Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q9M2Z3

Entry ID Method Resolution Chain Position Source
AF-Q9M2Z3-F1 Predicted AlphaFoldDB

74 variants for Q9M2Z3

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_3_18132021_G_T 27 V>L No 1000Genomes
tmp_3_18132051_G_A 37 E>K No 1000Genomes
ENSVATH12649766 43 K>I No 1000Genomes
ENSVATH12649767 52 V>F No 1000Genomes
ENSVATH02472989 57 F>I No 1000Genomes
ENSVATH02472989 57 F>V No 1000Genomes
tmp_3_18132123_C_T 61 L>F No 1000Genomes
tmp_3_18132384_G_A 77 G>S No 1000Genomes
ENSVATH14404365 99 D>E No 1000Genomes
tmp_3_18132558_G_C 101 G>A No 1000Genomes
tmp_3_18132582_C_T 109 S>L No 1000Genomes
ENSVATH14404366 120 C>Y No 1000Genomes
tmp_3_18132663_G_C 136 C>S No 1000Genomes
tmp_3_18132668_G_A 138 D>N No 1000Genomes
tmp_3_18132838_G_A 148 A>T No 1000Genomes
tmp_3_18132853_G_A 153 E>K No 1000Genomes
tmp_3_18132953_A_G 161 S>G No 1000Genomes
ENSVATH06274805 171 A>P No 1000Genomes
tmp_3_18132999_G_A 176 R>K No 1000Genomes
ENSVATH12649788 184 G>C No 1000Genomes
ENSVATH06274809 185 Y>C No 1000Genomes
tmp_3_18133120_T_G 185 Y>D No 1000Genomes
ENSVATH06274817 214 S>N No 1000Genomes
tmp_3_18133736_A_C 227 K>T No 1000Genomes
tmp_3_18133754_G_T 233 R>M No 1000Genomes
ENSVATH06274820 242 E>D No 1000Genomes
tmp_3_18133781_A_G 242 E>G No 1000Genomes
tmp_3_18133787_T_C 244 V>A No 1000Genomes
tmp_3_18133846_C_A 264 P>T No 1000Genomes
tmp_3_18133852_G_A 266 V>M No 1000Genomes
ENSVATH00409420 282 N>I No 1000Genomes
ENSVATH00409421 293 Q>R No 1000Genomes
ENSVATH00409422 306 A>T No 1000Genomes
tmp_3_18134462_C_T 322 R>C No 1000Genomes
ENSVATH14404371 347 K>E No 1000Genomes
ENSVATH14404372 349 A>P No 1000Genomes
ENSVATH00409429 358 N>I No 1000Genomes
ENSVATH02473027 361 S>T No 1000Genomes
tmp_3_18134718_A_C 373 H>P No 1000Genomes
ENSVATH12649834 374 K>* No 1000Genomes
ENSVATH00409434 378 P>L No 1000Genomes
tmp_3_18135106_G_T 383 V>L No 1000Genomes
ENSVATH06274839 384 S>Y No 1000Genomes
ENSVATH02473046 404 D>H No 1000Genomes
ENSVATH00409436 410 S>T No 1000Genomes
tmp_3_18135211_G_A 418 V>I No 1000Genomes
tmp_3_18135726_G_T 430 K>N No 1000Genomes
tmp_3_18135740_C_A 435 A>E No 1000Genomes
ENSVATH06274857 435 A>S No 1000Genomes
tmp_3_18135776_A_T 447 K>M No 1000Genomes
ENSVATH14404406 456 S>F No 1000Genomes
tmp_3_18135853_A_G 473 T>A No 1000Genomes
tmp_3_18135886_G_A 484 A>T No 1000Genomes
ENSVATH02473061 489 E>Q No 1000Genomes
tmp_3_18135914_C_T 493 S>F No 1000Genomes
ENSVATH02473062 500 R>C No 1000Genomes
tmp_3_18135943_G_A 503 D>N No 1000Genomes
ENSVATH00409443 507 R>K No 1000Genomes
tmp_3_18135958_G_A 508 E>K No 1000Genomes
ENSVATH06274858 512 N>K No 1000Genomes
ENSVATH00409444 516 N>T No 1000Genomes
ENSVATH06274859 520 L>M No 1000Genomes
ENSVATH02473064 528 P>S No 1000Genomes
ENSVATH06274860 542 C>Y No 1000Genomes
ENSVATH06274861 543 P>L No 1000Genomes
ENSVATH12649897 544 E>Q No 1000Genomes
ENSVATH00409445 545 A>S No 1000Genomes
ENSVATH14404409 546 R>P No 1000Genomes
tmp_3_18136083_C_G 549 S>R No 1000Genomes
ENSVATH00409446 566 T>S No 1000Genomes
tmp_3_18136171_G_A 579 E>K No 1000Genomes
tmp_3_18136220_G_T 595 R>M No 1000Genomes
tmp_3_18136232_T_C 599 I>T No 1000Genomes
ENSVATH06274862 600 L>Q No 1000Genomes

