Q9M9W7

SS
Gene name
PME22 (ARATH22, At3g05620, F18C1.11)
Protein name
Putative pectinesterase/pectinesterase inhibitor 22
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G05620
EC number
3.1.1.11: Carboxylic ester hydrolases
Protein Class

Descriptions

(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.

Autoinhibitory domains (AIDs)

35-197 (PMEI region) SS

Target domain

240-526 (Pectinesterase domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9M9W7

Entry ID Method Resolution Chain Position Source
AF-Q9M9W7-F1 Predicted AlphaFoldDB

54 variants for Q9M9W7

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH02115918 5 T>I No 1000Genomes
ENSVATH02115918 5 T>N No 1000Genomes
tmp_3_1631745_G_A 8 L>F No 1000Genomes
ENSVATH05777074 12 L>V No 1000Genomes
tmp_3_1631718_T_A,C 17 T>A No 1000Genomes
ENSVATH05777073 17 T>I No 1000Genomes
tmp_3_1631718_T_A,C 17 T>S No 1000Genomes
ENSVATH05777072 20 Y>C No 1000Genomes
ENSVATH05777071 25 L>F No 1000Genomes
tmp_3_1631679_C_T 30 E>K No 1000Genomes
ENSVATH00307702 31 D>E No 1000Genomes
ENSVATH00307701 51 V>I No 1000Genomes
ENSVATH02115917 55 W>R No 1000Genomes
tmp_3_1631585_G_C 61 S>W No 1000Genomes
ENSVATH02115916 72 R>C No 1000Genomes
ENSVATH02115916 72 R>S No 1000Genomes
ENSVATH05777064 75 V>A No 1000Genomes
tmp_3_1631509_C_T 86 M>I No 1000Genomes
ENSVATH05777061 94 M>T No 1000Genomes
tmp_3_1631415_C_A 118 E>* No 1000Genomes
tmp_3_1631369_C_T 133 G>E No 1000Genomes
ENSVATH02115913 139 D>G No 1000Genomes
ENSVATH00307700 173 E>G No 1000Genomes
tmp_3_1631204_G_C 188 T>S No 1000Genomes
tmp_3_1631187_C_T 194 V>I No 1000Genomes
ENSVATH05777057 205 P>S No 1000Genomes
tmp_3_1631141_G_A 209 S>F No 1000Genomes
tmp_3_1631112_C_T 219 E>K No 1000Genomes
ENSVATH05777056 226 E>K No 1000Genomes
tmp_3_1631067_G_A 234 P>S No 1000Genomes
tmp_3_1631063_C_A 235 S>I No 1000Genomes
ENSVATH02115911 236 V>A No 1000Genomes
ENSVATH02115908 245 I>V No 1000Genomes
ENSVATH05777053 259 N>D No 1000Genomes
ENSVATH05777052 279 K>R No 1000Genomes
ENSVATH00307698 300 Q>H No 1000Genomes
ENSVATH05777051 302 I>V No 1000Genomes
ENSVATH05777050 311 Q>H No 1000Genomes
tmp_3_1630829_A_C 313 L>R No 1000Genomes
tmp_3_1630302_C_T 330 A>T No 1000Genomes
ENSVATH05777043 333 I>M No 1000Genomes
tmp_3_1630271_C_A 340 G>V No 1000Genomes
tmp_3_1630262_T_C 343 N>S No 1000Genomes
ENSVATH13874173 379 Y>* No 1000Genomes
ENSVATH10508793 434 Q>* No 1000Genomes
tmp_3_1629926_C_T 455 R>K No 1000Genomes
tmp_3_1629803_C_T 496 W>* No 1000Genomes
tmp_3_1629800_C_A 497 R>L No 1000Genomes
ENSVATH05777042 499 S>P No 1000Genomes
tmp_3_1629746_G_C 515 A>G No 1000Genomes
tmp_3_1629692_G_A 533 T>I No 1000Genomes
tmp_3_1629683_G_A 536 T>I No 1000Genomes
ENSVATH10508792 536 T>P No 1000Genomes
tmp_3_1629671_C_G 540 G>A No 1000Genomes

No associated diseases with Q9M9W7

3 regional properties for Q9M9W7

Type Name Position InterPro Accession
domain 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 386 - 715 IPR002073
conserved_site 3'5'-cyclic nucleotide phosphodiesterase, conserved site 502 - 513 IPR023174
domain Phosphodiesterase 4 upstream conserved regions (UCR) 223 - 339 IPR040844

Functions

Description
EC Number 3.1.1.11 Carboxylic ester hydrolases
Subcellular Localization
  • Secreted, cell wall
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

3 GO annotations of molecular function

Name Definition
aspartyl esterase activity Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue.
pectinesterase activity Catalysis of the reaction: pectin + n H2O = n methanol + pectate.
pectinesterase inhibitor activity Binds to and stops, prevents or reduces the activity of pectinesterase.

2 GO annotations of biological process

Name Definition
cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly.
pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.

