Q9LIK0

PR
Gene name
PKP1 (PK1, At3g22960, F5N5.15)
Protein name
Plastidial pyruvate kinase 1, chloroplastic
Names
PK1, PKp1, Pyruvate kinase II, Pyruvate kinase isozyme A, PKP-ALPHA
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G22960
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

18-109 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9LIK0

Entry ID Method Resolution Chain Position Source
AF-Q9LIK0-F1 Predicted AlphaFoldDB

14 variants for Q9LIK0

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00341199 9 T>S No 1000Genomes
ENSVATH02181727 52 S>P No 1000Genomes
ENSVATH10878042 100 V>F No 1000Genomes
ENSVATH02181728 160 G>C No 1000Genomes
ENSVATH02181728 160 G>S No 1000Genomes
ENSVATH10878044 178 I>V No 1000Genomes
ENSVATH05889787 200 A>S No 1000Genomes
tmp_3_8140110_T_A 215 S>T No 1000Genomes
tmp_3_8140413_A_G 281 S>G No 1000Genomes
ENSVATH10878169 359 L>V No 1000Genomes
ENSVATH02181767 405 L>F No 1000Genomes
ENSVATH02181768 453 R>K No 1000Genomes
tmp_3_8141347_T_G 481 F>L No 1000Genomes
ENSVATH05889806 551 L>I No 1000Genomes

No associated diseases with Q9LIK0

3 regional properties for Q9LIK0

Type Name Position InterPro Accession
domain Pyruvate kinase, barrel 117 - 462 IPR015793
domain Pyruvate kinase, C-terminal 487 - 586 IPR015795
active_site Pyruvate kinase, active site 339 - 351 IPR018209

Functions

Description
EC Number
Subcellular Localization
  • Plastid, chloroplast stroma
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
chloroplast stroma The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
magnesium ion binding Binding to a magnesium (Mg) ion.
potassium ion binding Binding to a potassium ion (K+).
pyruvate kinase activity Catalysis of the reaction: = ADP + H(+) + phosphoenolpyruvate => ATP + pyruvate.

3 GO annotations of biological process

Name Definition
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
seed maturation A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P52489 PYK2 Pyruvate kinase 2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
P00549 CDC19 Pyruvate kinase 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
P11979 PKM Pyruvate kinase PKM Felis catus (Cat) (Felis silvestris catus) SS
P00548 PKM Pyruvate kinase PKM Gallus gallus (Chicken) SS
Q29536 PKLR Pyruvate kinase PKLR Canis lupus familiaris (Dog) (Canis familiaris) SS
O62619 PyK Pyruvate kinase Drosophila melanogaster (Fruit fly) SS
P30613 PKLR Pyruvate kinase PKLR Homo sapiens (Human) SS
P14618 PKM Pyruvate kinase PKM Homo sapiens (Human) EV
P52480 Pkm Pyruvate kinase PKM Mus musculus (Mouse) SS
P53657 Pklr Pyruvate kinase PKLR Mus musculus (Mouse) SS
P12928 Pklr Pyruvate kinase PKLR Rattus norvegicus (Rat) SS
P11980 Pkm Pyruvate kinase PKM Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MSQSIQFSTP SHTPHLLHLP HSQFNRPLSS ISFRRFPLTT IKYTSIRASS SSSPSPDLDS
70 80 90 100 110 120
SSSSSSSQVL LSPNGTGAVK SDERSVVATA VTTDTSGIEV DTVTEAELKE NGFRSTRRTK
130 140 150 160 170 180
LICTIGPATC GFEQLEALAV GGMNVARLNM CHGTRDWHRG VIRSVRRLNE EKGFAVAIMM
190 200 210 220 230 240
DTEGSEIHMG DLGGEASAKA EDGEVWTFTV RAFDSSRPER TISVSYDGFA EDVRVGDELL
250 260 270 280 290 300
VDGGMVRFEV IEKIGPDVKC LCTDPGLLLP RANLTFWRDG SLVRERNAML PTISSKDWLD
310 320 330 340 350 360
IDFGIAEGVD FIAVSFVKSA EVINHLKSYL AARSRGGEIG VIAKIESIDS LTNLEEIILA
370 380 390 400 410 420
SDGAMVARGD LGAQIPLEQV PAAQQRIVQV CRALNKPVIV ASQLLESMIE YPTPTRAEVA
430 440 450 460 470 480
DVSEAVRQRS DALMLSGESA MGQFPDKALT VLRTVSLRIE RWWREEKRHE SVPLQAIGSS
490 500 510 520 530 540
FSDKISEEIC NSAAKMANNL GVDAVFVYTT SGHMASLVSR CRPDCPIFAF TTTTSVRRRL
550 560 570 580 590
NLQWGLIPFR LSFSDDMESN LNKTFSLLKS RGMIKSGDLV IAVSDMLQSI QVMNVP