Q9NHC3

SS
Gene name
ced-2 (Y41D4B.13)
Protein name
Cell death abnormality protein 2
Names
Cell-corpse engulfment protein CED-2
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_Y41D4B.13
EC number
Protein Class

Descriptions

CRK regulates transcription and cytoskeletal reorganization for cell growth and motility by linking tyrosine kinases to small G proteins. The mouse c-Crk protein contains The SH2 and nSH3 domains are used to recruit their target proteins. The cSH3 negatively regulates the function of nSH3. In human Crk, nSH3 domain is also regulated by SH2 domain and inter-SH3 domain region.

Autoinhibitory domains (AIDs)

216-277 (cSH3 domain) SS

Target domain

119-173 (N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q9NHC3

Entry ID Method Resolution Chain Position Source
3QWX X-ray 201 A X 1-174 PDB
3QWY X-ray 252 A A/B 1-279 PDB
AF-Q9NHC3-F1 Predicted AlphaFoldDB

No variants for Q9NHC3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9NHC3

No associated diseases with Q9NHC3

2 regional properties for Q9NHC3

Type Name Position InterPro Accession
domain Gasdermin, pore forming domain 3 - 233 IPR040460
domain Gasdermin, PUB domain 254 - 418 IPR041263

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
protein-containing complex binding Binding to a macromolecular complex.
receptor tyrosine kinase binding Binding to a receptor that possesses protein tyrosine kinase activity.
signaling adaptor activity The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.

9 GO annotations of biological process

Name Definition
actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
apoptotic process involved in development Any apoptotic process that is involved in anatomical structure development.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues.
engulfment of apoptotic cell The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.
positive regulation of distal tip cell migration Any process that activates or increases the frequency, rate or extent of distal tip cell migration.
positive regulation of engulfment of apoptotic cell Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell.
programmed cell death A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q04929 CRK Adapter molecule crk Gallus gallus (Chicken) SS
Q9XYM0 Crk Adapter molecule Crk Drosophila melanogaster (Fruit fly) SS
P46109 CRKL Crk-like protein Homo sapiens (Human) SS
P46108 CRK Adapter molecule crk Homo sapiens (Human) EV
P47941 Crkl Crk-like protein Mus musculus (Mouse) SS
Q64010 Crk Adapter molecule crk Mus musculus (Mouse) EV SS
Q5U2U2 Crkl Crk-like protein Rattus norvegicus (Rat) SS
Q63768 Crk Adapter molecule crk Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MTTNGFDPFE WRSFYFPGMS REEAHKLLGE PQVSIGTFLM RDSSRPGEYS LTVREADEGN
70 80 90 100 110 120
AVCHYLIERG EPKEDGTAAA GVKIANQSFP DIPALLNHFK MRVLTEASLL AAYKKPIIEV
130 140 150 160 170 180
VVGTFKFTGE RETDLPFEQG ERLEILSKTN QDWWEARNAL GTTGLVPANY VQIQMEFHND
190 200 210 220 230 240
RTSKGASQSS IGSSGGGAER FSSASTSSDN IELQPRLPAK AKVTFDRVPN AYDPTQLRVK
250 260 270
KGQTVLVTQK MSNGMYKAEL DGQIGSVPHT YLRFTAVSE