Q9LW83
Gene name |
CES101 (At3g16030, MSL1.2) |
Protein name |
G-type lectin S-receptor-like serine/threonine-protein kinase CES101 |
Names |
Protein CALLUS EXPRESSION OF RBCS 101 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G16030 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
669-676 (Activation loop from InterPro)
Target domain |
527-816 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
687-694 (Activation loop from InterPro)
Target domain |
527-816 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9LW83
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LW83-F1 | Predicted | AlphaFoldDB |
96 variants for Q9LW83
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_5439633_A_C | 9 | T>P | No | 1000Genomes | |
| ENSVATH02149955 | 13 | F>L | No | 1000Genomes | |
| ENSVATH00325992 | 23 | Q>E | No | 1000Genomes | |
| ENSVATH05840908 | 40 | V>D | No | 1000Genomes | |
| ENSVATH00325994 | 42 | A>T | Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [10c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average leaf number at flowering time of 4 plants of the same accession were collected [10c and 16 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| ENSVATH02149958 | 48 | L>V | No | 1000Genomes | |
| tmp_3_5439774_T_C | 56 | S>P | No | 1000Genomes | |
| ENSVATH05840909 | 63 | I>M | No | 1000Genomes | |
| ENSVATH05840910 | 64 | W>C | No | 1000Genomes | |
| ENSVATH09463470 | 71 | S>N | No | 1000Genomes | |
| ENSVATH05840911 | 72 | G>V | No | 1000Genomes | |
| ENSVATH02149969 | 134 | M>I | No | 1000Genomes | |
| ENSVATH02149970 | 135 | D>E | No | 1000Genomes | |
| ENSVATH02149972 | 139 | S>L | No | 1000Genomes | |
| ENSVATH02149973 | 141 | K>M | No | 1000Genomes | |
| ENSVATH00325995 | 143 | T>M | No | 1000Genomes | |
| ENSVATH10708987 | 164 | N>H | No | 1000Genomes | |
| tmp_3_5440137_A_C | 166 | K>Q | No | 1000Genomes | |
| ENSVATH02149982 | 167 | T>N | No | 1000Genomes | |
| ENSVATH02149984 | 181 | L>* | No | 1000Genomes | |
| ENSVATH07963122 | 184 | S>P | No | 1000Genomes | |
| ENSVATH02149986 | 187 | F>L | No | 1000Genomes | |
| ENSVATH02149988 | 193 | D>A | No | 1000Genomes | |
| ENSVATH02149993 | 204 | L>R | No | 1000Genomes | |
| ENSVATH02149995 | 207 | V>M | No | 1000Genomes | |
| ENSVATH05840913 | 217 | G>D | No | 1000Genomes | |
| ENSVATH02150000 | 223 | K>E | No | 1000Genomes | |
| ENSVATH00325998 | 227 | N>H | No | 1000Genomes | |
| ENSVATH07963127 | 230 | I>L | No | 1000Genomes | |
| ENSVATH02150003 | 234 | V>I | No | 1000Genomes | |
| ENSVATH00325999 | 248 | E>Q | No | 1000Genomes | |
| ENSVATH02150006 | 249 | N>K | No | 1000Genomes | |
| ENSVATH02150007 | 251 | G>A | No | 1000Genomes | |
| ENSVATH05840914 | 253 | P>T | No | 1000Genomes | |
| tmp_3_5440403_A_T | 254 | L>F | No | 1000Genomes | |
| ENSVATH05840917 | 258 | I>V | No | 1000Genomes | |
| ENSVATH00326001 | 259 | R>M | No | 1000Genomes | |
| tmp_3_5440534_T_C | 298 | F>S | No | 1000Genomes | |
| tmp_3_5440590_C_T | 317 | P>S | No | 1000Genomes | |
| ENSVATH10708992 | 326 | R>G | No | 1000Genomes | |
| ENSVATH00326006 | 327 | K>E | No | 1000Genomes | |
| ENSVATH05840921 | 327 | K>N | No | 1000Genomes | |
| ENSVATH05840922 | 333 | Y>N | No | 1000Genomes | |
| tmp_3_5440695_G_T | 352 | G>* | No | 1000Genomes | |
| ENSVATH02150012 | 378 | V>L | No | 1000Genomes | |
| ENSVATH02150016 | 433 | I>M | No | 1000Genomes | |
| ENSVATH02150017 | 436 | V>L | No | 1000Genomes | |
| ENSVATH02150018 | 438 | W>C | No | 1000Genomes | |
| ENSVATH02150021 | 441 | I>M | No | 1000Genomes | |
| tmp_3_5441165_T_A | 470 | L>H | No | 1000Genomes | |
| ENSVATH00326015 | 476 | S>P | No | 1000Genomes | |
