Q9LSV3

PR
Gene name
WAKL16 (At3g25490, MWL2.11)
Protein name
Putative wall-associated receptor kinase-like 16
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G25490
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

24-128 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

250-274 (Activation loop from InterPro)

Target domain

108-391 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9LSV3

Entry ID Method Resolution Chain Position Source
AF-Q9LSV3-F1 Predicted AlphaFoldDB

122 variants for Q9LSV3

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH10975107 3 L>V No 1000Genomes
ENSVATH02201753 6 V>I No 1000Genomes
tmp_3_9241744_T_G 7 V>G No 1000Genomes
ENSVATH02201754 8 Y>* No 1000Genomes
ENSVATH02201756 10 V>L No 1000Genomes
ENSVATH10975108 11 A>S No 1000Genomes
tmp_3_9241766_C_A 14 F>L No 1000Genomes
ENSVATH00349292 21 I>F No 1000Genomes
ENSVATH02201758 22 A>G No 1000Genomes
tmp_3_9241794_A_C,G 24 I>L No 1000Genomes
ENSVATH05912702 24 I>M No 1000Genomes
tmp_3_9241794_A_C,G 24 I>V No 1000Genomes
tmp_3_9241807_A_T 28 K>M No 1000Genomes
ENSVATH02201759 28 K>N No 1000Genomes
tmp_3_9241814_A_T 30 L>F No 1000Genomes
ENSVATH00349293 34 M>I No 1000Genomes
ENSVATH05912703 35 I>V No 1000Genomes
ENSVATH14005346 36 I>V No 1000Genomes
ENSVATH05912709 45 S>N No 1000Genomes
tmp_3_9241981_G_C 57 R>T No 1000Genomes
ENSVATH05912710 59 H>Y No 1000Genomes
ENSVATH05912711 62 D>N No 1000Genomes
ENSVATH02201763 70 F>V No 1000Genomes
tmp_3_9242027_GA_TA,G 72 E>D No 1000Genomes
ENSVATH05912712 75 G>S No 1000Genomes
tmp_3_9242046_T_A 79 L>M No 1000Genomes
ENSVATH00349297 83 L>V No 1000Genomes
ENSVATH02201768 89 S>P No 1000Genomes
ENSVATH00349298 96 F>L No 1000Genomes
ENSVATH05912713 97 T>M No 1000Genomes
ENSVATH10975113 105 T>A No 1000Genomes
ENSVATH02201770 107 G>D No 1000Genomes
ENSVATH10975114 107 G>S No 1000Genomes
ENSVATH00349299 112 R>K No 1000Genomes
ENSVATH00349300 117 G>R No 1000Genomes
ENSVATH10975156 118 G>S No 1000Genomes
tmp_3_9242167_A_T 119 Q>L No 1000Genomes
ENSVATH00349301 120 W>G No 1000Genomes
tmp_3_9242176_T_G 122 V>G No 1000Genomes
ENSVATH10975157 128 P>L No 1000Genomes
ENSVATH02201772 129 D>H No 1000Genomes
ENSVATH02201772 129 D>N No 1000Genomes
ENSVATH00349302 130 N>K No 1000Genomes
tmp_3_9242209_T_C 133 V>A No 1000Genomes
ENSVATH05912715 133 V>F No 1000Genomes
tmp_3_9242248_T_A 146 V>E No 1000Genomes
ENSVATH05912717 151 N>D No 1000Genomes
ENSVATH02201773 164 V>F No 1000Genomes
ENSVATH02201774 167 L>V No 1000Genomes
tmp_3_9242354_T_G 181 Y>* No 1000Genomes
ENSVATH00349303 185 T>S No 1000Genomes
ENSVATH02201777 191 D>N No 1000Genomes
ENSVATH02201777 191 D>Y No 1000Genomes
tmp_3_9242394_G_C 195 G>R No 1000Genomes
ENSVATH00349304 197 M>L No 1000Genomes
ENSVATH00349305 199 V>A No 1000Genomes
ENSVATH05912719 207 R>L No 1000Genomes
tmp_3_9242442_G_A 211 A>T No 1000Genomes
ENSVATH05912720 216 G>R No 1000Genomes
ENSVATH00349307 218 I>L No 1000Genomes
ENSVATH00349307 218 I>V No 1000Genomes
