Q9M2F9
Gene name |
RH52 (At3g58570, F14P22.160) |
Protein name |
DEAD-box ATP-dependent RNA helicase 52 |
Names |
EC 3.6.4.13 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G58570 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
170-349 (DEAD box helicase domain) |
Relief mechanism |
|
Assay |
|
Target domain |
372-539 (C-terminal helicase domain) |
Relief mechanism |
|
Assay |
|
Target domain |
170-349 (DEAD box helicase domain);372-539 (C-terminal helicase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
- Floor SN et al. (2016) "Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3", The Journal of biological chemistry, 291, 2412-21
- Zhang ZM et al. (2013) "Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly", Cell reports, 5, 1269-78
Autoinhibited structure
Activated structure
1 structures for Q9M2F9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9M2F9-F1 | Predicted | AlphaFoldDB |
37 variants for Q9M2F9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_21657247_C_T | 50 | P>L | No | 1000Genomes | |
| ENSVATH06338945 | 51 | G>D | No | 1000Genomes | |
| ENSVATH06338946 | 57 | G>E | No | 1000Genomes | |
| ENSVATH06338947 | 60 | G>D | No | 1000Genomes | |
| tmp_3_21657286_G_A | 63 | S>N | No | 1000Genomes | |
| tmp_3_21657292_A_T,G | 65 | Y>C | No | 1000Genomes | |
| tmp_3_21657292_A_T,G | 65 | Y>F | No | 1000Genomes | |
| ENSVATH12822076 | 70 | Q>P | No | 1000Genomes | |
| tmp_3_21657322_G_A | 75 | R>Q | No | 1000Genomes | |
| tmp_3_21657328_C_T | 77 | S>L | No | 1000Genomes | |
| ENSVATH02522128 | 78 | G>D | No | 1000Genomes | |
| tmp_3_21657453_C_G | 119 | Q>E | No | 1000Genomes | |
| tmp_3_21657513_G_A | 139 | D>N | No | 1000Genomes | |
| ENSVATH06338949 | 150 | E>K | No | 1000Genomes | |
| tmp_3_21657565_C_T | 156 | A>V | No | 1000Genomes | |
| ENSVATH06338951 | 182 | A>T | No | 1000Genomes | |
| ENSVATH14451836 | 207 | G>R | No | 1000Genomes | |
| ENSVATH06338952 | 213 | H>Q | No | 1000Genomes | |
| ENSVATH00426292 | 218 | R>H | No | 1000Genomes | |
| tmp_3_21658434_G_T | 299 | V>L | No | 1000Genomes | |
| ENSVATH02522134 | 332 | G>C | No | 1000Genomes | |
| tmp_3_21659297_T_C | 380 | V>A | No | 1000Genomes | |
| tmp_3_21659306_C_T | 383 | S>F | No | 1000Genomes | |
| ENSVATH02522137 | 404 | K>R | No | 1000Genomes | |
| ENSVATH12822121 | 455 | R>L | No | 1000Genomes | |
| ENSVATH06338977 | 544 | F>L | No | 1000Genomes | |
| tmp_3_21660108_T_A | 566 | F>Y | No | 1000Genomes | |
| tmp_3_21660114_G_A | 568 | R>Q | No | 1000Genomes | |
| ENSVATH02522139 | 569 | G>A | No | 1000Genomes | |
| tmp_3_21660116_G_A | 569 | G>S | No | 1000Genomes | |
| tmp_3_21660140_G_C | 577 | G>R | No | 1000Genomes | |
| tmp_3_21660147_G_A | 579 | G>D | No | 1000Genomes | |
| tmp_3_21660204_G_T | 598 | G>V | No | 1000Genomes | |
| tmp_3_21660240_G_A | 610 | G>D | No | 1000Genomes | |
| ENSVATH02522141 | 620 | G>V | No | 1000Genomes | |
| ENSVATH12822123 | 628 | G>V | No | 1000Genomes | |
| ENSVATH06338980 | 632 | V>I | No | 1000Genomes |
No associated diseases with Q9M2F9
5 regional properties for Q9M2F9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase, C-terminal domain-like | 385 - 539 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 170 - 349 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 165 - 376 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 146 - 174 | IPR014014 |
| domain | Ded1/Dbp1, DEAD-box helicase domain | 147 - 367 | IPR044763 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
28 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5W5U4 | DDX4 | Probable ATP-dependent RNA helicase DDX4 | Bos taurus (Bovine) | SS |
| Q6GVM6 | DDX3Y | ATP-dependent RNA helicase DDX3Y | Pan troglodytes (Chimpanzee) | SS |
| O15523 | DDX3Y | ATP-dependent RNA helicase DDX3Y | Homo sapiens (Human) | SS |
