Q9M2S4
Gene name |
LECRKS4 |
Protein name |
L-type lectin-domain containing receptor kinase S.4 |
Names |
LecRK-S.4 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G55550 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
489-496 (Activation loop from InterPro)
Target domain |
346-621 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
507-513 (Activation loop from InterPro)
Target domain |
346-621 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9M2S4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9M2S4-F1 | Predicted | AlphaFoldDB |
48 variants for Q9M2S4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_20602055_C_A | 7 | V>F | No | 1000Genomes | |
| ENSVATH06320609 | 20 | S>A | No | 1000Genomes | |
| ENSVATH06320609 | 20 | S>T | No | 1000Genomes | |
| ENSVATH12775768 | 36 | P>L | No | 1000Genomes | |
| ENSVATH06320607 | 71 | I>L | No | 1000Genomes | |
| ENSVATH00421056 | 77 | G>A | No | 1000Genomes | |
| tmp_3_20601730_C_T | 115 | R>K | No | 1000Genomes | |
| tmp_3_20601618_G_T | 152 | D>E | No | 1000Genomes | |
| tmp_3_20601616_A_G | 153 | I>T | No | 1000Genomes | |
| ENSVATH12775754 | 178 | A>D | No | 1000Genomes | |
| tmp_3_20601521_G_A | 185 | L>F | No | 1000Genomes | |
| ENSVATH06320603 | 230 | S>F | No | 1000Genomes | |
| ENSVATH00421055 | 232 | L>F | No | 1000Genomes | |
| ENSVATH06320601 | 255 | G>S | No | 1000Genomes | |
| ENSVATH12775752 | 259 | N>K | No | 1000Genomes | |
| ENSVATH02509429 | 264 | A>V | No | 1000Genomes | |
| ENSVATH06320600 | 267 | L>M | No | 1000Genomes | |
| ENSVATH00421054 | 300 | L>W | No | 1000Genomes | |
| tmp_3_20601166_G_A | 303 | A>V | No | 1000Genomes | |
| tmp_3_20601164_C_A | 304 | V>F | No | 1000Genomes | |
| ENSVATH00421053 | 316 | V>A | No | 1000Genomes | |
| ENSVATH06320598 | 316 | V>M | No | 1000Genomes | |
| tmp_3_20601095_G_C | 327 | L>V | No | 1000Genomes | |
| tmp_3_20601030_G_C | 348 | D>E | No | 1000Genomes | |
| ENSVATH06320597 | 368 | S>L | No | 1000Genomes | |
| tmp_3_20600921_C_G | 385 | V>L | No | 1000Genomes | |
| tmp_3_20600913_T_A | 387 | E>D | No | 1000Genomes | |
| tmp_3_20600856_C_A | 406 | L>F | No | 1000Genomes | |
| tmp_3_20600857_A_C | 406 | L>W | No | 1000Genomes | |
| ENSVATH00421051 | 436 | N>S | No | 1000Genomes | |
| ENSVATH02509427 | 457 | L>I | No | 1000Genomes | |
| ENSVATH14438913 | 471 | R>C | No | 1000Genomes | |
| ENSVATH06320596 | 482 | S>N | No | 1000Genomes | |
| ENSVATH14438912 | 483 | E>K | No | 1000Genomes | |
| ENSVATH06320595 | 487 | R>L | No | 1000Genomes | |
| tmp_3_20600495_T_C | 527 | T>A | No | 1000Genomes | |
| ENSVATH06320593 | 544 | G>R | No | 1000Genomes | |
| ENSVATH06320592 | 548 | I>V | No | 1000Genomes | |
| tmp_3_20600428_T_A | 549 | E>V | No | 1000Genomes | |
| tmp_3_20600410_T_A | 555 | E>V | No | 1000Genomes | |
| tmp_3_20600396_C_G | 560 | V>L | No | 1000Genomes | |
| tmp_3_20600342_T_C | 578 | R>G | No | 1000Genomes | |
| tmp_3_20600329_C_T | 582 | G>D | No | 1000Genomes | |
| ENSVATH06320589 | 583 | E>D | No | 1000Genomes | |
| tmp_3_20600258_C_T | 606 | V>I | No | 1000Genomes | |
| tmp_3_20600217_C_G | 619 | K>N | No | 1000Genomes | |
| tmp_3_20600188_G_C | 629 | A>G | No | 1000Genomes | |
| ENSVATH12775732 | 667 | T>S | No | 1000Genomes |
No associated diseases with Q9M2S4
1 regional properties for Q9M2S4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ZipA, C-terminal FtsZ-binding domain | 152 - 282 | IPR007449 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| transmembrane receptor protein serine/threonine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| defense response to oomycetes | Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
38 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P46197 | NPR2 | Atrial natriuretic peptide receptor 2 | Bos taurus (Bovine) | PR |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| P18910 | Npr1 | Atrial natriuretic peptide receptor 1 | Rattus norvegicus (Rat) | PR |
| P51842 | Gucy2f | Retinal guanylyl cyclase 2 | Rattus norvegicus (Rat) | PR |
| P16067 | Npr2 | Atrial natriuretic peptide receptor 2 | Rattus norvegicus (Rat) | PR |
