Q9LT35

PR
Gene name
NEK6 (At3g20860, MOE17.17)
Protein name
Serine/threonine-protein kinase Nek6
Names
NimA-related protein kinase 6, AtNek6
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G20860
EC number
2.7.11.34: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

252-379 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

145-167 (Activation loop from InterPro)

Target domain

4-257 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9LT35

Entry ID Method Resolution Chain Position Source
AF-Q9LT35-F1 Predicted AlphaFoldDB

25 variants for Q9LT35

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05872618 7 V>L No 1000Genomes
tmp_3_7306232_C_T 18 A>V No 1000Genomes
tmp_3_7306264_A_T 29 K>* No 1000Genomes
ENSVATH05872621 31 V>L No 1000Genomes
ENSVATH05872626 81 S>G No 1000Genomes
ENSVATH02170995 96 R>K No 1000Genomes
ENSVATH00336924 98 V>I No 1000Genomes
tmp_3_7307408_T_C 188 L>S No 1000Genomes
tmp_3_7307489_T_A 190 C>S No 1000Genomes
tmp_3_7307672_A_C 225 M>L No 1000Genomes
ENSVATH05872650 278 S>L No 1000Genomes
ENSVATH02171006 282 T>N No 1000Genomes
ENSVATH02171007 289 L>I No 1000Genomes
tmp_3_7308078_C_A 299 P>T No 1000Genomes
ENSVATH02171011 306 S>* No 1000Genomes
ENSVATH02171010 306 S>A No 1000Genomes
ENSVATH02171013 312 K>I No 1000Genomes
ENSVATH02171013 312 K>R No 1000Genomes
ENSVATH05872651 316 T>A No 1000Genomes
ENSVATH10813590 325 R>I No 1000Genomes
ENSVATH02171014 327 A>T No 1000Genomes
tmp_3_7308235_G_T 351 S>I No 1000Genomes
tmp_3_7308283_G_T 367 G>V No 1000Genomes
ENSVATH05872654 405 V>I No 1000Genomes
ENSVATH02171018 416 I>L No 1000Genomes

No associated diseases with Q9LT35

3 regional properties for Q9LT35

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 257 IPR000719
active_site Serine/threonine-protein kinase, active site 124 - 136 IPR008271
binding_site Protein kinase, ATP binding site 10 - 34 IPR017441

Functions

Description
EC Number 2.7.11.34 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
cortical microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.
lateral root formation The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper.
negative regulation of ethylene biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of an ethylene biosynthetic process.
protein phosphorylation The process of introducing a phosphate group on to a protein.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P22209 KIN3 Serine/threonine-protein kinase KIN3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q6P3R8 NEK5 Serine/threonine-protein kinase Nek5 Homo sapiens (Human) PR
Q8NE28 STKLD1 Serine/threonine kinase-like domain-containing protein STKLD1 Homo sapiens (Human) PR
P51957 NEK4 Serine/threonine-protein kinase Nek4 Homo sapiens (Human) PR
P51955 NEK2 Serine/threonine-protein kinase Nek2 Homo sapiens (Human) EV
Q8K1R7 Nek9 Serine/threonine-protein kinase Nek9 Mus musculus (Mouse) SS
Q7TSC3 Nek5 Serine/threonine-protein kinase Nek5 Mus musculus (Mouse) PR
O35942 Nek2 Serine/threonine-protein kinase Nek2 Mus musculus (Mouse) PR
Q10GB1 NEK1 Serine/threonine-protein kinase Nek1 Oryza sativa subsp japonica (Rice) PR
Q6ZEZ5 NEK3 Serine/threonine-protein kinase Nek3 Oryza sativa subsp japonica (Rice) PR
Q8RXT4 NEK4 Serine/threonine-protein kinase Nek4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SLI2 NEK1 Serine/threonine-protein kinase Nek1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDDYEVVEQI GRGAFGSAFL VIHKSERRKY VVKKIRLAKQ TERCKLAAIQ EMSLISKLKS
70 80 90 100 110 120
PYIVEYKDSW VEKDCVCIVT SYCEGGDMTQ MIKKSRGVFA SEEKLCRWMV QLLLAIDYLH
130 140 150 160 170 180
NNRVLHRDLK CSNIFLTKEN EVRLGDFGLA KLLGKDDLAS SMVGTPNYMC PELLADIPYG
190 200 210 220 230 240
YKSDIWSLGC CMFEVAAHQP AFKAPDMAAL INKINRSSLS PLPVMYSSSL KRLIKSMLRK
250 260 270 280 290 300
NPEHRPTAAE LLRHPHLQPY LAQCQNLSPV FKPVVSKSEH NTNENRTGLP PKTKSAKTPI
310 320 330 340 350 360
KHNQESEETE KKNKDTSSSS KDKERPAKSQ EMSVISTLTL LREFQKKSPK SEERAEALES
370 380 390 400 410
LLELCAGLLR QEKFDELEGV LKPFGDETVS SRETAIWLTK SLMNVKRKQN DDETNI