Q9M1C7

PR
Gene name
ABCC9 (MRP9, At3g60160, T2O9.140)
Protein name
ABC transporter C family member 9
Names
ABC transporter ABCC.9, AtABCC9, ATP-energized glutathione S-conjugate pump 9, Glutathione S-conjugate-transporting ATPase 9, Multidrug resistance-associated protein 9
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G60160
EC number
7.6.2.2: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

836-930 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9M1C7

Entry ID Method Resolution Chain Position Source
AF-Q9M1C7-F1 Predicted AlphaFoldDB

60 variants for Q9M1C7

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH02528810 10 E>K No 1000Genomes
tmp_3_22229082_C_T 12 G>D No 1000Genomes
ENSVATH00428908 14 H>R No 1000Genomes
tmp_3_22229011_C_T 36 A>T No 1000Genomes
tmp_3_22229010_G_A 36 A>V No 1000Genomes
tmp_3_22228788_G_A 110 S>L No 1000Genomes
ENSVATH12845132 118 V>I No 1000Genomes
tmp_3_22228675_G_A 148 P>S No 1000Genomes
tmp_3_22228627_A_T 164 S>T No 1000Genomes
tmp_3_22228583_C_A 178 E>D No 1000Genomes
ENSVATH02528809 178 E>G No 1000Genomes
tmp_3_22228585_C_T 178 E>K No 1000Genomes
ENSVATH06347576 191 S>Y No 1000Genomes
ENSVATH12845131 231 Y>S No 1000Genomes
ENSVATH06347573 239 N>K No 1000Genomes
ENSVATH14458945 240 A>T No 1000Genomes
ENSVATH02528807 296 G>E No 1000Genomes
ENSVATH12845130 297 P>S No 1000Genomes
ENSVATH12845129 315 A>T No 1000Genomes
tmp_3_22228117_G_T 334 L>I No 1000Genomes
ENSVATH12845128 363 A>S No 1000Genomes
ENSVATH02528805 419 V>I No 1000Genomes
ENSVATH14458943 446 Y>F No 1000Genomes
ENSVATH02528804 451 H>R No 1000Genomes
ENSVATH06347568 454 L>I No 1000Genomes
ENSVATH12845127 594 L>V No 1000Genomes
ENSVATH06347565 597 S>I No 1000Genomes
ENSVATH06347564 610 Q>R No 1000Genomes
ENSVATH12845126 611 S>N No 1000Genomes
tmp_3_22227255_C_A 621 C>F No 1000Genomes
ENSVATH12845125 623 K>E No 1000Genomes
ENSVATH06347562 623 K>N No 1000Genomes
ENSVATH02528800 688 T>K No 1000Genomes
tmp_3_22227037_T_G 694 K>Q No 1000Genomes
ENSVATH14458941 721 S>R No 1000Genomes
ENSVATH06347560 723 K>N No 1000Genomes
tmp_3_22226624_A_G 801 I>T No 1000Genomes
ENSVATH12845102 810 V>A No 1000Genomes
tmp_3_22226582_T_C 815 E>G No 1000Genomes
ENSVATH06347557 819 A>S No 1000Genomes
ENSVATH06347555 845 I>K No 1000Genomes
tmp_3_22226396_C_G 848 E>Q No 1000Genomes
ENSVATH02528799 872 K>I No 1000Genomes
ENSVATH14458940 910 D>N No 1000Genomes
ENSVATH02528798 996 I>V No 1000Genomes
tmp_3_22225899_C_A 1013 M>I No 1000Genomes
tmp_3_22225872_C_A 1022 M>I No 1000Genomes
tmp_3_22225594_C_T 1084 A>T No 1000Genomes
ENSVATH06347550 1180 V>L No 1000Genomes
ENSVATH12845096 1185 G>V No 1000Genomes
tmp_3_22225111_C_T 1190 S>N No 1000Genomes
tmp_3_22224955_C_G 1242 G>A No 1000Genomes
tmp_3_22224914_C_T 1256 V>I No 1000Genomes
ENSVATH12845082 1274 N>D No 1000Genomes
ENSVATH06347549 1312 T>A No 1000Genomes
tmp_3_22224425_G_A 1364 A>V No 1000Genomes
ENSVATH06347547 1382 D>N No 1000Genomes
ENSVATH12845081 1399 L>* No 1000Genomes
ENSVATH06347545 1473 P>L No 1000Genomes
ENSVATH06347544 1500 G>D No 1000Genomes

