Q9LU46
PR
Gene name |
RH35 (At5g51280, MWD22.23) |
Protein name |
DEAD-box ATP-dependent RNA helicase 35 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G51280 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LU46
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LU46-F1 | Predicted | AlphaFoldDB |
16 variants for Q9LU46
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_20841511_A_G | 19 | E>G | No | 1000Genomes | |
| tmp_5_20841540_C_T | 29 | L>F | No | 1000Genomes | |
| tmp_5_20841559_C_T | 35 | A>V | No | 1000Genomes | |
| tmp_5_20841672_C_A | 73 | Q>K | No | 1000Genomes | |
| ENSVATH12697734 | 122 | S>N | No | 1000Genomes | |
| tmp_5_20841919_G_C | 155 | R>T | No | 1000Genomes | |
| ENSVATH07394331 | 182 | A>S | No | 1000Genomes | |
| ENSVATH07394332 | 214 | M>L | No | 1000Genomes | |
| ENSVATH03408379 | 247 | A>T | No | 1000Genomes | |
| ENSVATH14625146 | 254 | Y>H | No | 1000Genomes | |
| ENSVATH12697766 | 254 | Y>S | No | 1000Genomes | |
| tmp_5_20842331_G_A | 292 | M>I | No | 1000Genomes | |
| tmp_5_20843184_G_A | 439 | A>T | No | 1000Genomes | |
| tmp_5_20843187_A_C | 440 | I>L | No | 1000Genomes | |
| tmp_5_20843506_G_T | 546 | G>V | No | 1000Genomes | |
| ENSVATH12697806 | 588 | R>S | No | 1000Genomes |
No associated diseases with Q9LU46
6 regional properties for Q9LU46
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase, C-terminal | 372 - 532 | IPR001650 |
| domain | Zinc finger, CCHC-type | 549 - 565 | IPR001878 |
| domain | DEAD/DEAH box helicase domain | 170 - 347 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 165 - 376 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 146 - 174 | IPR014014 |
| domain | DDX41, DEAD-box helicase domain | 157 - 362 | IPR044113 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| spliceosomal complex | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| zinc ion binding | Binding to a zinc ion (Zn). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
18 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9V3C0 | abs | ATP-dependent RNA helicase abstrakt | Drosophila melanogaster (Fruit fly) | PR |
| Q9UJV9 | DDX41 | Probable ATP-dependent RNA helicase DDX41 | Homo sapiens (Human) | PR |
| Q91VN6 | Ddx41 | Probable ATP-dependent RNA helicase DDX41 | Mus musculus (Mouse) | PR |
| Q5Z6G5 | Os06g0697200 | DEAD-box ATP-dependent RNA helicase 35B | Oryza sativa subsp japonica (Rice) | PR |
| Q0E3X4 | Os02g0150100 | DEAD-box ATP-dependent RNA helicase 35A | Oryza sativa subsp japonica (Rice) | PR |
| Q9SZB4 | RH43 | Putative DEAD-box ATP-dependent RNA helicase 43 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94A52 | EIF4A3 | Eukaryotic initiation factor 4A-III homolog | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LA13 | RH11 | DEAD-box ATP-dependent RNA helicase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84W89 | RH37 | DEAD-box ATP-dependent RNA helicase 37 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M2F9 | RH52 | DEAD-box ATP-dependent RNA helicase 52 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q93ZG7 | RH38 | DEAD-box ATP-dependent RNA helicase 38 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C718 | RH20 | DEAD-box ATP-dependent RNA helicase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56XG6 | RH15 | DEAD-box ATP-dependent RNA helicase 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFN6 | RH56 | DEAD-box ATP-dependent RNA helicase 56 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E9C3 | RH58 | DEAD-box ATP-dependent RNA helicase 58, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4R3 | RH30 | DEAD-box ATP-dependent RNA helicase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8H136 | RH14 | DEAD-box ATP-dependent RNA helicase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FZ92 | RH44 | Putative DEAD-box ATP-dependent RNA helicase 44 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESIMEEADS | YIEYVSVAER | RAIAAQKILQ | RKGKASELEE | EADKEKLAEA | KPSLLVQATQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LKRDVPEVSA | TEQIILQEKE | MMEHLSDKKT | LMSVRELAKG | ITYTEPLLTG | WKPPLHIRKM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SSKQRDLIRK | QWHIIVNGDD | IPPPIKNFKD | MKFPRPVLDT | LKEKGIVQPT | PIQVQGLPVI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LAGRDMIGIA | FTGSGKTLVF | VLPMIMIALQ | EEMMMPIAAG | EGPIGLIVCP | SRELARQTYE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VVEQFVAPLV | EAGYPPLRSL | LCIGGIDMRS | QLEVVKRGVH | IVVATPGRLK | DMLAKKKMSL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DACRYLTLDE | ADRLVDLGFE | DDIREVFDHF | KSQRQTLLFS | ATMPTKIQIF | ARSALVKPVT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VNVGRAGAAN | LDVIQEVEYV | KQEAKIVYLL | ECLQKTSPPV | LIFCENKADV | DDIHEYLLLK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GVEAVAIHGG | KDQEDREYAI | SSFKAGKKDV | LVATDVASKG | LDFPDIQHVI | NYDMPAEIEN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YVHRIGRTGR | CGKTGIATTF | INKNQSETTL | LDLKHLLQEA | KQRIPPVLAE | LNDPMEEAET |
| 550 | 560 | 570 | 580 | 590 | |
| IANASGVKGC | AYCGGLGHRI | RDCPKLEHQK | SVAISNSRKD | YFGSGGYRGE | I |