Q9LPZ9
SS
Gene name |
SD113 (CBRLK1, RKS2, At1g11350, T23J18.2) |
Protein name |
G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 |
Names |
EC 2.7.11.1 , Calmodulin-binding receptor-like protein kinase 1 , Receptor-like protein kinase 2 , S-domain-1 , SD1 receptor kinase 13 , SD1-13 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G11350 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 (SD113) is annotated based on its experimentally validated activation loop, which is expected to act as accessory element in the autoinhibition of SD113.
Autoinhibitory domains (AIDs)
Accessory elements
654-661 (Activation loop from InterPro)
Target domain |
512-798 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
672-679 (Activation loop from InterPro)
Target domain |
512-798 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
1 structures for Q9LPZ9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LPZ9-F1 | Predicted | AlphaFoldDB |
63 variants for Q9LPZ9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04557487 | 2 | G>D | No | 1000Genomes | |
| ENSVATH04557486 | 10 | T>P | No | 1000Genomes | |
| ENSVATH04557485 | 11 | L>F | No | 1000Genomes | |
| ENSVATH01035339 | 15 | S>F | No | 1000Genomes | |
| ENSVATH04557484 | 27 | F>L | No | 1000Genomes | |
| ENSVATH04557483 | 35 | E>A | No | 1000Genomes | |
| tmp_1_3820644_C_T | 37 | V>I | No | 1000Genomes | |
| ENSVATH04557482 | 39 | S>T | No | 1000Genomes | |
| tmp_1_3820628_C_T | 42 | S>N | No | 1000Genomes | |
| tmp_1_3820554_G_A | 67 | P>S | No | 1000Genomes | |
| tmp_1_3820514_G_A | 80 | P>L | No | 1000Genomes | |
| ENSVATH04557479 | 103 | G>R | No | 1000Genomes | |
| tmp_1_3820437_G_A | 106 | H>Y | No | 1000Genomes | |
| ENSVATH01035338 | 112 | L>F | No | 1000Genomes | |
| ENSVATH04557477 | 116 | A>S | No | 1000Genomes | |
| ENSVATH10974530 | 124 | L>* | No | 1000Genomes | |
| ENSVATH10974528 | 132 | L>M | No | 1000Genomes | |
| tmp_1_3820349_G_A | 135 | T>I | No | 1000Genomes | |
| tmp_1_3820286_G_A | 156 | P>L | No | 1000Genomes | |
| tmp_1_3820284_T_C | 157 | T>A | No | 1000Genomes | |
| ENSVATH00017710 | 159 | S>R | No | 1000Genomes | |
| ENSVATH04557476 | 164 | T>R | No | 1000Genomes | |
| tmp_1_3820238_A_C | 172 | L>R | No | 1000Genomes | |
| ENSVATH04557475 | 200 | V>I | No | 1000Genomes | |
| tmp_1_3820086_T_G | 223 | N>H | No | 1000Genomes | |
| ENSVATH10974527 | 241 | G>E | No | 1000Genomes | |
| tmp_1_3820017_A_G | 246 | S>P | No | 1000Genomes | |
| tmp_1_3819935_A_G | 273 | I>T | No | 1000Genomes | |
| ENSVATH01035337 | 273 | I>V | No | 1000Genomes | |
| tmp_1_3819843_C_T | 304 | G>R | No | 1000Genomes | |
| ENSVATH00017709 | 339 | Q>L | No | 1000Genomes | |
| ENSVATH00017709 | 339 | Q>R | No | 1000Genomes | |
| ENSVATH10974526 | 341 | E>K | No | 1000Genomes | |
| tmp_1_3819719_T_A | 345 | N>I | No | 1000Genomes | |
| tmp_1_3819698_C_G | 352 | S>T | No | 1000Genomes | |
| tmp_1_3819689_A_T | 355 | F>Y | No | 1000Genomes | |
| ENSVATH04557473 | 408 | M>I | No | 1000Genomes | |
| ENSVATH00017708 | 429 | K>N | No | 1000Genomes | |
| ENSVATH01035336 | 445 | A>V | No | 1000Genomes | |
| ENSVATH04557468 | 492 | Y>C | No | 1000Genomes | |
| ENSVATH04557468 | 492 | Y>F | No | 1000Genomes | |
| ENSVATH00017707 | 501 | E>D | No | 1000Genomes | |
| tmp_1_3819074_C_T | 504 | V>M | No | 1000Genomes | |
| tmp_1_3818911_C_T | 530 | R>K | No | 1000Genomes | |
| ENSVATH04557464 | 544 | R>Q | No | 1000Genomes | |
| ENSVATH04557463 | 554 | V>M | No | 1000Genomes | |
| tmp_1_3818723_A_C | 593 | L>V | No | 1000Genomes | |
| tmp_1_3818705_C_A | 599 | D>Y | No | 1000Genomes | |
| tmp_1_3818585_C_T | 604 | R>K | No | 1000Genomes | |
| ENSVATH00017706 | 612 | F>L | No | 1000Genomes | |
| tmp_1_3818520_G_A | 626 | H>Y | No | 1000Genomes | |
| ENSVATH04557459 | 640 | A>P | No | 1000Genomes | |
| tmp_1_3818408_T_A | 663 | Q>L | No | 1000Genomes | |
| ENSVATH04557457 | 670 | S>R | No | 1000Genomes | |