| ENSVATH10709042 | 477 | T>A | No | 1000Genomes | |
| ENSVATH00326016 | 478 | L>Q | No | 1000Genomes | |
| tmp_3_5441402_G_A | 481 | G>D | No | 1000Genomes | |
| tmp_3_5441415_C_A | 485 | D>E | No | 1000Genomes | |
| ENSVATH02150047 | 491 | L>R | No | 1000Genomes | |
| ENSVATH00326017 | 496 | E>D | No | 1000Genomes | |
| ENSVATH05840928 | 499 | R>C | No | 1000Genomes | |
| ENSVATH07963195 | 500 | R>* | No | 1000Genomes | |
| tmp_3_5441459_G_A | 500 | R>Q | No | 1000Genomes | |
| tmp_3_5441504_T_A | 515 | F>Y | No | 1000Genomes | |
| ENSVATH00326018 | 519 | S>T | No | 1000Genomes | |
| ENSVATH05840929 | 523 | A>T | No | 1000Genomes | |
| ENSVATH02150056 | 530 | A>V | No | 1000Genomes | |
| ENSVATH02150068 | 562 | G>E | No | 1000Genomes | |
| tmp_3_5441774_A_G | 582 | N>S | No | 1000Genomes | |
| ENSVATH02150073 | 585 | K>M | No | 1000Genomes | |
| ENSVATH02150072 | 585 | K>Q | No | 1000Genomes | |
| ENSVATH05840930 | 587 | L>I | No | 1000Genomes | |
| ENSVATH02150074 | 591 | V>I | No | 1000Genomes | |
| ENSVATH02150075 | 594 | D>E | No | 1000Genomes | |
| ENSVATH00326024 | 604 | P>S | No | 1000Genomes | |
| ENSVATH02150086 | 619 | I>N | No | 1000Genomes | |
| ENSVATH02150089 | 624 | K>N | No | 1000Genomes | |
| ENSVATH02150088 | 624 | K>T | No | 1000Genomes | |
| tmp_3_5442017_A_G | 641 | H>R | No | 1000Genomes | |
| ENSVATH02150092 | 656 | G>S | No | 1000Genomes | |
| ENSVATH02150096 | 683 | K>R | No | 1000Genomes | |
| ENSVATH02150111 | 708 | A>T | No | 1000Genomes | |
| ENSVATH00326033 | 734 | D>E | No | 1000Genomes | |
| ENSVATH02150121 | 752 | N>D | No | 1000Genomes | |
| ENSVATH02150122 | 753 | R>Q | No | 1000Genomes | |
| ENSVATH02150124 | 754 | V>I | No | 1000Genomes | |
| ENSVATH02150125 | 755 | R>H | No | 1000Genomes | |
| ENSVATH10709090 | 784 | Q>E | No | 1000Genomes | |
| ENSVATH00326038 | 807 | A>V | No | 1000Genomes | |
| ENSVATH02150133 | 818 | D>Y | No | 1000Genomes | |
| tmp_3_5442704_G_T | 819 | G>C | No | 1000Genomes | |
| ENSVATH02150134 | 820 | P>S | No | 1000Genomes | |
| ENSVATH02150134 | 820 | P>T | No | 1000Genomes | |
| ENSVATH02150136 | 821 | P>R | No | 1000Genomes | |
| ENSVATH10709091 | 824 | S>L | No | 1000Genomes | |
| ENSVATH13927914 | 825 | P>Q | No | 1000Genomes | |
| ENSVATH10709093 | 833 | E>D | No | 1000Genomes | |
| ENSVATH00326040 | 834 | M>L | No | 1000Genomes | |
| ENSVATH05840932 | 837 | V>I | No | 1000Genomes |
No associated diseases with Q9LW83
5 regional properties for Q9LW83
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 527 - 816 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 531 - 799 | IPR001245 |
| domain | Bulb-type lectin domain | 24 - 176 | IPR001480 |
| domain | PAN/Apple domain | 334 - 416 | IPR003609 |
| active_site | Serine/threonine-protein kinase, active site | 648 - 660 | IPR008271 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| response to fungus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. |
34 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q06807 | TEK | Angiopoietin-1 receptor | Bos taurus (Bovine) | SS |
| Q06805 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Bos taurus (Bovine) | PR |
| P09208 | InR | Insulin-like receptor | Drosophila melanogaster (Fruit fly) | SS |
| P06213 | INSR | Insulin receptor | Homo sapiens (Human) | EV |
| P08069 | IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens (Human) | EV |
| P14616 | INSRR | Insulin receptor-related protein | Homo sapiens (Human) | SS |
| P35590 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Homo sapiens (Human) | PR |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| P24062 | Igf1r | Insulin-like growth factor 1 receptor | Rattus norvegicus (Rat) | SS |
