Q9M276
PR
Gene name |
ATHB-12 (At3g61890, F21F14.60) |
Protein name |
Homeobox-leucine zipper protein ATHB-12 |
Names |
HD-ZIP protein ATHB-12, Homeodomain transcription factor ATHB-12 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G61890 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9M276
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9M276-F1 | Predicted | AlphaFoldDB |
23 variants for Q9M276
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00431558 | 5 | D>E | No | 1000Genomes | |
| tmp_3_22915176_T_C | 22 | K>E | No | 1000Genomes | |
| tmp_3_22915046_C_T | 65 | G>E | No | 1000Genomes | |
| tmp_3_22914973_T_G | 89 | K>N | No | 1000Genomes | |
| ENSVATH14467612 | 96 | A>T | No | 1000Genomes | |
| ENSVATH06357862 | 113 | Q>L | No | 1000Genomes | |
| tmp_3_22914900_A_T | 114 | S>T | No | 1000Genomes | |
| tmp_3_22914899_G_T | 114 | S>Y | No | 1000Genomes | |
| ENSVATH14467611 | 121 | R>T | No | 1000Genomes | |
| ENSVATH00431557 | 138 | C>S | No | 1000Genomes | |
| ENSVATH00431557 | 138 | C>Y | No | 1000Genomes | |
| tmp_3_22914624_C_T | 144 | A>T | No | 1000Genomes | |
| tmp_3_22914617_C_T | 146 | S>N | No | 1000Genomes | |
| tmp_3_22914598_A_T | 152 | H>Q | No | 1000Genomes | |
| ENSVATH12876654 | 153 | N>I | No | 1000Genomes | |
| ENSVATH00431556 | 160 | G>V | No | 1000Genomes | |
| tmp_3_22914561_C_G | 165 | G>R | No | 1000Genomes | |
| ENSVATH06357858 | 167 | V>D | No | 1000Genomes | |
| ENSVATH06357858 | 167 | V>G | No | 1000Genomes | |
| ENSVATH14467610 | 169 | C>S | No | 1000Genomes | |
| tmp_3_22914539_C_G | 172 | G>A | No | 1000Genomes | |
| tmp_3_22914537_C_T | 173 | D>N | No | 1000Genomes | |
| tmp_3_22914470_T_C | 195 | N>S | No | 1000Genomes |
No associated diseases with Q9M276
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| response to abscisic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. |
| response to osmotic stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. |
| response to virus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. |
| response to water deprivation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9XSK0 | CRX | Cone-rod homeobox protein | Bos taurus (Bovine) | PR |
| F1NEA7 | DMBX1 | Diencephalon/mesencephalon homeobox protein 1 | Gallus gallus (Chicken) | PR |
| P50577 | DLX5 | Homeobox protein DLX-5 | Gallus gallus (Chicken) | PR |
| Q8SQ03 | CRX | Cone-rod homeobox protein | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q03014 | HHEX | Hematopoietically-expressed homeobox protein HHEX | Homo sapiens (Human) | PR |
| P32243 | OTX2 | Homeobox protein OTX2 | Homo sapiens (Human) | PR |
| O14813 | PHOX2A | Paired mesoderm homeobox protein 2A | Homo sapiens (Human) | PR |
| O95076 | ALX3 | Homeobox protein aristaless-like 3 | Homo sapiens (Human) | PR |
| O43186 | CRX | Cone-rod homeobox protein | Homo sapiens (Human) | PR |
| Q99801 | NKX3-1 | Homeobox protein Nkx-3.1 | Homo sapiens (Human) | PR |
| Q62066 | Phox2a | Paired mesoderm homeobox protein 2A | Mus musculus (Mouse) | PR |
| O54751 | Crx | Cone-rod homeobox protein | Mus musculus (Mouse) | PR |
| P70397 | Dlx6 | Homeobox protein DLX-6 | Mus musculus (Mouse) | PR |
| P80206 | Otx2 | Homeobox protein OTX2 | Mus musculus (Mouse) | PR |
| Q62782 | Phox2a | Paired mesoderm homeobox protein 2A | Rattus norvegicus (Rat) | PR |
| Q5VPE5 | HOX28 | Homeobox-leucine zipper protein HOX28 | Oryza sativa subsp japonica (Rice) | PR |
| A3BYC1 | HOX25 | Homeobox-leucine zipper protein HOX25 | Oryza sativa subsp japonica (Rice) | PR |
| Q6H6S3 | HOX24 | Homeobox-leucine zipper protein HOX24 | Oryza sativa subsp japonica (Rice) | PR |
| Q7XUJ5 | HOX22 | Homeobox-leucine zipper protein HOX22 | Oryza sativa subsp japonica (Rice) | PR |
| P46603 | HAT9 | Homeobox-leucine zipper protein HAT9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN29 | ATHB-52 | Homeobox-leucine zipper protein ATHB-52 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q28FN6 | otx2 | Homeobox protein OTX2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q566X8 | dmbx1b | Diencephalon/mesencephalon homeobox protein 1-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q91994 | otx1b | Homeobox protein OTX1 B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q98875 | dlx1a | Homeobox protein Dlx1a | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q98878 | dlx4b | Homeobox protein Dlx4b | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q9IAV3 | hhex | Hematopoietically-expressed homeobox protein hhex | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEEGDFFNCC | FSEISSGMTM | NKKKMKKSNN | QKRFSEEQIK | SLELIFESET | RLEPRKKVQV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ARELGLQPRQ | VAIWFQNKRA | RWKTKQLEKE | YNTLRANYNN | LASQFEIMKK | EKQSLVSELQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RLNEEMQRPK | EEKHHECCGD | QGLALSSSTE | SHNGKSEPEG | RLDQGSVLCN | DGDYNNNIKT |
| 190 | 200 | 210 | 220 | 230 | |
| EYFGFEEETD | HELMNIVEKA | DDSCLTSSEN | WGGFNSDSLL | DQSSSNYPNW | WEFWS |