Q9LMN7
PR
Gene name |
WAK5 (At1g21230, F16F4.9) |
Protein name |
Wall-associated receptor kinase 5 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G21230 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
550-574 (Activation loop from InterPro)
Target domain |
408-691 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9LMN7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LMN7-F1 | Predicted | AlphaFoldDB |
91 variants for Q9LMN7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04614662 | 14 | Y>S | No | 1000Genomes | |
| ENSVATH00035340 | 16 | A>T | No | 1000Genomes | |
| tmp_1_7430045_G_T | 22 | K>N | No | 1000Genomes | |
| ENSVATH11693215 | 23 | A>T | No | 1000Genomes | |
| ENSVATH11693216 | 27 | D>A | No | 1000Genomes | |
| ENSVATH01080457 | 35 | D>N | No | 1000Genomes | |
| ENSVATH01080458 | 37 | P>T | No | 1000Genomes | |
| ENSVATH01080459 | 42 | F>Y | No | 1000Genomes | |
| tmp_1_7430124_T_C | 49 | Y>H | No | 1000Genomes | |
| tmp_1_7430128_A_C | 50 | Y>S | No | 1000Genomes | |
| ENSVATH04614664 | 57 | N>S | No | 1000Genomes | |
| ENSVATH04614665 | 63 | D>G | No | 1000Genomes | |
| ENSVATH01080462 | 69 | S>G | No | 1000Genomes | |
| tmp_1_7430235_A_C | 86 | I>L | No | 1000Genomes | |
| ENSVATH11693217 | 93 | Y>D | No | 1000Genomes | |
| tmp_1_7430269_C_T | 97 | T>I | No | 1000Genomes | |
| tmp_1_7430268_A_T | 97 | T>S | No | 1000Genomes | |
| ENSVATH00035346 | 100 | D>E | No | 1000Genomes | |
| tmp_1_7430362_C_T | 128 | A>V | No | 1000Genomes | |
| tmp_1_7430372_C_A | 131 | S>R | No | 1000Genomes | |
| tmp_1_7430408_G_A | 143 | M>I | No | 1000Genomes | |
| ENSVATH01080466 | 152 | P>Q | No | 1000Genomes | |
| tmp_1_7430443_A_T | 155 | K>I | No | 1000Genomes | |
| tmp_1_7430464_G_C | 162 | C>S | No | 1000Genomes | |
| ENSVATH01080469 | 204 | M>I | No | 1000Genomes | |
| ENSVATH11693219 | 239 | V>L | No | 1000Genomes | |
| ENSVATH13936811 | 246 | G>R | No | 1000Genomes | |
| tmp_1_7430725_C_G | 249 | T>R | No | 1000Genomes | |
| tmp_1_7430800_C_T | 274 | S>L | No | 1000Genomes | |
| tmp_1_7430803_A_G | 275 | D>G | No | 1000Genomes | |
| ENSVATH00035353 | 287 | I>R | No | 1000Genomes | |
| ENSVATH00035353 | 287 | I>T | No | 1000Genomes | |
| tmp_1_7430921_C_A | 288 | H>N | No | 1000Genomes | |
| ENSVATH01080488 | 291 | S>L | No | 1000Genomes | |
| ENSVATH07520718 | 294 | S>N | No | 1000Genomes | |
| ENSVATH00035354 | 295 | T>I | No | 1000Genomes | |
| ENSVATH11693220 | 299 | T>I | No | 1000Genomes | |
| tmp_1_7430963_A_C | 302 | S>R | No | 1000Genomes | |
| ENSVATH01080489 | 322 | D>N | No | 1000Genomes | |
| ENSVATH01080490 | 323 | T>K | No | 1000Genomes | |
| tmp_1_7431066_T_C | 336 | V>A | No | 1000Genomes | |
| ENSVATH00035357 | 337 | L>F | No | 1000Genomes | |
| tmp_1_7431171_G_A | 343 | G>R | No | 1000Genomes | |
| ENSVATH04614675 | 350 | T>S | No | 1000Genomes | |
| ENSVATH01080503 | 360 | H>Q | No | 1000Genomes | |
| tmp_1_7431226_G_A | 361 | R>Q | No | 1000Genomes | |
| ENSVATH01080505 | 385 | G>A | No | 1000Genomes | |
| tmp_1_7431297_G_A | 385 | G>R | No | 1000Genomes | |
| ENSVATH01080505 | 385 | G>V | No | 1000Genomes | |
| tmp_1_7431300_G_A | 386 | A>T | No | 1000Genomes | |
| ENSVATH01080507 | 409 | N>D | No | 1000Genomes | |
| ENSVATH01080508 | 411 | S>N | No | 1000Genomes | |
| ENSVATH00035359 | 428 | Q>P | No | 1000Genomes | |
| ENSVATH01080513 | 432 | I>T | No | 1000Genomes | |
| tmp_1_7431635_G_A | 497 | M>I | No | 1000Genomes | |
| ENSVATH01080516 | 497 | M>L | No | 1000Genomes | |
| tmp_1_7431646_C_T | 501 | S>L | No | 1000Genomes | |
| ENSVATH04614681 | 503 | T>R | No | 1000Genomes | |
| ENSVATH13936812 | 521 | L>P | No | 1000Genomes | |
| ENSVATH01080520 | 524 | Y>S | No | 1000Genomes | |
| tmp_1_7431721_C_T | 526 | S>F | No | 1000Genomes | |
| ENSVATH11693223 | 536 | T>N | No | 1000Genomes | |
| ENSVATH04614682 | 538 | N>K | No | 1000Genomes | |
| tmp_1_7431783_G_A | 547 | A>T | No | 1000Genomes | |
| ENSVATH01080521 | 551 | D>E | No | 1000Genomes | |
| ENSVATH04614684 | 554 | A>T | No | 1000Genomes | |