ENSVATH10975160 222 H>P No 1000Genomes
ENSVATH00349309 222 H>Y No 1000Genomes
ENSVATH02201779 232 R>C No 1000Genomes
ENSVATH02201780 232 R>H No 1000Genomes
ENSVATH02201780 232 R>L No 1000Genomes
ENSVATH02201779 232 R>S No 1000Genomes
ENSVATH02201782 243 E>K No 1000Genomes
ENSVATH05912721 244 N>T No 1000Genomes
ENSVATH05912722 245 L>I No 1000Genomes
ENSVATH10975161 254 A>V No 1000Genomes
ENSVATH00349310 258 K>M No 1000Genomes
ENSVATH10975164 259 P>S No 1000Genomes
ENSVATH05912724 268 M>I No 1000Genomes
ENSVATH00349312 276 L>V No 1000Genomes
ENSVATH00349313 285 L>I No 1000Genomes
ENSVATH02201785 289 K>N No 1000Genomes
ENSVATH05912726 291 D>V No 1000Genomes
tmp_3_9242711_G_T 300 M>I No 1000Genomes
tmp_3_9242712_G_A 301 E>K No 1000Genomes
tmp_3_9242724_G_C 305 G>R No 1000Genomes
ENSVATH02201787 307 K>Q No 1000Genomes
ENSVATH10975196 312 E>A No 1000Genomes
ENSVATH02201788 315 E>D No 1000Genomes
tmp_3_9242766_C_A 319 H>N No 1000Genomes
ENSVATH05912728 320 L>S No 1000Genomes
tmp_3_9242772_G_A 321 V>M No 1000Genomes
ENSVATH00349314 325 V>L No 1000Genomes
ENSVATH10975197 326 L>F No 1000Genomes
ENSVATH10975198 335 E>V No 1000Genomes
ENSVATH00349315 345 E>D No 1000Genomes
tmp_3_9242849_C_A 346 N>K No 1000Genomes
tmp_3_9242860_T_G 350 I>S No 1000Genomes
tmp_3_9242872_C_T 354 A>V No 1000Genomes
ENSVATH05912729 356 V>D No 1000Genomes
ENSVATH00349317 358 V>L No 1000Genomes
ENSVATH00349318 359 E>D No 1000Genomes
tmp_3_9242896_G_A 362 R>K No 1000Genomes
ENSVATH02201792 363 L>P No 1000Genomes
ENSVATH02201795 367 E>D No 1000Genomes
tmp_3_9242910_G_A 367 E>K No 1000Genomes
ENSVATH05912730 368 R>G No 1000Genomes
ENSVATH14005347 369 P>S No 1000Genomes
tmp_3_9242929_A_C 373 E>A No 1000Genomes
ENSVATH00349319 375 A>V No 1000Genomes
tmp_3_9242940_G_A 377 E>K No 1000Genomes
tmp_3_9242986_A_T 392 D>V No 1000Genomes
ENSVATH02201797 395 P>L No 1000Genomes
ENSVATH02201796 395 P>T No 1000Genomes
ENSVATH00349324 399 V>E No 1000Genomes
ENSVATH02201799 401 L>F No 1000Genomes
tmp_3_9243022_G_T 404 S>I No 1000Genomes
ENSVATH00349326 407 V>L No 1000Genomes
ENSVATH00349327 410 Q>P No 1000Genomes
ENSVATH00349328 411 G>S No 1000Genomes
ENSVATH00349329 412 H>Y No 1000Genomes
ENSVATH00349330 416 R>L No 1000Genomes
ENSVATH02201801 421 N>I No 1000Genomes
ENSVATH00349331 421 N>K No 1000Genomes
ENSVATH00349332 422 K>T No 1000Genomes
ENSVATH05912731 428 D>E No 1000Genomes
tmp_3_9243097_T_A 429 I>N No 1000Genomes

No associated diseases with Q9LSV3

3 regional properties for Q9LSV3

Type Name Position InterPro Accession
domain Protein kinase domain 108 - 391 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 111 - 377 IPR001245
active_site Serine/threonine-protein kinase, active site 229 - 241 IPR008271

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
cell surface receptor signaling pathway The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
protein phosphorylation The process of introducing a phosphate group on to a protein.

