	280	P>S		No	ClinGen gnomAD
rs749641359 CA6397177	281	Y>*		No	ClinGen ExAC gnomAD
CA383432096 rs1157151205	281	Y>C		No	ClinGen gnomAD
CA6397176 rs780934024	281	Y>H		No	ClinGen ExAC gnomAD
CA6397180 rs760188932	283	V>A		No	ClinGen ExAC gnomAD
rs774986463 CA6397179	283	V>L		No	ClinGen ExAC gnomAD
rs1321437057 CA383432127	284	A>T		No	ClinGen TOPMed
rs1357474902 CA383432141	285	I>V		No	ClinGen gnomAD
CA231823846 CA383432172 rs1047374411	287	M>I		No	ClinGen gnomAD
CA6397182 rs775374814	287	M>L		No	ClinGen ExAC gnomAD
rs775374814 CA6397183	287	M>V		No	ClinGen ExAC gnomAD
CA6397184 rs371520861	288	W>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA383432184 rs1295806315	288	W>L		No	ClinGen TOPMed
rs1308096867 CA383432193	289	S>G		No	ClinGen gnomAD
rs754106376 CA383432197	289	S>N		No	ClinGen ExAC gnomAD
CA383432191 rs1308096867	289	S>R		No	ClinGen gnomAD
rs754106376 CA6397185	289	S>T		No	ClinGen ExAC gnomAD
rs373007519 CA231823880	291	G>R		No	ClinGen ESP TOPMed
CA6397186 rs377369723	292	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA383432265 rs1447101371	295	A>G		No	ClinGen TOPMed
CA383432267 rs1210797005	296	E>K		No	ClinGen gnomAD
rs750221184 CA6397188	298	Y>D		No	ClinGen ExAC gnomAD
rs750221184 CA231823904	298	Y>H		No	ClinGen ExAC gnomAD
CA383432314 rs1432454099	300	G>R		No	ClinGen TOPMed
rs1565542001 CA383432329	301	Y>C		No	ClinGen Ensembl
rs758208345 CA6397190	302	P>S		No	ClinGen ExAC gnomAD
CA6397192 rs575268141	304	F>L		No	ClinGen 1000Genomes ExAC gnomAD
rs150673847 CA6397193	305	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs900639812 CA231823972	306	G>R		No	ClinGen TOPMed
CA6397196 rs757693098	307	E>D		No	ClinGen ExAC
rs1232724867 CA383432394	307	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1464414228 CA383432407	308	N>D		No	ClinGen gnomAD
CA383432446 rs779355419	311	E>*		No	ClinGen ExAC TOPMed gnomAD
rs779355419 CA6397197	311	E>K		No	ClinGen ExAC TOPMed gnomAD
CA383432443 rs779355419	311	E>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	312	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746248271 CA6397198	312	Q>H		No	ClinGen ExAC gnomAD
CA383432474 rs1227301074	313	L>R		No	ClinGen gnomAD
CA383432495 rs1448596213	315	C>Y		No	ClinGen gnomAD
CA6397199 rs200900846	317	M>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1565542962 CA383433389	319	V>M		No	ClinGen Ensembl
CA6397222 rs769960503	320	L>V		No	ClinGen ExAC gnomAD
rs201862244 CA383433454	322	L>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201862244 CA6397223	322	L>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs766256962 CA6397225	323	P>L		No	ClinGen ExAC TOPMed gnomAD
rs759452878 CA6397227	324	P>L		No	ClinGen ExAC gnomAD
rs139849675 CA6397228	325	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs760294743 CA6397230	326	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6397232 rs201010702	327	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1454871252 CA383433590	328	I>M		No	ClinGen TOPMed
CA383433615 rs1380546799	329	Q>R		No	ClinGen TOPMed
rs758684611 CA6397234	332	S>F		No	ClinGen ExAC
rs992611095 CA383433703	333	R>K		No	ClinGen TOPMed
CA231826537 rs992611095	333	R>T		No	ClinGen TOPMed
rs752737393 CA231826545	334	R>K		No	ClinGen Ensembl
rs751880189 CA6397236	338	F>V		No	ClinGen ExAC gnomAD
rs1205918764 CA383422660	341	K>T		No	ClinGen gnomAD
rs1438742386 CA383422676	342	G>D		No	ClinGen gnomAD
CA383422668 rs1236014703	342	G>S		No	ClinGen TOPMed gnomAD
rs1178840162 CA383422708	344	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1591809793 CA383422766	347	I>T		No	ClinGen Ensembl
rs1476752804 CA383422790	348	T>S		No	ClinGen gnomAD
rs768727442 CA6397270	349	N>D		No	ClinGen ExAC gnomAD
rs373652947 CA6397271	349	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1565543968 CA383422830	351	R>G		No	ClinGen Ensembl
TCGA novel	351	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs543567366 CA6397274	352	G>E		No	ClinGen 1000Genomes ExAC gnomAD
rs1446398559 CA383422978	353	K>E		No	ClinGen gnomAD
rs200164942 CA6397277	353	K>R		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	354	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768937539	355	R>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA383423012 rs1231093500	355	R>K		No	ClinGen gnomAD
rs768937539	355	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs968326572 CA231786851	356	Y>N		No	ClinGen TOPMed
rs759883221 CA6397279	357	P>A		No	ClinGen ExAC gnomAD
