Q9M376
Gene name |
VAMP727 (At3g54300, F24B22.260) |
Protein name |
Vesicle-associated membrane protein 727 |
Names |
AtVAMP727 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G54300 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
149-209 (v-SNARE coiled-coil homology) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
- Wen W et al. (2010) "Lipid-Induced conformational switch controls fusion activity of longin domain SNARE Ykt6", Molecular cell, 37, 383-95
- Martinez-Arca S et al. (2003) "A dual mechanism controlling the localization and function of exocytic v-SNAREs", Proceedings of the National Academy of Sciences of the United States of America, 100, 9011-6
- Gonzalez LC Jr et al. (2001) "A novel snare N-terminal domain revealed by the crystal structure of Sec22b", The Journal of biological chemistry, 276, 24203-11
- Mancias JD et al. (2007) "The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope", Molecular cell, 26, 403-14
Autoinhibited structure
Activated structure
1 structures for Q9M376
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9M376-F1 | Predicted | AlphaFoldDB |
12 variants for Q9M376
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_20110087_C_G | 14 | G>A | No | 1000Genomes | |
| ENSVATH12755610 | 31 | I>V | No | 1000Genomes | |
| ENSVATH06313263 | 59 | V>I | No | 1000Genomes | |
| tmp_3_20109945_A_T | 61 | N>K | No | 1000Genomes | |
| ENSVATH14432739 | 63 | F>L | No | 1000Genomes | |
| ENSVATH06313254 | 84 | R>Q | No | 1000Genomes | |
| ENSVATH06313250 | 121 | V>I | No | 1000Genomes | |
| tmp_3_20109517_C_G | 142 | S>T | No | 1000Genomes | |
| ENSVATH06313215 | 179 | E>D | No | 1000Genomes | |
| ENSVATH12755587 | 218 | A>T | No | 1000Genomes | |
| ENSVATH12755554 | 225 | I>S | No | 1000Genomes | |
| ENSVATH14432694 | 229 | W>L | No | 1000Genomes |
No associated diseases with Q9M376
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| CORVET complex | A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p. |
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| SNARE complex | A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| protein targeting to vacuole | The process of directing proteins towards the vacuole, usually using signals contained within the protein. |
| vacuole organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12255 | NYV1 | Vacuolar v-SNARE NYV1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q17QI5 | VAMP7 | Vesicle-associated membrane protein 7 | Bos taurus (Bovine) | SS |
| Q5ZL74 | VAMP7 | Vesicle-associated membrane protein 7 | Gallus gallus (Chicken) | SS |
| P51809 | VAMP7 | Vesicle-associated membrane protein 7 | Homo sapiens (Human) | EV |
| P70280 | Vamp7 | Vesicle-associated membrane protein 7 | Mus musculus (Mouse) | SS |
| Q9JHW5 | Vamp7 | Vesicle-associated membrane protein 7 | Rattus norvegicus (Rat) | SS |
| O49377 | VAMP711 | Vesicle-associated membrane protein 711 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FMR5 | VAMP714 | Vesicle-associated membrane protein 714 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFP1 | VAMP713 | Vesicle-associated membrane protein 713 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SIQ9 | VAMP712 | Vesicle-associated membrane protein 712 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQKGLIYSF | VAKGTVVLAE | HTPYSGNFST | IAVQCLQKLP | TNSSKYTYSC | DGHTFNFLVD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NGFVFLVVAD | ESTGRSVPFV | FLERVKEDFK | KRYEASIKND | ERHPLADEDE | DDDLFGDRFS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VAYNLDREFG | PILKEHMQYC | MSHPEEMSKL | SKLKAQITEV | KGIMMDNIEK | VLDRGEKIEL |
| 190 | 200 | 210 | 220 | 230 | |
| LVDKTENLQF | QADSFQRQGR | QLRRKMWLQS | LQMKLMVAGA | VFSFILIVWV | VACGGFKCSS |