Q9M1Z5

SS
Gene name
MPK10 (At3g59790, F24G16.60)
Protein name
Mitogen-activated protein kinase 10
Names
AtMPK10 , MAP kinase 10 , EC 2.7.11.24
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G59790
EC number
2.7.11.24: Protein-serine/threonine kinases
Protein Class

Descriptions

MAPK1 encodes Mitogen-activated protein kinase 1, and is involved in diverse cellular responses by phosphorylating cytoplasmic and nuclear proteins. Unlike other MAP kinases, MAPK1 activates via dual phosphorylation of Thr-186 and Tyr-193 within the activation lip, and mutations at Q105 alone were sufficient for autoactivation. Additionally, in the inactive form, L76, Q10 and I87 form a structural unit that restrains intramolecular autophosphorylation by preventing interactions between activation lip residues and the catalytic base (D149) needed for phosphoryl transfer. Mutations at L76, I87 and additionally S153 increased basal specific activity via autophosphorylation of Thr-186 and Tyr-193.

Autoinhibitory domains (AIDs)

109-188 (Autoinhibitory region) SS

Target domain

59-345 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9M1Z5

Entry ID Method Resolution Chain Position Source
AF-Q9M1Z5-F1 Predicted AlphaFoldDB

33 variants for Q9M1Z5

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06345458 2 E>K No 1000Genomes
ENSVATH00428326 15 E>K No 1000Genomes
tmp_3_22092512_C_T 22 P>L No 1000Genomes
ENSVATH12839030 41 G>S No 1000Genomes
tmp_3_22092578_T_C 44 I>T No 1000Genomes
ENSVATH12839031 57 A>T No 1000Genomes
ENSVATH12839032 67 G>S No 1000Genomes
tmp_3_22092998_A_T 93 Q>H No 1000Genomes
tmp_3_22092996_C_A 93 Q>K No 1000Genomes
tmp_3_22093008_A_G 97 N>D No 1000Genomes
ENSVATH06345467 101 A>T No 1000Genomes
tmp_3_22093056_C_T 113 H>Y No 1000Genomes
ENSVATH06345472 135 E>Q No 1000Genomes
tmp_3_22093290_G_C 161 D>H No 1000Genomes
tmp_3_22093416_A_T 175 K>M No 1000Genomes
ENSVATH06345474 175 K>N No 1000Genomes
tmp_3_22093463_A_C 191 N>H No 1000Genomes
tmp_3_22093551_A_T 220 Y>F No 1000Genomes
ENSVATH02527139 235 S>T No 1000Genomes
tmp_3_22093833_A_C 283 E>D No 1000Genomes
ENSVATH06345479 297 R>M No 1000Genomes
ENSVATH06345480 313 N>Y No 1000Genomes
ENSVATH00428333 319 I>T No 1000Genomes
ENSVATH00428334 335 S>A No 1000Genomes
ENSVATH12839057 336 V>I No 1000Genomes
ENSVATH00428336 345 L>V No 1000Genomes
ENSVATH12839058 347 S>P No 1000Genomes
ENSVATH06345482 349 H>Q No 1000Genomes
ENSVATH12839059 364 D>N No 1000Genomes
ENSVATH00428337 366 D>N No 1000Genomes
ENSVATH06345483 367 E>Q No 1000Genomes
ENSVATH06345484 385 A>T No 1000Genomes
ENSVATH06345486 389 E>K No 1000Genomes

No associated diseases with Q9M1Z5

3 regional properties for Q9M1Z5

Type Name Position InterPro Accession
domain Protein kinase domain 60 - 345 IPR000719
conserved_site Mitogen-activated protein (MAP) kinase, conserved site 95 - 198 IPR003527
active_site Serine/threonine-protein kinase, active site 182 - 194 IPR008271

Functions

Description
EC Number 2.7.11.24 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase activity Catalysis of the reaction
protein serine kinase activity Catalysis of the reactions

3 GO annotations of biological process

Name Definition
auxin transport The directed movement of auxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Auxins are a group of plant hormones that regulates aspects of plant growth.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
xylem and phloem pattern formation The regionalization process that gives rise to the patterning of the conducting tissues. An example of this process is found in Arabidopsis thaliana.

