AiPD: Autoinhibited Protein Database

Q9NQU5

Gene name	PAK6 (PAK5)
Protein name	Serine/threonine-protein kinase PAK 6
Names	PAK-5, p21-activated kinase 6, PAK-6
Species	Homo sapiens (Human)
KEGG Pathway	hsa:56924
EC number
Protein Class	SERINE/THREONINE-PROTEIN KINASE TAO (PTHR48015)

Descriptions

The p21-activated protein kinases5 (PAK5) belongs to group II PAK family and is involved in actin cytoskeleton regulation, cell growth, migration and survival, and so on. Group II PAKs (PAK4, 5, and 6) harbor well-conserved pseudosubstrate sequences. For PAK4, the N-terminal inhibitory segment contains two pseudopeptide sequences (FTGLPR at 32th and RPKPLV at 49th) that bind to the active site of the kinase domain as a pseudosubstrate. Like PAK4, PAK6 catalytic activity is inhibited by a peptide corresponding to its N-terminal pseudosubstrate (RRPKPVVDP at 49th).
PAKs are activated by the binding of GTP-loaded Cdc42 (or Rac) to the CRIB domain, which disrupts the dimer and unfolds autoinhibitory region. After releasing autoinhibitory region, kinase domain is then autophosphorylated for full activation.

Autoinhibitory domains (AIDs)

Target domain	407-658 (Protein kinase domain)
Relief mechanism	Partner binding
Assay	Peptide inhibitor test, Structural analysis

AID

49-55 (Inhibitory segment)

Target domain

407-658 (Protein kinase domain)

Relief mechanism

Partner binding (Binding of Cdc42 or Rac1 to CRIB domain)

Assay

Peptide inhibitor test, Structural analysis

Accessory elements

543-566 (Activation loop from InterPro)

Target domain	385-681 (Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100

Ching YP et al. (2003) "Identification of an autoinhibitory domain of p21-activated protein kinase 5", The Journal of biological chemistry, 278, 33621-4

Bautista L et al. (2020) "p21-Activated Kinases in Thyroid Cancer", Endocrinology, 161,

Ha BH et al. (2012) "Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate", Proceedings of the National Academy of Sciences of the United States of America, 109, 16107-12

Chong C et al. (2001) "The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity", The Journal of biological chemistry, 276, 17347-53

Wang J et al. (2011) "Structural insights into the autoactivation mechanism of p21-activated protein kinase", Structure (London, England : 1993), 19, 1752-61

Lei M et al. (2000) "Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch", Cell, 102, 387-97

Totaro A et al. (2007) "Identification of an intramolecular interaction important for the regulation of GIT1 functions", Molecular biology of the cell, 18, 5124-38

Rousseau V et al. (2003) "A new constitutively active brain PAK3 isoform displays modified specificities toward Rac and Cdc42 GTPases", The Journal of biological chemistry, 278, 3912-20

Dan C et al. (2002) "PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells", Molecular and cellular biology, 22, 567-77

Kaur R et al. (2005) "Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase", The Journal of biological chemistry, 280, 3323-30

Gao J et al. (2013) "Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6", PloS one, 8, e77818

Autoinhibited structure

Activated structure

7 structures for Q9NQU5

Entry ID	Method	Resolution	Chain	Position	Source
2C30	X-ray	160 A	A	383-681	PDB
2ODB	X-ray	240 A	B	11-45	PDB
4KS7	X-ray	140 A	A	385-674	PDB
4KS8	X-ray	195 A	A	385-674	PDB
6QDR	X-ray	161 A	B	94-104	PDB
6QDS	X-ray	172 A	B	94-104	PDB
AF-Q9NQU5-F1	Predicted				AlphaFoldDB