No associated diseases with Q9M1C7

18 regional properties for Q9M1C7

Type Name Position InterPro Accession
domain SNF2, N-terminal 632 - 914 IPR000330
domain Chromo/chromo shadow domain 378 - 463 IPR000953-1
domain Chromo/chromo shadow domain 499 - 555 IPR000953-2
domain Helicase, C-terminal 944 - 1107 IPR001650
domain Zinc finger, RING-type 268 - 309 IPR001841-1
domain Zinc finger, RING-type 331 - 372 IPR001841-2
domain Zinc finger, PHD-type 267 - 310 IPR001965-1
domain Zinc finger, PHD-type 330 - 373 IPR001965-2
conserved_site DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site 758 - 767 IPR002464
domain CHD subfamily II, SANT-like domain 1272 - 1421 IPR009462
domain Domain of unknown function DUF1087 1188 - 1253 IPR009463
domain CHD, C-terminal 2 1511 - 1662 IPR012957
domain CHD, N-terminal 97 - 150 IPR012958
domain Helicase superfamily 1/2, ATP-binding domain 612 - 823 IPR014001
conserved_site Zinc finger, PHD-type, conserved site 268 - 309 IPR019786
domain Zinc finger, PHD-finger 265 - 312 IPR019787-1
domain Zinc finger, PHD-finger 328 - 375 IPR019787-2
domain Chromo domain 502 - 554 IPR023780

Functions

Description
EC Number 7.6.2.2 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.

3 GO annotations of molecular function

Name Definition
ABC-type xenobiotic transporter activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.

2 GO annotations of biological process

Name Definition
response to nematode Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