42 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9SRX4 PME7 Probable pectinesterase/pectinesterase inhibitor 7 Arabidopsis thaliana (Mouse-ear cress) SS
Q1JPL7 PME18 Pectinesterase/pectinesterase inhibitor 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q84JX1 PME19 Probable pectinesterase/pectinesterase inhibitor 19 Arabidopsis thaliana (Mouse-ear cress) SS
O49298 PME6 Probable pectinesterase/pectinesterase inhibitor 6 Arabidopsis thaliana (Mouse-ear cress) SS
Q42534 PME2 Pectinesterase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q43867 PME1 Pectinesterase 1 Arabidopsis thaliana (Mouse-ear cress) SS
O48711 PME12 Probable pectinesterase/pectinesterase inhibitor 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q7Y201 PME13 Probable pectinesterase/pectinesterase inhibitor 13 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SKX2 PME16 Probable pectinesterase/pectinesterase inhibitor 16 Arabidopsis thaliana (Mouse-ear cress) SS
O22149 PME17 Probable pectinesterase/pectinesterase inhibitor 17 Arabidopsis thaliana (Mouse-ear cress) SS
O80722 PME4 Pectinesterase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV8 PME5 Pectinesterase 5 Arabidopsis thaliana (Mouse-ear cress) SS
O22256 PME20 Probable pectinesterase/pectinesterase inhibitor 20 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GX86 PME21 Probable pectinesterase/pectinesterase inhibitor 21 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GXA1 PME23 Probable pectinesterase/pectinesterase inhibitor 23 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SG77 PME24 Putative pectinesterase/pectinesterase inhibitor 24 Arabidopsis thaliana (Mouse-ear cress) SS
O49006 PME3 Pectinesterase/pectinesterase inhibitor 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q9STY3 PME33 Probable pectinesterase/pectinesterase inhibitor 33 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LYT5 PME35 Probable pectinesterase/pectinesterase inhibitor 35 Arabidopsis thaliana (Mouse-ear cress) SS
Q84R10 PME36 Probable pectinesterase/pectinesterase inhibitor 36 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV6 VGDH2 Probable pectinesterase/pectinesterase inhibitor VGDH2 Arabidopsis thaliana (Mouse-ear cress) SS
O81320 PME38 Putative pectinesterase/pectinesterase inhibitor 38 Arabidopsis thaliana (Mouse-ear cress) SS
O81415 PME39 Probable pectinesterase/pectinesterase inhibitor 39 Arabidopsis thaliana (Mouse-ear cress) SS
O81301 PME40 Probable pectinesterase/pectinesterase inhibitor 40 Arabidopsis thaliana (Mouse-ear cress) SS
Q8RXK7 PME41 Probable pectinesterase/pectinesterase inhibitor 41 Arabidopsis thaliana (Mouse-ear cress) SS
Q1PEC0 PME42 Probable pectinesterase/pectinesterase inhibitor 42 Arabidopsis thaliana (Mouse-ear cress) SS
O23447 PME43 Putative pectinesterase/pectinesterase inhibitor 43 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY7 PME44 Probable pectinesterase/pectinesterase inhibitor 44 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY6 PME45 Putative pectinesterase/pectinesterase inhibitor 45 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF78 PME46 Probable pectinesterase/pectinesterase inhibitor 46 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF77 PME47 Probable pectinesterase/pectinesterase inhibitor 47 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXD9 PME51 Probable pectinesterase/pectinesterase inhibitor 51 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E989 PME54 Probable pectinesterase/pectinesterase inhibitor 54 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E8Z8 PME28 Putative pectinesterase/pectinesterase inhibitor 28 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FJ21 PME58 Probable pectinesterase/pectinesterase inhibitor 58 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN5 PME59 Probable pectinesterase/pectinesterase inhibitor 59 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN4 PME60 Probable pectinesterase/pectinesterase inhibitor 60 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FK05 PME61 Probable pectinesterase/pectinesterase inhibitor 61 Arabidopsis thaliana (Mouse-ear cress) SS
Q8L7Q7 PME64 Probable pectinesterase/pectinesterase inhibitor 64 Arabidopsis thaliana (Mouse-ear cress) SS
Q94CB1 PME25 Probable pectinesterase/pectinesterase inhibitor 25 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXK7 PME32 Probable pectinesterase/pectinesterase inhibitor 32 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M3B0 PME34 Probable pectinesterase/pectinesterase inhibitor 34 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MGITTALLLV MLMSVHTSSY ETTILKPYKE DNFRSLVAKA CQFIDAHELC VSNIWTHVKE
70 80 90 100 110 120
SGHGLNPHSV LRAAVKEAHD KAKLAMERIP TVMMLSIRSR EQVAIEDCKE LVGFSVTELA
130 140 150 160 170 180
WSMLEMNKLH GGGGIDLDDG SHDAAAAGGN LKTWLSAAMS NQDTCLEGFE GTERKYEELI
190 200 210 220 230 240
KGSLRQVTQL VSNVLDMYTQ LNALPFKASR NESVIASPEW LTETDESLMM RHDPSVMHPN
250 260 270 280 290 300
TVVAIDGKGK YRTINEAINE APNHSTKRYV IYVKKGVYKE NIDLKKKKTN IMLVGDGIGQ
310 320 330 340 350 360
TIITGDRNFM QGLTTFRTAT VAVSGRGFIA KDITFRNTAG PQNRQAVALR VDSDQSAFYR
370 380 390 400 410 420
CSVEGYQDTL YAHSLRQFYR DCEIYGTIDF IFGNGAAVLQ NCKIYTRVPL PLQKVTITAQ
430 440 450 460 470 480
GRKSPNQNTG FVIQNSYVLA TQPTYLGRPW KLYSRTVYMN TYMSQLVQPR GWLEWFGNFA
490 500 510 520 530 540
LDTLWYGEYN NIGPGWRSSG RVKWPGYHIM DKRTALSFTV GSFIDGRRWL PATGVTFTAG
LAN