Q9M092
PR
Gene name |
WAKL17 (At4g31100, F6E21.20) |
Protein name |
Wall-associated receptor kinase-like 17 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G31100 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9M092
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9M092-F1 | Predicted | AlphaFoldDB |
65 variants for Q9M092
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH02946647 | 4 | K>I | No | 1000Genomes | |
| tmp_4_15123950_C_T | 30 | S>L | No | 1000Genomes | |
| ENSVATH14319058 | 43 | G>E | No | 1000Genomes | |
| ENSVATH02946648 | 51 | F>L | No | 1000Genomes | |
| ENSVATH12329099 | 60 | E>K | No | 1000Genomes | |
| tmp_4_15124072_T_C | 71 | S>P | No | 1000Genomes | |
| ENSVATH06806240 | 78 | L>F | No | 1000Genomes | |
| tmp_4_15124111_G_A | 84 | E>K | No | 1000Genomes | |
| tmp_4_15124122_T_A | 87 | S>R | No | 1000Genomes | |
| ENSVATH06806241 | 89 | H>L | No | 1000Genomes | |
| ENSVATH12329100 | 110 | C>Y | No | 1000Genomes | |
| ENSVATH12329101 | 129 | F>L | No | 1000Genomes | |
| ENSVATH06806242 | 130 | V>I | No | 1000Genomes | |
| tmp_4_15124290_C_A | 143 | S>R | No | 1000Genomes | |
| ENSVATH00546275 | 167 | S>L | No | 1000Genomes | |
| tmp_4_15124368_C_A | 169 | S>R | No | 1000Genomes | |
| ENSVATH06806243 | 175 | F>L | No | 1000Genomes | |
| tmp_4_15124421_C_T | 187 | A>V | No | 1000Genomes | |
| ENSVATH08372212 | 191 | T>A | No | 1000Genomes | |
| ENSVATH06806244 | 198 | M>I | No | 1000Genomes | |
| tmp_4_15124534_A_G | 225 | N>D | No | 1000Genomes | |
| ENSVATH12329102 | 228 | K>N | No | 1000Genomes | |
| ENSVATH00546276 | 229 | S>L | No | 1000Genomes | |
| tmp_4_15124556_G_T | 232 | S>I | No | 1000Genomes | |
| ENSVATH14319059 | 240 | L>* | No | 1000Genomes | |
| tmp_4_15124624_C_T | 255 | Q>* | No | 1000Genomes | |
| ENSVATH00546277 | 260 | R>T | No | 1000Genomes | |
| tmp_4_15124750_C_A | 297 | Q>K | No | 1000Genomes | |
| ENSVATH06806247 | 298 | S>G | No | 1000Genomes | |
| ENSVATH12329103 | 301 | C>Y | No | 1000Genomes | |
| tmp_4_15124766_T_A | 302 | I>K | No | 1000Genomes | |
| ENSVATH12329104 | 320 | C>W | No | 1000Genomes | |
| tmp_4_15124865_G_T | 335 | R>I | No | 1000Genomes | |
| tmp_4_15125008_C_A | 344 | P>T | No | 1000Genomes | |
| ENSVATH12329136 | 357 | E>G | No | 1000Genomes | |
| tmp_4_15125083_G_A | 369 | A>T | No | 1000Genomes | |
| tmp_4_15125210_T_C | 382 | V>A | No | 1000Genomes | |
| ENSVATH12329138 | 430 | R>G | No | 1000Genomes | |
| tmp_4_15125372_A_T | 436 | E>V | No | 1000Genomes | |
| tmp_4_15125404_A_G | 447 | N>D | No | 1000Genomes | |
| ENSVATH06806250 | 453 | G>C | No | 1000Genomes | |
| tmp_4_15125431_G_T | 456 | G>C | No | 1000Genomes | |
| ENSVATH12329139 | 461 | G>R | No | 1000Genomes | |
| tmp_4_15125527_G_A | 488 | E>K | No | 1000Genomes | |
| ENSVATH02946651 | 536 | D>Y | No | 1000Genomes | |
| tmp_4_15125686_T_A | 541 | W>R | No | 1000Genomes | |
| tmp_4_15125701_C_T | 546 | R>C | No | 1000Genomes | |
| ENSVATH02946652 | 547 | I>N | No | 1000Genomes | |
| tmp_4_15125719_G_T | 552 | A>S | No | 1000Genomes | |
| ENSVATH00546278 | 595 | V>I | No | 1000Genomes | |
| tmp_4_15125854_A_T | 597 | I>L | No | 1000Genomes | |
| tmp_4_15125900_A_G | 612 | Y>C | No | 1000Genomes | |
| ENSVATH06806253 | 643 | D>E | No | 1000Genomes | |
| ENSVATH12329140 | 647 | I>V | No | 1000Genomes | |
| tmp_4_15126031_A_G | 656 | I>V | No | 1000Genomes | |
| ENSVATH06806254 | 657 | A>T | No | 1000Genomes | |
| tmp_4_15126039_G_T | 658 | L>F | No | 1000Genomes | |
| tmp_4_15126059_C_T | 665 | A>V | No | 1000Genomes | |
| ENSVATH06806256 | 695 | A>E | No | 1000Genomes | |
| ENSVATH02946653 | 704 | R>K | No | 1000Genomes | |
| ENSVATH12329141 | 728 | V>L | No | 1000Genomes | |
| ENSVATH02946654 | 754 | G>E | No | 1000Genomes | |
| ENSVATH06806257 | 767 | S>N | No | 1000Genomes | |
| tmp_4_15126367_A_T | 768 | I>F | No | 1000Genomes | |
| ENSVATH14319062 | 776 | D>E | No | 1000Genomes |
No associated diseases with Q9M092
5 regional properties for Q9M092
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 444 - 719 | IPR000719 |
| domain | EGF-like calcium-binding domain | 336 - 363 | IPR001881 |
| active_site | Serine/threonine-protein kinase, active site | 566 - 578 | IPR008271 |
| domain | Wall-associated receptor kinase | 197 - 305 | IPR013695 |