26 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38735 VMR1 ABC transporter ATP-binding protein/permease VMR1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P0CE68 NFT1 ABC transporter NFT1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q8HXQ5 ABCC1 Multidrug resistance-associated protein 1 Bos taurus (Bovine) PR
Q2QLE5 CFTR Cystic fibrosis transmembrane conductance regulator Pan troglodytes (Chimpanzee) PR
P91660 Rh5 Probable multidrug resistance-associated protein lethal(2)03659 Drosophila melanogaster (Fruit fly) PR
P13569 CFTR Cystic fibrosis transmembrane conductance regulator Homo sapiens (Human) PR
O95255 ABCC6 ATP-binding cassette sub-family C member 6 Homo sapiens (Human) PR
O15438 ABCC3 ATP-binding cassette sub-family C member 3 Homo sapiens (Human) PR
Q92887 ABCC2 ATP-binding cassette sub-family C member 2 Homo sapiens (Human) SS
O15439 ABCC4 ATP-binding cassette sub-family C member 4 Homo sapiens (Human) PR
P33527 ABCC1 Multidrug resistance-associated protein 1 Homo sapiens (Human) PR
Q96J66 ABCC11 ATP-binding cassette sub-family C member 11 Homo sapiens (Human) PR
B2RX12 Abcc3 ATP-binding cassette sub-family C member 3 Mus musculus (Mouse) PR
Q8VI47 Abcc2 ATP-binding cassette sub-family C member 2 Mus musculus (Mouse) SS
P26361 Cftr Cystic fibrosis transmembrane conductance regulator Mus musculus (Mouse) PR
O35379 Abcc1 Multidrug resistance-associated protein 1 Mus musculus (Mouse) PR
Q80WJ6 Abcc12 ATP-binding cassette sub-family C member 12 Mus musculus (Mouse) PR
Q6PQZ2 CFTR Cystic fibrosis transmembrane conductance regulator Sus scrofa (Pig) PR
Q8CG09 Abcc1 Multidrug resistance-associated protein 1 Rattus norvegicus (Rat) PR
Q63120 Abcc2 ATP-binding cassette sub-family C member 2 Rattus norvegicus (Rat) EV
Q6Y306 Abcc12 ATP-binding cassette sub-family C member 12 Rattus norvegicus (Rat) PR
Q00553 CFTR Cystic fibrosis transmembrane conductance regulator Macaca mulatta (Rhesus macaque) PR
Q8VZZ4 ABCC6 ABC transporter C family member 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8G9 ABCC1 ABC transporter C family member 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8H0 ABCC12 ABC transporter C family member 12 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SKX0 ABCC13 ABC transporter C family member 13 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MFKPFGFAAE TGSHLLTTQW LQLGNSLCLK ERISIAMQVT FLAFFLIHLA LKWFGVVRNR
70 80 90 100 110 120
GSNDVEEDLK KQSITVKQSF SYNISLLCSV SILGTHCFIL LLLFRDSVVS RCDSSVSVFS
130 140 150 160 170 180
AEVSQSFSWL FVSVVVVKIR ERRLVKFPWM LRSWWLCSFI LSFSFDAHFI TAKHEPLEFQ
190 200 210 220 230 240
DYADLTGLLA SLFLLAVSIR GKTGFHLLES SGNTEPLLLG DQTEQNKKDS YSSSSPYGNA
250 260 270 280 290 300
TLFQRITFSW INPLFSLGYK RPLEKDDVPD IDVKDSARFC SHAFDQKLKT TKEKEGPGNA
310 320 330 340 350 360
FFYNSVLRYV WRKAAINAVF AVVNASTAYI GPYLINDFVE FLSEKQSQSL NHGYLLALGF
370 380 390 400 410 420
LTAKIVETVT QRQWIFGARQ LGLRLRAALI SHIYQKGLVL SSQSRQSHTS GEIINYMSVD
430 440 450 460 470 480
VQRITDFIWY VNNIWMLPIQ IFSAIYILQK HLGLGALAAL VTTLMVMACN YPLTRLQRNY
490 500 510 520 530 540
QSDIMNAKDD RMKATSEILK NMKILKLQAW DNQFLNKVKT LRKKEYDCLW KSLRLQAFTT
550 560 570 580 590 600
FILWGAPSLI SVVTFVTCML MGVKLTAGAV LSALATFQML QSPIFGLPDL LSALVQSKVS
610 620 630 640 650 660
ADRIASYLQQ SETQKDAVEY CSKDHTELSV EIENGAFSWE PESSRPTLDD IELKVKSGMK
670 680 690 700 710 720
VAVCGAVGSG KSSLLSSILG EIQKLKGTVR VSGKQAYVPQ SPWILSGTIR DNILFGSMYE
730 740 750 760 770 780
SEKYERTVKA CALIKDFELF SNGDLTEIGE RGINMSGGQK QRIQIARAVY QNADIYLLDD
790 800 810 820 830 840
PFSAVDAHTG RELFEDCLMG ILKDKTVLYV THQVEFLPAA DLILVMQNGR VMQAGKFEEL
850 860 870 880 890 900
LKQNIGFEVL VGAHNEALDS ILSIEKSSRN FKEGSKDDTA SIAESLQTHC DSEHNISTEN
910 920 930 940 950 960
KKKEAKLVQD EETEKGVIGK EVYLAYLTTV KGGLLVPFII LAQSCFQMLQ IASNYWMAWT
970 980 990 1000 1010 1020
APPTAESIPK LGMGRILLVY ALLAAGSSLC VLARTILVAI GGLSTAETFF SRMLCSIFRA
1030 1040 1050 1060 1070 1080
PMSFFDSTPT GRILNRASTD QSVLDLEMAV KLGWCAFSII QIVGTIFVMS QVAWQVCVIF
1090 1100 1110 1120 1130 1140
IPVAVACVFY QRYYTPTARE LSRMSGVERA PILHHFAESL AGATTIRAFD QRDRFISSNL
1150 1160 1170 1180 1190 1200
VLIDSHSRPW FHVASAMEWL SFRLNLLSHF VFAFSLVLLV TLPEGVINPS IAGLGVTYGL
1210 1220 1230 1240 1250 1260
SLNVLQATVI WNICNAENKM ISVERILQYS KIPSEAPLVI DGHRPLDNWP NVGSIVFRDL
1270 1280 1290 1300 1310 1320
QVRYAEHFPA VLKNITCEFP GGKKIGVVGR TGSGKSTLIQ ALFRIVEPSQ GTIVIDNVDI
1330 1340 1350 1360 1370 1380
TKIGLHDLRS RLGIIPQDPA LFDGTIRLNL DPLAQYTDHE IWEAIDKCQL GDVIRAKDER
1390 1400 1410 1420 1430 1440
LDATVVENGE NWSVGQRQLV CLGRVLLKKS NILVLDEATA SVDSATDGVI QKIINQEFKD
1450 1460 1470 1480 1490 1500
RTVVTIAHRI HTVIESDLVL VLSDGRIAEF DSPAKLLQRE DSFFSKLIKE YSLRSNHFAG
SNDLLS