96 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32485 HOG1 Mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P16892 FUS3 Mitogen-activated protein kinase FUS3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
P14681 KSS1 Mitogen-activated protein kinase KSS1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
A5PKJ4 MAPK7 Mitogen-activated protein kinase 7 Bos taurus (Bovine) SS
P46196 MAPK1 Mitogen-activated protein kinase 1 Bos taurus (Bovine) SS
Q3T0N5 MAPK13 Mitogen-activated protein kinase 13 Bos taurus (Bovine) SS
Q5F3W3 MAPK6 Mitogen-activated protein kinase 6 Gallus gallus (Chicken) SS
P79996 MAPK9 Mitogen-activated protein kinase 9 Gallus gallus (Chicken) PR
Q95NE7 MAPK14 Mitogen-activated protein kinase 14 Pan troglodytes (Chimpanzee) SS
Q9N272 MAPK13 Mitogen-activated protein kinase 13 Pan troglodytes (Chimpanzee) SS
Q9W354 Erk7 Extracellular signal-regulated kinase 7 Drosophila melanogaster (Fruit fly) SS
O61443 p38b Mitogen-activated protein kinase p38b Drosophila melanogaster (Fruit fly) SS
O62618 p38a Mitogen-activated protein kinase p38a Drosophila melanogaster (Fruit fly) SS
P83100 p38c Putative mitogen-activated protein kinase 14C Drosophila melanogaster (Fruit fly) SS
P40417 rl Mitogen-activated protein kinase ERK-A Drosophila melanogaster (Fruit fly) SS
Q13164 MAPK7 Mitogen-activated protein kinase 7 Homo sapiens (Human) SS
Q8TD08 MAPK15 Mitogen-activated protein kinase 15 Homo sapiens (Human) SS
P31152 MAPK4 Mitogen-activated protein kinase 4 Homo sapiens (Human) SS
Q16659 MAPK6 Mitogen-activated protein kinase 6 Homo sapiens (Human) SS
P45983 MAPK8 Mitogen-activated protein kinase 8 Homo sapiens (Human) EV
P45984 MAPK9 Mitogen-activated protein kinase 9 Homo sapiens (Human) SS
P53779 MAPK10 Mitogen-activated protein kinase 10 Homo sapiens (Human) EV
P53778 MAPK12 Mitogen-activated protein kinase 12 Homo sapiens (Human) SS
O15264 MAPK13 Mitogen-activated protein kinase 13 Homo sapiens (Human) SS
Q15759 MAPK11 Mitogen-activated protein kinase 11 Homo sapiens (Human) SS
Q16539 MAPK14 Mitogen-activated protein kinase 14 Homo sapiens (Human) SS
P28482 MAPK1 Mitogen-activated protein kinase 1 Homo sapiens (Human) EV
P27361 MAPK3 Mitogen-activated protein kinase 3 Homo sapiens (Human) SS
Q9WVS8 Mapk7 Mitogen-activated protein kinase 7 Mus musculus (Mouse) SS
Q80Y86 Mapk15 Mitogen-activated protein kinase 15 Mus musculus (Mouse) SS
O08911 Mapk12 Mitogen-activated protein kinase 12 Mus musculus (Mouse) SS
P63085 Mapk1 Mitogen-activated protein kinase 1 Mus musculus (Mouse) SS
Q61532 Mapk6 Mitogen-activated protein kinase 6 Mus musculus (Mouse) SS
Q63844 Mapk3 Mitogen-activated protein kinase 3 Mus musculus (Mouse) SS
Q6P5G0 Mapk4 Mitogen-activated protein kinase 4 Mus musculus (Mouse) SS
Q9WUI1 Mapk11 Mitogen-activated protein kinase 11 Mus musculus (Mouse) SS