| conserved_site | EGF-like calcium-binding, conserved site | 336 - 362 | IPR018097 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell surface receptor signaling pathway | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
34 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P28693 | EPHB2 | Ephrin type-B receptor 2 | Gallus gallus (Chicken) | PR |
| P29318 | EPHA3 | Ephrin type-A receptor 3 | Gallus gallus (Chicken) | SS |
| Q07497 | EPHB5 | Ephrin type-B receptor 5 | Gallus gallus (Chicken) | PR |
| Q07496 | EPHA4 | Ephrin type-A receptor 4 | Gallus gallus (Chicken) | SS |
| O42422 | EPHA7 | Ephrin type-A receptor 7 | Gallus gallus (Chicken) | SS |
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| P54755 | EPHA5 | Ephrin type-A receptor 5 | Gallus gallus (Chicken) | SS |
| Q07498 | EPHB3 | Ephrin type-B receptor 3 | Gallus gallus (Chicken) | SS |
| P06213 | INSR | Insulin receptor | Homo sapiens (Human) | EV |
| P08069 | IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens (Human) | EV |
| P14616 | INSRR | Insulin receptor-related protein | Homo sapiens (Human) | SS |
| P00533 | EGFR | Epidermal growth factor receptor | Homo sapiens (Human) | EV |
| Q15303 | ERBB4 | Receptor tyrosine-protein kinase erbB-4 | Homo sapiens (Human) | SS |
| P04626 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (Human) | SS |
| P21860 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | Homo sapiens (Human) | SS |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| Q7X8C5 | WAKL2 | Wall-associated receptor kinase-like 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYA3 | WAKL10 | Wall-associated receptor kinase-like 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C9L5 | WAKL9 | Wall-associated receptor kinase-like 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9S9M2 | WAKL4 | Wall-associated receptor kinase-like 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LMN7 | WAK5 | Wall-associated receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8JFR5 | kita | Mast/stem cell growth factor receptor kita | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8N6 | csf1r | Macrophage colony-stimulating factor 1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5GIT4 | kdr | Vascular endothelial growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90Z00 | fgfr1a | Fibroblast growth factor receptor 1-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5MD89 | flt4 | Vascular endothelial growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JG38 | fgfr2 | Fibroblast growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8X3 | fgfr3 | Fibroblast growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSYKNTNNSH | LILFKLLLLL | ILYSADLTAS | SSCRSECGGC | KCGGIAIPYP | FGIGKGCYLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KSYEIECLNT | SGKLVPFLSV | ISKEVVSIHL | PGRQSFGSVR | VRSPITSAGC | SSDGKDSAPV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MNLTDSPFFV | SDINNLVGVG | CSSKVSLEHI | KQNMVGCELN | CSTTNASDSN | SIPFFDKTGC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SFSYTFAQVC | TGNKPEDMGC | DGRGCCQASL | PREPQQVIGI | RIESNDGKST | TSGDCRVAFL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TDEFFSLSKL | TKPEQLHAKR | YATLSLGWIM | QTRNTSFVNS | LACKIRKDTD | TAYSNDQSIK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CICDYTMSII | SDIRYANCEC | NLGYKGNPYD | SDGCRDIDEC | KENPKYCKET | DTCVNFEGGY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RCVGDKTKAI | MIGAGTGFGV | LVLVGGVWWL | RKFLVKRRMA | KRKKKFFKRN | GGLLLQQELN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TRQGVVEKAR | IFTSKELEKA | TENFSENRVL | GHGGQGTVYK | GMLVDGRTVA | VKKSKVIDED |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KLQEFINEVV | ILSQINHRHV | VKLLGCCLET | EVPILVYEFI | INGNLFKHIH | EEEADDYTMI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| WGMRLRIAVD | IAGALSYLHS | AASSPIYHRD | IKSTNILLDE | KYRAKVADFG | TSRSVTIDQT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HWTTVISGTV | GYVDPEYYRS | SQYTEKSDVY | SFGVILAELI | TGDKPVIMVQ | NTQEIIALAE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| HFRVAMKERR | LSDIMDARIR | DDSKPEQVMA | VANLAMKCLS | SRGRNRPNMR | EVFTELERIC |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TSPEDSQVQN | RIDEEEEEDG | VEEEEEVVTI | VHRGDSWSIG | VTAPASSIVA | SPPSSDVEPL |
| NPLLTW |