| Q64716 | Insrr | Insulin receptor-related protein | Rattus norvegicus (Rat) | SS |
| P15127 | Insr | Insulin receptor | Rattus norvegicus (Rat) | SS |
| Q9SXB5 | At1g11303 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11303 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64783 | At1g61370 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64770 | At1g61490 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61490 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SYA0 | At1g61500 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81833 | SD11 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64780 | At1g61400 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61400 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64776 | At1g61440 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61440 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SY95 | At1g61550 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61550 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64778 | At1g61420 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61420 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64774 | At1g61460 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61460 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64782 | SD129 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64793 | At1g67520 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g67520 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB8 | At1g11330 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11330 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDQ3 | CRK34 | Cysteine-rich receptor-like protein kinase 34 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64784 | At1g61360 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61360 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWSNCIFLTL | FTFYLFLGQS | CCQTDTLLQG | QYLKDGQELV | SAFNIFKLKF | FNFENSSNWY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGIWYNNFYL | SGAVWIANRN | NPVLGRSGSL | TVDSLGRLRI | LRGASSLLEL | SSTETTGNTT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LKLLDSGNLQ | LQEMDSDGSM | KRTLWQSFDY | PTDTLLPGMK | LGFNVKTGKR | WELTSWLGDT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LPASGSFVFG | MDDNITNRLT | ILWLGNVYWA | SGLWFKGGFS | LEKLNTNGFI | FSFVSTESEH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YFMYSGDENY | GGPLFPRIRI | DQQGSLQKIN | LDGVKKHVHC | SPSVFGEELE | YGCYQQNFRN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CVPARYKEVT | GSWDCSPFGF | GYTYTRKTYD | LSYCSRFGYT | FRETVSPSAE | NGFVFNEIGR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RLSSYDCYVK | CLQNCSCVAY | ASTNGDGTGC | EIWNTDPTNE | NSASHHPRTI | YIRIKGSKLA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ATWLVVVASL | FLIIPVTWLI | IYLVLRKFKI | KGTNFVSESL | KMISSQSCSL | TNKRLSTLRV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GSTIDQEMLL | LELGIERRRR | GKRSARNNNN | ELQIFSFESV | AFATDYFSDA | NKLGEGGFGP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VYKGRLIDGE | EVAIKRLSLA | SGQGLVEFKN | EAMLIAKLQH | TNLVKLLGCC | VEKDEKMLIY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EYMPNKSLDY | FLFDPLRKIV | LDWKLRFRIM | EGIIQGLLYL | HKYSRLKVIH | RDIKAGNILL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DEDMNPKISD | FGMARIFGAQ | ESKANTKRVA | GTFGYMSPEY | FREGLFSAKS | DVFSFGVLML |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EIICGRKNNS | FHHDSEGPLN | LIVHVWNLFK | ENRVREVIDP | SLGDSAVENP | QVLRCVQVAL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LCVQQNADDR | PSMLDVVSMI | YGDGNNALSL | PKEPAFYDGP | PRSSPEMEVE | PPEMENVSAN |
| RVTITVMEAR |