Q9LVL5
Gene name |
WNK4 (At5g58350, MCK7.22) |
Protein name |
Probable serine/threonine-protein kinase WNK4 |
Names |
AtWNK4, Protein kinase with no lysine 4 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G58350 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
165-187 (Activation loop from InterPro)
Target domain |
19-277 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9LVL5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LVL5-F1 | Predicted | AlphaFoldDB |
19 variants for Q9LVL5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00740760 | 34 | Y>F | No | 1000Genomes | |
| tmp_5_23585706_T_C | 43 | I>T | No | 1000Genomes | |
| tmp_5_23586039_A_T | 128 | Q>H | No | 1000Genomes | |
| tmp_5_23586070_C_T | 139 | H>Y | No | 1000Genomes | |
| tmp_5_23586431_A_C | 233 | K>N | No | 1000Genomes | |
| tmp_5_23586438_G_C | 236 | G>R | No | 1000Genomes | |
| ENSVATH00740762 | 300 | N>S | No | 1000Genomes | |
| tmp_5_23586921_T_G | 347 | F>C | No | 1000Genomes | |
| tmp_5_23586939_A_G | 353 | N>S | No | 1000Genomes | |
| tmp_5_23587080_C_A | 400 | T>N | No | 1000Genomes | |
| ENSVATH03447896 | 402 | H>Y | No | 1000Genomes | |
| tmp_5_23587113_C_G | 411 | S>C | No | 1000Genomes | |
| ENSVATH07444817 | 456 | S>C | No | 1000Genomes | |
| ENSVATH00740765 | 474 | V>A | No | 1000Genomes | |
| ENSVATH03447898 | 507 | N>T | No | 1000Genomes | |
| tmp_5_23587490_A_G | 509 | S>G | No | 1000Genomes | |
| tmp_5_23587541_G_A | 526 | V>M | No | 1000Genomes | |
| ENSVATH14639216 | 561 | A>G | No | 1000Genomes | |
| ENSVATH14639217 | 567 | P>R | No | 1000Genomes |
No associated diseases with Q9LVL5
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UHY1 | NRBP1 | Nuclear receptor-binding protein | Homo sapiens (Human) | PR |
| Q9H4A3 | WNK1 | Serine/threonine-protein kinase WNK1 | Homo sapiens (Human) | SS |
| Q96J92 | WNK4 | Serine/threonine-protein kinase WNK4 | Homo sapiens (Human) | SS |
| Q9Y3S1 | WNK2 | Serine/threonine-protein kinase WNK2 | Homo sapiens (Human) | SS |
| Q9BYP7 | WNK3 | Serine/threonine-protein kinase WNK3 | Homo sapiens (Human) | SS |
| Q8TDX7 | NEK7 | Serine/threonine-protein kinase Nek7 | Homo sapiens (Human) | EV |
| Q80UE6 | Wnk4 | Serine/threonine-protein kinase WNK4 | Mus musculus (Mouse) | SS |
| Q99J45 | Nrbp1 | Nuclear receptor-binding protein | Mus musculus (Mouse) | PR |
| P83741 | Wnk1 | Serine/threonine-protein kinase WNK1 | Mus musculus (Mouse) | SS |
| Q3UH66 | Wnk2 | Serine/threonine-protein kinase WNK2 | Mus musculus (Mouse) | SS |
| Q80XP9 | Wnk3 | Serine/threonine-protein kinase WNK3 | Mus musculus (Mouse) | SS |
| Q6R2V0 | WNK1 | Serine/threonine-protein kinase WNK1 | Sus scrofa (Pig) | SS |
| Q7TPK6 | Wnk4 | Serine/threonine-protein kinase WNK4 | Rattus norvegicus (Rat) | SS |
| Q9JIH7 | Wnk1 | Serine/threonine-protein kinase WNK1 | Rattus norvegicus (Rat) | EV |
| P59895 | Nek6 | Serine/threonine-protein kinase Nek6 | Rattus norvegicus (Rat) | SS |
| D3ZBE5 | Nek7 | Serine/threonine-protein kinase Nek7 | Rattus norvegicus (Rat) | SS |
| E9PTG8 | Stk10 | Serine/threonine-protein kinase 10 | Rattus norvegicus (Rat) | PR |
| G5EFM9 | nekl-3 | Serine/threonine-protein kinase nekl-3 | Caenorhabditis elegans | PR |
| X5M5N0 | wnk-1 | Serine/threonine-protein kinase WNK | Caenorhabditis elegans | SS |
| Q8RXE5 | WNK10 | Probable serine/threonine-protein kinase WNK10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q944Q0 | WNK8 | Serine/threonine-protein kinase WNK8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STK6 | WNK3 | Probable serine/threonine-protein kinase WNK3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LST2 | WNK7 | Probable serine/threonine-protein kinase WNK7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNMNQVAEYV | ETDPTGRYGR | FAEILGRGAM | KTVYKAIDEK | LGIEVAWSQV | KLKEVLRSSV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DLQRLYSEVH | LLSTLNHKSI | IRFYTSWIDV | HNHTLNFITE | LFTSGTLRQY | KNKYLRIDIR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AIKSWARQIL | EGLVYLHEHD | PPVIHRDLKC | DNIFVNGHLG | QVKIGDLGLA | RMLRDCHSAH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SIIGTPEFMA | PELYEENYNE | LIDVYSFGMC | FLEMITSEFP | YSECNHPAQI | YKKVVGGKLP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GAFYRVGDIE | AQRFIGKCLV | SASKRVSAKE | LLQDPFLASD | ESWMVYTSGA | GNPKPFLNEN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EMDTLKLEDD | ELRTEMSIAG | KLGAEDNKID | LEVQIAYDNG | LANNVFFPFD | IMNDTSIDVA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KEMVKELEII | DWEPVEIAKM | IDGAISSLVS | DWKYEEDDET | PHDHHRHRTD | SFHSSSSHAS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SSQASLSNYM | ARGLQDWVQD | DLHDETYSQS | SSHSGSYSNL | NYIAVDEYSS | QSPVMSRTHN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MTRFCPEESS | HLQSGQANAY | AASSSTNRSL | ASDNRTLTRN | RSLVDVQRQL | LHRSPGEEAR |
| 550 | 560 | 570 | |||
| KRRLFKTVGD | VETVGFQSPY | AVSRKPPSSR | R |