Q9M1G4

PR
Gene name
LECRK15 (At3g45430, F9K21.10)
Protein name
Probable L-type lectin-domain containing receptor kinase I.5
Names
LecRK-I.5
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G45430
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

611-674 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

503-509 (Activation loop from InterPro)

Target domain

344-625 (Protein kinase domain)

Relief mechanism

Assay

485-492 (Activation loop from InterPro)

Target domain

344-625 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9M1G4

Entry ID Method Resolution Chain Position Source
AF-Q9M1G4-F1 Predicted AlphaFoldDB

113 variants for Q9M1G4

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH02435664 3 K>E No 1000Genomes
ENSVATH02435662 8 I>F No 1000Genomes
ENSVATH02435662 8 I>V No 1000Genomes
ENSVATH02435661 9 W>C No 1000Genomes
tmp_3_16662744_A_C 14 F>V No 1000Genomes
tmp_3_16662740_T_A 15 H>L No 1000Genomes
ENSVATH02435659 26 T>S No 1000Genomes
tmp_3_16662705_T_A 27 S>C No 1000Genomes
ENSVATH14368629 32 G>D No 1000Genomes
ENSVATH02435658 34 G>D No 1000Genomes
ENSVATH12521162 37 N>S No 1000Genomes
ENSVATH06230494 38 L>F No 1000Genomes
ENSVATH02435656 39 A>S No 1000Genomes
ENSVATH02435655 41 D>Y No 1000Genomes
tmp_3_16662654_C_T 44 A>T No 1000Genomes
tmp_3_16662642_G_T 48 P>T No 1000Genomes
ENSVATH00400150 53 Q>R No 1000Genomes
tmp_3_16662613_G_T 57 D>E No 1000Genomes
ENSVATH14368628 61 Q>* No 1000Genomes
ENSVATH06230493 61 Q>R No 1000Genomes
ENSVATH00400149 72 D>E No 1000Genomes
ENSVATH02435654 72 D>V No 1000Genomes
tmp_3_16662564_T_C 74 S>G No 1000Genomes
ENSVATH06230492 81 F>Y No 1000Genomes
ENSVATH06230488 105 I>V No 1000Genomes
ENSVATH06230487 106 S>C No 1000Genomes
ENSVATH06230486 113 R>Q No 1000Genomes
ENSVATH06230485 120 M>I No 1000Genomes
ENSVATH02435653 130 S>F No 1000Genomes
ENSVATH12521159 137 A>T No 1000Genomes
ENSVATH06230484 150 E>A No 1000Genomes
ENSVATH02435651 156 I>V No 1000Genomes
tmp_3_16662300_T_A,G 162 N>H No 1000Genomes
tmp_3_16662300_T_A,G 162 N>Y No 1000Genomes
tmp_3_16662275_G_A 170 P>L No 1000Genomes
ENSVATH06230481 171 A>S No 1000Genomes
tmp_3_16662272_G_A 171 A>V No 1000Genomes
ENSVATH02435650 178 A>E No 1000Genomes
ENSVATH12521157 186 L>F No 1000Genomes
ENSVATH12521157 186 L>I No 1000Genomes
ENSVATH12521156 193 Q>K No 1000Genomes
ENSVATH02435649 199 H>R No 1000Genomes
tmp_3_16662180_C_G 202 V>L No 1000Genomes
ENSVATH02435648 217 L>F No 1000Genomes
ENSVATH12521155 222 R>Q No 1000Genomes
ENSVATH00400140 224 M>I No 1000Genomes
ENSVATH02435647 227 S>L No 1000Genomes
ENSVATH06230477 228 E>G No 1000Genomes