| P43293 | PBL11 | Probable serine/threonine-protein kinase PBL11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN94 | At5g59670 | Receptor-like protein kinase At5g59670 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| C0LGG3 | At1g51820 | Probable LRR receptor-like serine/threonine-protein kinase At1g51820 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43298 | TMK1 | Receptor protein kinase TMK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGI2 | At1g67720 | Probable LRR receptor-like serine/threonine-protein kinase At1g67720 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQR3 | At2g14510 | Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O80939 | LECRK41 | L-type lectin-domain containing receptor kinase IV.1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LIG2 | At3g21340 | Receptor-like protein kinase At3g21340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1G4 | LECRK15 | Probable L-type lectin-domain containing receptor kinase I.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SNA3 | At3g46340 | Putative receptor-like protein kinase At3g46340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STF0 | LECRKS3 | Receptor like protein kinase S.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M345 | LECRK42 | L-type lectin-domain containing receptor kinase IV.2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96285 | LECRK55 | L-type lectin-domain containing receptor kinase V.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81292 | LECRK43 | L-type lectin-domain containing receptor kinase IV.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81291 | LECRK44 | L-type lectin-domain containing receptor kinase IV.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWZ5 | SD25 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FG33 | LECRKS5 | Probable L-type lectin-domain containing receptor kinase S.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGW2 | PAM74 | Probable LRR receptor-like serine/threonine-protein kinase PAM74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN93 | At5g59680 | Probable LRR receptor-like serine/threonine-protein kinase At5g59680 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84JQ4 | PRK2 | Pollen receptor-like kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZS4 | NIK3 | Protein NSP-INTERACTING KINASE 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AG2 | SERK1 | Somatic embryogenesis receptor kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64477 | At2g19130 | G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9XIC7 | SERK2 | Somatic embryogenesis receptor kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSR8 | LECRK19 | L-type lectin-domain containing receptor kinase I.9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQTFAVILL | LLIFLTHLVS | SLIQDFSFIG | FKKASPNLTL | NGVAEIAPTG | AIRLTTETQR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VIGHAFYSLP | IRFKPIGVNR | ALSFSTSFAI | AMVPEFVTLG | GHGLAFAITP | TPDLRGSLPS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QYLGLLNSSR | VNFSSHFFAV | EFDTVRDLEF | EDINDNHVGI | DINSMESSIS | TPAGYFLANS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TKKELFLDGG | RVIQAWIDYD | SNKKRLDVKL | SPFSEKPKLS | LLSYDVDLSS | VLGDEMYVGF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SASTGLLASS | HYILGWNFNM | SGEAFSLSLP | SLPRIPSSIK | KRKKKRQSLI | LGVSLLCSLL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IFAVLVAASL | FVVRKVKDED | RVEEWELDFG | PHRFSYRELK | KATNGFGDKE | LLGSGGFGKV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YKGKLPGSDE | FVAVKRISHE | SRQGVREFMS | EVSSIGHLRH | RNLVQLLGWC | RRRDDLLLVY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DFMPNGSLDM | YLFDENPEVI | LTWKQRFKII | KGVASGLLYL | HEGWEQTVIH | RDIKAANVLL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DSEMNGRVGD | FGLAKLYEHG | SDPGATRVVG | TFGYLAPELT | KSGKLTTSTD | VYAFGAVLLE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VACGRRPIET | SALPEELVMV | DWVWSRWQSG | DIRDVVDRRL | NGEFDEEEVV | MVIKLGLLCS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NNSPEVRPTM | RQVVMYLEKQ | FPSPEVVPAP | DFLDANDSMC | LDERSGSAGE | FEDFVDSARF |
| 670 | 680 | ||||
| YSGPNETTTS | SIFSFSGKTR | TDPR |