68 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y616 IRAK3 Interleukin-1 receptor-associated kinase 3 Homo sapiens (Human) PR
P53667 LIMK1 LIM domain kinase 1 Homo sapiens (Human) PR
P53671 LIMK2 LIM domain kinase 2 Homo sapiens (Human) PR
P06213 INSR Insulin receptor Homo sapiens (Human) EV
P08069 IGF1R Insulin-like growth factor 1 receptor Homo sapiens (Human) EV
P14616 INSRR Insulin receptor-related protein Homo sapiens (Human) SS
P00533 EGFR Epidermal growth factor receptor Homo sapiens (Human) EV
Q15303 ERBB4 Receptor tyrosine-protein kinase erbB-4 Homo sapiens (Human) SS
P04626 ERBB2 Receptor tyrosine-protein kinase erbB-2 Homo sapiens (Human) SS
P21860 ERBB3 Receptor tyrosine-protein kinase erbB-3 Homo sapiens (Human) SS
Q8K4B2 Irak3 Interleukin-1 receptor-associated kinase 3 Mus musculus (Mouse) PR
Q8CFA1 Irak2 Interleukin-1 receptor-associated kinase-like 2 Mus musculus (Mouse) PR
O54785 Limk2 LIM domain kinase 2 Mus musculus (Mouse) PR
O08644 Ephb6 Ephrin type-B receptor 6 Mus musculus (Mouse) PR
P54763 Ephb2 Ephrin type-B receptor 2 Mus musculus (Mouse) SS
Q03137 Epha4 Ephrin type-A receptor 4 Mus musculus (Mouse) SS
Q60751 Igf1r Insulin-like growth factor 1 receptor Mus musculus (Mouse) SS
Q61772 Epha7 Ephrin type-A receptor 7 Mus musculus (Mouse) SS
Q8BYG9 Epha10 Ephrin type-A receptor 10 Mus musculus (Mouse) SS
Q8CBF3 Ephb1 Ephrin type-B receptor 1 Mus musculus (Mouse) SS
P54754 Ephb3 Ephrin type-B receptor 3 Mus musculus (Mouse) SS
Q9WTL4 Insrr Insulin receptor-related protein Mus musculus (Mouse) SS
O09127 Epha8 Ephrin type-A receptor 8 Mus musculus (Mouse) SS
Q60629 Epha5 Ephrin type-A receptor 5 Mus musculus (Mouse) SS
P15208 Insr Insulin receptor Mus musculus (Mouse) SS
P54761 Ephb4 Ephrin type-B receptor 4 Mus musculus (Mouse) PR
Q61527 Erbb4 Receptor tyrosine-protein kinase erbB-4 Mus musculus (Mouse) SS
Q61526 Erbb3 Receptor tyrosine-protein kinase erbB-3 Mus musculus (Mouse) SS
Q01279 Egfr Epidermal growth factor receptor Mus musculus (Mouse) SS
Q62413 Epha6 Ephrin type-A receptor 6 Mus musculus (Mouse) SS
P29319 Epha3 Ephrin type-A receptor 3 Mus musculus (Mouse) SS
Q2HWD6 KIT Mast/stem cell growth factor receptor Kit Sus scrofa (Pig) SS
Q4QQS0 Irak2 Interleukin-1 receptor-associated kinase-like 2 Rattus norvegicus (Rat) PR
O08680 Epha3 Ephrin type-A receptor 3 Rattus norvegicus (Rat) SS
P54757 Epha5 Ephrin type-A receptor 5 Rattus norvegicus (Rat) SS
P54759 Epha7 Ephrin type-A receptor 7 Rattus norvegicus (Rat) SS
P09759 Ephb1 Ephrin type-B receptor 1 Rattus norvegicus (Rat) SS
P0C0K7 Ephb6 Ephrin type-B receptor 6 Rattus norvegicus (Rat) SS
Q9ASQ5 CRCK3 Calmodulin-binding receptor-like cytoplasmic kinase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LPS5 SERK5 Somatic embryogenesis receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWW0 ALE2 Receptor-like serine/threonine-protein kinase ALE2 Arabidopsis thaliana (Mouse-ear cress) PR
P93050 BSH Probable LRR receptor-like serine/threonine-protein kinase RKF3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRP3 At3g17420 Probable receptor-like protein kinase At3g17420 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STF0 LECRKS3 Receptor like protein kinase S.3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SCZ4 FER Receptor-like protein kinase FERONIA Arabidopsis thaliana (Mouse-ear cress) PR
