Q9NB31
Gene name |
cst-1 |
Protein name |
Serine/threonine-protein kinase cst-1 |
Names |
STE20-like kinase 1, STE20-like kinase MST, cMST |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F14H12.4 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
171-194 (Activation loop from InterPro)
Target domain |
35-286 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9NB31
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9NB31-F1 | Predicted | AlphaFoldDB |
No variants for Q9NB31
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9NB31 | |||||
No associated diseases with Q9NB31
7 regional properties for Q9NB31
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 1299 - 1377 | IPR001680-1 |
| repeat | WD40 repeat | 1404 - 1441 | IPR001680-2 |
| repeat | WD40 repeat | 1444 - 1486 | IPR001680-3 |
| repeat | WD40 repeat | 1494 - 1615 | IPR001680-4 |
| domain | Kinesin motor domain | 6 - 379 | IPR001752 |
| conserved_site | WD40 repeat, conserved site | 1323 - 1337 | IPR019775 |
| conserved_site | Kinesin motor domain, conserved site | 268 - 279 | IPR019821 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| determination of adult lifespan | The pathways that regulate the duration of the adult phase of the life-cycle of an animal. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| muscle cell development | The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| protein tetramerization | The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. |
| regulation of MAPK cascade | Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9L6 | STK4 | Serine/threonine-protein kinase 4 | Bos taurus (Bovine) | SS |
| Q3SWY6 | STK25 | Serine/threonine-protein kinase 25 | Bos taurus (Bovine) | PR |
| Q5ZJK4 | STK4 | Serine/threonine-protein kinase 4 | Gallus gallus (Chicken) | SS |
| Q9Y6E0 | STK24 | Serine/threonine-protein kinase 24 | Homo sapiens (Human) | PR |
| Q13188 | STK3 | Serine/threonine-protein kinase 3 | Homo sapiens (Human) | SS |
| O00506 | STK25 | Serine/threonine-protein kinase 25 | Homo sapiens (Human) | PR |
| Q13043 | STK4 | Serine/threonine-protein kinase 4 | Homo sapiens (Human) | EV |
| Q9Z2W1 | Stk25 | Serine/threonine-protein kinase 25 | Mus musculus (Mouse) | PR |
| Q9JI10 | Stk3 | Serine/threonine-protein kinase 3 | Mus musculus (Mouse) | SS |
| Q9JI11 | Stk4 | Serine/threonine-protein kinase 4 | Mus musculus (Mouse) | PR |
| Q99JT2 | Stk26 | Serine/threonine-protein kinase 26 | Mus musculus (Mouse) | PR |
| Q99KH8 | Stk24 | Serine/threonine-protein kinase 24 | Mus musculus (Mouse) | PR |
| O54748 | Stk3 | Serine/threonine-protein kinase 3 | Rattus norvegicus (Rat) | SS |
| A4K2T0 | STK4 | Serine/threonine-protein kinase 4 | Macaca mulatta (Rhesus macaque) | PR |
| H2L099 | gck-1 | Germinal center kinase 1 | Caenorhabditis elegans | PR |
| G5EFU0 | pak-2 | Serine/threonine-protein kinase pak-2 | Caenorhabditis elegans | PR |
| G5EGQ3 | max-2 | Serine/threonine-protein kinase max-2 | Caenorhabditis elegans | SS |
| Q17850 | pak-1 | Serine/threonine-protein kinase pak-1 | Caenorhabditis elegans | PR |
| Q6P3Q4 | stk4 | Serine/threonine-protein kinase 4 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q7ZUQ3 | stk3 | Serine/threonine-protein kinase 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPPSTDSSRR | NSEEGSSDGF | KLDSSALNKP | PEEVFDIVGK | LGEGSYGSVH | KAIHRESGHV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LAIKKVPVDT | DLQEIIKEIS | IMQQCKSKYV | VKYYGSYFKH | SDLWIVMEYC | GAGSISDIMR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ARRKPLSEQE | ISAVLRDTLK | GLQYLHDLKK | IHRDIKAGNI | LLNTDGIAKL | ADFGVAGQLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DTMAKRNTVI | GTPFWMAPEV | IEEIGYDTKA | DIWSLGITAI | EMAEGRPPYS | DIHPMRAIFM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IPTKPPPTFK | KPEEWSSEFN | DFIRSCLIKK | PEERKTALRL | CEHTFIKNAP | GCDIMQLMIQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DAQEKAILGQ | APMAASSGND | ATLLSEGMST | MIDGGESTLV | QHKDNYVTAQ | SLRSQMESLR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IGGEIPKSAY | IPGSSKNGNS | PRVQPPGHTA | SASDPSKNQP | FAQDGTGPNF | QLGTSESSYK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DASYNMMNTE | AEYENRFQRA | VVDGDFEFLR | NITLDELIRR | KESLDSEMEE | EIRELQRRYK |
| 490 | |||||
| TKRQPILDVI | EIKKRLQ |