Q9M342

PR
Gene name
WAKL15 (At3g53840, F5K20_140)
Protein name
Wall-associated receptor kinase-like 15
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G53840
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

273-372 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9M342

Entry ID Method Resolution Chain Position Source
AF-Q9M342-F1 Predicted AlphaFoldDB

78 variants for Q9M342

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH14430651 7 S>F No 1000Genomes
tmp_3_19945596_C_T 9 T>I No 1000Genomes
ENSVATH06310327 13 L>F No 1000Genomes
ENSVATH06310328 17 I>T No 1000Genomes
tmp_3_19945659_C_G 30 P>R No 1000Genomes
tmp_3_19945674_C_T 35 T>I No 1000Genomes
ENSVATH00418125 57 D>N No 1000Genomes
tmp_3_19945785_A_G 72 N>S No 1000Genomes
tmp_3_19945787_C_T 73 P>S No 1000Genomes
ENSVATH14430652 76 T>K No 1000Genomes
ENSVATH12748617 77 I>S No 1000Genomes
tmp_3_19945873_C_G 101 I>M No 1000Genomes
ENSVATH14430653 104 H>Q No 1000Genomes
ENSVATH06310331 105 G>S No 1000Genomes
tmp_3_19945930_C_G 120 N>K No 1000Genomes
tmp_3_19945934_G_A 122 V>I No 1000Genomes
ENSVATH12748618 135 Y>* No 1000Genomes
ENSVATH06310334 144 D>E No 1000Genomes
tmp_3_19946054_T_C 162 C>R No 1000Genomes
tmp_3_19946063_G_A 165 V>M No 1000Genomes
tmp_3_19946099_G_A 177 V>I No 1000Genomes
tmp_3_19946154_G_A 195 S>N No 1000Genomes
tmp_3_19946163_A_T 198 N>I No 1000Genomes
ENSVATH06310335 198 N>Y No 1000Genomes
tmp_3_19946190_A_T 207 K>I No 1000Genomes
tmp_3_19946220_G_A 217 W>* No 1000Genomes
tmp_3_19946236_A_C 222 E>D No 1000Genomes
ENSVATH14430654 226 K>Q No 1000Genomes
ENSVATH06310336 232 R>I No 1000Genomes
ENSVATH06310337 234 L>V No 1000Genomes
ENSVATH02501682 242 D>N No 1000Genomes
ENSVATH02501683 252 F>L No 1000Genomes
ENSVATH02501684 260 D>N No 1000Genomes
ENSVATH12748624 262 V>G No 1000Genomes
ENSVATH06310339 274 R>G No 1000Genomes
tmp_3_19946476_G_T 274 R>L No 1000Genomes
ENSVATH00418128 276 S>C No 1000Genomes
ENSVATH02501686 295 A>P No 1000Genomes
tmp_3_19946712_A_G 305 T>A No 1000Genomes
ENSVATH06310342 311 N>K No 1000Genomes
tmp_3_19946764_G_C 322 S>T No 1000Genomes
tmp_3_19946792_G_T 331 L>F No 1000Genomes
ENSVATH14430678 336 T>A No 1000Genomes
ENSVATH06310343 342 F>Y No 1000Genomes
ENSVATH14430679 352 D>Y No 1000Genomes
tmp_3_19946907_A_G 370 K>E No 1000Genomes
ENSVATH00418134 386 L>I No 1000Genomes
ENSVATH06310346 395 I>T No 1000Genomes
ENSVATH12748652 422 M>I No 1000Genomes
tmp_3_19947075_G_A 426 V>I No 1000Genomes
tmp_3_19947078_T_C 427 Y>H No 1000Genomes
tmp_3_19947083_A_T,C 428 E>D No 1000Genomes
ENSVATH06310349 433 G>R No 1000Genomes
tmp_3_19947109_A_G,T 437 E>G No 1000Genomes
tmp_3_19947109_A_G,T 437 E>V No 1000Genomes
tmp_3_19947146_A_T 449 L>F No 1000Genomes
ENSVATH02501690 465 T>M No 1000Genomes
ENSVATH12748654 477 S>P No 1000Genomes
tmp_3_19947235_C_G 479 P>R No 1000Genomes
ENSVATH06310351 479 P>S No 1000Genomes
ENSVATH14430681 487 S>* No 1000Genomes
ENSVATH06310352 493 D>N No 1000Genomes
ENSVATH06310356 527 L>F No 1000Genomes
tmp_3_19947438_G_T 547 G>W No 1000Genomes
ENSVATH14430683 550 L>F No 1000Genomes
tmp_3_19947492_G_C 565 E>Q No 1000Genomes
ENSVATH12748685 566 E>* No 1000Genomes
tmp_3_19947501_G_A 568 D>N No 1000Genomes
ENSVATH12748686 592 I>V No 1000Genomes
ENSVATH06310363 594 I>K No 1000Genomes
ENSVATH06310364 602 E>V No 1000Genomes
ENSVATH06310365 606 A>E No 1000Genomes
tmp_3_19947642_G_T 615 V>L No 1000Genomes
tmp_3_19947652_C_G 618 T>R No 1000Genomes
ENSVATH06310366 619 R>G No 1000Genomes
tmp_3_19947664_G_C 622 R>P No 1000Genomes
ENSVATH02501693 630 K>E No 1000Genomes
ENSVATH06310368 634 N>S No 1000Genomes

