Q9LV11

SS
Gene name
AHA11 (At5g62670, MRG21.9)
Protein name
ATPase 11, plasma membrane-type
Names
EC 7.1.2.1 , Proton pump 11
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G62670
EC number
7.1.2.1: Hydron translocation linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The plasma membrane H+-ATPase belongs to the superfamily of P-type ATPases. The H+-ATPase is responsible for the ATP-fuelled ejection of protons from the cell and is an important component in the generation of the trans-membrane H+ gradient in plant cells. The H+-ATPase AHA2 is controlled by an autoinhibitory C-terminal regulatory domain and activated by 14-3-3 proteins which bind to the part of the enzyme. In two regions of the C-terminus, alteration of the residues leads to increased pump activity. One region stretches from K863 to L885 and includes two residues (Q879 and R880) that are conserved between plant and fungal H+-ATPases. The other region, incorporating S904 to L919, is situated in an extension of the C-terminus unique to plant H+-ATPases.

Autoinhibitory domains (AIDs)

871-893 (Autoinhibitory domain I) SS

Target domain

313-541 (ATPase domain)

Relief mechanism

Partner binding

Assay

911-926 (Autoinhibitory domain II) SS

Target domain

313-541 (ATPase domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9LV11

Entry ID Method Resolution Chain Position Source
AF-Q9LV11-F1 Predicted AlphaFoldDB

30 variants for Q9LV11

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_25159501_G_T 3 D>Y No 1000Genomes
tmp_5_25159510_G_A 6 E>K No 1000Genomes
ENSVATH12909000 42 A>V No 1000Genomes
ENSVATH07468865 141 D>N No 1000Genomes
tmp_5_25160802_C_T 234 T>I No 1000Genomes
ENSVATH07468873 272 R>H No 1000Genomes
ENSVATH07468875 325 A>V No 1000Genomes
ENSVATH12909042 368 Q>H No 1000Genomes
ENSVATH12909041 368 Q>K No 1000Genomes
tmp_5_25161807_G_A 395 G>D No 1000Genomes
ENSVATH07468878 416 I>F No 1000Genomes
ENSVATH07468879 420 G>S No 1000Genomes
ENSVATH07468882 469 V>I No 1000Genomes
tmp_5_25162217_C_T 473 T>M No 1000Genomes
tmp_5_25162715_G_A 556 D>N No 1000Genomes
tmp_5_25162879_G_A 579 R>Q No 1000Genomes
tmp_5_25163278_T_C 661 V>A No 1000Genomes
ENSVATH14645829 662 L>F No 1000Genomes
tmp_5_25163430_A_G 670 I>M No 1000Genomes
ENSVATH00748268 672 K>Q No 1000Genomes
ENSVATH07468899 726 M>I No 1000Genomes
tmp_5_25163742_T_C 730 I>T No 1000Genomes
ENSVATH12909058 734 A>T No 1000Genomes
ENSVATH08584133 746 G>R No 1000Genomes
tmp_5_25164125_G_T 796 V>L No 1000Genomes
tmp_5_25164140_C_T 801 L>F No 1000Genomes
tmp_5_25164296_G_T 822 G>V No 1000Genomes
tmp_5_25164349_A_G 840 I>V No 1000Genomes
tmp_5_25164380_G_A 850 R>H No 1000Genomes
ENSVATH07468910 866 V>I No 1000Genomes

No associated diseases with Q9LV11

6 regional properties for Q9LV11

Type Name Position InterPro Accession
domain Arf GTPase activating protein 1 - 124 IPR001164
repeat Ankyrin repeat 132 - 228 IPR002110
domain GIT, Spa2 homology (SHD) domain 273 - 303 IPR013724-1
domain GIT, Spa2 homology (SHD) domain 337 - 367 IPR013724-2
domain ARF GTPase-activating protein GIT1, C-terminal 652 - 764 IPR022018
domain Arf GTPase-activating protein GIT1/2, coiled-coil domain 418 - 482 IPR032352

Functions

Description
EC Number 7.1.2.1 Hydron translocation linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction
metal ion binding Binding to a metal ion.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
P-type proton-exporting transporter activity Enables the transfer of protons from one side of a membrane to the other according to the reaction