Q9Z1B7 Mapk13 Mitogen-activated protein kinase 13 Mus musculus (Mouse) SS
Q91Y86 Mapk8 Mitogen-activated protein kinase 8 Mus musculus (Mouse) PR
Q9WTU6 Mapk9 Mitogen-activated protein kinase 9 Mus musculus (Mouse) PR
P47811 Mapk14 Mitogen-activated protein kinase 14 Mus musculus (Mouse) SS
Q9Z2A6 Mapk15 Mitogen-activated protein kinase 15 Rattus norvegicus (Rat) SS
P0C865 Mapk7 Mitogen-activated protein kinase 7 Rattus norvegicus (Rat) SS
P27704 Mapk6 Mitogen-activated protein kinase 6 Rattus norvegicus (Rat) SS
P63086 Mapk1 Mitogen-activated protein kinase 1 Rattus norvegicus (Rat) SS
Q63538 Mapk12 Mitogen-activated protein kinase 12 Rattus norvegicus (Rat) SS
P49186 Mapk9 Mitogen-activated protein kinase 9 Rattus norvegicus (Rat) PR
P21708 Mapk3 Mitogen-activated protein kinase 3 Rattus norvegicus (Rat) SS
P70618 Mapk14 Mitogen-activated protein kinase 14 Rattus norvegicus (Rat) SS
Q9WTY9 Mapk13 Mitogen-activated protein kinase 13 Rattus norvegicus (Rat) SS
Q63454 Mapk4 Mitogen-activated protein kinase 4 Rattus norvegicus (Rat) SS
Q5ZCI1 MPK10 Mitogen-activated protein kinase 10 Oryza sativa subsp. japonica (Rice) SS
Q5VP69 MPK16 Mitogen-activated protein kinase 16 Oryza sativa subsp. japonica (Rice) SS
Q5SN53 MPK8 Mitogen-activated protein kinase 8 Oryza sativa subsp. japonica (Rice) SS
Q0E459 MPK13 Mitogen-activated protein kinase 13 Oryza sativa subsp. japonica (Rice) SS
Q6Z437 MPK3 Mitogen-activated protein kinase 3 Oryza sativa subsp. japonica (Rice) SS
Q10N20 MPK5 Mitogen-activated protein kinase 5 Oryza sativa subsp. japonica (Rice) SS
Q75KK8 MPK14 Mitogen-activated protein kinase 14 Oryza sativa subsp. japonica (Rice) SS
Q67C40 MPK7 Mitogen-activated protein kinase 7 Oryza sativa subsp. japonica (Rice) SS
Q6L5F7 MPK17 Mitogen-activated protein kinase 17 Oryza sativa subsp. japonica (Rice) SS
Q5VN19 MPK11 Mitogen-activated protein kinase 11 Oryza sativa subsp. japonica (Rice) SS
Q5Z859 MPK4 Mitogen-activated protein kinase 4 Oryza sativa subsp. japonica (Rice) SS
Q5Z9J0 MPK12 Mitogen-activated protein kinase 12 Oryza sativa subsp. japonica (Rice) SS
Q5J4W4 MPK2 Mitogen-activated protein kinase 2 Oryza sativa subsp. japonica (Rice) SS
Q336X9 MPK6 Mitogen-activated protein kinase 6 Oryza sativa subsp. japonica (Rice) SS
Q53N72 MPK15 Mitogen-activated protein kinase 15 Oryza sativa subsp. japonica (Rice) SS
Q84UI5 MPK1 Mitogen-activated protein kinase 1 Oryza sativa subsp. japonica (Rice) SS
Q11179 mapk-15 Mitogen-activated protein kinase 15 Caenorhabditis elegans SS
O44514 pmk-3 Mitogen-activated protein kinase pmk-3 Caenorhabditis elegans PR
G5EBT1 sma-5 Mitogen-activated protein kinase sma-5 Caenorhabditis elegans SS
Q17446 pmk-1 Mitogen-activated protein kinase pmk-1 Caenorhabditis elegans SS
Q8MXI4 pmk-2 Mitogen-activated protein kinase pmk-2 Caenorhabditis elegans SS
O44408 kgb-1 GLH-binding kinase 1 Caenorhabditis elegans PR