No associated diseases with Q9M342

3 regional properties for Q9M342

Type Name Position InterPro Accession
domain Protein kinase domain 354 - 639 IPR000719
active_site Serine/threonine-protein kinase, active site 480 - 492 IPR008271
binding_site Protein kinase, ATP binding site 360 - 382 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
cell surface receptor signaling pathway The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
protein phosphorylation The process of introducing a phosphate group on to a protein.

68 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6XUX0 DSTYK Dual serine/threonine and tyrosine protein kinase Gallus gallus (Chicken) PR
Q9Y616 IRAK3 Interleukin-1 receptor-associated kinase 3 Homo sapiens (Human) PR
P53667 LIMK1 LIM domain kinase 1 Homo sapiens (Human) PR
P53671 LIMK2 LIM domain kinase 2 Homo sapiens (Human) PR
P06213 INSR Insulin receptor Homo sapiens (Human) EV
P08069 IGF1R Insulin-like growth factor 1 receptor Homo sapiens (Human) EV
P14616 INSRR Insulin receptor-related protein Homo sapiens (Human) SS
P00533 EGFR Epidermal growth factor receptor Homo sapiens (Human) EV
Q15303 ERBB4 Receptor tyrosine-protein kinase erbB-4 Homo sapiens (Human) SS
P04626 ERBB2 Receptor tyrosine-protein kinase erbB-2 Homo sapiens (Human) SS
P21860 ERBB3 Receptor tyrosine-protein kinase erbB-3 Homo sapiens (Human) SS
Q8K4B2 Irak3 Interleukin-1 receptor-associated kinase 3 Mus musculus (Mouse) PR
Q8CFA1 Irak2 Interleukin-1 receptor-associated kinase-like 2 Mus musculus (Mouse) PR
O54785 Limk2 LIM domain kinase 2 Mus musculus (Mouse) PR
O08644 Ephb6 Ephrin type-B receptor 6 Mus musculus (Mouse) PR
P54763 Ephb2 Ephrin type-B receptor 2 Mus musculus (Mouse) SS
Q03137 Epha4 Ephrin type-A receptor 4 Mus musculus (Mouse) SS
Q60751 Igf1r Insulin-like growth factor 1 receptor Mus musculus (Mouse) SS
Q61772 Epha7 Ephrin type-A receptor 7 Mus musculus (Mouse) SS
Q8BYG9 Epha10 Ephrin type-A receptor 10 Mus musculus (Mouse) SS
Q8CBF3 Ephb1 Ephrin type-B receptor 1 Mus musculus (Mouse) SS
P54754 Ephb3 Ephrin type-B receptor 3 Mus musculus (Mouse) SS
Q9WTL4 Insrr Insulin receptor-related protein Mus musculus (Mouse) SS
O09127 Epha8 Ephrin type-A receptor 8 Mus musculus (Mouse) SS
Q60629 Epha5 Ephrin type-A receptor 5 Mus musculus (Mouse) SS
P15208 Insr Insulin receptor Mus musculus (Mouse) SS
P54761 Ephb4 Ephrin type-B receptor 4 Mus musculus (Mouse) PR
Q61527 Erbb4 Receptor tyrosine-protein kinase erbB-4 Mus musculus (Mouse) SS
Q61526 Erbb3 Receptor tyrosine-protein kinase erbB-3 Mus musculus (Mouse) SS
Q01279 Egfr Epidermal growth factor receptor Mus musculus (Mouse) SS
Q62413 Epha6 Ephrin type-A receptor 6 Mus musculus (Mouse) SS
P29319 Epha3 Ephrin type-A receptor 3 Mus musculus (Mouse) SS
Q4QQS0 Irak2 Interleukin-1 receptor-associated kinase-like 2 Rattus norvegicus (Rat) PR
O08680 Epha3 Ephrin type-A receptor 3 Rattus norvegicus (Rat) SS
P54757 Epha5 Ephrin type-A receptor 5 Rattus norvegicus (Rat) SS
P54759 Epha7 Ephrin type-A receptor 7 Rattus norvegicus (Rat) SS
P09759 Ephb1 Ephrin type-B receptor 1 Rattus norvegicus (Rat) SS
P0C0K7 Ephb6 Ephrin type-B receptor 6 Rattus norvegicus (Rat) SS
Q9ASQ5 CRCK3 Calmodulin-binding receptor-like cytoplasmic kinase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LPS5 SERK5 Somatic embryogenesis receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWW0 ALE2 Receptor-like serine/threonine-protein kinase ALE2 Arabidopsis thaliana (Mouse-ear cress) PR