2 GO annotations of biological process

Name Definition
proton export across plasma membrane The directed movement of hydrogen ions (protons) from inside a cell, across the plasma membrane and into the extracellular region.
regulation of intracellular pH Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P83970 ha1 Plasma membrane ATPase Triticum aestivum (Wheat) SS
Q80XR2 Atp2c1 Calcium-transporting ATPase type 2C member 1 Mus musculus (Mouse) PR
A7L9Z8 Atp2c2 Calcium-transporting ATPase type 2C member 2 Mus musculus (Mouse) PR
Q7XPY2 Os04g0656100 Plasma membrane ATPase Oryza sativa subsp. japonica (Rice) SS
P20431 AHA3 ATPase 3, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
P20649 AHA1 ATPase 1, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q43128 AHA10 ATPase 10, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9LY32 AHA7 ATPase 7, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9M2A0 AHA8 ATPase 8, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9SH76 AHA6 ATPase 6, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9SJB3 AHA5 ATPase 5, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9SU58 AHA4 ATPase 4, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
P19456 AHA2 ATPase 2, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) EV
Q42556 AHA9 ATPase 9, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
P22180 LHA1 Plasma membrane ATPase 1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) SS
10 20 30 40 50 60
MGDKEEVLEA VLKETVDLEN VPIEEVFESL RCSREGLTTE AADERLALFG HNKLEEKKES
70 80 90 100 110 120
KFLKFLGFMW NPLSWVMEAA AIMAIALANG GGKPPDWQDF VGIITLLVIN STISFIEENN
130 140 150 160 170 180
AGNAAAALMA RLAPKAKVLR DGRWGEQDAA ILVPGDIISI KLGDIVPADA RLLEGDPLKI
190 200 210 220 230 240
DQSSLTGESL PVTKGPGDGV YSGSTCKQGE LEAVVIATGV HTFFGKAAHL VDTTNHVGHF
250 260 270 280 290 300
QQVLTAIGNF CICSIAVGMI IEIVVMYPIQ HRAYRPGIDN LLVLLIGGIP IAMPTVLSVT
310 320 330 340 350 360
MAIGSHRLSQ QGAITKRMTA IEEMAGMDVL CSDKTGTLTL NKLTVDKNLI EVFTKGVDAD
370 380 390 400 410 420
TVVLMAAQAS RLENQDAIDA AIVGMLADPK EARAGVREVH FLPFNPTDKR TALTYIDSDG
430 440 450 460 470 480
KMHRVSKGAP EQILNLAHNR AEIERRVHAV IDKFAERGLR SLAVAYQEVP EGTKESAGGP
490 500 510 520 530 540
WQFMGLMPLF DPPRHDSAET IRRALNLGVN VKMITGDQLA IGKETGRRLG MGTNMYPSSA
550 560 570 580 590 600
LLGQHKDESI GALPIDDLIE KADGFAGVFP EHKYEIVKRL QARKHICGMT GDGVNDAPAL
610 620 630 640 650 660
KKADIGIAVA DATDAARSAS DIVLTEPGLS VIISAVLTSR AIFQRMKNYT IYAVSITIRI
670 680 690 700 710 720
VLGFMLLALI WKFDFPPFMV LIIAILNDGT IMTISKDRVK PSPLPDSWKL SEIFATGVVF
730 740 750 760 770 780
GSYMAMMTVI FFWAAYKTDF FPRTFGVSTL EKTAHDDFRK LASAIYLQVS IISQALIFVT
790 800 810 820 830 840
RSRSWSYVER PGMLLVVAFI LAQLVATLIA VYANWSFAAI EGIGWGWAGV IWLYNIVFYI
850 860 870 880 890 900
PLDIIKFLIR YALSGRAWDL VIEQRVAFTR QKDFGKEQRE LQWAHAQRTL HGLQAPDAKM
910 920 930 940 950
FPERTHFNEL SQMAEEAKRR AEIARLRELH TLKGHVESVV RLKGLDIETI QQAYTV