Q9M2Z3
Gene name |
SEND1 |
Protein name |
Single-strand DNA endonuclease 1 |
Names |
AtSEND1, Flap endonuclease GEN-like 2, XPG-like endonuclease 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G48900 |
EC number |
|
Protein Class |
|

Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure

Activated structure

1 structures for Q9M2Z3
Entry ID | Method | Resolution | Chain | Position | Source |
---|---|---|---|---|---|
AF-Q9M2Z3-F1 | Predicted | AlphaFoldDB |
74 variants for Q9M2Z3
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
tmp_3_18132021_G_T | 27 | V>L | No | 1000Genomes | |
tmp_3_18132051_G_A | 37 | E>K | No | 1000Genomes | |
ENSVATH12649766 | 43 | K>I | No | 1000Genomes | |
ENSVATH12649767 | 52 | V>F | No | 1000Genomes | |
ENSVATH02472989 | 57 | F>I | No | 1000Genomes | |
ENSVATH02472989 | 57 | F>V | No | 1000Genomes | |
tmp_3_18132123_C_T | 61 | L>F | No | 1000Genomes | |
tmp_3_18132384_G_A | 77 | G>S | No | 1000Genomes | |
ENSVATH14404365 | 99 | D>E | No | 1000Genomes | |
tmp_3_18132558_G_C | 101 | G>A | No | 1000Genomes | |
tmp_3_18132582_C_T | 109 | S>L | No | 1000Genomes | |
ENSVATH14404366 | 120 | C>Y | No | 1000Genomes | |
tmp_3_18132663_G_C | 136 | C>S | No | 1000Genomes | |
tmp_3_18132668_G_A | 138 | D>N | No | 1000Genomes | |
tmp_3_18132838_G_A | 148 | A>T | No | 1000Genomes | |
tmp_3_18132853_G_A | 153 | E>K | No | 1000Genomes | |
tmp_3_18132953_A_G | 161 | S>G | No | 1000Genomes | |
ENSVATH06274805 | 171 | A>P | No | 1000Genomes | |
tmp_3_18132999_G_A | 176 | R>K | No | 1000Genomes | |
ENSVATH12649788 | 184 | G>C | No | 1000Genomes | |
ENSVATH06274809 | 185 | Y>C | No | 1000Genomes | |
tmp_3_18133120_T_G | 185 | Y>D | No | 1000Genomes | |
ENSVATH06274817 | 214 | S>N | No | 1000Genomes | |
tmp_3_18133736_A_C | 227 | K>T | No | 1000Genomes | |
tmp_3_18133754_G_T | 233 | R>M | No | 1000Genomes | |
ENSVATH06274820 | 242 | E>D | No | 1000Genomes | |
tmp_3_18133781_A_G | 242 | E>G | No | 1000Genomes | |
tmp_3_18133787_T_C | 244 | V>A | No | 1000Genomes | |
tmp_3_18133846_C_A | 264 | P>T | No | 1000Genomes | |
tmp_3_18133852_G_A | 266 | V>M | No | 1000Genomes | |
ENSVATH00409420 | 282 | N>I | No | 1000Genomes | |
ENSVATH00409421 | 293 | Q>R | No | 1000Genomes | |
ENSVATH00409422 | 306 | A>T | No | 1000Genomes | |
tmp_3_18134462_C_T | 322 | R>C | No | 1000Genomes | |
ENSVATH14404371 | 347 | K>E | No | 1000Genomes | |
ENSVATH14404372 | 349 | A>P | No | 1000Genomes | |
ENSVATH00409429 | 358 | N>I | No | 1000Genomes | |
ENSVATH02473027 | 361 | S>T | No | 1000Genomes | |
tmp_3_18134718_A_C | 373 | H>P | No | 1000Genomes | |
ENSVATH12649834 | 374 | K>* | No | 1000Genomes | |
ENSVATH00409434 | 378 | P>L | No | 1000Genomes | |
tmp_3_18135106_G_T | 383 | V>L | No | 1000Genomes | |
ENSVATH06274839 | 384 | S>Y | No | 1000Genomes | |
ENSVATH02473046 | 404 | D>H | No | 1000Genomes | |
ENSVATH00409436 | 410 | S>T | No | 1000Genomes | |
tmp_3_18135211_G_A | 418 | V>I | No | 1000Genomes | |
tmp_3_18135726_G_T | 430 | K>N | No | 1000Genomes | |
tmp_3_18135740_C_A | 435 | A>E | No | 1000Genomes | |
ENSVATH06274857 | 435 | A>S | No | 1000Genomes | |
tmp_3_18135776_A_T | 447 | K>M | No | 1000Genomes | |
ENSVATH14404406 | 456 | S>F | No | 1000Genomes | |
tmp_3_18135853_A_G | 473 | T>A | No | 1000Genomes | |
tmp_3_18135886_G_A | 484 | A>T | No | 1000Genomes | |
ENSVATH02473061 | 489 | E>Q | No | 1000Genomes | |
tmp_3_18135914_C_T | 493 | S>F | No | 1000Genomes | |
ENSVATH02473062 | 500 | R>C | No | 1000Genomes | |
tmp_3_18135943_G_A | 503 | D>N | No | 1000Genomes | |
ENSVATH00409443 | 507 | R>K | No | 1000Genomes | |