627 variants for Q9NQU5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA391703662 RCV000678673 rs1407997977	619	P>T	Keratoconus [ClinVar]	Yes	ClinGen ClinVar dbSNP gnomAD
rs1370253658 CA391696783	3	R>C		No	ClinGen gnomAD
VAR_035631 rs201346085 COSM32838 CA7476388	3	R>H	large_intestine a colorectal cancer sample; somatic mutation [Cosmic, UniProt]	No	ClinGen cosmic curated UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
CA391696787 rs201346085	3	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7476389 rs776347957	9	R>C		No	ClinGen ExAC gnomAD
rs61733786 CA7476390	9	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs61733786 CA391696831	9	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs750664475 CA7476392	13	S>L		No	ClinGen ExAC gnomAD
CA268800745 rs760311307	14	A>P		No	ClinGen TOPMed gnomAD
rs11544039 CA7476393 COSM3769579	14	A>V	pancreas [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs879175191 CA268800817	17	N>Y		No	ClinGen Ensembl
CA7476397 rs781765489	18	F>L		No	ClinGen ExAC gnomAD
CA268800821 rs915549436	19	Q>H		No	ClinGen TOPMed
CA391696894 rs1485889183	19	Q>R		No	ClinGen gnomAD
CA7476398 rs748484001	21	R>C		No	ClinGen ExAC TOPMed gnomAD
CA391696906 rs748484001	21	R>G		No	ClinGen ExAC TOPMed gnomAD
rs547614545 CA7476399	21	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7476402 rs149132419	27	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs774916409 CA7476403	28	P>S		No	ClinGen ExAC gnomAD
TCGA novel	29	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs539480299 CA268800871	30	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA268800872 rs897183037	30	E>D		No	ClinGen TOPMed
CA7476404 rs539480299	30	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1396011915 CA391696986	33	F>S		No	ClinGen gnomAD
rs1465862364 CA391696992	34	V>L		No	ClinGen gnomAD
rs1462729610 CA391697013	37	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA391697008 rs1383390192	37	P>S		No	ClinGen gnomAD
rs372639063 CA7476407	38	P>A		No	ClinGen ESP ExAC TOPMed
CA7476409 rs142256590	38	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7476410 rs142256590	38	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7476408 rs142256590	38	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1363864584 CA391697018	39	Q>*		No	ClinGen TOPMed gnomAD
rs1360936135 CA391697019	39	Q>R		No	ClinGen TOPMed
rs1029959783 CA268800898	41	Q>E		No	ClinGen TOPMed
rs1566852642 CA391697046	42	N>K		No	ClinGen Ensembl
rs766638892 CA7476412	46	T>P		No	ClinGen ExAC gnomAD
rs753610524 CA7476414	48	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs369235955 CA7476413	48	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs753304529 CA7476416	49	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs756513847 CA7476417	49	R>H		No	ClinGen ExAC TOPMed gnomAD
CA7476419 rs750072898	50	P>H		No	ClinGen ExAC gnomAD
rs1432956864 CA391697093	51	K>T		No	ClinGen gnomAD
COSM109372 rs146905959 CA268800955	52	P>L	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs371738802 CA7476422	53	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs371738802 CA7476421	53	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA7476424 rs781079784	54	V>E		No	ClinGen ExAC gnomAD
rs147960311 CA7476423	54	V>M		No	ClinGen ESP ExAC gnomAD
TCGA novel	56	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7476425 rs748152028	56	P>S		No	ClinGen ExAC gnomAD
CA7476426 rs768438138	57	S>L	Variant assessed as Somatic; 0.0003696 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7476428 rs762812600	58	R>*		No	ClinGen ExAC TOPMed gnomAD
CA7476429 rs771018312 COSM1219146	58	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA391697145 rs780868410	61	R>G		No	ClinGen ExAC TOPMed gnomAD
rs376432897 CA268801007	61	R>Q		No	ClinGen TOPMed gnomAD
rs780868410 CA7476430	61	R>W		No	ClinGen ExAC TOPMed gnomAD
CA7476431 rs759664815	63	Q>R		No	ClinGen ExAC gnomAD
rs372069647 CA268801018 CA391697187	67	M>I		No	ClinGen Ensembl
rs753249143 CA7476433	67	M>V		No	ClinGen ExAC TOPMed gnomAD
CA391697213 rs1222392199	69	T>I		No	ClinGen TOPMed gnomAD
CA268801928 rs964388909	70	V>M		No	ClinGen TOPMed
CA7476456 rs762056961	72	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs777247289 CA7476455	72	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs751201488 CA391697242	75	A>P		No	ClinGen ExAC TOPMed gnomAD
rs751201488 CA7476458	75	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1162257290 COSM241039 CA391697245	75	A>V	large_intestine prostate [Cosmic]	No	ClinGen cosmic curated gnomAD
rs752111070 CA7476461	76	M>I		No	ClinGen ExAC gnomAD
rs2412504 CA7476460 VAR_019993	76	M>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA268801978 rs751561716	77	P>L		No	ClinGen TOPMed gnomAD
rs777548160 CA7476463	80	G>S		No	ClinGen ExAC gnomAD
rs949588571 CA268802024	82	I>V		No	ClinGen TOPMed gnomAD
rs562965278 CA391697295	83	S>*		No	ClinGen ExAC TOPMed gnomAD
rs562965278 CA7476464	83	S>L		No	ClinGen ExAC TOPMed gnomAD
rs778905710 CA7476467	84	G>A		No	ClinGen ExAC gnomAD
rs778905710 CA7476466	84	G>V		No	ClinGen ExAC gnomAD
CA391697308 rs1211358122	86	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs138470960 CA391697318	87	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs775883867 CA391697320	88	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7476469 rs775883867	88	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs768822725 CA7476471	90	Q>R		No	ClinGen ExAC gnomAD
CA391697352 rs1426833506	92	L>S		No	ClinGen TOPMed
CA7476473 rs546721230	94	V>L		No	ClinGen ExAC gnomAD
rs1388022893 CA391697375	96	S>G		No	ClinGen gnomAD
rs1595592690 CA391697396	99	T>P		No	ClinGen Ensembl
rs765747411 CA7476475	101	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs763340659 CA7476476	101	R>H		No	ClinGen ExAC gnomAD
CA7476474 rs765747411	101	R>S		No	ClinGen ExAC TOPMed gnomAD
rs36081263 VAR_051655 CA7476477	103	R>C		No	ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD
CA7476478 rs752441056	103	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs752441056 CA391697419	103	R>L		No	ClinGen ExAC TOPMed gnomAD
CA7476479 rs755547814	106	T>P		No	ClinGen ExAC gnomAD
rs993162567 CA268802116	106	T>S		No	ClinGen TOPMed
rs1482620196 CA391697439	107	S>G		No	ClinGen TOPMed
rs778995699 CA7476483	108	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs137969148 CA7476482	108	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs375852612 CA268802164	109	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs758320541 CA7476485	109	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs375852612 CA7476484	109	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA7476487 rs149461942	110	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs576083093 CA7476486	110	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7476488 rs768608561	111	A>T		No	ClinGen ExAC TOPMed gnomAD
