Q9LSR8
Gene name |
LECRK19 |
Protein name |
L-type lectin-domain containing receptor kinase I.9 |
Names |
LecRK-I.9, LecRK79, Protein DOES NOT RESPOND TO NUCLEOTIDES 1, Purinoreceptor kinase 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G60300 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
485-492 (Activation loop from InterPro)
Target domain |
344-616 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
503-509 (Activation loop from InterPro)
Target domain |
344-616 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9LSR8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LSR8-F1 | Predicted | AlphaFoldDB |
39 variants for Q9LSR8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_24264925_C_T | 22 | Q>* | No | 1000Genomes | |
| tmp_5_24264963_C_A | 34 | D>E | No | 1000Genomes | |
| tmp_5_24264984_C_G | 41 | D>E | No | 1000Genomes | |
| ENSVATH07454760 | 42 | K>N | No | 1000Genomes | |
| ENSVATH03457302 | 45 | I>V | No | 1000Genomes | |
| tmp_5_24265047_G_A | 62 | M>I | No | 1000Genomes | |
| tmp_5_24265113_C_A | 84 | H>Q | No | 1000Genomes | |
| ENSVATH07454762 | 140 | L>F | No | 1000Genomes | |
| ENSVATH14642242 | 193 | Q>H | No | 1000Genomes | |
| ENSVATH14642243 | 201 | T>I | No | 1000Genomes | |
| ENSVATH07454764 | 229 | L>H | No | 1000Genomes | |
| ENSVATH03457304 | 286 | V>A | No | 1000Genomes | |
| ENSVATH14642245 | 289 | L>V | No | 1000Genomes | |
| tmp_5_24265732_A_G | 291 | I>V | No | 1000Genomes | |
| tmp_5_24265744_G_A | 295 | V>I | No | 1000Genomes | |
| ENSVATH14642246 | 314 | R>H | No | 1000Genomes | |
| tmp_5_24265806_G_T | 315 | K>N | No | 1000Genomes | |
| ENSVATH07454766 | 360 | R>G | No | 1000Genomes | |
| ENSVATH03457306 | 373 | R>G | No | 1000Genomes | |
| ENSVATH00744662 | 377 | N>T | No | 1000Genomes | |
| ENSVATH07454767 | 394 | C>W | No | 1000Genomes | |
| tmp_5_24266191_G_A | 444 | V>M | No | 1000Genomes | |
| tmp_5_24266354_A_G | 498 | N>S | No | 1000Genomes | |
| ENSVATH12873251 | 559 | C>S | No | 1000Genomes | |
| ENSVATH07454770 | 564 | K>M | No | 1000Genomes | |
| ENSVATH07454771 | 586 | M>V | No | 1000Genomes | |
| tmp_5_24266693_A_T | 611 | Y>F | No | 1000Genomes | |
| ENSVATH00744664 | 634 | V>I | No | 1000Genomes | |
| ENSVATH00744665 | 640 | S>F | No | 1000Genomes | |
| ENSVATH07454773 | 650 | L>F | No | 1000Genomes | |
| ENSVATH03457307 | 660 | P>A | No | 1000Genomes | |
| ENSVATH07454774 | 688 | A>P | No | 1000Genomes | |
| ENSVATH14642249 | 709 | S>F | No | 1000Genomes | |
| ENSVATH12873254 | 709 | S>P | No | 1000Genomes | |
| tmp_5_24267864_A_G | 731 | Q>R | No | 1000Genomes | |
| ENSVATH00744668 | 736 | F>L | No | 1000Genomes | |
| ENSVATH07454791 | 752 | I>V | No | 1000Genomes | |
| ENSVATH07454792 | 753 | V>A | No | 1000Genomes | |
| ENSVATH14642255 | 759 | F>V | No | 1000Genomes |
No associated diseases with Q9LSR8
5 regional properties for Q9LSR8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 344 - 616 | IPR000719 |
| domain | Legume lectin domain | 25 - 273 | IPR001220 |
| active_site | Serine/threonine-protein kinase, active site | 464 - 476 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 350 - 372 | IPR017441 |
| binding_site | Legume lectin, beta chain, Mn/Ca-binding site | 136 - 142 | IPR019825 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| transmembrane receptor protein serine/threonine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to ATP | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. |
| defense response | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| defense response to oomycetes | Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism. |
| extracellular ATP signaling | The series of molecular signals mediated by the detection of extracellular ATP. |
| focal adhesion assembly | The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of jasmonic acid mediated signaling pathway | Any process that modulates the frequency, rate or extent of jasmonic acid mediated signaling pathway. |
| response to wounding | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P46197 | NPR2 | Atrial natriuretic peptide receptor 2 | Bos taurus (Bovine) | PR |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| O80939 | LECRK41 | L-type lectin-domain containing receptor kinase IV.1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81291 | LECRK44 | L-type lectin-domain containing receptor kinase IV.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81292 | LECRK43 | L-type lectin-domain containing receptor kinase IV.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1G4 | LECRK15 | Probable L-type lectin-domain containing receptor kinase I.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M345 | LECRK42 | L-type lectin-domain containing receptor kinase IV.2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STF0 | LECRKS3 | Receptor like protein kinase S.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2S4 | LECRKS4 | L-type lectin-domain containing receptor kinase S.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96285 | LECRK55 | L-type lectin-domain containing receptor kinase V.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FG33 | LECRKS5 | Probable L-type lectin-domain containing receptor kinase S.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARWLLQILI | ISSLHLSSVS | SQQETSFVYE | SFLDRQNLYL | DKSAIVLPSG | LLQLTNASEH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QMGHAFHKKP | IEFSSSGPLS | FSTHFVCALV | PKPGFEGGHG | IVFVLSPSMD | FTHAESTRYL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GIFNASTNGS | SSYHVLAVEL | DTIWNPDFKD | IDHNHVGIDV | NSPISVAIAS | ASYYSDMKGS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NESINLLSGN | PIQVWVDYEG | TLLNVSVAPL | EVQKPTRPLL | SHPINLTELF | PNRSSLFAGF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SAATGTAISD | QYILWWSFSI | DRGSLQRLDI | SKLPEVPHPR | APHKKVSTLI | ILLPVCLAIL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VLAVLAGLYF | RRRRKYSEVS | ETWEKEFDAH | RFSYRSLFKA | TKGFSKDEFL | GKGGFGEVYR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GNLPQGREIA | VKRVSHNGDE | GVKQFVAEVV | SMRCLKHRNL | VPLFGYCRRK | RELLLVSEYM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PNGSLDEHLF | DDQKPVLSWS | QRLVVVKGIA | SALWYLHTGA | DQVVLHRDVK | ASNIMLDAEF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HGRLGDFGMA | RFHEHGGNAA | TTAAVGTVGY | MAPELITMGA | STGTDVYAFG | VFMLEVTCGR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RPVEPQLQVE | KRHMIKWVCE | CWKKDSLLDA | TDPRLGGKFV | AEEVEMVMKL | GLLCSNIVPE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SRPTMEQVVL | YLNKNLPLPD | FSPYTLGIGT | FAPVLVDASS | LVVSSASWSL | SGPSMSSSSP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NHSPYAWQST | DQPWGQTIDT | KNSLHIVAEP | EKPSPAVKMV | TLPAEDPQSN | HSSISSQRVQ |
| 730 | 740 | 750 | 760 | ||
| PVKREKRRLH | QILVAFPWIN | KQYFKLGLPK | HIVHVSLFFF | LQLARL |