Q9LIG2
Gene name |
At3g21340 (MHC9.2) |
Protein name |
Receptor-like protein kinase At3g21340 |
Names |
Leucine-rich repeat receptor-like protein kinase At3g21340 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G21340 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
734-741 (Activation loop from InterPro)
Target domain |
592-865 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
752-759 (Activation loop from InterPro)
Target domain |
592-865 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9LIG2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LIG2-F1 | Predicted | AlphaFoldDB |
91 variants for Q9LIG2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05877027 | 4 | H>R | No | 1000Genomes | |
| tmp_3_7515914_A_C | 8 | I>M | No | 1000Genomes | |
| tmp_3_7515904_C_A | 12 | A>S | No | 1000Genomes | |
| tmp_3_7515893_G_T | 15 | F>L | No | 1000Genomes | |
| ENSVATH00338007 | 64 | Q>E | No | 1000Genomes | |
| ENSVATH00338006 | 74 | A>E | No | 1000Genomes | |
| tmp_3_7515604_A_G | 78 | I>T | No | 1000Genomes | |
| ENSVATH05877026 | 82 | P>S | No | 1000Genomes | |
| ENSVATH00338005 | 91 | D>Y | No | 1000Genomes | |
| ENSVATH05877025 | 94 | R>* | No | 1000Genomes | |
| tmp_3_7515510_G_C | 109 | I>M | No | 1000Genomes | |
| tmp_3_7515488_T_G | 117 | N>H | No | 1000Genomes | |
| ENSVATH05877024 | 128 | D>N | No | 1000Genomes | |
| tmp_3_7515437_T_G | 134 | N>H | No | 1000Genomes | |
| tmp_3_7515425_T_G | 138 | T>P | No | 1000Genomes | |
| tmp_3_7515403_G_T | 145 | T>N | No | 1000Genomes | |
| tmp_3_7515404_T_G | 145 | T>P | No | 1000Genomes | |
| tmp_3_7515368_T_C | 157 | I>V | No | 1000Genomes | |
| tmp_3_7515247_T_G | 197 | Y>S | No | 1000Genomes | |
| tmp_3_7514812_A_G | 239 | I>T | No | 1000Genomes | |
| ENSVATH02173137 | 241 | S>I | No | 1000Genomes | |
| ENSVATH05877013 | 243 | N>T | No | 1000Genomes | |
| ENSVATH13959253 | 261 | T>P | No | 1000Genomes | |
| tmp_3_7514744_A_T | 262 | F>I | No | 1000Genomes | |
| ENSVATH13959252 | 276 | T>A | No | 1000Genomes | |
| ENSVATH10826082 | 287 | I>V | No | 1000Genomes | |
| ENSVATH10826081 | 289 | T>A | No | 1000Genomes | |
| ENSVATH10826080 | 293 | L>F | No | 1000Genomes | |
| ENSVATH10826079 | 301 | T>S | No | 1000Genomes | |
| tmp_3_7514573_C_T | 319 | E>K | No | 1000Genomes | |
| tmp_3_7514560_T_A | 323 | Y>F | No | 1000Genomes | |
| tmp_3_7514554_G_C | 325 | T>R | No | 1000Genomes | |
| tmp_3_7514507_T_A | 341 | T>S | No | 1000Genomes | |
| ENSVATH05877009 | 342 | P>S | No | 1000Genomes | |
| tmp_3_7514483_G_T | 349 | L>I | No | 1000Genomes | |
| ENSVATH05877008 | 350 | M>I | No | 1000Genomes | |
| ENSVATH05877007 | 353 | L>V | No | 1000Genomes | |
| tmp_3_7514448_A_T | 360 | D>E | No | 1000Genomes | |
| ENSVATH05877004 | 363 | Q>E | No | 1000Genomes | |
| ENSVATH02173136 | 368 | P>R | No | 1000Genomes | |
| ENSVATH13959251 | 378 | Q>E | No | 1000Genomes | |
| ENSVATH05876993 | 384 | S>N | No | 1000Genomes | |
| tmp_3_7514289_T_G | 386 | I>L | No | 1000Genomes | |
| tmp_3_7514285_C_G | 387 | S>T | No | 1000Genomes | |
| ENSVATH02173134 | 397 | Q>H | No | 1000Genomes | |
| ENSVATH05876992 | 398 | F>V | No | 1000Genomes | |
| ENSVATH02173133 | 401 | E>K | No | 1000Genomes | |
| ENSVATH05876991 | 410 | N>I | No | 1000Genomes | |
| ENSVATH05876991 | 410 | N>S | No | 1000Genomes | |
| ENSVATH02173131 | 434 | I>V | No | 1000Genomes | |
| ENSVATH02173130 | 435 | Q>E | No | 1000Genomes | |
