Q9LSH2
Gene name |
GAD5 (At3g17760, MIG5.6) |
Protein name |
Glutamate decarboxylase 5 |
Names |
GAD 5 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G17760 |
EC number |
4.1.1.15: Carboxy-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LSH2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LSH2-F1 | Predicted | AlphaFoldDB |
15 variants for Q9LSH2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00329840 | 12 | H>N | No | 1000Genomes | |
| tmp_3_6080232_T_A | 139 | K>N | No | 1000Genomes | |
| ENSVATH05852780 | 145 | K>R | No | 1000Genomes | |
| tmp_3_6080030_G_A | 170 | A>V | No | 1000Genomes | |
| ENSVATH07965148 | 173 | F>V | No | 1000Genomes | |
| ENSVATH13938090 | 200 | E>A | No | 1000Genomes | |
| tmp_3_6079826_G_A | 238 | T>I | No | 1000Genomes | |
| ENSVATH05852774 | 269 | S>T | No | 1000Genomes | |
| tmp_3_6079701_C_G | 280 | V>L | No | 1000Genomes | |
| tmp_3_6079261_G_A | 373 | P>S | No | 1000Genomes | |
| ENSVATH00329837 | 436 | I>M | No | 1000Genomes | |
| ENSVATH13938088 | 453 | L>F | No | 1000Genomes | |
| tmp_3_6079012_C_T | 456 | A>T | No | 1000Genomes | |
| tmp_3_6079005_G_C | 458 | A>G | No | 1000Genomes | |
| tmp_3_6078975_A_G | 468 | V>A | No | 1000Genomes |
No associated diseases with Q9LSH2
5 regional properties for Q9LSH2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PDZ domain | 115 - 196 | IPR001478-1 |
| domain | PDZ domain | 223 - 301 | IPR001478-2 |
| domain | PDZ domain | 329 - 412 | IPR001478-3 |
| domain | PDZ domain | 467 - 548 | IPR001478-4 |
| domain | PDZ domain 6 | 492 - 532 | IPR041489 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.1.15 | Carboxy-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasmodesma | A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| glutamate decarboxylase activity | Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| glutamate catabolic process | The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q04792 | GAD1 | Glutamate decarboxylase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P69908 | gadA | Glutamate decarboxylase alpha | Escherichia coli (strain K12) | PR |
| P69910 | gadB | Glutamate decarboxylase beta | Escherichia coli (strain K12) | EV |
| Q42521 | GAD1 | Glutamate decarboxylase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9ZPS3 | GAD4 | Glutamate decarboxylase 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P54767 | Glutamate decarboxylase | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVLATNSDSD | EHLHSTFASR | YVRAVVPRFK | MPDHCMPKDA | AYQVINDELM | LDGNPRLNLA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SFVTTWMEPE | CDKLIMDSVN | KNYVDMDEYP | VTTELQNRCV | NMIANLFHAP | VGEDEAAIGC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GTVGSSEAIM | LAGLAFKRKW | QHRRKAQGLP | IDKPNIVTGA | NVQVCWEKFA | RYFEVELKEV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KLSEDYYVMD | PAKAVEMVDE | NTICVAAILG | STLTGEFEDV | KQLNDLLAEK | NAETGWETPI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HVDAASGGFI | APFLYPDLEW | DFRLPWVKSI | NVSGHKYGLV | YAGVGWVVWR | TKDDLPEELV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FHINYLGADQ | PTFTLNFSKG | SSQIIAQYYQ | FIRLGFEGYK | NIMENCMDNA | RRLREGIEMT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GKFNIVSKDI | GVPLVAFSLK | DSSKHTVFEI | AESLRKFGWI | IPAYTMPADA | QHIAVLRVVI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| REDFSRGLAD | RLITHIIQVL | KEIEGLPSRI | AHLAAAAAVS | GDDEEVKVKT | AKMSLEDITK |
| 490 | |||||
| YWKRLVEHKR | NIVC |