| Q9NQI0 | DDX4 | Probable ATP-dependent RNA helicase DDX4 | Homo sapiens (Human) | SS |
| O00571 | DDX3X | ATP-dependent RNA helicase DDX3X | Homo sapiens (Human) | EV |
| P16381 | D1Pas1 | Putative ATP-dependent RNA helicase Pl10 | Mus musculus (Mouse) | SS |
| Q61496 | Ddx4 | ATP-dependent RNA helicase DDX4 | Mus musculus (Mouse) | SS |
| Q62095 | Ddx3y | ATP-dependent RNA helicase DDX3Y | Mus musculus (Mouse) | SS |
| Q62167 | Ddx3x | ATP-dependent RNA helicase DDX3X | Mus musculus (Mouse) | SS |
| Q6GWX0 | DDX4 | Probable ATP-dependent RNA helicase DDX4 | Sus scrofa (Pig) | SS |
| Q2R1M8 | Os11g0599500 | DEAD-box ATP-dependent RNA helicase 52C | Oryza sativa subsp. japonica (Rice) | SS |
| Q6Z4K6 | PL10B | DEAD-box ATP-dependent RNA helicase 52B | Oryza sativa subsp. japonica (Rice) | SS |
| Q75HJ0 | PL10A | DEAD-box ATP-dependent RNA helicase 37 | Oryza sativa subsp. japonica (Rice) | SS |
| O01836 | glh-3 | ATP-dependent RNA helicase glh-3 | Caenorhabditis elegans | PR |
| D0PV95 | laf-1 | ATP-dependent RNA helicase laf-1 | Caenorhabditis elegans | SS |
| Q84W89 | RH37 | DEAD-box ATP-dependent RNA helicase 37 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8LA13 | RH11 | DEAD-box ATP-dependent RNA helicase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9C718 | RH20 | DEAD-box ATP-dependent RNA helicase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94A52 | EIF4A3 | Eukaryotic initiation factor 4A-III homolog | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56XG6 | RH15 | DEAD-box ATP-dependent RNA helicase 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZG7 | RH38 | DEAD-box ATP-dependent RNA helicase 38 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFN6 | RH56 | DEAD-box ATP-dependent RNA helicase 56 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SZB4 | RH43 | Putative DEAD-box ATP-dependent RNA helicase 43 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LU46 | RH35 | DEAD-box ATP-dependent RNA helicase 35 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E9C3 | RH58 | DEAD-box ATP-dependent RNA helicase 58, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4R3 | RH30 | DEAD-box ATP-dependent RNA helicase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FZ92 | RH44 | Putative DEAD-box ATP-dependent RNA helicase 44 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8H136 | RH14 | DEAD-box ATP-dependent RNA helicase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSNSWADVS | ESERAPSGGG | WGYSRPSRTN | YVPPHLRSRT | PSSEFVAPSP | GNNDRGGYGG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ANSGYGGRGQ | GYGGRGSGYG | GRGGPVGGWN | ARSGGWDRRD | TETNPFGNDG | NADPAVNEQE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NTVINFEAYE | DIPIETSGDN | VPPPVNTFAE | IDLGEALNLN | IQRCKYVKPT | PVQRNAIPIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AAGRDLMACA | QTGSGKTAAF | CFPIISGIMK | DQHIERPRGV | RGVYPLAVIL | SPTRELACQI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HDEARKFSYQ | TGVKVVVAYG | GTPVNQQIRE | LERGVDILVA | TPGRLNDLLE | RGRVSLQMVR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FLALDEADRM | LDMGFEPQIR | KIVQQMDMPP | PGVRQTMLFS | ATFPREIQRL | ASDFLSNYIF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LAVGRVGSST | DLIVQRVEFV | HDSDKRSHLM | DLLHAQRENG | NQGKQALTLV | FVETKKGADS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LENWLCINGF | PATTIHGDRS | QQEREVALRS | FKTGRTPILV | ATDVAARGLD | IPHVAHVVNF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DLPNDIDDYV | HRIGRTGRAG | NSGLATAFFN | DNNTTMAKPL | AELMQEANQE | VPDWLTRYAS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RASFGGGKNR | RSGGRFGGRD | FRRESFSRGG | GGADYYGGGG | GYGGVPGGGY | GAMPGGYGPV |
| 610 | 620 | 630 | 640 | ||
| PGGGYGNVPG | GGYAPYGRGG | GAYYGPGGYG | TVPNQGYGPG | VASAWD |