| ENSVATH05876987 | 445 | L>F | No | 1000Genomes | |
| ENSVATH00337996 | 454 | I>V | No | 1000Genomes | |
| ENSVATH00337995 | 460 | D>V | No | 1000Genomes | |
| ENSVATH02173125 | 462 | K>N | No | 1000Genomes | |
| ENSVATH02173122 | 468 | N>D | No | 1000Genomes | |
| ENSVATH10826004 | 485 | K>N | No | 1000Genomes | |
| ENSVATH10826002 | 493 | E>Q | No | 1000Genomes | |
| tmp_3_7513524_C_T | 510 | G>S | No | 1000Genomes | |
| tmp_3_7513512_C_G | 514 | A>P | No | 1000Genomes | |
| ENSVATH07968539 | 519 | V>I | No | 1000Genomes | |
| tmp_3_7513485_T_C | 523 | I>V | No | 1000Genomes | |
| ENSVATH13959248 | 529 | F>I | No | 1000Genomes | |
| ENSVATH05876981 | 530 | V>A | No | 1000Genomes | |
| ENSVATH05876980 | 535 | S>F | No | 1000Genomes | |
| ENSVATH05876979 | 536 | A>T | No | 1000Genomes | |
| ENSVATH05876978 | 538 | A>T | No | 1000Genomes | |
| ENSVATH05876976 | 540 | F>Y | No | 1000Genomes | |
| ENSVATH05876975 | 541 | F>L | No | 1000Genomes | |
| ENSVATH05876974 | 548 | T>S | No | 1000Genomes | |
| ENSVATH05876968 | 562 | V>A | No | 1000Genomes | |
| ENSVATH05876967 | 573 | S>T | No | 1000Genomes | |
| ENSVATH13959246 | 576 | M>I | No | 1000Genomes | |
| tmp_3_7513215_C_A | 580 | R>I | No | 1000Genomes | |
| ENSVATH05876965 | 617 | V>I | No | 1000Genomes | |
| tmp_3_7512857_T_A | 666 | E>V | No | 1000Genomes | |
| tmp_3_7512714_C_T | 689 | E>K | No | 1000Genomes | |
| tmp_3_7512699_T_C | 694 | I>V | No | 1000Genomes | |
| tmp_3_7512542_C_T | 718 | V>I | No | 1000Genomes | |
| ENSVATH00337986 | 730 | H>Q | No | 1000Genomes | |
| ENSVATH13959234 | 752 | T>I | No | 1000Genomes | |
| tmp_3_7512421_G_A | 758 | P>L | No | 1000Genomes | |
| ENSVATH02173097 | 792 | L>P | No | 1000Genomes | |
| ENSVATH13959230 | 797 | S>R | No | 1000Genomes | |
| tmp_3_7512122_A_G | 809 | L>S | No | 1000Genomes | |
| tmp_3_7512023_G_A | 842 | S>L | No | 1000Genomes | |
| ENSVATH05876946 | 869 | N>S | No | 1000Genomes | |
| ENSVATH05876945 | 880 | S>L | No | 1000Genomes | |
| ENSVATH02173094 | 882 | S>N | No | 1000Genomes | |
| ENSVATH05876944 | 887 | S>G | No | 1000Genomes | |
| tmp_3_7511874_T_C | 892 | I>V | No | 1000Genomes |
No associated diseases with Q9LIG2
5 regional properties for Q9LIG2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 592 - 865 | IPR000719 |
| repeat | Leucine-rich repeat | 416 - 474 | IPR001611 |
| active_site | Serine/threonine-protein kinase, active site | 713 - 725 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 598 - 620 | IPR017441 |
| domain | Malectin-like domain | 36 - 358 | IPR024788 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
32 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| P20594 | NPR2 | Atrial natriuretic peptide receptor 2 | Homo sapiens (Human) | PR |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P24786 | NTRK3 | NT-3 growth factor receptor | Sus scrofa (Pig) | SS |
| P35739 | Ntrk1 | High affinity nerve growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q03351 | Ntrk3 | NT-3 growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q63604 | Ntrk2 | BDNF/NT-3 growth factors receptor | Rattus norvegicus (Rat) | SS |