tmp_3_18135958_G_A | 508 | E>K | No | 1000Genomes | |
ENSVATH06274858 | 512 | N>K | No | 1000Genomes | |
ENSVATH00409444 | 516 | N>T | No | 1000Genomes | |
ENSVATH06274859 | 520 | L>M | No | 1000Genomes | |
ENSVATH02473064 | 528 | P>S | No | 1000Genomes | |
ENSVATH06274860 | 542 | C>Y | No | 1000Genomes | |
ENSVATH06274861 | 543 | P>L | No | 1000Genomes | |
ENSVATH12649897 | 544 | E>Q | No | 1000Genomes | |
ENSVATH00409445 | 545 | A>S | No | 1000Genomes | |
ENSVATH14404409 | 546 | R>P | No | 1000Genomes | |
tmp_3_18136083_C_G | 549 | S>R | No | 1000Genomes | |
ENSVATH00409446 | 566 | T>S | No | 1000Genomes | |
tmp_3_18136171_G_A | 579 | E>K | No | 1000Genomes | |
tmp_3_18136220_G_T | 595 | R>M | No | 1000Genomes | |
tmp_3_18136232_T_C | 599 | I>T | No | 1000Genomes | |
ENSVATH06274862 | 600 | L>Q | No | 1000Genomes |
1 associated diseases with Q9M2Z3
Without disease ID
1 regional properties for Q9M2Z3
Type | Name | Position | InterPro Accession |
---|---|---|---|
domain | Protein kinase domain | 69 - 379 | IPR000719 |
1 GO annotations of cellular component
Name | Definition |
---|---|
nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
Name | Definition |
---|---|
5'-flap endonuclease activity | Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. |
crossover junction endodeoxyribonuclease activity | Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). |
metal ion binding | Binding to a metal ion. |
3 GO annotations of biological process
Name | Definition |
---|---|
DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
telomere maintenance | Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. |
UV protection | Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV. |
8 homologous proteins in AiPD
UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
---|---|---|---|---|
Q58DH8 | FEN1 | Flap endonuclease 1 | Bos taurus (Bovine) | PR |
Q5ZLN4 | FEN1 | Flap endonuclease 1 | Gallus gallus (Chicken) | PR |
Q9VRJ0 | Gen | Flap endonuclease GEN | Drosophila melanogaster (Fruit fly) | PR |
P39748 | FEN1 | Flap endonuclease 1 | Homo sapiens (Human) | PR |
Q5XIP6 | Fen1 | Flap endonuclease 1 | Rattus norvegicus (Rat) | PR |
Q75LI2 | FEN1B | Flap endonuclease 1-B | Oryza sativa subsp japonica (Rice) | PR |
Q9SXQ6 | FEN1A | Flap endonuclease 1-A | Oryza sativa subsp japonica (Rice) | PR |
C5YUK3 | FEN1-A | Flap endonuclease 1-A | Sorghum bicolor (Sorghum) (Sorghum vulgare) | PR |
10 | 20 | 30 | 40 | 50 | 60 |
MGVKYLWDVL | EPCKKTFPLD | HLQNKRVCVD | LSCWMVELHK | VNKSYCATKE | KVYLRGFFHR |
70 | 80 | 90 | 100 | 110 | 120 |
LRALIALNCS | IILVSDGAIP | GIKVPTYKRR | LKARFEIADD | GVEPSKETSL | KRNMGSEFSC |
130 | 140 | 150 | 160 | 170 | 180 |
IIKEAKVIAS | TLGILCLDGI | EEAEAQCALL | NSESLCDACF | SFDSDIFLFG | AKTVYREICL |
190 | 200 | 210 | 220 | 230 | 240 |
GEGGYVVCYE | MDDIKKKLGL | GRNSLIALAL | LLGSDYSQGV | RGLRQEKACE | LVRSIGDNVI |
250 | 260 | 270 | 280 | 290 | 300 |
LEKVASEGLS | FAEKPRKSKK | QVRPSVCSKK | GTLPLVVING | NNRDPERLEE | IKQVIDAFMN |
310 | 320 | 330 | 340 | 350 | 360 |
PKCHQADSNT | VSRALAEFSF | QRTKLQEICH | QFFEWPPEKT | DEYILPKVAE | RNLRRFANLQ |
370 | 380 | 390 | 400 | 410 | 420 |
SRSTEVEVNL | PLHKPQMPEK | CPVSEIIKTR | KVQGRECFEV | SWNDLEGLES | SIVPADLVER |
430 | 440 | 450 | 460 | 470 | 480 |
ACPEKIIEFK | EKMAAKKKKP | KPKQKQKETS | SPTKSSSLVE | LSLELQHLDL | NSTSLVSRST |
490 | 500 | 510 | 520 | 530 | 540 |
LEEAEQENEQ | QNSKKHDYLR | LIDSPDRENC | NNAWSNRDRL | GVGMSSFPLY | PETEVIDLIS |
550 | 560 | 570 | 580 | 590 | |
PCPEARSRSV | SRSYQEQKSH | DHQLETVIEL | SDSETDDEEH | CKKARELRIF | LQNIRKDIIL |