Q9M3B0
SS
Gene name |
PME34 (ARATH34, At3g49220, F2K15.80) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 34 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G49220 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
284-581 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q9M3B0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9M3B0-F1 | Predicted | AlphaFoldDB |
33 variants for Q9M3B0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_18249852_A_G | 5 | R>G | No | 1000Genomes | |
| ENSVATH02475602 | 13 | G>D | No | 1000Genomes | |
| tmp_3_18249882_G_A | 15 | V>I | No | 1000Genomes | |
| ENSVATH12657779 | 33 | Q>L | No | 1000Genomes | |
| ENSVATH06277413 | 43 | K>R | No | 1000Genomes | |
| ENSVATH06277414 | 47 | V>L | No | 1000Genomes | |
| ENSVATH00410332 | 71 | K>Q | No | 1000Genomes | |
| tmp_3_18250058_C_A,G | 73 | N>K | No | 1000Genomes | |
| tmp_3_18250058_C_A,G | 73 | N>K | No | 1000Genomes | |
| ENSVATH12657780 | 106 | D>E | No | 1000Genomes | |
| ENSVATH00410334 | 106 | D>N | No | 1000Genomes | |
| tmp_3_18250207_C_G | 123 | T>S | No | 1000Genomes | |
| tmp_3_18250270_T_G | 144 | V>G | No | 1000Genomes | |
| tmp_3_18250278_C_T | 147 | P>S | No | 1000Genomes | |
| tmp_3_18250332_G_A | 165 | V>I | No | 1000Genomes | |
| tmp_3_18250339_C_A | 167 | A>E | No | 1000Genomes | |
| tmp_3_18250488_G_A | 217 | A>T | No | 1000Genomes | |
| ENSVATH00410338 | 236 | S>N | No | 1000Genomes | |
| ENSVATH12657782 | 240 | D>E | No | 1000Genomes | |
| ENSVATH14406461 | 249 | N>S | No | 1000Genomes | |
| tmp_3_18250637_G_A | 266 | M>I | No | 1000Genomes | |
| tmp_3_18250641_C_T | 268 | P>S | No | 1000Genomes | |
| tmp_3_18250666_T_C | 276 | M>T | No | 1000Genomes | |
| tmp_3_18250750_A_G | 304 | K>R | No | 1000Genomes | |
| tmp_3_18250771_G_A | 311 | R>H | No | 1000Genomes | |
| ENSVATH12657783 | 315 | I>V | No | 1000Genomes | |
| tmp_3_18250794_G_A | 319 | A>T | No | 1000Genomes | |
| tmp_3_18251085_T_A | 365 | S>T | No | 1000Genomes | |
| tmp_3_18253064_G_A | 405 | R>Q | No | 1000Genomes | |
| ENSVATH14406489 | 424 | F>L | No | 1000Genomes | |
| ENSVATH12657895 | 488 | D>N | No | 1000Genomes | |
| tmp_3_18253537_G_A | 563 | V>I | No | 1000Genomes | |
| tmp_3_18253577_C_G | 576 | A>G | No | 1000Genomes |
No associated diseases with Q9M3B0
3 regional properties for Q9M3B0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Heat shock protein 70, conserved site | 9 - 16 | IPR018181-1 |
| conserved_site | Heat shock protein 70, conserved site | 197 - 210 | IPR018181-2 |
| conserved_site | Heat shock protein 70, conserved site | 334 - 348 | IPR018181-3 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plant-type cell wall | A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
| regulation of stomatal movement | Any process that modulates the frequency, rate or extent of stomatal movement. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGYERLGPSG | ATGSVTTSTT | TAPILNQVST | SEQPENNNRR | SKKKLVVSSI | VLAISLILAA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AIFAGVRSRL | KLNQSVPGLA | RKPSQAISKA | CELTRFPELC | VDSLMDFPGS | LAASSSKDLI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HVTVNMTLHH | FSHALYSSAS | LSFVDMPPRA | RSAYDSCVEL | LDDSVDALSR | ALSSVVSSSA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KPQDVTTWLS | AALTNHDTCT | EGFDGVDDGG | VKDHMTAALQ | NLSELVSNCL | AIFSASHDGD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DFAGVPIQNR | RLLGVEEREE | KFPRWMRPKE | REILEMPVSQ | IQADIIVSKD | GNGTCKTISE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AIKKAPQNST | RRIIIYVKAG | RYEENNLKVG | RKKINLMFVG | DGKGKTVISG | GKSIFDNITT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FHTASFAATG | AGFIARDITF | ENWAGPAKHQ | AVALRIGADH | AVIYRCNIIG | YQDTLYVHSN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RQFFRECDIY | GTVDFIFGNA | AVVLQNCSIY | ARKPMDFQKN | TITAQNRKDP | NQNTGISIHA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SRVLAASDLQ | ATNGSTQTYL | GRPWKLFSRT | VYMMSYIGGH | VHTRGWLEWN | TTFALDTLYY |
| 550 | 560 | 570 | 580 | 590 | |
| GEYLNSGPGS | GLGQRVSWPG | YRVINSTAEA | NRFTVAEFIY | GSSWLPSTGV | SFLAGLSI |