| P43293 | PBL11 | Probable serine/threonine-protein kinase PBL11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGG3 | At1g51820 | Probable LRR receptor-like serine/threonine-protein kinase At1g51820 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGW2 | PAM74 | Probable LRR receptor-like serine/threonine-protein kinase PAM74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN93 | At5g59680 | Probable LRR receptor-like serine/threonine-protein kinase At5g59680 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN94 | At5g59670 | Receptor-like protein kinase At5g59670 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SNA3 | At3g46340 | Putative receptor-like protein kinase At3g46340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQR3 | At2g14510 | Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P43298 | TMK1 | Receptor protein kinase TMK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGI2 | At1g67720 | Probable LRR receptor-like serine/threonine-protein kinase At1g67720 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2S4 | LECRKS4 | L-type lectin-domain containing receptor kinase S.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWZ5 | SD25 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64556 | At2g19230 | Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g19230 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84JQ4 | PRK2 | Pollen receptor-like kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZS4 | NIK3 | Protein NSP-INTERACTING KINASE 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AG2 | SERK1 | Somatic embryogenesis receptor kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64477 | At2g19130 | G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9XIC7 | SERK2 | Somatic embryogenesis receptor kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEYHPQAIRL | CALIFISFYA | LLHLVEAQDQ | KGFISLDCGS | LPNEPPYNDP | STGLTYSTDD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GFVQSGKTGR | IQKAFESIFS | KPSLKLRYFP | DGFRNCYTLN | VTQDTNYLIK | AVFVYGNYDG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LNNPPSFDLY | LGPNLWVTVD | MNGRTNGTIQ | EIIHKTISKS | LQVCLVKTGT | SSPMINTLEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RPLKNNTYNT | QSGSLKYFFR | YYFSGSGQNI | RYPDDVNDRK | WYPFFDAKEW | TELTTNLNIN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSNGYAPPEV | VMASASTPIS | TFGTWNFSWL | LPSSTTQFYV | YMHFAEIQTL | RSLDTREFKV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TLNGKLAYER | YSPKTLATET | IFYSTPQQCE | DGTCLLELTK | TPKSTLPPLM | NALEVFTVID |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FPQMETNPDD | VAAIKSIQST | YGLSKISWQG | DPCVPKQFLW | EGLNCNNLDN | STPPIVTSLN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LSSSHLTGII | AQGIQNLTHL | QELDLSNNNL | TGGIPEFLAD | IKSLLVINLS | GNNFNGSIPQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ILLQKKGLKL | ILEGNANLIC | PDGLCVNKAG | NGGAKKMNVV | IPIVASVAFV | VVLGSALAFF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FIFKKKKTSN | SQDLGPSSYT | QVSEVRTIRS | SESAIMTKNR | RFTYSEVVTM | TNNFERVLGK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GGFGMVYHGT | VNNTEQVAVK | MLSHSSSQGY | KEFKAEVELL | LRVHHKNLVG | LVGYCDEGEN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LALIYEYMAN | GDLREHMSGK | RGGSILNWET | RLKIVVESAQ | GLEYLHNGCK | PPMVHRDVKT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TNILLNEHLH | AKLADFGLSR | SFPIEGETHV | STVVAGTPGY | LDPEYYRTNW | LNEKSDVYSF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GIVLLEIITN | QLVINQSREK | PHIAEWVGLM | LTKGDIQNIM | DPKLYGDYDS | GSVWRAVELA |
| 850 | 860 | 870 | 880 | 890 | |
| MSCLNPSSAR | RPTMSQVVIE | LNECLSYENA | RGGTSQNMNS | ESSIEVSMNF | DIGATPDAR |