| tmp_1_3818382_C_A | 672 | V>L | No | 1000Genomes | |
| tmp_1_3818198_C_T | 702 | V>I | No | 1000Genomes | |
| tmp_1_3818132_T_C | 724 | N>D | No | 1000Genomes | |
| ENSVATH04557453 | 761 | V>L | No | 1000Genomes | |
| ENSVATH04557452 | 778 | T>M | No | 1000Genomes | |
| ENSVATH04557451 | 784 | S>T | No | 1000Genomes | |
| tmp_1_3817823_T_A | 799 | I>L | No | 1000Genomes | |
| tmp_1_3817812_C_A | 802 | R>S | No | 1000Genomes | |
| ENSVATH10974441 | 816 | R>K | No | 1000Genomes |
No associated diseases with Q9LPZ9
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to salicylic acid stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus. |
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| recognition of pollen | A cell recognition process in which pollen is recognized and either accepted or rejected by cells in the stigma. |
68 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q06805 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Bos taurus (Bovine) | PR |
| Q06807 | TEK | Angiopoietin-1 receptor | Bos taurus (Bovine) | SS |
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q8AXY6 | MUSK | Muscle, skeletal receptor tyrosine protein kinase | Gallus gallus (Chicken) | SS |
| P09208 | InR | Insulin-like receptor | Drosophila melanogaster (Fruit fly) | SS |
| P06213 | INSR | Insulin receptor | Homo sapiens (Human) | EV |
| P30530 | AXL | Tyrosine-protein kinase receptor UFO | Homo sapiens (Human) | PR |
| Q01973 | ROR1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Homo sapiens (Human) | PR |
| P08069 | IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens (Human) | EV |
| P14616 | INSRR | Insulin receptor-related protein | Homo sapiens (Human) | SS |
| Q01974 | ROR2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Homo sapiens (Human) | EV |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| P35590 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Homo sapiens (Human) | PR |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| P24062 | Igf1r | Insulin-like growth factor 1 receptor | Rattus norvegicus (Rat) | SS |
| Q62838 | Musk | Muscle, skeletal receptor tyrosine protein kinase | Rattus norvegicus (Rat) | SS |
| Q64716 | Insrr | Insulin receptor-related protein | Rattus norvegicus (Rat) | SS |
| P57097 | Mertk | Tyrosine-protein kinase Mer | Rattus norvegicus (Rat) | SS |
| P15127 | Insr | Insulin receptor | Rattus norvegicus (Rat) | SS |
| P43293 | PBL11 | Probable serine/threonine-protein kinase PBL11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN94 | At5g59670 | Receptor-like protein kinase At5g59670 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64770 | At1g61490 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61490 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64783 | At1g61370 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SXB5 | At1g11303 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11303 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGG3 | At1g51820 | Probable LRR receptor-like serine/threonine-protein kinase At1g51820 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SYA0 | At1g61500 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P43298 | TMK1 | Receptor protein kinase TMK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGI2 | At1g67720 | Probable LRR receptor-like serine/threonine-protein kinase At1g67720 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQR3 | At2g14510 | Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LW83 | CES101 | G-type lectin S-receptor-like serine/threonine-protein kinase CES101 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LIG2 | At3g21340 | Receptor-like protein kinase At3g21340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SNA3 | At3g46340 | Putative receptor-like protein kinase At3g46340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2S4 | LECRKS4 | L-type lectin-domain containing receptor kinase S.