P93050 BSH Probable LRR receptor-like serine/threonine-protein kinase RKF3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRP3 At3g17420 Probable receptor-like protein kinase At3g17420 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STF0 LECRKS3 Receptor like protein kinase S.3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SCZ4 FER Receptor-like protein kinase FERONIA Arabidopsis thaliana (Mouse-ear cress) PR
Q9LYN6 At3g56050 Probable inactive receptor-like protein kinase At3g56050 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZJ9 CRCK2 Calmodulin-binding receptor-like cytoplasmic kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
P43293 PBL11 Probable serine/threonine-protein kinase PBL11 Arabidopsis thaliana (Mouse-ear cress) PR
Q94C25 At5g20050 Probable receptor-like protein kinase At5g20050 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FLW0 At5g24010 Probable receptor-like protein kinase At5g24010 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E8W4 ANX2 Receptor-like protein kinase ANXUR2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTC0 PBL19 Probable serine/threonine-protein kinase PBL19 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIL7 CRCK1 Calmodulin-binding receptor-like cytoplasmic kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q0WNY5 WAKL18 Wall-associated receptor kinase-like 18 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSV3 WAKL16 Putative wall-associated receptor kinase-like 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q7X8C5 WAKL2 Wall-associated receptor kinase-like 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9S9M2 WAKL4 Wall-associated receptor kinase-like 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LMN7 WAK5 Wall-associated receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C9L5 WAKL9 Wall-associated receptor kinase-like 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VYA3 WAKL10 Wall-associated receptor kinase-like 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M092 WAKL17 Wall-associated receptor kinase-like 17 Arabidopsis thaliana (Mouse-ear cress) PR
Q8JFR5 kita Mast/stem cell growth factor receptor kita Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9I8N6 csf1r Macrophage colony-stimulating factor 1 receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5GIT4 kdr Vascular endothelial growth factor receptor 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q90Z00 fgfr1a Fibroblast growth factor receptor 1-A Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5MD89 flt4 Vascular endothelial growth factor receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q8JG38 fgfr2 Fibroblast growth factor receptor 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9I8X3 fgfr3 Fibroblast growth factor receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MELPWLSLTT FTLSLLIYFS STTQAFKRCP NCGSTRVPYP LSTGLDCGDP GYRIRCDNYG
70 80 90 100 110 120
SLWFDTLNGS TNPIKTIDPS GQRFVLRPPG FEQNKCVSVD IKYHGIQLDL NLPFNVSCSN
130 140 150 160 170 180
TVIIMNCTKD GLDAYSSQGF NCSDNSLCHK FLNANLEARG NCRGVTSCCW YKTGASVNTY
190 200 210 220 230 240
KVYRARPDMC SAYQSFMNLD LTIPVSKWGE PAVEILWEAP REPVCKSQGD CRDLLNSVCS
250 260 270 280 290 300
NDSTNLGQKR CFCKKGFQWD SVNAVCEVNR CSKRKSCKRW SNLPLLGGLA GGVGAILIAG
310 320 330 340 350 360
FITKTIVSKQ NRRIAGNQSW ASVRKLHRNL LSINSTGLDR IFTGKEIVKA TDNFAKSNLL
370 380 390 400 410 420
GFGGFGEVFK GNLDDGTTVA VKRAKLGNEK SIYQIVNEVQ ILCQVSHKNL VKLLGCCIEL
430 440 450 460 470 480
EMPVLVYEFV PNGTLFEHIY GGGGGGGGLY DHLPLRRRLM IAHQTAQGLD YLHSSSSPPI
490 500 510 520 530 540
YHRDVKSSNI LLDENLDVKV ADFGLSRLGV SDVSHVTTCA QGTLGYLDPE YYLNFQLTDK
550 560 570 580 590 600
SDVYSFGVVL FELLTCKKAI DFNREEEDVN LVVFVRKALK EGRLMDVIDP VIGIGATEKE
610 620 630
IESMKALGVL AELCVKETRQ CRPTMQVAAK EIENILHGI