Q9LFP1
SS
Gene name |
VAMP713 (At5g11150, F2I11.40) |
Protein name |
Vesicle-associated membrane protein 713 |
Names |
AtVAMP713 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G11150 |
EC number |
|
Protein Class |
|
Descriptions
VAMP7 is involved in the targeting and/or fusion of transport vesicles to their target membrane. Longin domain negatively regulates the ability of VAMP7 like other SNARE attachment proteins including Ykt6.
Autoinhibitory domains (AIDs)
Target domain |
127-187 (v-SNARE coiled-coil homology) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
- Wen W et al. (2010) "Lipid-Induced conformational switch controls fusion activity of longin domain SNARE Ykt6", Molecular cell, 37, 383-95
- Martinez-Arca S et al. (2003) "A dual mechanism controlling the localization and function of exocytic v-SNAREs", Proceedings of the National Academy of Sciences of the United States of America, 100, 9011-6
- Gonzalez LC Jr et al. (2001) "A novel snare N-terminal domain revealed by the crystal structure of Sec22b", The Journal of biological chemistry, 276, 24203-11
- Mancias JD et al. (2007) "The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope", Molecular cell, 26, 403-14
Autoinhibited structure
Activated structure
1 structures for Q9LFP1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LFP1-F1 | Predicted | AlphaFoldDB |
13 variants for Q9LFP1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH10694330 | 2 | A>T | No | 1000Genomes | |
| ENSVATH00616588 | 29 | S>A | No | 1000Genomes | |
| ENSVATH03045814 | 53 | I>V | No | 1000Genomes | |
| tmp_5_3547638_G_T | 69 | D>E | No | 1000Genomes | |
| ENSVATH06951978 | 72 | A>D | No | 1000Genomes | |
| ENSVATH06951978 | 72 | A>V | No | 1000Genomes | |
| tmp_5_3547396_C_T | 83 | D>N | No | 1000Genomes | |
| tmp_5_3547309_G_C | 112 | L>V | No | 1000Genomes | |
| ENSVATH06951963 | 117 | E>D | No | 1000Genomes | |
| ENSVATH00616581 | 163 | T>A | No | 1000Genomes | |
| ENSVATH10694243 | 170 | T>S | No | 1000Genomes | |
| ENSVATH00616576 | 206 | A>V | No | 1000Genomes | |
| ENSVATH13991441 | 212 | H>L | No | 1000Genomes |
No associated diseases with Q9LFP1
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| HOPS complex | A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
| vacuole | A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| response to salt stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12255 | NYV1 | Vacuolar v-SNARE NYV1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q17QI5 | VAMP7 | Vesicle-associated membrane protein 7 | Bos taurus (Bovine) | SS |
| Q5ZL74 | VAMP7 | Vesicle-associated membrane protein 7 | Gallus gallus (Chicken) | SS |
| P51809 | VAMP7 | Vesicle-associated membrane protein 7 | Homo sapiens (Human) | EV |
| P70280 | Vamp7 | Vesicle-associated membrane protein 7 | Mus musculus (Mouse) | SS |
| Q9JHW5 | Vamp7 | Vesicle-associated membrane protein 7 | Rattus norvegicus (Rat) | SS |
| O49377 | VAMP711 | Vesicle-associated membrane protein 711 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FMR5 | VAMP714 | Vesicle-associated membrane protein 714 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M376 | VAMP727 | Vesicle-associated membrane protein 727 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SIQ9 | VAMP712 | Vesicle-associated membrane protein 712 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAIIFALVAR | GTVVLSEFSA | TSTNASSISK | QILEKLPGND | SDSHMSYSQD | RYIFHVKRTD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GLTVLCMADE | TAGRNIPFAF | LDDIHQRFVK | TYGRAIHSAQ | AYSMNDEFSR | VLSQQMEFYS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NDPNADRMSR | IKGEMSQVRN | VMIENIDKVL | DRGERLELLV | DKTENMQGNT | FRFRKQARRY |
| 190 | 200 | 210 | 220 | ||
| RTIMWWRNVK | LTIALILVLA | LVVYIAMAFV | CHGPSLPSCF | K |