ENSVATH02435645 232 R>S No 1000Genomes
tmp_3_16662024_C_G 254 G>R No 1000Genomes
ENSVATH02435643 263 L>I No 1000Genomes
tmp_3_16661989_C_A 265 Q>H No 1000Genomes
ENSVATH06230475 265 Q>L No 1000Genomes
ENSVATH02435642 266 L>S No 1000Genomes
tmp_3_16661982_C_T 268 D>N No 1000Genomes
ENSVATH14368626 292 A>P No 1000Genomes
ENSVATH14368625 295 V>I No 1000Genomes
ENSVATH00400138 301 V>G No 1000Genomes
tmp_3_16661862_C_T 308 V>I No 1000Genomes
ENSVATH06230474 313 K>* No 1000Genomes
ENSVATH06230473 313 K>M No 1000Genomes
tmp_3_16661839_C_G 315 K>N No 1000Genomes
tmp_3_16661834_G_A 317 A>V No 1000Genomes
ENSVATH06230472 318 E>D No 1000Genomes
ENSVATH14368623 320 S>R No 1000Genomes
tmp_3_16661820_G_A 322 P>S No 1000Genomes
tmp_3_16661792_C_G 331 R>P No 1000Genomes
ENSVATH06230471 341 T>A No 1000Genomes
ENSVATH02435641 342 K>E No 1000Genomes
tmp_3_16661741_C_T 348 R>K No 1000Genomes
ENSVATH06230470 351 G>E No 1000Genomes
tmp_3_16661686_G_T 366 N>K No 1000Genomes
ENSVATH14368622 383 K>Q No 1000Genomes
ENSVATH06230468 394 S>N No 1000Genomes
tmp_3_16661589_T_C 399 N>D No 1000Genomes
ENSVATH06230467 411 G>S No 1000Genomes
tmp_3_16661542_T_A 414 L>F No 1000Genomes
tmp_3_16661523_G_T 421 P>T No 1000Genomes
tmp_3_16661499_A_T 429 L>M No 1000Genomes
ENSVATH12521124 431 D>G No 1000Genomes
ENSVATH06230465 440 S>F No 1000Genomes
ENSVATH00400136 443 F>Y No 1000Genomes
ENSVATH00400135 444 V>A No 1000Genomes
tmp_3_16661423_A_G 454 F>S No 1000Genomes
ENSVATH02435638 458 T>I No 1000Genomes
tmp_3_16661401_T_A 461 E>D No 1000Genomes
ENSVATH14368621 467 R>* No 1000Genomes
tmp_3_16661364_C_T 474 V>I No 1000Genomes
tmp_3_16661339_C_A 482 G>V No 1000Genomes
tmp_3_16661219_G_T 522 T>N No 1000Genomes
ENSVATH02435634 523 I>V No 1000Genomes
ENSVATH12521120 524 T>I No 1000Genomes
ENSVATH02435628 555 I>L No 1000Genomes
ENSVATH14368619 565 D>E No 1000Genomes
ENSVATH14368618 566 S>P No 1000Genomes
ENSVATH14368617 568 L>F No 1000Genomes
ENSVATH02435626 570 A>T No 1000Genomes
ENSVATH06230459 571 K>R No 1000Genomes
tmp_3_16661058_C_T 576 G>R No 1000Genomes
ENSVATH06230458 585 E>K No 1000Genomes
tmp_3_16661021_A_G 588 M>T No 1000Genomes
ENSVATH06230456 599 P>S No 1000Genomes
ENSVATH00400130 605 M>I No 1000Genomes
ENSVATH06230455 614 G>R No 1000Genomes
ENSVATH12521116 616 L>F No 1000Genomes
tmp_3_16660890_T_A 632 T>S No 1000Genomes
ENSVATH14368591 643 V>I No 1000Genomes
tmp_3_16660838_T_C 649 N>S No 1000Genomes
tmp_3_16660834_C_G 650 W>C No 1000Genomes
ENSVATH02435614 667 E>G No 1000Genomes
ENSVATH02435613 669 P>A No 1000Genomes
ENSVATH02435611 672 F>L No 1000Genomes
ENSVATH02435612 672 F>S No 1000Genomes