CA7476489 rs781276189	112	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA7476490 rs781276189	112	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs770247462 CA7476491	113	S>P		No	ClinGen ExAC gnomAD
CA268802217 rs891324777	114	L>P		No	ClinGen TOPMed gnomAD
rs1161302230 CA391697488	117	L>P		No	ClinGen gnomAD
CA391697485 rs1283380102	117	L>V		No	ClinGen gnomAD
rs773732686 CA7476492	118	G>E		No	ClinGen ExAC gnomAD
CA391697494 rs773732686	118	G>V		No	ClinGen ExAC gnomAD
rs370496102 CA268802238	119	D>N		No	ClinGen Ensembl
CA7476494 rs578125124	119	D>V		No	ClinGen ExAC gnomAD
CA7476495 rs555418845	120	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA268802273 rs1009036281	122	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA7476496 rs760433390	122	W>C		No	ClinGen ExAC TOPMed gnomAD
CA7476497 rs202073596	125	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	127	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1329227512 CA391697560	128	M>R		No	ClinGen gnomAD
CA268802364 rs868398637	128	M>V		No	ClinGen Ensembl
CA391697564 rs1472249285	129	Y>N		No	ClinGen TOPMed
rs1429885154 CA391697568	129	Y>S		No	ClinGen TOPMed
rs761436778 CA7476499	132	S>G		No	ClinGen ExAC TOPMed gnomAD
rs375526083 CA268802378	132	S>R		No	ClinGen ESP TOPMed gnomAD
rs765214803 CA7476500	133	P>L		No	ClinGen ExAC gnomAD
rs750429926 CA7476501	134	Q>*		No	ClinGen ExAC gnomAD
rs373050572 CA268802396	134	Q>L		No	ClinGen Ensembl
CA7476503 rs779962106	137	R>C		No	ClinGen ExAC TOPMed gnomAD
rs751329273 CA7476504	137	R>H		No	ClinGen ExAC TOPMed gnomAD
rs751329273 CA7476505	137	R>L		No	ClinGen ExAC TOPMed gnomAD
CA391697623 rs748178787	138	T>I		No	ClinGen ExAC gnomAD
CA7476506 rs781300780	138	T>P		No	ClinGen ExAC TOPMed gnomAD
CA7476507 rs748178787	138	T>S		No	ClinGen ExAC gnomAD
CA391697626 rs749858992	139	D>A		No	ClinGen ExAC
rs376277766 CA268802500	139	D>E		No	ClinGen ExAC gnomAD
CA7476510 rs749858992	139	D>G		No	ClinGen ExAC
CA7476509 rs778221199	139	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1323151746 CA391697633	140	P>L		No	ClinGen gnomAD
CA391697629 rs1329139382	140	P>S		No	ClinGen TOPMed
rs1329641636 CA391697635	141	H>N		No	ClinGen gnomAD
rs201017672 CA391697643	142	G>R		No	ClinGen ExAC TOPMed gnomAD
rs201017672 CA7476514	142	G>S		No	ClinGen ExAC TOPMed gnomAD
CA391697650 rs1329656142	143	L>F		No	ClinGen TOPMed
CA391697671 rs1227210160	146	S>N		No	ClinGen gnomAD
CA7476515 rs768311750	147	C>R		No	ClinGen ExAC gnomAD
rs369750707 CA7476518	148	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs373280531 CA7476519 CA391697690	149	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs951923899 CA268802569	150	G>D		No	ClinGen gnomAD
rs762930141 CA7476520	150	G>S		No	ClinGen ExAC gnomAD
rs35593179 VAR_051656 CA7476522	151	T>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs754753286 CA7476523	152	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs141846316 CA391697726	155	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1370204392 CA391697724	155	H>R		No	ClinGen gnomAD
CA7476525 rs370397655	155	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs756180270 CA7476527	156	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1388913857 CA391697745	158	M>V		No	ClinGen gnomAD
rs777888104 CA7476528	159	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7476531 rs779315797	160	W>*		No	ClinGen ExAC gnomAD
rs146254732 CA7476530	160	W>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA391697766 rs1336724077	161	P>S		No	ClinGen gnomAD
rs776421325 CA7476534	162	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1255814118 CA391697782	163	P>L		No	ClinGen TOPMed
CA7476535 rs747870399	163	P>S		No	ClinGen ExAC TOPMed gnomAD
CA391697796 rs1356881607	165	S>I		No	ClinGen gnomAD
rs1356881607 CA391697794	165	S>N		No	ClinGen gnomAD
CA391697795 rs1356881607	165	S>T		No	ClinGen gnomAD
rs529361666 CA7476536	166	P>L		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	166	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA268802718 rs925312360	167	R>Q		No	ClinGen TOPMed gnomAD
CA7476537 rs772785753	167	R>W		No	ClinGen ExAC gnomAD
CA391697807 rs1443058928	168	V>I		No	ClinGen TOPMed gnomAD
CA7476542 rs767281349	170	P>H		No	ClinGen ExAC TOPMed gnomAD
rs767281349 CA268802741	170	P>L		No	ClinGen ExAC TOPMed gnomAD
CA7476541 rs759346423	170	P>S		No	ClinGen ExAC gnomAD
CA391697818 rs759346423	170	P>T		No	ClinGen ExAC gnomAD
CA7476543 rs752901337	171	N>S		No	ClinGen ExAC TOPMed gnomAD
CA391697830 rs1305097773	172	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7476544 rs756270578	172	G>R		No	ClinGen ExAC gnomAD
rs764300808 CA391697838	174	A>P		No	ClinGen ExAC TOPMed gnomAD
rs764300808 CA7476545	174	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1396079549 CA391697843	175	A>T		No	ClinGen gnomAD
CA7476547 rs757303621	177	A>G		No	ClinGen ExAC
rs1463328748 CA391697875	179	S>F		No	ClinGen TOPMed
CA391697879 rs1379975202	180	L>P		No	ClinGen TOPMed gnomAD
rs1387943473 CA391697877	180	L>V		No	ClinGen TOPMed
rs191280501 CA7476549	181	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7476548 rs779450855	181	G>S		No	ClinGen ExAC gnomAD
rs191280501 CA7476550	181	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	183	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747386668 CA7476552	183	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1336876803 CA391697893	183	A>V		No	ClinGen gnomAD
CA268802801 rs944223823	184	E>G		No	ClinGen Ensembl
VAR_040972 rs56349744 CA7476554	184	E>K		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
TCGA novel	185	F>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1481787791 CA391697911	186	Q>*		No	ClinGen TOPMed
CA7476556 rs770390614	187	G>D		No	ClinGen ExAC gnomAD
rs376068775 CA7476555	187	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs368829109 CA7476557	188	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1178742957 CA391697928	189	S>A		No	ClinGen gnomAD
CA391697931 rs1378608525	189	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA7476559 RCV000971621 rs149315160	190	Q>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs775199257 CA7476560	191	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7476561 rs61732685 RCV000964146	191	R>H		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs764247717 CA7476562	193	L>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1364068491 CA391697952	193	L>V		No	ClinGen gnomAD