CA231786856 rs965297175	358	D>H		No	ClinGen TOPMed
CA383423067 rs1225858001	359	S>F		No	ClinGen gnomAD
CA6397282 rs756556537	360	K>R		No	ClinGen ExAC gnomAD
CA231786869 rs975670498	361	D>G		No	ClinGen gnomAD
CA6397283 rs377022681	362	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA6397284 rs753917453	362	L>P		No	ClinGen ExAC gnomAD
rs757322889 CA6397286	363	T>M		No	ClinGen ExAC gnomAD
rs757322889 CA6397285	363	T>R		No	ClinGen ExAC gnomAD
CA383423136 rs370312719 CA231786898	364	M>I		No	ClinGen ESP TOPMed gnomAD
CA6397289 rs779937110	364	M>V		No	ClinGen ExAC gnomAD
CA383423140 rs144235733	365	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs144235733 CA6397290	365	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA6397292 rs202082140	368	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6397294 rs182164909	369	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs762146419 CA6397293	370	D>V		No	ClinGen ESP ExAC
CA231786919 rs779385374	371	T>I		No	ClinGen ExAC gnomAD
CA6397295 rs779385374	371	T>N		No	ClinGen ExAC gnomAD
CA383423231 rs1170210530	372	S>G		No	ClinGen gnomAD
rs1591809904 CA383423247	373	F>L		No	ClinGen Ensembl
CA383423276 rs1225949153	375	D>V		No	ClinGen gnomAD
CA6397296 rs772850145	375	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs748797716 CA231786936	376	F>S		No	ClinGen TOPMed
rs1390587827 CA383423300	377	L>F		No	ClinGen gnomAD
rs1317686040 CA383423328	379	R>K		No	ClinGen gnomAD
rs200748194 CA231786949	380	C>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200748194 CA6397298	380	C>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs775784384 CA6397299	380	C>Y		No	ClinGen ExAC gnomAD
TCGA novel	381	L>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761058659 CA383423364	382	V>I		No	ClinGen ExAC TOPMed gnomAD
CA6397300 rs761058659	382	V>L		No	ClinGen ExAC TOPMed gnomAD
rs189959614 CA6397319	383	W>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
TCGA novel	386	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201628488 CA6397320	388	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6397321 rs199775562	388	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6397322 rs777057114	389	M>I		No	ClinGen ExAC gnomAD
CA383424693 rs1488601771	391	P>A		No	ClinGen gnomAD
CA6397323 rs372119957	391	P>L	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA383424736 rs1187110039	392	D>G		No	ClinGen gnomAD
rs1423021798 CA383424727	392	D>Y		No	ClinGen gnomAD
rs1309092786 CA383424822	396	K>R		No	ClinGen TOPMed
CA6397326 rs201883485	397	H>N		No	ClinGen ExAC TOPMed gnomAD
rs1359945884 CA383424953	402	Q>*		No	ClinGen gnomAD
rs1454807225 CA383424968	402	Q>H		No	ClinGen gnomAD
CA383424963 rs1210967438	402	Q>R		No	ClinGen TOPMed gnomAD
CA383424974 rs1291129675	403	S>A		No	ClinGen TOPMed gnomAD
CA6397328 rs751885774	404	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs374813443 CA6397327	404	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs780786523 CA6397330	410	P>L		No	ClinGen ExAC gnomAD
CA6397331 rs780786523	410	P>R		No	ClinGen ExAC gnomAD
CA383425166 rs1353786560	412	P>S		No	ClinGen gnomAD
TCGA novel	413	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1217952203 CA383425187	413	Q>R		No	ClinGen gnomAD
CA383425205 rs1182695267	414	T>N		No	ClinGen TOPMed
TCGA novel	415	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775563511 CA231788039	415	L>P		No	ClinGen TOPMed gnomAD
rs35113975 CA383425217	415	L>V		No	ClinGen ExAC gnomAD
rs770480005 CA6397336	416	R>K		No	ClinGen ExAC gnomAD
CA383425267 rs1253767911	418	S>Y		No	ClinGen TOPMed
rs1483502062 CA383425316	421	F>L		No	ClinGen TOPMed
rs1446715134 CA383425372	423	P>L		No	ClinGen gnomAD
rs1176977845 CA383425411	425	E>D		No	ClinGen gnomAD
rs11554758 CA231788057	425	E>Q		No	ClinGen Ensembl
CA231788066 rs1052965741	427	R>G		No	ClinGen TOPMed
rs891585142 CA231788069	427	R>M		No	ClinGen TOPMed
rs1161933948 CA383425470	429	D>H		No	ClinGen gnomAD
CA6397333 rs1565544821	431	V>D		No	ClinGen Ensembl
CA6397340 rs535517489	432	Q>*		No	ClinGen 1000Genomes ExAC gnomAD
CA6397342 rs776812376	434	C>R		No	ClinGen ExAC gnomAD
CA383425527 rs1233105292	437	S>A		No	ClinGen TOPMed
CA6397343 rs141423818	437	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs141423818 CA6397344	437	S>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs763109309 CA6397346	438	S>N		No	ClinGen ExAC gnomAD
CA383425538 rs766629556	439	R>*		No	ClinGen ExAC gnomAD
rs766629556 CA6397347	439	R>G		No	ClinGen ExAC gnomAD