P39745 mpk-1 Mitogen-activated protein kinase mpk-1 Caenorhabditis elegans SS
O23236 MPK14 Mitogen-activated protein kinase 14 Arabidopsis thaliana (Mouse-ear cress) SS
Q39021 MPK1 Mitogen-activated protein kinase 1 Arabidopsis thaliana (Mouse-ear cress) SS
Q39022 MPK2 Mitogen-activated protein kinase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q39023 MPK3 Mitogen-activated protein kinase 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q39024 MPK4 Mitogen-activated protein kinase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q39025 MPK5 Mitogen-activated protein kinase 5 Arabidopsis thaliana (Mouse-ear cress) SS
Q39026 MPK6 Mitogen-activated protein kinase 6 Arabidopsis thaliana (Mouse-ear cress) SS
Q39027 MPK7 Mitogen-activated protein kinase 7 Arabidopsis thaliana (Mouse-ear cress) SS
Q84M93 MPK17 Mitogen-activated protein kinase 17 Arabidopsis thaliana (Mouse-ear cress) SS
Q8W4J2 MPK16 Mitogen-activated protein kinase 16 Arabidopsis thaliana (Mouse-ear cress) SS
Q9C5C0 MPK18 Mitogen-activated protein kinase 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LM33 MPK8 Mitogen-activated protein kinase 8 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LUC3 MPK19 Mitogen-activated protein kinase 19 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SJG9 MPK20 Mitogen-activated protein kinase 20 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GYQ5 MPK12 Mitogen-activated protein kinase 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LV37 MPK9 Mitogen-activated protein kinase 9 Arabidopsis thaliana (Mouse-ear cress) SS
Q9C9U4 MPK15 Mitogen-activated protein kinase 15 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LMM5 MPK11 Mitogen-activated protein kinase 11 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LQQ9 MPK13 Mitogen-activated protein kinase 13 Arabidopsis thaliana (Mouse-ear cress) SS
P43294 MHK Serine/threonine-protein kinase MHK Arabidopsis thaliana (Mouse-ear cress) PR
O42376 mapk12 Mitogen-activated protein kinase 12 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9DGE2 mapk14a Mitogen-activated protein kinase 14A Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9DGE1 mapk14b Mitogen-activated protein kinase 14B Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MEPTNDAETL ETQGEVTTAI WPSSQILKTT IDIPGTLSHD GRYIQYNLFG HIFELPAKYK
70 80 90 100 110 120
PPIRPIGRGA CGIVCSAVDS ETNEKVAIKK ITQVFDNTIE AKRTLREIKL LRHFDHENIV
130 140 150 160 170 180
AIRDVILPPQ RDSFEDVYIV NELMEFDLYR TLKSDQELTK DHGMYFMYQI LRGLKYIHSA
190 200 210 220 230 240
NVLHRDLKPS NLLLSTQCDL KICDFGLARA TPESNLMTEY VVTRWYRAPE LLLGSSDYTA
250 260 270 280 290 300
AIDVWSVGCI FMEIMNREPL FPGKDQVNQL RLLLELIGTP SEEELGSLSE YAKRYIRQLP
310 320 330 340 350 360
TLPRQSFTEK FPNVPPLAID LVEKMLTFDP KQRISVKEAL AHPYLSSFHD ITDEPECSEP
370 380 390
FNFDLDEHPF SEEQFRELIY CEALAFNPET SND