1 associated diseases with Q9M2Z3

Without disease ID

1 regional properties for Q9M2Z3

Type Name Position InterPro Accession
domain Protein kinase domain 69 - 379 IPR000719

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
5'-flap endonuclease activity Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.
crossover junction endodeoxyribonuclease activity Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).
metal ion binding Binding to a metal ion.

3 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
telomere maintenance Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
UV protection Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q58DH8 FEN1 Flap endonuclease 1 Bos taurus (Bovine) PR
Q5ZLN4 FEN1 Flap endonuclease 1 Gallus gallus (Chicken) PR
Q9VRJ0 Gen Flap endonuclease GEN Drosophila melanogaster (Fruit fly) PR
P39748 FEN1 Flap endonuclease 1 Homo sapiens (Human) PR
Q5XIP6 Fen1 Flap endonuclease 1 Rattus norvegicus (Rat) PR
Q75LI2 FEN1B Flap endonuclease 1-B Oryza sativa subsp japonica (Rice) PR
Q9SXQ6 FEN1A Flap endonuclease 1-A Oryza sativa subsp japonica (Rice) PR
C5YUK3 FEN1-A Flap endonuclease 1-A Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
10 20 30 40 50 60
MGVKYLWDVL EPCKKTFPLD HLQNKRVCVD LSCWMVELHK VNKSYCATKE KVYLRGFFHR
70 80 90 100 110 120
LRALIALNCS IILVSDGAIP GIKVPTYKRR LKARFEIADD GVEPSKETSL KRNMGSEFSC
130 140 150 160 170 180
IIKEAKVIAS TLGILCLDGI EEAEAQCALL NSESLCDACF SFDSDIFLFG AKTVYREICL
190 200 210 220 230 240
GEGGYVVCYE MDDIKKKLGL GRNSLIALAL LLGSDYSQGV RGLRQEKACE LVRSIGDNVI
250 260 270 280 290 300
LEKVASEGLS FAEKPRKSKK QVRPSVCSKK GTLPLVVING NNRDPERLEE IKQVIDAFMN
310 320 330 340 350 360
PKCHQADSNT VSRALAEFSF QRTKLQEICH QFFEWPPEKT DEYILPKVAE RNLRRFANLQ
370 380 390 400 410 420
SRSTEVEVNL PLHKPQMPEK CPVSEIIKTR KVQGRECFEV SWNDLEGLES SIVPADLVER
430 440 450 460 470 480
ACPEKIIEFK EKMAAKKKKP KPKQKQKETS SPTKSSSLVE LSLELQHLDL NSTSLVSRST
490 500 510 520 530 540
LEEAEQENEQ QNSKKHDYLR LIDSPDRENC NNAWSNRDRL GVGMSSFPLY PETEVIDLIS
550 560 570 580 590
PCPEARSRSV SRSYQEQKSH DHQLETVIEL SDSETDDEEH CKKARELRIF LQNIRKDIIL