CA383425539 rs1373431711	439	R>K		No	ClinGen gnomAD
CA231788091 rs766629129	441	A>P		No	ClinGen Ensembl
TCGA novel	441	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6397370 rs545558326	442	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs763944754 CA6397373	445	T>I		No	ClinGen ExAC TOPMed gnomAD
rs763944754 CA383425595	445	T>N		No	ClinGen ExAC TOPMed gnomAD
CA6397374 rs753642121	447	E>G		No	ClinGen ExAC TOPMed
rs753642121 CA383425609	447	E>V		No	ClinGen ExAC TOPMed
CA383425628 rs1270602776	450	E>G		No	ClinGen gnomAD
VAR_014948 CA6397376 rs1801016	454	D>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs749869548 CA6397377	457	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA383425679 rs749869548	457	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1169986712 CA383425682	458	K>E		No	ClinGen TOPMed
CA6397379 rs547789452	460	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA383425703 rs1193543221	461	Q>*		No	ClinGen gnomAD
CA231788415 rs770701789	462	H>Y		No	ClinGen TOPMed gnomAD
rs746739303 CA6397380	463	S>*		No	ClinGen ExAC TOPMed gnomAD
CA6397381 rs754680021	464	G>C		No	ClinGen ExAC TOPMed gnomAD
rs1412547175 CA383425735	466	Q>E		No	ClinGen gnomAD
CA6397382 rs778228796	466	Q>R		No	ClinGen ExAC gnomAD
CA383425745 rs1565545232	467	Q>R		No	ClinGen Ensembl
CA231788440 rs937148792	468	D>Y		No	ClinGen TOPMed
rs749696146 CA6397384	469	C>S		No	ClinGen ExAC TOPMed gnomAD
rs749696146 CA6397383	469	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs762165041 CA6397385	470	L>H		No	ClinGen ExAC TOPMed gnomAD
rs762165041 CA6397386	470	L>R		No	ClinGen ExAC TOPMed gnomAD
CA6397387 rs765652115	471	Q>R		No	ClinGen ExAC gnomAD
CA383425779 rs369962777	472	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1311712231 CA383425784	473	G>A		No	ClinGen TOPMed
rs760827391 CA6397389	473	G>R	Variant assessed as Somatic; 0.001017 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1382256542 CA383425793	475	D>H		No	ClinGen gnomAD
rs373008691 CA231788456	476	T>I		No	ClinGen ESP TOPMed
rs1317308515 CA383425807	477	V>F		No	ClinGen TOPMed gnomAD
rs1205126918 CA383425832	481	Q>*		No	ClinGen gnomAD
CA231788462 rs113141119	483	V>A		No	ClinGen TOPMed gnomAD
CA6397392 rs761636641	485	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs765058701 CA6397394	486	P>S		No	ClinGen ExAC TOPMed gnomAD
CA6397393 rs765058701	486	P>T		No	ClinGen ExAC TOPMed gnomAD
rs757838690 CA6397395	487	K>E		No	ClinGen ExAC TOPMed gnomAD
CA231788490 rs1005525503	487	K>N		No	ClinGen Ensembl
rs765844679 CA6397396	487	K>R		No	ClinGen ExAC TOPMed gnomAD
rs369127483 CA6397397	488	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1369954172 CA383425903	488	K>R		No	ClinGen gnomAD
rs199555716 CA6397398	489	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	491	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383426005 rs1159090043	492	A>V		No	ClinGen gnomAD
CA383426028 rs1410013691	493	V>G		No	ClinGen gnomAD
rs781027073 CA6397399	494	G>R		No	ClinGen ExAC TOPMed gnomAD
CA6397401 rs568761673	494	G>V		No	ClinGen 1000Genomes ExAC
CA383426064 rs757689952	495	A>G		No	ClinGen ExAC TOPMed gnomAD
rs757689952 CA6397402	495	A>V		No	ClinGen ExAC TOPMed gnomAD
CA383426084 rs1591812248	496	E>G		No	ClinGen Ensembl
CA383426108 rs1591812253	497	V>G		No	ClinGen Ensembl
rs537540413 CA6397404	499	M>V		No	ClinGen 1000Genomes ExAC gnomAD
CA383426170 rs1374770756	500	T>I		No	ClinGen gnomAD
CA231788517 rs759186486	501	S>F		No	ClinGen gnomAD
rs759186486 CA383426186	501	S>Y		No	ClinGen gnomAD
CA383426205 rs1321512576	502	P>L		No	ClinGen gnomAD
CA6397406 rs551096769	503	G>R		No	ClinGen 1000Genomes ExAC gnomAD
rs747121514 CA6397407	505	S>G		No	ClinGen ExAC gnomAD
rs768834407 CA6397408	505	S>N		No	ClinGen ExAC gnomAD
rs376587934 CA6397409	506	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA383426380 rs1436748893	511	K>N		No	ClinGen gnomAD
CA6397410 rs761579374	511	K>R		No	ClinGen ExAC gnomAD
CA6397413 rs570890165	515	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA383426507 rs1034092114	517	P>H		No	ClinGen TOPMed gnomAD
rs1034092114 CA231788539	517	P>L		No	ClinGen TOPMed gnomAD
rs1175597883 CA383426502	517	P>S		No	ClinGen gnomAD
CA383426522 rs1470795094	518	P>A		No	ClinGen gnomAD
CA383426546 rs370396256	519	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs370396256 CA6397414	519	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1398316561 CA383426596	521	V>C		No	ClinGen gnomAD