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81833 | SD11 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWZ5 | SD25 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGW2 | PAM74 | Probable LRR receptor-like serine/threonine-protein kinase PAM74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN93 | At5g59680 | Probable LRR receptor-like serine/threonine-protein kinase At5g59680 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64780 | At1g61400 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61400 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64776 | At1g61440 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61440 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SY95 | At1g61550 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61550 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64778 | At1g61420 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61420 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64774 | At1g61460 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61460 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64782 | SD129 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84JQ4 | PRK2 | Pollen receptor-like kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZS4 | NIK3 | Protein NSP-INTERACTING KINASE 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AG2 | SERK1 | Somatic embryogenesis receptor kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64477 | At2g19130 | G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9XIC7 | SERK2 | Somatic embryogenesis receptor kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB8 | At1g11330 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11330 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64793 | At1g67520 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g67520 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDQ3 | CRK34 | Cysteine-rich receptor-like protein kinase 34 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64784 | At1g61360 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61360 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGCLLILLLT | LICFSLRLCL | ATDVITFSSE | FRDSETVVSN | HSTFRFGFFS | PVNSTGRYAG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IWFNNIPVQT | VVWVANSNSP | INDSSGMVSI | SKEGNLVVMD | GRGQVHWSTN | VLVPVAANTF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YARLLNTGNL | VLLGTTNTGD | EILWESFEHP | QNIYLPTMSL | ATDTKTGRSL | KLRSWKSPFD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PSPGRYSAGL | IPLPFPELVV | WKDDLLMWRS | GPWNGQYFIG | LPNMDYRINL | FELTLSSDNR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GSVSMSYAGN | TLLYHFLLDS | EGSVFQRDWN | VAIQEWKTWL | KVPSTKCDTY | ATCGQFASCR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FNPGSTPPCM | CIRGFKPQSY | AEWNNGNWTQ | GCVRKAPLQC | ESRDNNDGSR | KSDGFVRVQK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MKVPHNPQRS | GANEQDCPES | CLKNCSCTAY | SFDRGIGCLL | WSGNLMDMQE | FSGTGVVFYI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RLADSEFKKR | TNRSIVITVT | LLVGAFLFAG | TVVLALWKIA | KHREKNRNTR | LLNERMEALS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SNDVGAILVN | QYKLKELPLF | EFQVLAVATN | NFSITNKLGQ | GGFGAVYKGR | LQEGLDIAVK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RLSRTSGQGV | EEFVNEVVVI | SKLQHRNLVR | LLGFCIEGEE | RMLVYEFMPE | NCLDAYLFDP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VKQRLLDWKT | RFNIIDGICR | GLMYLHRDSR | LKIIHRDLKA | SNILLDENLN | PKISDFGLAR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IFQGNEDEVS | TVRVVGTYGY | MAPEYAMGGL | FSEKSDVFSL | GVILLEIVSG | RRNSSFYNDG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QNPNLSAYAW | KLWNTGEDIA | LVDPVIFEEC | FENEIRRCVH | VGLLCVQDHA | NDRPSVATVI |
| 790 | 800 | 810 | 820 | ||
| WMLSSENSNL | PEPKQPAFIP | RRGTSEVESS | GQSDPRASIN | NVSLTKITGR |