CA391697962 rs1331493048	194	Q>H		No	ClinGen gnomAD
CA268802828 rs200417617	196	G>D		No	ClinGen 1000Genomes
rs765293693 CA391697974	197	A>P		No	ClinGen ExAC TOPMed gnomAD
CA7476565 rs765293693	197	A>T		No	ClinGen ExAC TOPMed gnomAD
CA7476566 RCV000971622 rs144246288	198	C>Y		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs780741317 CA391697987	199	L>P		No	ClinGen ExAC gnomAD
CA7476568 rs780741317	199	L>Q		No	ClinGen ExAC gnomAD
CA7476569 rs751924621	200	Q>R		No	ClinGen ExAC gnomAD
rs1368409522 CA391698007	202	S>Y		No	ClinGen TOPMed
rs1183099482 CA391698014	203	P>L		No	ClinGen TOPMed
rs1197359349 CA391698016	204	P>A		No	ClinGen TOPMed gnomAD
rs1197359349 CA391698017	204	P>S		No	ClinGen TOPMed gnomAD
rs55920845 CA391698025	205	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7476571 rs55920845 VAR_040973	205	G>E		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7476573 rs141487285	207	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1294937746 CA391698042	208	P>L		No	ClinGen gnomAD
rs35501648 CA391698038	208	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs35501648 RCV000948425 VAR_040974 CA7476575	208	P>T		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1391097596 CA391698045	209	P>S		No	ClinGen gnomAD
rs34869667 CA391698052	210	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
VAR_040975 CA7476576 rs34869667	210	T>M		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs147727470 CA7476577	211	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA391698054 rs1228965092	211	G>S		No	ClinGen gnomAD
rs371550083 CA268802943	212	T>A		No	ClinGen ESP TOPMed
rs760437193 CA7476578	213	N>H		No	ClinGen ExAC gnomAD
CA391698066 rs1223970801	213	N>S		No	ClinGen TOPMed gnomAD
CA7476580 rs3743135 VAR_019994	215	H>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7476579 rs768477949	215	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1473180777 CA391698106	218	K>N		No	ClinGen gnomAD
rs761887113 CA7476581	219	A>T		No	ClinGen ExAC gnomAD
CA7476583 rs556758169	221	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA391698127 rs1566854315	222	H>R		No	ClinGen Ensembl
rs181253186 CA7476584	222	H>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA391698135 rs766971719	223	G>D		No	ClinGen ExAC gnomAD
CA7476586 rs766971719	223	G>V		No	ClinGen ExAC gnomAD
CA7476587 rs752153732	226	E>K		No	ClinGen ExAC gnomAD
CA7476590 rs753117422	227	A>D		No	ClinGen ExAC gnomAD
CA7476589 rs781727329	227	A>S		No	ClinGen ExAC TOPMed gnomAD
rs753117422 CA391698161	227	A>V		No	ClinGen ExAC gnomAD
CA391698164 rs1305992289	228	R>Q		No	ClinGen TOPMed gnomAD
rs756792521 CA7476592	228	R>W		No	ClinGen ExAC TOPMed gnomAD
CA391698170 rs1230152097	229	P>L		No	ClinGen gnomAD
rs778657940 CA7476594	229	P>T		No	ClinGen ExAC TOPMed gnomAD
CA7476595 rs745313213	232	C>F		No	ClinGen ExAC gnomAD
CA268803107 rs771616530	234	V>L		No	ClinGen ExAC TOPMed gnomAD
CA7476596 rs771616530	234	V>M		No	ClinGen ExAC TOPMed gnomAD
CA7476597 rs779932751	236	S>L		No	ClinGen ExAC gnomAD
rs746389249 CA7476599	238	T>I		No	ClinGen ExAC TOPMed
rs746389249 CA391698222	238	T>K		No	ClinGen ExAC TOPMed
CA391698225 rs1204991527	239	G>D		No	ClinGen gnomAD
CA7476600 rs776225431	239	G>S		No	ClinGen ExAC
CA391698232 rs1479359879	240	R>M		No	ClinGen gnomAD
CA7476601 rs367656601	242	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1595593806 CA391698256	244	E>G		No	ClinGen Ensembl
rs1223904821 CA391698260	245	G>S		No	ClinGen TOPMed
rs1443583667 CA391698269	246	S>N		No	ClinGen gnomAD
CA7476603 rs773532116	248	S>T		No	ClinGen ExAC TOPMed gnomAD
CA391698290 rs752100756	249	P>L		No	ClinGen ExAC TOPMed gnomAD
CA7476606 rs752100756	249	P>R		No	ClinGen ExAC TOPMed gnomAD
rs371445081 CA7476605	249	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA391698292 rs1455182455	250	K>Q		No	ClinGen TOPMed
CA7476609 rs752963669	252	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7476608 rs768072309	252	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7476611 rs374286048	253	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA391698318 rs1300099122	254	S>N		No	ClinGen gnomAD
CA391698335 rs1343313765	256	L>R		No	ClinGen gnomAD
rs750127946 CA7476612	257	K>R		No	ClinGen ExAC gnomAD
rs143324236 CA7476614	258	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143324236 CA7476613	258	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7476615 rs746529258	258	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7476616 rs746529258	258	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1237497362 CA391698345	259	R>G		No	ClinGen TOPMed gnomAD
rs747873967 CA7476618	261	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1247362863 CA391698365	262	R>*		No	ClinGen TOPMed
rs61739745 CA7476619	262	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1449817721 CA391698377	264	M>V		No	ClinGen gnomAD
rs773304292 CA7476620	265	F>L		No	ClinGen ExAC gnomAD
rs749582633 CA7476621	269	A>G		No	ClinGen ExAC
rs911637638 CA268803348	271	T>A		No	ClinGen TOPMed
rs774504023 CA7476623 COSM1191621	276	S>N	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs759719893 CA7476624	278	K>M		No	ClinGen ExAC TOPMed gnomAD
CA391698482 rs1370202458	280	G>D		No	ClinGen gnomAD
rs776109877 CA7476626	281	P>L		No	ClinGen ExAC TOPMed gnomAD
rs767862380 CA7476625	281	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1269590977 CA391698499	283	P>L		No	ClinGen gnomAD
CA7476628 rs764583754	283	P>S		No	ClinGen ExAC gnomAD
rs750060851 CA7476629	284	Q>E		No	ClinGen ExAC
rs1465034116 CA391698505	284	Q>H		No	ClinGen gnomAD
CA391698511 rs757982465	285	S>I		No	ClinGen ExAC TOPMed gnomAD
CA7476630 rs757982465	285	S>N		No	ClinGen ExAC TOPMed gnomAD
CA391698521 rs1478888396	286	K>N		No	ClinGen TOPMed gnomAD
rs1174474272 CA391698518	286	K>R		No	ClinGen TOPMed
rs1595601854 CA391699361	288	N>T		No	ClinGen Ensembl
rs1358077388 CA391699394	291	F>L		No	ClinGen TOPMed gnomAD
CA268808879 rs75694545	291	F>S		No	ClinGen Ensembl
CA7476655 COSM1640221 rs777880762	292	R>*	stomach [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs150100570 CA7476656	292	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs371298913 CA7476657	293	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs371298913 CA7476658	293	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA7476660 rs772030152	294	P>L		No	ClinGen ExAC gnomAD
rs772030152 CA391699415	294	P>R		No	ClinGen ExAC gnomAD
CA391699412 rs1252520074	294	P>S		No	ClinGen gnomAD
CA7476662 rs747091766	296	K>N		No	ClinGen ExAC gnomAD
rs1163196284 CA391699444	297	D>G		No	ClinGen gnomAD
rs1473222923 CA391699439	297	D>N		No	ClinGen TOPMed gnomAD
