Q9LXK7
SS
Gene name |
PME32 (ARATH32, At3g43270, F7K15.120) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 32 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G43270 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
214-511 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q9LXK7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LXK7-F1 | Predicted | AlphaFoldDB |
71 variants for Q9LXK7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_15225107_T_A | 6 | Q>H | No | 1000Genomes | |
| tmp_3_15225070_T_A | 19 | I>F | No | 1000Genomes | |
| ENSVATH06159598 | 23 | S>P | No | 1000Genomes | |
| ENSVATH06159597 | 29 | F>L | No | 1000Genomes | |
| tmp_3_15225027_T_G | 33 | D>A | No | 1000Genomes | |
| ENSVATH06159596 | 37 | M>I | No | 1000Genomes | |
| tmp_3_15225011_C_A,T | 38 | E>D | No | 1000Genomes | |
| ENSVATH06159594 | 55 | V>I | No | 1000Genomes | |
| ENSVATH12210986 | 60 | K>N | No | 1000Genomes | |
| ENSVATH00389744 | 72 | A>V | No | 1000Genomes | |
| ENSVATH12210985 | 73 | G>A | No | 1000Genomes | |
| tmp_3_15224888_A_C | 79 | N>K | No | 1000Genomes | |
| tmp_3_15224890_T_A | 79 | N>Y | No | 1000Genomes | |
| tmp_3_15224869_C_A | 86 | D>Y | No | 1000Genomes | |
| tmp_3_15224851_C_T | 92 | A>T | No | 1000Genomes | |
| tmp_3_15224815_A_C | 104 | S>A | No | 1000Genomes | |
| tmp_3_15224809_T_C | 106 | N>D | No | 1000Genomes | |
| ENSVATH02377204 | 108 | K>Q | No | 1000Genomes | |
| tmp_3_15223750_T_C | 110 | N>D | No | 1000Genomes | |
| ENSVATH12210682 | 116 | G>S | No | 1000Genomes | |
| ENSVATH12210681 | 117 | S>L | No | 1000Genomes | |
| ENSVATH00389736 | 120 | R>K | No | 1000Genomes | |
| tmp_3_15223711_T_A | 123 | I>L | No | 1000Genomes | |
| ENSVATH06159565 | 126 | A>V | No | 1000Genomes | |
| ENSVATH12210680 | 127 | L>F | No | 1000Genomes | |
| ENSVATH14294676 | 130 | Q>H | No | 1000Genomes | |
| ENSVATH02377201 | 131 | D>E | No | 1000Genomes | |
| ENSVATH12210679 | 136 | G>S | No | 1000Genomes | |
| ENSVATH00389733 | 154 | K>R | No | 1000Genomes | |
| tmp_3_15223587_G_C | 164 | T>R | No | 1000Genomes | |
| ENSVATH02377196 | 173 | P>L | No | 1000Genomes | |
| ENSVATH14294675 | 177 | P>A | No | 1000Genomes | |
| ENSVATH02377194 | 181 | Q>H | No | 1000Genomes | |
| ENSVATH06159562 | 184 | T>K | No | 1000Genomes | |
| ENSVATH00389731 | 188 | S>G | No | 1000Genomes | |
| ENSVATH02377191 | 200 | G>D | No | 1000Genomes | |
| ENSVATH00389729 | 212 | V>I | No | 1000Genomes | |
| tmp_3_15223411_C_A,T | 223 | G>* | No | 1000Genomes | |
| tmp_3_15223411_C_A,T | 223 | G>R | No | 1000Genomes | |
| ENSVATH06159559 | 226 | T>M | No | 1000Genomes | |
| tmp_3_15223386_G_A | 231 | A>V | No | 1000Genomes | |
| ENSVATH06159557 | 233 | L>F | No | 1000Genomes | |
| ENSVATH06159556 | 234 | A>T | No | 1000Genomes | |
| ENSVATH06159555 | 237 | D>E | No | 1000Genomes | |
| ENSVATH14294644 | 238 | Y>C | No | 1000Genomes | |
| tmp_3_15223366_A_C | 238 | Y>D | No | 1000Genomes | |
| tmp_3_15223327_C_T | 251 | V>M | No | 1000Genomes | |
| tmp_3_15223276_C_A | 268 | V>F | No | 1000Genomes | |
| ENSVATH06159554 | 281 | R>W | No | 1000Genomes | |
| ENSVATH12210637 | 306 | D>G | No | 1000Genomes | |
| tmp_3_15223065_G_C | 307 | I>M | No | 1000Genomes | |
| tmp_3_15223040_C_T | 316 | E>K | No | 1000Genomes | |
| tmp_3_15223010_C_T | 326 | D>N | No | 1000Genomes | |
| ENSVATH06159548 | 327 | T>A | No | 1000Genomes | |
| ENSVATH12210636 | 329 | L>F | No | 1000Genomes | |
| ENSVATH00389724 | 336 | A>G | No | 1000Genomes | |
| ENSVATH14294643 | 341 | Q>E | No | 1000Genomes | |
| tmp_3_15222883_T_G | 368 | D>A | No | 1000Genomes | |
| tmp_3_15222736_T_C | 417 | D>G | No | 1000Genomes | |
| ENSVATH06159543 | 420 | L>P | No | 1000Genomes | |
| tmp_3_15222722_A_T | 422 | L>I | No | 1000Genomes | |
| tmp_3_15222644_C_A | 448 | D>Y | No | 1000Genomes | |
| tmp_3_15222629_C_T | 453 | V>I | No | 1000Genomes | |
| ENSVATH00389719 | 481 | L>F | No | 1000Genomes | |
| ENSVATH00389718 | 483 | R>H | No | 1000Genomes | |
| tmp_3_15222508_A_G | 493 | L>S | No | 1000Genomes | |
| ENSVATH00389717 | 495 | T>I | No | 1000Genomes | |
| ENSVATH14294640 | 496 | S>L | No | 1000Genomes | |
| ENSVATH12210612 | 507 | L>F | No | 1000Genomes | |
| tmp_3_15222461_G_T | 509 | Q>K | No | 1000Genomes | |
| ENSVATH00389714 | 522 | I>F | No | 1000Genomes |
No associated diseases with Q9LXK7
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKFRQMGSS | IFFLFLIIIS | LCSAHKEAFS | STDLVQMECL | RVPPLEFAEA | AKTVVDAITK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AVAIVSKFDK | KAGKSRVSNA | IVDCVDLLDS | AAEELSWIIS | ASQSPNGKDN | STGDVGSDLR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TWISAALSNQ | DTCLDGFEGT | NGIIKKIVAG | GLSKVGTTVR | NLLTMVHSPP | SKPKPKPIKA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QTMTKAHSGF | SKFPSWVKPG | DRKLLQTDNI | TVADAVVAAD | GTGNFTTISD | AVLAAPDYST |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KRYVIHVKRG | VYVENVEIKK | KKWNIMMVGD | GIDATVITGN | RSFIDGWTTF | RSATFAVSGR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GFIARDITFQ | NTAGPEKHQA | VAIRSDTDLG | VFYRCAMRGY | QDTLYAHSMR | QFFRECIITG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TVDFIFGDAT | AVFQSCQIKA | KQGLPNQKNS | ITAQGRKDPN | EPTGFTIQFS | NIAADTDLLL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NLNTTATYLG | RPWKLYSRTV | FMQNYMSDAI | NPVGWLEWNG | NFALDTLYYG | EYMNSGPGAS |
| 490 | 500 | 510 | 520 | ||
| LDRRVKWPGY | HVLNTSAEAN | NFTVSQLIQG | NLWLPSTGIT | FIAGLVS |