Q9MA15

PR
Gene name
ABC1K3
Protein name
Protein ACTIVITY OF BC1 COMPLEX KINASE 3, chloroplastic
Names
ABC1-LIKE KINASE 3, Protein REPRESSOR OF BDR1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G79600
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-254 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9MA15

Entry ID Method Resolution Chain Position Source
AF-Q9MA15-F1 Predicted AlphaFoldDB

18 variants for Q9MA15

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH14494716 21 R>H No 1000Genomes
tmp_1_29952456_G_T 21 R>S No 1000Genomes
ENSVATH00150166 31 K>N No 1000Genomes
ENSVATH05175344 57 A>P No 1000Genomes
tmp_1_29952321_C_T 66 A>T No 1000Genomes
tmp_1_29952239_G_A 93 A>V No 1000Genomes
ENSVATH00150163 128 L>F No 1000Genomes
tmp_1_29952046_A_C 132 I>M No 1000Genomes
tmp_1_29951983_G_C 153 I>M No 1000Genomes
ENSVATH13840541 209 S>A No 1000Genomes
tmp_1_29951678_G_A 216 S>F No 1000Genomes
tmp_1_29951633_T_A 231 Y>F No 1000Genomes
tmp_1_29951013_A_G 438 S>P No 1000Genomes
tmp_1_29950866_G_A 487 P>S No 1000Genomes
ENSVATH13840539 639 T>R No 1000Genomes
tmp_1_29950359_A_T 656 S>T No 1000Genomes
tmp_1_29950325_A_G 667 I>T No 1000Genomes
tmp_1_29950148_T_A 698 Q>L No 1000Genomes

No associated diseases with Q9MA15

2 regional properties for Q9MA15

Type Name Position InterPro Accession
domain Protein kinase domain 216 - 546 IPR000719
domain ABC1 atypical kinase-like domain 185 - 429 IPR004147

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Plastid, chloroplast, plastoglobule
  • Plastid, chloroplast
  • Colocalizes with the chlorophyll autofluorescence of mature chloroplasts
  • In cotyledons of seedlings grown in continuous red light, only observed in the chloroplasts losing chlorophyll autofluorescence
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
plastoglobule A lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

10 GO annotations of biological process

Name Definition
cellular response to nitrogen starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen.
chloroplast organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast.
plastoglobule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plastoglobule. Plastoglobule is a lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids.
protein phosphorylation The process of introducing a phosphate group on to a protein.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
regulation of tocopherol cyclase activity Any process that modulates the frequency, rate or extent of tocopherol cyclase activity.
response to high light intensity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus.
response to photooxidative stress Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a photooxidative stress, the light-dependent generation of active oxygen species. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
response to red light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
response to water deprivation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P0A6A0 ubiB Probable protein kinase UbiB Escherichia coli (strain K12) SS
Q86TW2 ADCK1 AarF domain-containing protein kinase 1 Homo sapiens (Human) SS
Q3MIX3 ADCK5 Uncharacterized aarF domain-containing protein kinase 5 Homo sapiens (Human) SS
O04212 At2g40090 Putative ABC1 protein At2g40090 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSLVVGQSLG LTLVGDGLSL RNSKINVGKS KFFSVNRRRL ARAALVQARP KEDGAAASPS
70 80 90 100 110 120
PSSRPASVVQ YRRADLADDL QAEARALGRA IDASIYSPEL IARKHGSQPF KALRRSLEIL
130 140 150 160 170 180
GALGGFALKL GIDQKQGNLE KNMKKRAIEL RRIFTRLGPT FVKLGQGLST RPDLCPPDYL
190 200 210 220 230 240
EELAELQDAL PTFPDAEAFA CIERELDLSL ETIFSSVSPE PIAAASLGQV YKAQLRYSGQ
250 260 270 280 290 300
VVAVKVQRPG IEEAIGLDFY LIRGVGKLIN KYVDFITTDV LTLIDEFACR VYQELNYVQE
310 320 330 340 350 360
AQNARRFKKL YADKADVLVP DIFWDYTSRK VLTMEWVEGT KLNEQLAIES QGLKVLDLVN
370 380 390 400 410 420
TGIQCSLRQL LEYGFFHADP HPGNLLATPD GKLAFLDFGM MSETPEEARF AIIGHVVHLV
430 440 450 460 470 480
NRDYEAMARD YYALKFLSPD VDVTPIIPAL RDFFDDALNY TVSELNFKTL VDGLGAVFYQ
490 500 510 520 530 540
YPFNVPPYYA LILRSLTVLE GLALYADPNF KVLAASYPYF AKRLLTDPNP YLRDALIELL
550 560 570 580 590 600
FKDGKFRWNR LENLLQQGSK DRDFSAKDAL QPVLKLLLDP NGEELRLLVI KEAVRVSEAI
610 620 630 640 650 660
ALGTVVDTYN SLPEFLRSLV FNGNGNGPLT MSTAELQSTL ELRDQVSRIW GLLQSSESFD
670 680 690 700 710
PAILQPILQV LQQPEARRLG GRVAGGVGQR LAARFLQQLL RATTPSSAPS P