CA391699454 rs1383701420	298	N>S		No	ClinGen gnomAD
rs769159586 CA7476663	299	P>T		No	ClinGen ExAC gnomAD
CA391699473 rs1040558528	300	P>L		No	ClinGen TOPMed
CA268808948 rs1040558528	300	P>Q		No	ClinGen TOPMed
rs777172218 CA7476664	300	P>S		No	ClinGen ExAC gnomAD
CA7476665 rs762134147	303	V>M		No	ClinGen ExAC gnomAD
rs1399228355 CA391699506	304	A>T		No	ClinGen TOPMed
CA7476667 rs773982331	306	A>G		No	ClinGen ExAC gnomAD
CA268808996 rs374205024	311	S>L		No	ClinGen ESP TOPMed gnomAD
CA7476670 rs752209695	312	D>A		No	ClinGen ExAC gnomAD
rs371922217 CA7476671	313	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs764096964 CA7476672	314	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1194032400 CA391699628	315	V>L		No	ClinGen gnomAD
CA7476675 rs778909474	317	T>A		No	ClinGen ExAC TOPMed gnomAD
rs778909474 CA391699647	317	T>P		No	ClinGen ExAC TOPMed gnomAD
CA7476677 rs758608674	319	S>T		No	ClinGen ExAC gnomAD
CA268809043 rs965694957	320	P>L		No	ClinGen TOPMed
rs200107644 CA7476678	320	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1566857606 CA391699711	323	T>S		No	ClinGen Ensembl
rs759202398 CA7476679	324	S>L	Variant assessed as Somatic; 4.625e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM3361359 CA268809063 rs866737297	329	P>L	kidney Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs868358280 CA268809066	332	S>F		No	ClinGen Ensembl
rs781664567 CA7476681	332	S>P		No	ClinGen ExAC gnomAD
TCGA novel	333	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs143993282 CA7476682	334	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs770302351 CA7476683	334	R>H		No	ClinGen ExAC TOPMed gnomAD
CA7476685 rs773501708	335	T>I		No	ClinGen ExAC gnomAD
rs773501708 CA7476684	335	T>K		No	ClinGen ExAC gnomAD
VAR_019995 CA7476686 rs3743137	337	P>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs536947257 CA268809100	339	T>I		No	ClinGen 1000Genomes TOPMed
CA7476689 rs550706939	341	Q>E		No	ClinGen 1000Genomes ExAC gnomAD
rs371395174 CA7476690	342	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1324359981 CA391699933	343	P>A		No	ClinGen gnomAD
rs750185540 CA7476693	345	R>Q		No	ClinGen ExAC gnomAD
rs371593698 CA7476692	345	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA391699981 rs1201627654 COSM233037	348	P>S	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
CA7476694 rs201684963	349	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1403289161 COSM1517042 CA391700003	350	G>E	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs553217842 CA7476696	350	G>R		No	ClinGen 1000Genomes ExAC gnomAD
CA7476697 rs755041870	351	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs267604171 CA391700023	352	P>H		No	ClinGen ExAC gnomAD
rs267604171 CA7476700	352	P>L		No	ClinGen ExAC gnomAD
TCGA novel	353	R>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369825628 CA7476701	353	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1303293188 COSM961115 CA391700032	353	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs749639508 CA7476702	354	T>I		No	ClinGen ExAC gnomAD
CA391700036 rs1595602287	354	T>P		No	ClinGen Ensembl
rs1281402492 CA391700053	355	W>S		No	ClinGen gnomAD
rs566841147 CA7476705	357	A>D		No	ClinGen 1000Genomes ExAC gnomAD
CA7476704 rs775199852	357	A>T		No	ClinGen ExAC TOPMed gnomAD
rs776213543 CA391700111	359	I>M		No	ClinGen ExAC TOPMed gnomAD
CA7476708 rs761432480	362	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1473327400 CA391700225	367	P>L		No	ClinGen gnomAD
rs142340502 CA268809218	368	Q>R		No	ClinGen ESP TOPMed gnomAD
CA7476710 rs202233605	370	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA7476711 rs202233605	370	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA7476712 rs377762904	371	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7476714 rs755129680	372	V>G		No	ClinGen ExAC TOPMed gnomAD
rs1267730521 CA391700325	375	G>R		No	ClinGen gnomAD
rs767760161 CA7476715	375	G>V		No	ClinGen ExAC gnomAD
CA7476716 rs569144141	376	A>T		No	ClinGen ExAC gnomAD
VAR_040976 CA7476717 rs55806501	376	A>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs139850733 CA7476720	379	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs749822688 CA7476719	379	G>S		No	ClinGen ExAC gnomAD
CA391700380 rs1315308061	380	E>D		No	ClinGen gnomAD
CA391700369 rs1356295773	380	E>K		No	ClinGen TOPMed
rs779088483 CA7476721	381	D>V		No	ClinGen ExAC gnomAD
rs746237876 CA7476722	382	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1359186065 CA391700442	385	V>G		No	ClinGen gnomAD
rs145336671 CA7476724	388	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM313872 CA391700532 rs1442440874	390	F>L	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
CA391700546 rs539392829	391	K>N		No	ClinGen gnomAD
CA7476725 rs747631902	392	A>T		No	ClinGen ExAC TOPMed gnomAD
rs147750062 CA268809324	393	A>V		No	ClinGen ESP TOPMed gnomAD
CA7476727 rs773188058	396	M>T		No	ClinGen ExAC gnomAD
rs1423834659 CA391700642	400	Q>*		No	ClinGen gnomAD
rs1372374637 CA391700659	401	G>D		No	ClinGen gnomAD
CA7476730 rs773980926	401	G>R		No	ClinGen ExAC
rs771921802 CA268809353	402	D>H		No	ClinGen Ensembl
rs544933416 CA7476731	403	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs544933416 CA268809362	403	P>T		No	ClinGen 1000Genomes ExAC gnomAD
CA7476733 rs752954384	404	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs767701022 CA7476732	404	R>W		No	ClinGen ExAC gnomAD
CA7476734 rs760735362	405	L>P		No	ClinGen ExAC gnomAD
TCGA novel	408	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1382486009 CA391700736	409	S>G		No	ClinGen gnomAD
TCGA novel	409	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA391700739 rs1244302233	409	S>T		No	ClinGen gnomAD
rs757638158 CA7476737	411	V>M		No	ClinGen ExAC gnomAD
TCGA novel	414	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758876076 CA7476740	415	E>K		No	ClinGen ExAC TOPMed gnomAD
CA391700828 rs780988330	416	G>A		No	ClinGen ExAC gnomAD
CA7476741 rs780988330	416	G>V		No	ClinGen ExAC gnomAD
CA391700843 rs1243425395	418	T>A		No	ClinGen gnomAD
CA391700850 rs1443748950	418	T>I		No	ClinGen gnomAD
rs1243425395 CA391700841	418	T>P		No	ClinGen gnomAD
CA7476743 rs769503362	419	G>S		No	ClinGen ExAC TOPMed gnomAD
CA391700875 rs1169657232	421	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs145812191 CA7476744	425	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7476746 rs145647822	425	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145812191 CA7476745	425	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA268809508 rs952119008	426	E>*		No	ClinGen TOPMed gnomAD
CA268809546 rs774318821	426	E>D		No	ClinGen ExAC TOPMed gnomAD