Q9LYN6 At3g56050 Probable inactive receptor-like protein kinase At3g56050 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZJ9 CRCK2 Calmodulin-binding receptor-like cytoplasmic kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
P43293 PBL11 Probable serine/threonine-protein kinase PBL11 Arabidopsis thaliana (Mouse-ear cress) PR
Q94C25 At5g20050 Probable receptor-like protein kinase At5g20050 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FLW0 At5g24010 Probable receptor-like protein kinase At5g24010 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E8W4 ANX2 Receptor-like protein kinase ANXUR2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTC0 PBL19 Probable serine/threonine-protein kinase PBL19 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIL7 CRCK1 Calmodulin-binding receptor-like cytoplasmic kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q0WNY5 WAKL18 Wall-associated receptor kinase-like 18 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M342 WAKL15 Wall-associated receptor kinase-like 15 Arabidopsis thaliana (Mouse-ear cress) PR
Q7X8C5 WAKL2 Wall-associated receptor kinase-like 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9S9M2 WAKL4 Wall-associated receptor kinase-like 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LMN7 WAK5 Wall-associated receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C9L5 WAKL9 Wall-associated receptor kinase-like 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VYA3 WAKL10 Wall-associated receptor kinase-like 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M092 WAKL17 Wall-associated receptor kinase-like 17 Arabidopsis thaliana (Mouse-ear cress) PR
Q8JFR5 kita Mast/stem cell growth factor receptor kita Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9I8N6 csf1r Macrophage colony-stimulating factor 1 receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5GIT4 kdr Vascular endothelial growth factor receptor 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q90Z00 fgfr1a Fibroblast growth factor receptor 1-A Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5MD89 flt4 Vascular endothelial growth factor receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q8JG38 fgfr2 Fibroblast growth factor receptor 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9I8X3 fgfr3 Fibroblast growth factor receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MKLQHVVYLV AIFFVVAIFV IACIEENKYL VWIMIILANT TNILSLVRSI SYIKNIRKHQ
70 80 90 100 110 120
KDTKIQRQLF FEKNGGGMLI ERLSGAGSSN IDFKIFTEED MKEATNGYDV SRILGQGGQW
130 140 150 160 170 180
TVYKGILPDN SIVAIKKTRL GDNNQVEQFI NEVLVLSQIN HRNVVKLLGC CLETEVPLLV
190 200 210 220 230 240
YEFITGGSLF DHLHGSMFVS SLTWEHRLEI AIEVAGAIAY LHSGASIPII HRDIKTENIL
250 260 270 280 290 300
LDENLTAKVA DFGASKLKPM DKEQLTTMVQ GTLGYLDPEY YTTWLLNEKS DVYSFGVVLM
310 320 330 340 350 360
ELISGQKALC FERPETSKHL VSYFVLATKE NRLHEIIDDQ VLNEENQREI HEAARVAVEC
370 380 390 400 410 420
TRLKGEERPR MIEVAAELET LRAKTTKHNW LDQYPEENVH LLGSNIVSAQ GHTSSRGYDN
430
NKNVARFDIE AGR