AiPD: Autoinhibited Protein Database

Gene name	WAG2 (At3g14370, MLN21.15)
Protein name	Serine/threonine-protein kinase WAG2
Names
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT3G14370
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-111 (Predicted disordered autoinhibitory region) PR

1-111 (Predicted disordered autoinhibitory region)

cis-regPred

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9LUL2-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_3_4799456_C_T	5	D>N	No	1000Genomes
ENSVATH05829305	8	F>L	No	1000Genomes
ENSVATH10672966	74	A>V	No	1000Genomes
ENSVATH10672965	79	S>P	No	1000Genomes
ENSVATH02143759	93	H>Q	No	1000Genomes
tmp_3_4799051_G_A	140	L>F	No	1000Genomes
ENSVATH00322936	156	D>N	No	1000Genomes
ENSVATH05829297	187	I>T	No	1000Genomes
tmp_3_4798904_G_A	189	P>S	No	1000Genomes
tmp_3_4798802_C_T	223	E>K	No	1000Genomes
tmp_3_4798789_A_G	227	V>A	No	1000Genomes
ENSVATH05829295	246	S>C	No	1000Genomes
tmp_3_4798729_C_T	247	R>H	No	1000Genomes
tmp_3_4798715_A_T	252	S>T	No	1000Genomes
ENSVATH02143758	263	S>C	No	1000Genomes
tmp_3_4798661_C_T	270	A>T	No	1000Genomes
tmp_3_4798658_C_T	271	E>K	No	1000Genomes
tmp_3_4798646_C_G	275	E>Q	No	1000Genomes
ENSVATH05829291	331	G>S	No	1000Genomes
ENSVATH05829286	357	H>Q	No	1000Genomes
ENSVATH05829285	358	M>V	No	1000Genomes
ENSVATH05829284	362	L>S	No	1000Genomes
ENSVATH05829283	363	D>E	No	1000Genomes
ENSVATH05829276	427	S>G	No	1000Genomes
ENSVATH05829275	427	S>N	No	1000Genomes
ENSVATH05829274	445	L>M	No	1000Genomes
tmp_3_4798132_G_A	446	S>L	No	1000Genomes
tmp_3_4798121_G_A	450	R>C	No	1000Genomes
tmp_3_4798120_C_T	450	R>H	No	1000Genomes
ENSVATH05829271	455	S>G	No	1000Genomes
ENSVATH05829270	474	Y>*	No	1000Genomes
ENSVATH00322932	479	R>C	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	88 - 396	IPR000719
active_site	Serine/threonine-protein kinase, active site	209 - 221	IPR008271

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm, cytosol	Targeted to the cell periphery
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity	Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

Name	Definition
auxin polar transport	The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally.
auxin-activated signaling pathway	The series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription.
cotyledon development	The process whose specific outcome is the progression of the cotyledon over time, from its formation to the mature structure. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling.
protein phosphorylation	The process of introducing a phosphate group on to a protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P83099	Pkcdelta	Putative protein kinase C delta type homolog	Drosophila melanogaster (Fruit fly)	PR
P05130	Pkc53E	Protein kinase C, brain isozyme	Drosophila melanogaster (Fruit fly)	SS
P13677	inaC	Protein kinase C, eye isozyme	Drosophila melanogaster (Fruit fly)	SS
Q8INB9	Akt	RAC serine/threonine-protein kinase	Drosophila melanogaster (Fruit fly)	SS
Q9HBY8	SGK2	Serine/threonine-protein kinase Sgk2	Homo sapiens (Human)	SS
Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	Homo sapiens (Human)	SS
O00141	SGK1	Serine/threonine-protein kinase Sgk1	Homo sapiens (Human)	PR
Q9ERE3	Sgk3	Serine/threonine-protein kinase Sgk3	Mus musculus (Mouse)	PR
Q94E49	PID2	Protein kinase PINOID 2	Oryza sativa subsp japonica (Rice)	PR
Q0DCT8	Os06g0291600	Protein kinase G11A	Oryza sativa subsp japonica (Rice)	PR
O64682	PID	Protein kinase PINOID	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SUA3	D6PKL1	Serine/threonine-protein kinase D6PKL1	Arabidopsis thaliana (Mouse-ear cress)	PR
O48963	PHOT1	Phototropin-1	Arabidopsis thaliana (Mouse-ear cress)	PR