CA268809520 rs985255163	426	E>G		No	ClinGen TOPMed gnomAD
rs1595602708 CA391700943	427	K>R		No	ClinGen Ensembl
rs1300212269 CA391700951	428	H>N		No	ClinGen gnomAD
rs1247881638 CA391700957	428	H>R		No	ClinGen TOPMed
rs1300212269 CA391700953	428	H>Y		No	ClinGen gnomAD
CA7476748 rs759294194	429	S>L		No	ClinGen ExAC TOPMed gnomAD
CA391701781 rs759294194	429	S>W		No	ClinGen ExAC TOPMed gnomAD
CA391701784 rs1305234489	430	G>S		No	ClinGen gnomAD
rs775672184 CA7476750	430	G>V		No	ClinGen ExAC gnomAD
CA7476752 rs369042481	431	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA7476753 rs753819966	431	R>H	Variant assessed as Somatic; 5.897e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs753819966 CA391701806	431	R>L		No	ClinGen ExAC TOPMed gnomAD
CA7476754 rs761974400	433	V>M		No	ClinGen ExAC gnomAD
CA7476755 rs765632390	435	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1185850296 CA391701860	436	K>R		No	ClinGen gnomAD
rs1481443132 CA391701945	441	R>S		No	ClinGen gnomAD
rs980733153 CA268809634	442	K>*		No	ClinGen Ensembl
rs1177197569 CA391701975	443	Q>H		No	ClinGen gnomAD
CA7476756 rs751039749	444	Q>R		No	ClinGen ExAC gnomAD
CA7476758 rs780508332	445	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7476759 rs751980188	445	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA391702003 rs751980188	445	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1455070939 CA391702007	446	R>G		No	ClinGen TOPMed
CA391702024 rs1595602899	447	E>K		No	ClinGen Ensembl
rs770511787 CA7476763	450	F>L		No	ClinGen ExAC TOPMed gnomAD
rs745859307 CA7476765	452	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1290798417 CA391702222	456	M>L		No	ClinGen gnomAD
rs764899757 CA7476799	456	M>T		No	ClinGen ExAC gnomAD
rs1273714796 CA391702244	457	R>P		No	ClinGen gnomAD
rs1273714796 CA391702246	457	R>Q		No	ClinGen gnomAD
rs201655600 CA7476800	457	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA391702295 rs1595603306	460	Q>L		No	ClinGen Ensembl
CA7476803 rs201153660	463	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs780974985 CA7476805	464	V>L		No	ClinGen ExAC TOPMed gnomAD
CA391702353 rs780974985	464	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1383805995 CA391702372	465	V>L		No	ClinGen gnomAD
rs529880620 CA7476807	466	E>G		No	ClinGen 1000Genomes ExAC gnomAD
CA268809960 rs1015738858	467	M>K		No	ClinGen gnomAD
CA391702424 rs1328831566	468	Y>C		No	ClinGen gnomAD
rs1408924116 CA391702417	468	Y>H		No	ClinGen gnomAD
CA391702437 rs1452943453	469	K>R		No	ClinGen gnomAD
CA391702473 rs1338487157	471	Y>C		No	ClinGen TOPMed gnomAD
rs778192276 CA7476809	471	Y>H		No	ClinGen ExAC gnomAD
CA391702481 rs1229507748	472	L>V		No	ClinGen TOPMed gnomAD
rs749351655 CA7476810	473	V>L		No	ClinGen ExAC gnomAD
rs749351655 CA391702489	473	V>M		No	ClinGen ExAC gnomAD
CA7476812 rs34445577 VAR_051657	475	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen UniProt ExAC NCI-TCGA dbSNP gnomAD
CA7476813 rs760026583	476	E>K		No	ClinGen ExAC gnomAD
rs760026583 CA7476814	476	E>Q		No	ClinGen ExAC gnomAD
CA7476815 rs775883119	478	W>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7476817 rs761050162	480	L>F		No	ClinGen ExAC TOPMed gnomAD
rs761050162 CA7476816	480	L>I		No	ClinGen ExAC TOPMed gnomAD
rs750114826 CA7476818	481	M>T		No	ClinGen ExAC gnomAD
CA391702592 rs1373060023	483	F>L		No	ClinGen gnomAD
rs775743672 CA268809991	485	Q>*		No	ClinGen Ensembl
CA7476820 rs765858941	485	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs751036956 CA7476821	486	G>E		No	ClinGen ExAC gnomAD
CA7476822 rs754905439	487	G>E		No	ClinGen ExAC TOPMed gnomAD
CA391702645 rs1198700247	488	A>D		No	ClinGen TOPMed gnomAD
rs1436760929 CA391702640	488	A>T		No	ClinGen gnomAD
TCGA novel	491	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7476824 rs140245743	492	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA7476826 rs778140999	493	V>I		No	ClinGen ExAC TOPMed gnomAD
CA391702711 rs1445515286	495	Q>*		No	ClinGen TOPMed
CA268810014 rs372547442	496	V>I		No	ClinGen ESP ExAC gnomAD
CA7476828 rs372547442	496	V>L		No	ClinGen ESP ExAC gnomAD
CA7476845 rs752752648	498	L>R		No	ClinGen ExAC
TCGA novel	500	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA391702793 rs1293198742	500	E>K		No	ClinGen TOPMed gnomAD
CA391702794 rs1293198742	500	E>Q		No	ClinGen TOPMed gnomAD
CA7476849 rs757458339	501	E>G		No	ClinGen ExAC gnomAD
rs377397005 CA7476848	501	E>K		No	ClinGen ExAC TOPMed gnomAD
rs377397005 CA391702802	501	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1420446928 CA391702813	502	Q>H		No	ClinGen gnomAD
CA391702812 rs1595604119	502	Q>L		No	ClinGen Ensembl
rs1182090988 CA391702819	503	I>T		No	ClinGen gnomAD
CA391702833 rs1417694483	505	T>S		No	ClinGen gnomAD
CA268810235 rs960076117	512	Q>H		No	ClinGen TOPMed
CA268810232 rs924773501	512	Q>L		No	ClinGen TOPMed
CA391702884 rs1165371983	513	A>V		No	ClinGen gnomAD
VAR_040977	514	L>R	a lung small cell carcinoma sample; somatic mutation [UniProt]	No	UniProt
CA7476850 rs779024966	515	A>V		No	ClinGen ExAC gnomAD
rs1291799565 CA391702900	516	Y>C		No	ClinGen gnomAD
CA391702903 rs1392176646	517	L>M		No	ClinGen gnomAD
rs780605365 CA391702911	518	H>L		No	ClinGen ExAC TOPMed gnomAD
rs780605365 CA7476853	518	H>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	518	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747457346 CA391702919	519	A>G		No	ClinGen ExAC gnomAD
COSM187221 rs747457346 CA7476854	519	A>V	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA7476855 rs769157043	522	V>I		No	ClinGen ExAC TOPMed gnomAD
CA7476856 rs776943230	523	I>V		No	ClinGen ExAC TOPMed gnomAD
rs574508370 CA268810264	524	H>Q		No	ClinGen Ensembl
CA391702947 rs1423018143	524	H>Y		No	ClinGen TOPMed
rs748536361 CA7476857	525	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA391702953 rs1190509134	525	R>W		No	ClinGen TOPMed
rs1335857151 CA391702956	526	D>N		No	ClinGen gnomAD
CA391702966 rs1185161057	527	I>F		No	ClinGen gnomAD
rs1385647584 CA391702982	529	S>N		No	ClinGen gnomAD
CA391703000 rs1340911365	531	S>F		No	ClinGen gnomAD
CA268810271 rs915606382	535	T>N		No	ClinGen TOPMed gnomAD
rs1443856744 CA391703020	535	T>P		No	ClinGen TOPMed gnomAD
rs544478594 CA7476861	536	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs148062077 CA7476863	537	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA7476883 rs373086987	541	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs761663909 CA7476884	542	L>F		No	ClinGen ExAC gnomAD
CA391703084 rs1263425484	544	D>N		No	ClinGen gnomAD
CA7476888 rs766611697	546	G>R		No	ClinGen ExAC TOPMed gnomAD
rs751617316 CA7476889	549	A>V		No	ClinGen ExAC