No associated diseases with Q9M1G4

4 regional properties for Q9M1G4

Type Name Position InterPro Accession
domain Protein kinase domain 344 - 625 IPR000719
domain Legume lectin domain 26 - 272 IPR001220
active_site Serine/threonine-protein kinase, active site 464 - 476 IPR008271
binding_site Protein kinase, ATP binding site 350 - 372 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
carbohydrate binding Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
G protein-coupled purinergic nucleotide receptor activity Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
protein self-association Binding to a domain within the same polypeptide.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
transmembrane receptor protein serine/threonine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
defense response to oomycetes Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism.
PAMP-triggered immunity signalling pathway The series of molecular signals initiated by a ligand binding of a pattern recognition receptor (PRR) to activate a plant innate immune response. PAMP-triggered immunity PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
protein phosphorylation The process of introducing a phosphate group on to a protein.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P46197 NPR2 Atrial natriuretic peptide receptor 2 Bos taurus (Bovine) PR
Q24488 Ror Tyrosine-protein kinase transmembrane receptor Ror Drosophila melanogaster (Fruit fly) SS
Q9V6K3 Nrk Tyrosine-protein kinase transmembrane receptor Ror2 Drosophila melanogaster (Fruit fly) SS
Q06806 Tie1 Tyrosine-protein kinase receptor Tie-1 Mus musculus (Mouse) SS
Q02858 Tek Angiopoietin-1 receptor Mus musculus (Mouse) SS
O80939 LECRK41 L-type lectin-domain containing receptor kinase IV.1 Arabidopsis thaliana (Mouse-ear cress) PR
O81291 LECRK44 L-type lectin-domain containing receptor kinase IV.4 Arabidopsis thaliana (Mouse-ear cress) PR
O81292 LECRK43 L-type lectin-domain containing receptor kinase IV.3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M345 LECRK42 L-type lectin-domain containing receptor kinase IV.2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STF0 LECRKS3 Receptor like protein kinase S.3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M2S4 LECRKS4 L-type lectin-domain containing receptor kinase S.4 Arabidopsis thaliana (Mouse-ear cress) PR
Q96285 LECRK55 L-type lectin-domain containing receptor kinase V.5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FG33 LECRKS5 Probable L-type lectin-domain containing receptor kinase S.5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSR8 LECRK19 L-type lectin-domain containing receptor kinase I.9 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSKGLFLIWL ISSFHLISFS TSSKDTSFVF NGFGQSNLAL DGSATLLPNG LLQLAKDSQH
70 80 90 100 110 120
QMGHAFIKKP IDFSSSKPLS FSTHFVCALV PKPGFEGGHG ITFVISPTVD FTRAQPTRYM
130 140 150 160 170 180
GIFNASTNGS PSSHLFAVEL DTVRNPDFRE TNNNHIGIDV NNPISVESAP ASYFSKTAQK
190 200 210 220 230 240
NVSINLSSGK PIQVWVDYHG NVLNVSVAPL EAEKPSLPLL SRSMNLSEIF SRRRLFVGFA
250 260 270 280 290 300
AATGTSISYH YLLGWSFSTN RELSQLLDFS KLPQVPRPRA EHKKVQFALI IALPVILAIV
310 320 330 340 350 360
VMAVLAGVYY HRKKKYAEVS EPWEKKYGTH RFSYKSLYIA TKGFHKDRFL GRGGFGEVYR
370 380 390 400 410 420
GDLPLNKTVA VKRVSHDGEQ GMKQFVAEVV SMKSLKHRNL VPLLGYCRRK GELLLVSEYM
430 440 450 460 470 480
PNGSLDQHLF DDQSPVLSWS QRFVILKGIA SALFYLHTEA EQVVLHRDIK ASNVMLDAEL
490 500 510 520 530 540
NGRLGDFGMA RFHDHGGNAA TTAAVGTVGY MAPELITMGA STITDVYAFG VFLLEVACGR
550 560 570 580 590 600
KPVEFGVQVE KRFLIKWVCE CWKKDSLLDA KDPRLGEEFV PEEVELVMKL GLLCTNIVPE
610 620 630 640 650 660
SRPAMGQVVL YLSGNLPLPD FSPYTLGIGS FTPVVVDAAS LTVSFTSRNW SAPSASSSSA
670
NNSKDHEQPL EFKS