No associated diseases with Q9NR20

3 regional properties for Q9NR20

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	104 - 400	IPR000719
active_site	Serine/threonine-protein kinase, active site	226 - 238	IPR008271
binding_site	Protein kinase, ATP binding site	110 - 133	IPR017441

Functions

		Description
EC Number	2.7.12.1	Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization	[Isoform 1]: Cytoplasm ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding	Binding to a metal ion.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

2 GO annotations of biological process

Name	Definition
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.

10 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (Human)	PR
Q9H422	HIPK3	Homeodomain-interacting protein kinase 3	Homo sapiens (Human)	SS
Q8NE63	HIPK4	Homeodomain-interacting protein kinase 4	Homo sapiens (Human)	PR
Q9H2X6	HIPK2	Homeodomain-interacting protein kinase 2	Homo sapiens (Human)	EV
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (Human)	PR
Q3V016	Hipk4	Homeodomain-interacting protein kinase 4	Mus musculus (Mouse)	PR
Q61214	Dyrk1a	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Mus musculus (Mouse)	PR
Q9QZR5	Hipk2	Homeodomain-interacting protein kinase 2	Mus musculus (Mouse)	SS
Q8BI55	Dyrk4	Dual specificity tyrosine-phosphorylation-regulated kinase 4	Mus musculus (Mouse)	PR
Q4V793	Hipk4	Homeodomain-interacting protein kinase 4	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MPASELKASE	IPFHPSIKTQ	DPKAEEKSPK	KQKVTLTAAE	ALKLFKNQLS	PYEQSEILGY
70	80	90	100	110	120
AELWFLGLEA	KKLDTAPEKF	SKTSFDDEHG	FYLKVLHDHI	AYRYEVLETI	GKGSFGQVAK
130	140	150	160	170	180
CLDHKNNELV	ALKIIRNKKR	FHQQALMELK	ILEALRKKDK	DNTYNVVHMK	DFFYFRNHFC
190	200	210	220	230	240
ITFELLGINL	YELMKNNNFQ	GFSLSIVRRF	TLSVLKCLQM	LSVEKIIHCD	LKPENIVLYQ
250	260	270	280	290	300
KGQASVKVID	FGSSCYEHQK	VYTYIQSRFY	RSPEVILGHP	YDVAIDMWSL	GCITAELYTG
310	320	330	340	350	360
YPLFPGENEV	EQLACIMEVL	GLPPAGFIQT	ASRRQTFFDS	KGFPKNITNN	RGKKRYPDSK
370	380	390	400	410	420
DLTMVLKTYD	TSFLDFLRRC	LVWEPSLRMT	PDQALKHAWI	HQSRNLKPQP	RPQTLRKSNS
430	440	450	460	470	480
FFPSETRKDK	VQGCHHSSRK	ADEITKETTE	KTKDSPTKHV	QHSGDQQDCL	QHGADTVQLP
490	500	510
QLVDAPKKSE	AAVGAEVSMT	SPGQSKNFSL	KNTNVLPPIV