| tmp_1_7431819_C_T | 559 | P>S | No | 1000Genomes | |
| tmp_1_7431844_C_T | 567 | T>I | No | 1000Genomes | |
| tmp_1_7431944_G_T | 600 | M>I | No | 1000Genomes | |
| ENSVATH11693224 | 612 | E>K | No | 1000Genomes | |
| tmp_1_7431982_G_T | 613 | R>L | No | 1000Genomes | |
| ENSVATH13936813 | 621 | V>G | No | 1000Genomes | |
| ENSVATH04614687 | 631 | N>H | No | 1000Genomes | |
| tmp_1_7432081_A_G | 646 | N>S | No | 1000Genomes | |
| ENSVATH01080529 | 651 | Q>E | No | 1000Genomes | |
| ENSVATH01080530 | 651 | Q>R | No | 1000Genomes | |
| ENSVATH11693845 | 653 | S>F | No | 1000Genomes | |
| ENSVATH04614688 | 654 | A>V | No | 1000Genomes | |
| tmp_1_7432108_G_A | 655 | R>K | No | 1000Genomes | |
| ENSVATH01080532 | 677 | E>D | No | 1000Genomes | |
| ENSVATH01080533 | 682 | R>K | No | 1000Genomes | |
| ENSVATH01080535 | 683 | V>A | No | 1000Genomes | |
| ENSVATH04614689 | 692 | D>E | No | 1000Genomes | |
| ENSVATH01080536 | 703 | G>S | No | 1000Genomes | |
| ENSVATH01080537 | 709 | T>A | No | 1000Genomes | |
| tmp_1_7432270_C_T | 709 | T>M | No | 1000Genomes | |
| tmp_1_7432274_A_T | 710 | Q>H | No | 1000Genomes | |
| ENSVATH01080538 | 710 | Q>R | No | 1000Genomes | |
| ENSVATH04614690 | 715 | S>N | No | 1000Genomes | |
| ENSVATH00035362 | 722 | Q>H | No | 1000Genomes | |
| tmp_1_7432323_T_G | 727 | L>V | No | 1000Genomes |
No associated diseases with Q9LMN7
9 regional properties for Q9LMN7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| ptm | EGF-type aspartate/asparagine hydroxylation site | 296 - 307 | IPR000152 |
| domain | Protein kinase domain | 408 - 691 | IPR000719 |
| domain | EGF-like domain | 231 - 278 | IPR000742-1 |
| domain | EGF-like domain | 279 - 321 | IPR000742-2 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 411 - 678 | IPR001245 |
| domain | EGF-like calcium-binding domain | 279 - 321 | IPR001881 |
| active_site | Serine/threonine-protein kinase, active site | 529 - 541 | IPR008271 |
| conserved_site | EGF-like calcium-binding, conserved site | 279 - 305 | IPR018097 |
| domain | Wall-associated receptor kinase, galacturonan-binding domain | 29 - 81 | IPR025287 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| polysaccharide binding | Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell surface receptor signaling pathway | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
55 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3ZC95 | BTK | Tyrosine-protein kinase | Bos taurus (Bovine) | EV SS |
| P28693 | EPHB2 | Ephrin type-B receptor 2 | Gallus gallus (Chicken) | PR |
| P29318 | EPHA3 | Ephrin type-A receptor 3 | Gallus gallus (Chicken) | SS |
| Q07497 | EPHB5 | Ephrin type-B receptor 5 | Gallus gallus (Chicken) | PR |
| Q07496 | EPHA4 | Ephrin type-A receptor 4 | Gallus gallus (Chicken) | SS |
| O42422 | EPHA7 | Ephrin type-A receptor 7 | Gallus gallus (Chicken) | SS |
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| P54755 | EPHA5 | Ephrin type-A receptor 5 | Gallus gallus (Chicken) | SS |
| Q07498 | EPHB3 | Ephrin type-B receptor 3 | Gallus gallus (Chicken) | SS |
| P06213 | INSR | Insulin receptor | Homo sapiens (Human) | EV |
| P08069 | IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens (Human) | EV |
| P14616 | INSRR | Insulin receptor-related protein | Homo sapiens (Human) | SS |
| P00533 | EGFR | Epidermal growth factor receptor | Homo sapiens (Human) | EV |
| Q15303 | ERBB4 | Receptor tyrosine-protein kinase erbB-4 | Homo sapiens (Human) | SS |
| P04626 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (Human) | SS |
| P21860 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | Homo sapiens (Human) | SS |
| O08644 | Ephb6 | Ephrin type-B receptor 6 | Mus musculus (Mouse) | PR |
| P54763 | Ephb2 | Ephrin type-B receptor 2 | Mus musculus (Mouse) | SS |
| Q03137 | Epha4 | Ephrin type-A receptor 4 | Mus musculus (Mouse) | SS |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| Q61772 | Epha7 | Ephrin type-A receptor 7 | Mus musculus (Mouse) | SS |
