Q9NBK5

SS
Gene name
trc (CG8637)
Protein name
Serine/threonine-protein kinase tricornered
Names
EC 2.7.11.1 , NDR protein kinase , Serine/threonine-protein kinase 38-like , Serine/threonine-protein kinase tricorner
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG8637
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

STK38, called nuclear Dbf2-related kinase 1 (NDR1 protein kinase), is a subclass of the AGC family of protein kinases that are involved in the regulation of cell division and cell morphology. NDR kinase activity is regulated by phosphorylation and by the Ca2+-binding protein, S100B. MOB1 also stimulates NDR kinase activity and interacts with NDR. <br> A common feature of the NDR family of kinases is an insert in the catalytic domain of 30 - 60 amino acids between subdomains VII and VIII. The insert sequence is not highly conserved but contains in all cases many positively charged amino acids. Mutations of the residues within the insert (autoinhibitory element) increase kinase activity and the binding of MOB1 or S100B to the N-terminal domain (SMA domain) of NDR induces the release of autoinhibition.

Autoinhibitory domains (AIDs)

276-287 (Autoinhibitory sequence) SS

Target domain

93-394 (Protein kinase domain)

Relief mechanism

Partner binding

Assay

Accessory elements

233-245 (Activation loop from InterPro)

Target domain

93-394 (Protein kinase domain)

Relief mechanism

Assay

289-298 (Activation loop from InterPro)

Target domain

93-394 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9NBK5

Entry ID Method Resolution Chain Position Source
AF-Q9NBK5-F1 Predicted AlphaFoldDB

No variants for Q9NBK5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9NBK5

No associated diseases with Q9NBK5

5 regional properties for Q9NBK5

Type Name Position InterPro Accession
domain Protein kinase domain 93 - 394 IPR000719
domain AGC-kinase, C-terminal 395 - 463 IPR000961
active_site Serine/threonine-protein kinase, active site 212 - 224 IPR008271
binding_site Protein kinase, ATP binding site 99 - 122 IPR017441
domain Protein kinase, C-terminal 413 - 454 IPR017892

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Trc colocalizes with Mob1 to the cell periphery in wing cells and wing hairs
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cell body The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cell hair A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located.
cell periphery The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions

14 GO annotations of biological process

Name Definition
antennal morphogenesis The process in which the anatomical structures of the antenna are generated and organized.
chaeta development The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell.
dendrite morphogenesis The process in which the anatomical structures of a dendrite are generated and organized.
dendrite self-avoidance The process in which dendrites recognize and avoid contact with sister dendrites from the same cell.
imaginal disc-derived wing hair organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster.
imaginal disc-derived wing morphogenesis The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
microtubule sliding The movement of one microtubule along another microtubule.
negative regulation of neuron projection arborization Any process that stops, prevents or reduces the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of dendrite development Any process that modulates the frequency, rate or extent of dendrite development.
regulation of dendrite morphogenesis Any process that modulates the frequency, rate or extent of dendrite morphogenesis.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53894 CBK1 Serine/threonine-protein kinase CBK1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
A2VDV2 STK38 Serine/threonine-protein kinase 38 Bos taurus (Bovine) SS
Q9W0V1 Pdk1 3-phosphoinositide-dependent protein kinase 1 Drosophila melanogaster (Fruit fly) SS
A1Z9X0 aPKC Atypical protein kinase C Drosophila melanogaster (Fruit fly) SS
A1Z7T0 Pkn Serine/threonine-protein kinase N Drosophila melanogaster (Fruit fly) SS
P83099 Pkcdelta Putative protein kinase C delta type homolog Drosophila melanogaster (Fruit fly) PR
P13677 inaC Protein kinase C, eye isozyme Drosophila melanogaster (Fruit fly) SS
P05130 Pkc53E Protein kinase C, brain isozyme Drosophila melanogaster (Fruit fly) SS
Q8INB9 Akt RAC serine/threonine-protein kinase Drosophila melanogaster (Fruit fly) SS
Q96LW2 RSKR Ribosomal protein S6 kinase-related protein Homo sapiens (Human) PR
Q9Y2H1 STK38L Serine/threonine-protein kinase 38-like Homo sapiens (Human) EV
Q15208 STK38 Serine/threonine-protein kinase 38 Homo sapiens (Human) EV
Q7TSE6 Stk38l Serine/threonine-protein kinase 38-like Mus musculus (Mouse) SS
Q91VJ4 Stk38 Serine/threonine-protein kinase 38 Mus musculus (Mouse) SS
Q2L6W9 sax-1 Serine/threonine-protein kinase sax-1 Caenorhabditis elegans SS
10 20 30 40 50 60
MMSSRTQDAD GASIRFSDHT LDKATKAKVT LENYYSNLVT QYGERKQRLA KLEAQLKDES
70 80 90 100 110 120
LSEAQRQEKR LQHAQKETEY LRLKRLRLGV EDFEALKVIG RGAFGEVRLV QKKDTGHVYA
130 140 150 160 170 180
MKVLRKADML EKEQVAHVRA ERDVLVEADH QWVVKMYYSF QDPVNLYLIM EFLPGGDMMT
190 200 210 220 230 240
LLMKKDTLSE EGTQFYISET ALAIDSIHKL GFIHRDIKPD NLLLDARGHL KLSDFGLCTG
250 260 270 280 290 300
LKKSHRTDFY RDLSQAKPSD FIGTCASLSC SPMDSKRRAE SWKRNRRALA YSTVGTPDYI
310 320 330 340 350 360
APEVFLQTGY GPACDWWSLG VIMYEMLMGY PPFCSDNPQD TYRKVMNWRE TLIFPPEIPI
370 380 390 400 410 420
SEEAKETIIN FCCEADRRLG SQRGLEDLKS VPFFRGVDWE HIRERPAAIP VEVRSIDDTS
430 440 450 460
NFDEFPDVSL EIPSAPIPQG GEIAKDWVFI NYTYKRFEVR NLE