Q9JMK2

SS
Gene name
Csnk1e
Protein name
Casein kinase I isoform epsilon
Names
CKI-epsilon, CKIe
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:27373
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

Casein kinase I epsilon (CSNK1E) is a member of CKI family and is involved in signaling, circadian clock, DNA repair, and metabolism. The tail of autophosphorylated CKI琯 interacts with the kinase domain to block the active site. Proteolytic lysis of C-terminal region relieves autoinhibition.

Autoinhibitory domains (AIDs)

293-416 (C-terminal domain) SS

Target domain

9-287 (Protein kinase domain)

Relief mechanism

Cleavage, PTM

Assay

Accessory elements

148-178 (Activation loop from InterPro)

Target domain

9-287 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9JMK2

Entry ID Method Resolution Chain Position Source
AF-Q9JMK2-F1 Predicted AlphaFoldDB

1 variants for Q9JMK2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs238047958 370 A>V No Ensembl

No associated diseases with Q9JMK2

9 regional properties for Q9JMK2

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 601 - 824 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1219 - 1453 IPR003439-2
domain AAA+ ATPase domain 628 - 801 IPR003593-1
domain AAA+ ATPase domain 1245 - 1430 IPR003593-2
domain ABC transporter type 1, transmembrane domain 287 - 567 IPR011527-1
domain ABC transporter type 1, transmembrane domain 902 - 1182 IPR011527-2
conserved_site ABC transporter-like, conserved site 726 - 740 IPR017871
domain ABC transporter C family, six-transmembrane helical domain 2 900 - 1194 IPR044726
domain ABC transporter C family, six-transmembrane helical domain 1 288 - 575 IPR044746

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

16 GO annotations of biological process

Name Definition
cellular response to nerve growth factor stimulus A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
circadian behavior The specific behavior of an organism that recurs with a regularity of approximately 24 hours.
circadian regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
circadian rhythm Any biological process in an organism that recurs with a regularity of approximately 24 hours.
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
negative regulation of Wnt signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
positive regulation of amyloid-beta formation Any process that activates or increases the frequency, rate or extent of amyloid-beta formation.
positive regulation of canonical Wnt signaling pathway Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of non-canonical Wnt signaling pathway Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway.
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
positive regulation of Wnt signaling pathway Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of circadian rhythm Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
regulation of protein localization Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P29295 HRR25 Casein kinase I homolog HRR25 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P35508 CSNK1D Casein kinase I isoform delta Bos taurus (Bovine) SS
Q5ZLL1 CSNK1E Casein kinase I isoform epsilon Gallus gallus (Chicken) SS
Q86Y07 VRK2 Serine/threonine-protein kinase VRK2 Homo sapiens (Human) PR
P48730 CSNK1D Casein kinase I isoform delta Homo sapiens (Human) SS
P49674 CSNK1E Casein kinase I isoform epsilon Homo sapiens (Human) EV
Q9DC28 Csnk1d Casein kinase I isoform delta Mus musculus (Mouse) PR
Q8BN21 Vrk2 Serine/threonine-protein kinase VRK2 Mus musculus (Mouse) PR
Q06486 Csnk1d Casein kinase I isoform delta Rattus norvegicus (Rat) PR
P42169 C03C10.2 Putative casein kinase I C03C10.2 Caenorhabditis elegans PR
P34516 K06H7.8 Putative serine/threonine-protein kinase K06H7.1 Caenorhabditis elegans PR
Q6P647 csnk1d Casein kinase I isoform delta Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q7T2E3 csnk1da Casein kinase I isoform delta-A Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q7ZUS1 vrk1 Serine/threonine-protein kinase VRK1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q6P3K7 csnk1db Casein kinase I isoform delta-B Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MELRVGNKYR LGRKIGSGSF GDIYLGANIA SGEEVAIKLE CVKTKHPQLH IESKFYKMMQ
70 80 90 100 110 120
GGVGIPSIKW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH
130 140 150 160 170 180
SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA
190 200 210 220 230 240
SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL
250 260 270 280 290 300
CKGYPSEFST YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGAARN
310 320 330 340 350 360
PEDVDRERRE HEREERMGQL RGSATRALPP GPPTGATANR LRSAAEPVAS TPASRIQQTG
370 380 390 400 410
NTSPRAISRA DRERKVSMRL HRGAPANVSS SDLTGRQEVS RLAASQTSVP FDHLGK