Q9LFG1
PR
Gene name |
At3g53590 (F4P12.290) |
Protein name |
Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At3g53590 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
|
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LFG1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LFG1-F1 | Predicted | AlphaFoldDB |
No variants for Q9LFG1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9LFG1 | |||||
No associated diseases with Q9LFG1
12 regional properties for Q9LFG1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 614 - 886 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 618 - 883 | IPR001245 |
| repeat | Leucine-rich repeat | 152 - 211 | IPR001611-1 |
| repeat | Leucine-rich repeat | 272 - 330 | IPR001611-2 |
| repeat | Leucine-rich repeat, typical subtype | 150 - 173 | IPR003591-1 |
| repeat | Leucine-rich repeat, typical subtype | 174 - 198 | IPR003591-2 |
| repeat | Leucine-rich repeat, typical subtype | 222 - 246 | IPR003591-3 |
| repeat | Leucine-rich repeat, typical subtype | 270 - 295 | IPR003591-4 |
| repeat | Leucine-rich repeat, typical subtype | 317 - 341 | IPR003591-5 |
| active_site | Serine/threonine-protein kinase, active site | 734 - 746 | IPR008271 |
| domain | Leucine-rich repeat-containing N-terminal, plant-type | 34 - 69 | IPR013210 |
| binding_site | Protein kinase, ATP binding site | 620 - 642 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
28 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q91044 | NTRK3 | NT-3 growth factor receptor | Gallus gallus (Chicken) | SS |
| Q91987 | NTRK2 | BDNF/NT-3 growth factors receptor | Gallus gallus (Chicken) | SS |
| Q91009 | NTRK1 | High affinity nerve growth factor receptor | Gallus gallus (Chicken) | SS |
| Q5IS37 | NTRK3 | NT-3 growth factor receptor | Pan troglodytes (Chimpanzee) | SS |
| P04629 | NTRK1 | High affinity nerve growth factor receptor | Homo sapiens (Human) | EV |
| Q16288 | NTRK3 | NT-3 growth factor receptor | Homo sapiens (Human) | SS |
| Q16620 | NTRK2 | BDNF/NT-3 growth factors receptor | Homo sapiens (Human) | EV |
| O15146 | MUSK | Muscle, skeletal receptor tyrosine-protein kinase | Homo sapiens (Human) | EV |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| P24786 | NTRK3 | NT-3 growth factor receptor | Sus scrofa (Pig) | SS |
| P35739 | Ntrk1 | High affinity nerve growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q03351 | Ntrk3 | NT-3 growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q63604 | Ntrk2 | BDNF/NT-3 growth factors receptor | Rattus norvegicus (Rat) | SS |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| Q9FIL7 | CRCK1 | Calmodulin-binding receptor-like cytoplasmic kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIPPNINVLI | RSICINLVTS | LPLNFAYIFI | HFAVNALREI | KRSLIDPMRN | LSNWAKGDPC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NSNWTGIICF | GRSHNDGHFH | VRELQLMRLN | LSGELAPEVG | QLLYLEILDV | MWNNLTGRIP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LEIGRISSLK | LLLLNGNKFT | GSLPPELGNL | QNLNRLQVDE | NNITGSVPFS | FGNLRSIKHL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HLNNNTISGE | IPVELSKLPK | LVHMILDNNN | LTGTLPLELA | QLPSLTILQL | DNNNFEGSTI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PEAYGHFSRL | VKLSLRNCGL | QGSIPDLSRI | ENLSYLDLSW | NHLTGTIPES | KLSDNMTTIE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LSYNHLTGSI | PQSFSDLNSL | QLLSLENNSL | SGSVPTEIWQ | DKSFENNKLQ | VYDLNNNFSD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ATGNLRTPDN | VTLYLRGNPI | CKSTSIPMVT | QFFEYICGEK | KQTSTNSNTP | CSNVSCPFEN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VKVSPGICLC | TAPLSIDYRL | KSPSFFFFTP | YIERQFREYI | TSSLQLETHQ | LAIDRLVDEN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RLRPRMYLKL | VPKGRITFNK | SEVIRIRDRF | MSWSFNKTDF | FGPYELLDFP | LQGPYADLLA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QTSGIRTIVW | MMIVAGSVVA | ATVLSVTATL | LYVRKRRENS | HTLTKKRVFR | TISREIKGVK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KFSFVELSDA | TNGFDSSTLI | GRGSYGKVYK | GILSNKTEVA | IKRGEETSLQ | SEKEFLNEID |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LLSRLHHRNL | VSLIGYSSDI | GEQMLVYEYM | PNGNVRDWLS | ANAADTLSFS | MRSHVALGSA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KGILYLHTEA | NPPVIHRDIK | TSNILLDCQL | HAKVADFGLS | RLAPAFGEGD | GEPAHVSTVV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RGTPGYLDPE | YFMTQQLTVR | SDVYSFGVVL | LELLTGMHPF | FEGTHIIREV | RTANECGTVL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SVADSRMGQC | SPDKVKKLAE | LALWCCEDRP | ETRPPMSKVV | KELEGICQSV | REPEMFSETT |
| 910 | 920 | 930 | |||
| KLLCSKTSPS | SSSVPSPLSL | LPGSNLDSGF | FHAVKPR |