AiPD: Autoinhibited Protein Database

Gene name	RH51 (At3g18600, K24M9.9)
Protein name	DEAD-box ATP-dependent RNA helicase 51
Names
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT3G18600
EC number	3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-111 (Predicted disordered autoinhibitory region) PR

1-111 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9LIH9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH02161705	14	K>T	No	1000Genomes
tmp_3_6402947_G_A	21	R>C	No	1000Genomes
ENSVATH02161704	29	K>M	No	1000Genomes
ENSVATH02161703	29	K>N	No	1000Genomes
ENSVATH02161702	33	K>E	No	1000Genomes
tmp_3_6402899_C_A	37	V>L	No	1000Genomes
tmp_3_6402886_G_A	41	A>V	No	1000Genomes
ENSVATH05857765	44	T>M	No	1000Genomes
ENSVATH10765287	69	M>L	No	1000Genomes
tmp_3_6402796_T_A	71	D>V	No	1000Genomes
tmp_3_6402772_A_G	79	V>A	No	1000Genomes
tmp_3_6402750_C_T	86	M>I	No	1000Genomes
tmp_3_6402703_A_G	102	I>T	No	1000Genomes
ENSVATH05857763	106	E>D	No	1000Genomes
ENSVATH05857762	108	G>D	No	1000Genomes
tmp_3_6402489_C_T	142	A>T	No	1000Genomes
ENSVATH05857759	150	L>F	No	1000Genomes
ENSVATH00332112	152	F>Y	No	1000Genomes
ENSVATH02161683	179	N>T	No	1000Genomes
tmp_3_6402115_G_A	187	H>Y	No	1000Genomes
ENSVATH05857751	205	A>V	No	1000Genomes
ENSVATH00332105	210	S>N	No	1000Genomes
tmp_3_6401983_C_A	231	A>S	No	1000Genomes
tmp_3_6401533_T_C	259	K>R	No	1000Genomes
tmp_3_6401210_G_A	267	T>I	No	1000Genomes
ENSVATH00332097	294	H>Y	No	1000Genomes
tmp_3_6401030_C_T	302	R>H	No	1000Genomes
tmp_3_6400789_C_T	357	S>N	No	1000Genomes
tmp_3_6400787_C_T	358	D>N	No	1000Genomes
ENSVATH00332094	360	D>E	No	1000Genomes
ENSVATH05857733	367	G>D	No	1000Genomes
ENSVATH05857721	514	D>N	No	1000Genomes
ENSVATH10765134	542	R>K	No	1000Genomes
tmp_3_6399786_C_A	549	G>C	No	1000Genomes
tmp_3_6399785_C_A	549	G>V	No	1000Genomes
ENSVATH05857716	561	K>*	No	1000Genomes

Type	Name	Position	InterPro Accession
conserved_site	ATP-dependent RNA helicase DEAD-box, conserved site	241 - 249	IPR000629
domain	Helicase, C-terminal	321 - 468	IPR001650
domain	DEAD/DEAH box helicase domain	113 - 284	IPR011545
domain	Helicase superfamily 1/2, ATP-binding domain	108 - 312	IPR014001
domain	RNA helicase, DEAD-box type, Q motif	89 - 117	IPR014014
domain	Domain of unknown function DUF4217	469 - 532	IPR025313
domain	DDX18/Has1, DEAD-box helicase domain	100 - 296	IPR044773

		Description
EC Number	3.6.4.13	Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding	Binding to an RNA molecule or a portion thereof.
RNA helicase activity	Unwinding of an RNA helix, driven by ATP hydrolysis.

Name	Definition
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q03532	HAS1	ATP-dependent RNA helicase HAS1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q8K363	Ddx18	ATP-dependent RNA helicase DDX18	Mus musculus (Mouse)	PR
Q0DBS1	Os06g0535100	Putative DEAD-box ATP-dependent RNA helicase 51	Oryza sativa subsp japonica (Rice)	PR
O80792	RH33	Putative DEAD-box ATP-dependent RNA helicase 33	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FFQ1	RH31	DEAD-box ATP-dependent RNA helicase 31	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SB89	RH27	DEAD-box ATP-dependent RNA helicase 27	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SA27	RH36	DEAD-box ATP-dependent RNA helicase 36	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FVV4	RH55	DEAD-box ATP-dependent RNA helicase 55	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9CAI7	TIF4A-3	Eukaryotic initiation factor 4A-3	Arabidopsis thaliana (Mouse-ear cress)	PR
O22907	RH24	DEAD-box ATP-dependent RNA helicase 24	Arabidopsis thaliana (Mouse-ear cress)	PR
Q56X76	RH39	DEAD-box ATP-dependent RNA helicase 39	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8GY84	RH10	DEAD-box ATP-dependent RNA helicase 10	Arabidopsis thaliana (Mouse-ear cress)	PR
Q84TG1	RH57	DEAD-box ATP-dependent RNA helicase 57	Arabidopsis thaliana (Mouse-ear cress)	PR
P41377	TIF4A-2	Eukaryotic initiation factor 4A-2	Arabidopsis thaliana (Mouse-ear cress)	PR
P41376	EIF4A1	Eukaryotic initiation factor 4A-1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8H0U8	RH42	DEAD-box ATP-dependent RNA helicase 42	Arabidopsis thaliana (Mouse-ear cress)	SS