Q9LMT0

PR
Gene name
CDKD-3 (At1g18040, T10F20.5, T10O22.1)
Protein name
Cyclin-dependent kinase D-3
Names
CDKD3, CDK-activating kinase 2-At, CAK2-At
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G18040
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

267-391 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

151-174 (Activation loop from InterPro)

Target domain

12-292 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9LMT0

Entry ID Method Resolution Chain Position Source
AF-Q9LMT0-F1 Predicted AlphaFoldDB

14 variants for Q9LMT0

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH11440560 82 E>Q No 1000Genomes
tmp_1_6208907_T_A 83 N>I No 1000Genomes
ENSVATH11440559 107 S>P No 1000Genomes
tmp_1_6208823_A_G 111 I>T No 1000Genomes
ENSVATH04594913 188 G>S No 1000Genomes
ENSVATH01066203 252 P>L No 1000Genomes
tmp_1_6207652_C_T 279 A>T No 1000Genomes
ENSVATH11440467 307 P>H No 1000Genomes
ENSVATH01066201 308 V>I No 1000Genomes
tmp_1_6207456_C_T 318 G>S No 1000Genomes
tmp_1_6207420_G_T 330 R>S No 1000Genomes
tmp_1_6207384_C_T 342 V>I No 1000Genomes
tmp_1_6207370_C_G 346 K>N No 1000Genomes
ENSVATH11440466 364 L>V No 1000Genomes

No associated diseases with Q9LMT0

3 regional properties for Q9LMT0

Type Name Position InterPro Accession
domain Protein kinase domain 12 - 292 IPR000719
active_site Serine/threonine-protein kinase, active site 130 - 142 IPR008271
binding_site Protein kinase, ATP binding site 18 - 42 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription factor TFIIK complex A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

5 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IZL9 CDK20 Cyclin-dependent kinase 20 Homo sapiens (Human) PR
Q9JHU3 Cdk20 Cyclin-dependent kinase 20 Mus musculus (Mouse) PR
Q4KM34 Cdk20 Cyclin-dependent kinase 20 Rattus norvegicus (Rat) PR
P29620 CDKD-1 Cyclin-dependent kinase D-1 Oryza sativa subsp japonica (Rice) PR
Q9C9U2 CDKD-1 Cyclin-dependent kinase D-1 Arabidopsis thaliana (Mouse-ear cress) PR
F4I114 At1g09600 Probable serine/threonine-protein kinase At1g09600 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FGW5 CDKG1 Cyclin-dependent kinase G1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZVM9 At1g54610 Probable serine/threonine-protein kinase At1g54610 Arabidopsis thaliana (Mouse-ear cress) PR
A8WIP6 cdk20 Cyclin-dependent kinase 20 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MPEQPKKVAD RYLKQEVLGQ GTYGVVFKAT DTKTEQTVAI KKIRLGKQRE GVNITALREI
70 80 90 100 110 120
KMLKELKHPH IILLIDAFPH KENLHLVFEF METDLEAVIR DSNIFLSPAD IKSYLLMTFK
130 140 150 160 170 180
GLAYCHDKWV LHRDMKPNNL LIGVDGQLKL ADFGLARIFG SPNRKFTHQV FARWYRAPEL
190 200 210 220 230 240
LFGAKQYGAA VDVWAVACIF AELLLRRPFL QGNSDIDQLS KIFAAFGTPK ADQWPDLTKL
250 260 270 280 290 300
PDYVEYQFVP APSLRSLFPA VSDDALDLLS KMFTYDPKAR ISIKQALEHR YFTSAPAPTD
310 320 330 340 350 360
PAKLPKPVPK QDGKSSYGKH EAITVQSPPR KLRRVMPERG RVDSLKSHVD KDQQAPMSLD
370 380 390
FTILAERPPN RPTITSADRS HLKRKLDLEF Q