| Q8BYG9 | Epha10 | Ephrin type-A receptor 10 | Mus musculus (Mouse) | SS |
| Q8CBF3 | Ephb1 | Ephrin type-B receptor 1 | Mus musculus (Mouse) | SS |
| P54754 | Ephb3 | Ephrin type-B receptor 3 | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| O09127 | Epha8 | Ephrin type-A receptor 8 | Mus musculus (Mouse) | SS |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| Q61527 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Mus musculus (Mouse) | SS |
| Q61526 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Mus musculus (Mouse) | SS |
| Q01279 | Egfr | Epidermal growth factor receptor | Mus musculus (Mouse) | SS |
| Q62413 | Epha6 | Ephrin type-A receptor 6 | Mus musculus (Mouse) | SS |
| P29319 | Epha3 | Ephrin type-A receptor 3 | Mus musculus (Mouse) | SS |
| Q2HWD6 | KIT | Mast/stem cell growth factor receptor Kit | Sus scrofa (Pig) | SS |
| P24062 | Igf1r | Insulin-like growth factor 1 receptor | Rattus norvegicus (Rat) | SS |
| Q64716 | Insrr | Insulin receptor-related protein | Rattus norvegicus (Rat) | SS |
| Q62956 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Rattus norvegicus (Rat) | SS |
| Q62799 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Rattus norvegicus (Rat) | SS |
| P15127 | Insr | Insulin receptor | Rattus norvegicus (Rat) | SS |
| Q7X8C5 | WAKL2 | Wall-associated receptor kinase-like 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9S9M2 | WAKL4 | Wall-associated receptor kinase-like 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C9L5 | WAKL9 | Wall-associated receptor kinase-like 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYA3 | WAKL10 | Wall-associated receptor kinase-like 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M092 | WAKL17 | Wall-associated receptor kinase-like 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8JFR5 | kita | Mast/stem cell growth factor receptor kita | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8N6 | csf1r | Macrophage colony-stimulating factor 1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5GIT4 | kdr | Vascular endothelial growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90Z00 | fgfr1a | Fibroblast growth factor receptor 1-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5MD89 | flt4 | Vascular endothelial growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JG38 | fgfr2 | Fibroblast growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8X3 | fgfr3 | Fibroblast growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKVHSLFLMA | IFFYLAYTQL | VKAQPRDDCQ | TRCGDVPIDY | PFGISTGCYY | PGDDSFNITC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EEDKPNVLSN | IEVLNFNHSG | QLRGLIPRST | VCYDQQTNND | FESLWFRLDN | LSFSPNNKFT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVGCNAWALL | STFGIQNYST | GCMSLCDTPP | PPNSKCNGVG | CCRTEVSIPL | DSHRIETQPS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RFENMTSVEH | FNPCSYAFFV | EDGMFNFSSL | EDLKDLRNVT | RFPVLLDWSI | GNQTCEQVVG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RNICGGNSTC | FDSTRGKGYN | CKCLQGFDGN | PYLSDGCQDI | NECTTRIHNC | SDTSTCENTL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GSFHCQCPSG | SDLNTTTMSC | IDTPKEEPKY | LGWTTVLLGT | TIGFLIILLT | ISYIQQKMRH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RKNTELRQQF | FEQNGGGMLI | QRLSGAGPSN | VDVKIFTEEG | MKEATDGYNE | SRILGQGGQG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TVYKGILQDN | SIVAIKKARL | GDRSQVEQFI | NEVLVLSQIN | HRNVVKLLGC | CLETEVPLLV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YEFISSGTLF | DHLHGSMFDS | SLTWEHRLRI | AIEVAGTLAY | LHSYASIPII | HRDVKTANIL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LDENLTAKVA | DFGASRLIPM | DQEQLTTMVQ | GTLGYLDPEY | YNTGLLNEKS | DVYSFGVVLM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ELLSGEKALC | FERPQSSKHL | VSYFVSAMKE | NRLHEIIDGQ | VMNEYNQREI | QESARIAVEC |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TRIMGEERPS | MKEVAAELEA | LRVKTTKHQW | SDQYPKEVEH | LLGVQILSTQ | GDTSSIGYDS |
| 730 | |||||
| IQNVTRLDIE | TGR |