CA391703139 rs199802493	551	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA268810388 rs906266834	551	I>V		No	ClinGen TOPMed
CA268810392 rs113493588	552	S>N		No	ClinGen Ensembl
rs141761526 CA7476893	555	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs141761526 CA391703164	555	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs756662143 CA7476894	556	P>R		No	ClinGen ExAC gnomAD
rs1377138602 CA391703170	556	P>S		No	ClinGen TOPMed
CA268810403 rs753631628	558	R>K		No	ClinGen TOPMed
CA391703215 rs1372362998	563	G>E		No	ClinGen TOPMed
CA391703223 rs1413012313	564	T>S		No	ClinGen gnomAD
rs1469350323 CA391703253	568	M>I		No	ClinGen gnomAD
CA391703247 rs1346175776	568	M>L		No	ClinGen TOPMed gnomAD
CA391703251 rs1427220368	568	M>T		No	ClinGen gnomAD
rs779898625 CA7476898	571	E>Q		No	ClinGen ExAC gnomAD
CA268810440 rs778956144	573	I>T		No	ClinGen Ensembl
rs1406281161 CA391703295	575	R>K		No	ClinGen gnomAD
CA268810444 rs1020874245	577	L>S		No	ClinGen Ensembl
CA391703320 rs1283399029	579	A>T		No	ClinGen gnomAD
CA268810810 rs943478630	585	W>*		No	ClinGen TOPMed
CA391703412 rs1307789154	590	M>I		No	ClinGen TOPMed
rs1369160765 CA391703410	590	M>T		No	ClinGen TOPMed
rs1389373608 CA391703415	591	V>M		No	ClinGen gnomAD
rs767753997 CA7476927	592	I>T		No	ClinGen ExAC gnomAD
CA7476928 rs775380507	593	E>K		No	ClinGen ExAC TOPMed gnomAD
CA7476929 rs147489955	594	M>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1445615216 CA391703449	596	D>H		No	ClinGen gnomAD
rs564064166 CA268810824	596	D>V		No	ClinGen Ensembl
CA7476931 rs754433688	597	G>E		No	ClinGen ExAC gnomAD
CA391703457 rs1161618135	597	G>R		No	ClinGen TOPMed
CA391703474 rs1283573471	599	P>L		No	ClinGen gnomAD
CA391703477 rs1436025283	600	P>S		No	ClinGen TOPMed
rs1216359341 CA391703512	603	S>N		No	ClinGen gnomAD
rs765637734 CA7476933	604	D>E		No	ClinGen ExAC gnomAD
TCGA novel	606	P>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7476936 rs74468066	608	Q>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7476937 rs747582149	609	A>V		No	ClinGen ExAC gnomAD
CA268810870 rs1054668619	610	M>T		No	ClinGen Ensembl
CA7476938 rs139943572	611	K>N		No	ClinGen ESP ExAC gnomAD
rs1462092175 CA391703588	611	K>R		No	ClinGen gnomAD
CA268810889 rs201804704	612	R>S		No	ClinGen TOPMed gnomAD
TCGA novel	613	L>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7476939 rs143844489	614	R>Q	Variant assessed as Somatic; 4.64e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA7476942 rs774088079	616	S>R		No	ClinGen ExAC gnomAD
rs1222058076 CA391703644	617	P>T		No	ClinGen TOPMed
rs762276597 CA7476943	618	P>L		No	ClinGen ExAC TOPMed gnomAD
rs762276597 CA7476945	618	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs762276597 CA7476944	618	P>R		No	ClinGen ExAC TOPMed gnomAD
CA391703660 rs1407997977	619	P>S		No	ClinGen gnomAD
TCGA novel	619	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA391703681 rs1566859138	621	L>V		No	ClinGen Ensembl
CA391703706 rs1396428108	623	N>S		No	ClinGen gnomAD
TCGA novel	624	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371992889 CA268810933	625	H>D		No	ClinGen ESP
CA7476947 rs764291420	625	H>Q		No	ClinGen ExAC gnomAD
TCGA novel	625	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7476970 rs550108869	632	R>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA391703964 rs1375705472	632	R>Q		No	ClinGen gnomAD
CA391703973 rs1471068594	633	D>E		No	ClinGen gnomAD
rs1469469717 CA391703971	633	D>G		No	ClinGen TOPMed
TCGA novel	633	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	635	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766710648 CA7476972	637	R>G		No	ClinGen ExAC gnomAD
CA7476973 rs147232997	637	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
COSM961119 rs766710648 CA268811861	637	R>W	Variant assessed as Somatic; impact. endometrium haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs763671771 CA7476975	638	M>L		No	ClinGen ExAC gnomAD
rs1595608473 CA391704014	640	V>G		No	ClinGen Ensembl
CA7476978 rs778815914	641	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7476977 COSM2269113 rs756797198	641	R>W	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA7476980 rs758280121	642	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA391704024 rs1308891398	642	D>V		No	ClinGen TOPMed
rs1235261527 CA391704035	644	Q>*		No	ClinGen TOPMed
rs1046341696 CA268811886	644	Q>H		No	ClinGen TOPMed gnomAD
rs1279476884 CA391704037	644	Q>R		No	ClinGen gnomAD
CA268811888 rs774970017	646	R>G		No	ClinGen TOPMed gnomAD
TCGA novel	646	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779831380 CA7476982	646	R>S		No	ClinGen ExAC gnomAD
rs1264879400 CA391704050	646	R>T		No	ClinGen gnomAD
rs905064215 CA268811898	647	A>T		No	ClinGen TOPMed gnomAD
CA7476984 rs768900428	648	T>I		No	ClinGen ExAC gnomAD
rs374185464 CA7476986	650	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA7476987 rs770058646	651	E>*		No	ClinGen ExAC TOPMed gnomAD
CA391704076 rs770058646	651	E>K		No	ClinGen ExAC TOPMed gnomAD
CA391704099 rs1291888741	654	D>E		No	ClinGen gnomAD
CA268811956 rs898586749	654	D>V		No	ClinGen TOPMed
rs763453474 CA7476989	655	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA391704113 rs1490235911	656	P>L		No	ClinGen gnomAD
rs1192499871 CA391704118	657	F>S		No	ClinGen TOPMed
rs542450558 CA7476991	659	L>P		No	ClinGen ExAC TOPMed gnomAD
rs542450558 CA268811968	659	L>R		No	ClinGen ExAC TOPMed gnomAD
rs1566860158 CA391704134	660	Q>R		No	ClinGen Ensembl
CA7476993 rs763701428	662	G>E		No	ClinGen ExAC TOPMed gnomAD
rs759863961 CA7476992	662	G>R		No	ClinGen ExAC gnomAD
CA391704151 rs1321764232	663	L>P		No	ClinGen gnomAD
CA391704178 rs1263193509	667	L>P		No	ClinGen gnomAD
CA391704182 rs1445678288	668	V>L		No	ClinGen TOPMed
TCGA novel	668	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201637258 CA7476996	670	L>V		No	ClinGen ExAC
rs749904424 CA7476998	673	L>F		No	ClinGen ExAC TOPMed gnomAD
rs749904424 CA7476997	673	L>I		No	ClinGen ExAC TOPMed gnomAD
CA7476999 rs377614111	674	Y>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7477000 rs751339079	675	R>*		No	ClinGen ExAC TOPMed gnomAD
CA7477001 rs754797947 COSM1608316	675	R>Q	Variant assessed as Somatic; 0.0 impact. liver [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs781552729 CA7477002	677	Q>H		No	ClinGen ExAC gnomAD
CA391704238 rs1218737752	677	Q>R		No	ClinGen TOPMed
CA391704245 COSM961120 rs1256719444	678	T>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA391704240 rs1595608719	678	T>P		No	ClinGen Ensembl
rs1595608730 CA391704252	680	T>P		No	ClinGen Ensembl
CA391704260 rs1379584778	681	C>G		No	ClinGen gnomAD
rs1162694575 CA391704268	682	C>R		No	ClinGen gnomAD

