Q9LVM9
Gene name |
YKT62 |
Protein name |
VAMP-like protein YKT62 |
Names |
AtYKT62, ATGP1-like protein |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G58180 |
EC number |
|
Protein Class |
|
Descriptions
(Annotation based on sequence homology with Q5EGY4)
Most SNAREs are permanently anchored to membranes, but the SNARE Ykt6 is found both on intracellular membranes and in the cytoplasm. The SNARE core is autoinhibited by the N-terminal longin domain.
The dynamics of Ykt6 are believed to be governed by the reversible palmitoylation of the protein, which cycles Ykt6 between intracellular membranes and the cytoplasm. Palmitoylation of Ykt6 increases the partition coefficient of Ykt6 to membranes, thereby shifting some populations of the protein from the cytosol to cellular membranes. Palmitoylation-mediated membrane insertion will further shift the conformational equilibrium of Ykt6 to the open state. The specific membrane localization and the amount of membrane-associated Ykt6 are predicted to be affected by its reversible palmitoylation machinery in cells, as the majority of Ykt6 exists in the unpalmitoylated cytosolic form
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LVM9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LVM9-F1 | Predicted | AlphaFoldDB |
22 variants for Q9LVM9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH12839393 | 2 | K>N | No | 1000Genomes | |
| ENSVATH03447620 | 16 | R>P | No | 1000Genomes | |
| ENSVATH00740594 | 20 | I>V | No | 1000Genomes | |
| tmp_5_23544086_G_A | 26 | D>N | No | 1000Genomes | |
| ENSVATH12839394 | 29 | Q>P | No | 1000Genomes | |
| tmp_5_23544108_T_C | 33 | F>S | No | 1000Genomes | |
| ENSVATH03447621 | 46 | F>S | No | 1000Genomes | |
| ENSVATH00740596 | 53 | R>K | No | 1000Genomes | |
| ENSVATH00740597 | 60 | R>C | No | 1000Genomes | |
| ENSVATH00740598 | 79 | C>* | No | 1000Genomes | |
| ENSVATH00740599 | 80 | A>V | No | 1000Genomes | |
| ENSVATH00740600 | 89 | P>S | No | 1000Genomes | |
| ENSVATH12839417 | 100 | V>L | No | 1000Genomes | |
| ENSVATH03447632 | 103 | V>A | No | 1000Genomes | |
| ENSVATH14638988 | 117 | S>P | No | 1000Genomes | |
| ENSVATH00740601 | 120 | P>L | No | 1000Genomes | |
| ENSVATH00740602 | 132 | R>Q | No | 1000Genomes | |
| tmp_5_23544697_G_A | 138 | D>N | No | 1000Genomes | |
| ENSVATH12839418 | 160 | G>S | No | 1000Genomes | |
| tmp_5_23544931_A_T | 166 | E>V | No | 1000Genomes | |
| ENSVATH07444479 | 188 | Q>K | No | 1000Genomes | |
| tmp_5_23545147_C_G | 197 | T>R | No | 1000Genomes |
No associated diseases with Q9LVM9
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| SNARE complex | A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| SNAP receptor activity | Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| endoplasmic reticulum to Golgi vesicle-mediated transport | The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| vesicle fusion | Fusion of the membrane of a transport vesicle with its target membrane. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P36015 | YKT6 | Synaptobrevin homolog YKT6 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | EV |
| Q3T000 | YKT6 | Synaptobrevin homolog YKT6 | Bos taurus (Bovine) | SS |
| O15498 | YKT6 | Synaptobrevin homolog YKT6 | Homo sapiens (Human) | SS |
| Q9CQW1 | Ykt6 | Synaptobrevin homolog YKT6 | Mus musculus (Mouse) | SS |
| Q5EGY4 | Ykt6 | Synaptobrevin homolog YKT6 | Rattus norvegicus (Rat) | EV |
| Q9ZRD6 | YKT61 | VAMP-like protein YKT61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q6P816 | ykt6 | Synaptobrevin homolog YKT6 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q7ZUN8 | ykt6 | Synaptobrevin homolog YKT6 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKITALLVLK | CDPETREPVI | LANVSDLSQF | GKFSFYRSNF | EEFIVFIART | VARRTPPGQR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QSVKHEEYKV | HAYNINGLCA | VGFMDDHYPV | RSAFSLLNQV | LDVYQKDYGD | TWRFENSSQP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WPYLKEASDK | FRDPAEADKL | LKIQRELDET | KIILHKTIDG | VLARGEKLDS | LVEKSSELSL |
| 190 | |||||
| ASKMFYKQAK | KTNSCCTLL |