1 associated diseases with Q9NQU5

Without disease ID

5 regional properties for Q9NQU5

Type	Name	Position	InterPro Accession
domain	FKBP-type peptidyl-prolyl cis-trans isomerase domain	115 - 204	IPR001179
repeat	Tetratricopeptide repeat 2	307 - 339	IPR013105
repeat	Tetratricopeptide repeat	228 - 261	IPR019734-1
repeat	Tetratricopeptide repeat	272 - 305	IPR019734-2
repeat	Tetratricopeptide repeat	306 - 339	IPR019734-3

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	Cotranslocates into nucleus with AR in response to androgen induction
PANTHER Family	PTHR48015	SERINE/THREONINE-PROTEIN KINASE TAO
PANTHER Subfamily	PTHR48015:SF19	SERINE_THREONINE-PROTEIN KINASE PAK 6
PANTHER Protein Class	non-receptor serine/threonine protein kinase protein modifying enzyme
PANTHER Pathway Category	Inflammation mediated by chemokine and cytokine signaling pathway PAK Cytoskeletal regulation by Rho GTPase PAK

5 GO annotations of cellular component

Name	Definition
cell junction	A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
fibrillar center	A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

4 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

11 GO annotations of biological process

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
learning	Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
locomotory behavior	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
memory	The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
neuron projection arborization	The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
neuron projection extension	Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of MAPK cascade	Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.

26 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q12469	SKM1	Serine/threonine-protein kinase SKM1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q08E52	PAK1	Serine/threonine-protein kinase PAK 1	Bos taurus (Bovine)	SS
Q7YQL4	PAK3	Serine/threonine-protein kinase PAK 3	Pan troglodytes (Chimpanzee)	SS
Q9VXE5	mbt	Serine/threonine-protein kinase PAK mbt	Drosophila melanogaster (Fruit fly)	PR
Q9NQU5	PAK6	Serine/threonine-protein kinase PAK 6	Homo sapiens (Human)	EV
Q13043	STK4	Serine/threonine-protein kinase 4	Homo sapiens (Human)	EV
Q13188	STK3	Serine/threonine-protein kinase 3	Homo sapiens (Human)	SS
Q9P286	PAK5	Serine/threonine-protein kinase PAK 5	Homo sapiens (Human)	EV
O96013	PAK4	Serine/threonine-protein kinase PAK 4	Homo sapiens (Human)	EV
Q13177	PAK2	Serine/threonine-protein kinase PAK 2	Homo sapiens (Human)	EV
O75914	PAK3	Serine/threonine-protein kinase PAK 3	Homo sapiens (Human)	SS
Q13153	PAK1	Serine/threonine-protein kinase PAK 1	Homo sapiens (Human)	EV
O95819	MAP4K4	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (Human)	PR
Q8CIN4	Pak2	Serine/threonine-protein kinase PAK 2	Mus musculus (Mouse)	SS
O88643	Pak1	Serine/threonine-protein kinase PAK 1	Mus musculus (Mouse)	SS
Q61036	Pak3	Serine/threonine-protein kinase PAK 3	Mus musculus (Mouse)	SS
Q8C015	Pak5	Serine/threonine-protein kinase PAK 5	Mus musculus (Mouse)	SS
Q3ULB5	Pak6	Serine/threonine-protein kinase PAK 6	Mus musculus (Mouse)	PR
Q8BTW9	Pak4	Serine/threonine-protein kinase PAK 4	Mus musculus (Mouse)	PR
Q62829	Pak3	Serine/threonine-protein kinase PAK 3	Rattus norvegicus (Rat)	SS
Q64303	Pak2	Serine/threonine-protein kinase PAK 2	Rattus norvegicus (Rat)	SS
P35465	Pak1	Serine/threonine-protein kinase PAK 1	Rattus norvegicus (Rat)	SS
D4A280	Pak5	Serine/threonine-protein kinase PAK 5	Rattus norvegicus (Rat)	SS
Q17850	pak-1	Serine/threonine-protein kinase pak-1	Caenorhabditis elegans	PR
G5EGQ3	max-2	Serine/threonine-protein kinase max-2	Caenorhabditis elegans	SS
G5EFU0	pak-2	Serine/threonine-protein kinase pak-2	Caenorhabditis elegans	PR

10	20	30	40	50	60
MFRKKKKKRP	EISAPQNFQH	RVHTSFDPKE	GKFVGLPPQW	QNILDTLRRP	KPVVDPSRIT
70	80	90	100	110	120
RVQLQPMKTV	VRGSAMPVDG	YISGLLNDIQ	KLSVISSNTL	RGRSPTSRRR	AQSLGLLGDE
130	140	150	160	170	180
HWATDPDMYL	QSPQSERTDP	HGLYLSCNGG	TPAGHKQMPW	PEPQSPRVLP	NGLAAKAQSL
190	200	210	220	230	240
GPAEFQGASQ	RCLQLGACLQ	SSPPGASPPT	GTNRHGMKAA	KHGSEEARPQ	SCLVGSATGR
250	260	270	280	290	300
PGGEGSPSPK	TRESSLKRRL	FRSMFLSTAA	TAPPSSSKPG	PPPQSKPNSS	FRPPQKDNPP
310	320	330	340	350	360
SLVAKAQSLP	SDQPVGTFSP	LTTSDTSSPQ	KSLRTAPATG	QLPGRSSPAG	SPRTWHAQIS
370	380	390	400	410	420
TSNLYLPQDP	TVAKGALAGE	DTGVVTHEQF	KAALRMVVDQ	GDPRLLLDSY	VKIGEGSTGI
430	440	450	460	470	480
VCLAREKHSG	RQVAVKMMDL	RKQQRRELLF	NEVVIMRDYQ	HFNVVEMYKS	YLVGEELWVL
490	500	510	520	530	540
MEFLQGGALT	DIVSQVRLNE	EQIATVCEAV	LQALAYLHAQ	GVIHRDIKSD	SILLTLDGRV
550	560	570	580	590	600
KLSDFGFCAQ	ISKDVPKRKS	LVGTPYWMAP	EVISRSLYAT	EVDIWSLGIM	VIEMVDGEPP
610	620	630	640	650	660
YFSDSPVQAM	KRLRDSPPPK	LKNSHKVSPV	LRDFLERMLV	RDPQERATAQ	ELLDHPFLLQ
670	680
TGLPECLVPL	IQLYRKQTST	C