Q9JM52
PR
Gene name |
Mink1 |
Protein name |
Misshapen-like kinase 1 |
Names |
GCK family kinase MiNK, MAPK/ERK kinase kinase kinase 6, MEK kinase kinase 6, MEKKK 6, Misshapen/NIK-related kinase, Mitogen-activated protein kinase kinase kinase kinase 6 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:50932 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
170-193 (Activation loop from InterPro)
Target domain |
25-289 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9JM52
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JM52-F1 | Predicted | AlphaFoldDB |
49 variants for Q9JM52
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389111825 | 26 | E>K | No | EVA | |
| rs3389178444 | 29 | E>D | No | EVA | |
| rs3389187015 | 38 | Q>H | No | EVA | |
| rs3389172884 | 46 | K>R | No | EVA | |
| rs3389170965 | 56 | M>L | No | EVA | |
| rs3389172739 | 65 | E>V | No | EVA | |
| rs3389178428 | 92 | K>N | No | EVA | |
| rs3389174241 | 93 | S>C | No | EVA | |
| rs3401758182 | 152 | R>G | No | EVA | |
| rs3389175361 | 167 | V>I | No | EVA | |
| rs3389162061 | 214 | S>I | No | EVA | |
| rs3389187083 | 230 | A>T | No | EVA | |
| rs3389149013 | 256 | K>N | No | EVA | |
| rs3389173131 | 318 | E>* | No | EVA | |
| rs3389173131 | 318 | E>K | No | EVA | |
| rs3401793059 | 321 | Y>H | No | EVA | |
| rs3389187112 | 347 | G>S | No | EVA | |
| rs3389178386 | 366 | S>Y | No | EVA | |
| rs3389175411 | 411 | Q>E | No | EVA | |
| rs3389180845 | 413 | R>L | No | EVA | |
| rs3389178380 | 416 | R>Q | No | EVA | |
| rs3389173153 | 445 | A>T | No | EVA | |
| rs3401759072 | 454 | K>M | No | EVA | |
| rs3402370130 | 469 | L>HPLVFLGPTVGREGSAECGRVS* | No | EVA | |
| rs3389136986 | 526 | E>D | No | EVA | |
| rs3402287691 | 556 | A>T | No | EVA | |
| rs3389162050 | 576 | P>S | No | EVA | |
| rs3389148974 | 671 | V>I | No | EVA | |
| rs3389168624 | 705 | R>T | No | EVA | |
| rs3389171018 | 724 | L>R | No | EVA | |
| rs3389149030 | 741 | T>P | No | EVA | |
| rs3389174198 | 744 | D>E | No | EVA | |
| rs3389171046 | 771 | K>M | No | EVA | |
| rs3389185291 | 783 | E>* | No | EVA | |
| rs3389149061 | 858 | G>D | No | EVA | |
| rs3389148993 | 867 | T>N | No | EVA | |
| rs3402449034 | 906 | T>S | No | EVA | |
| rs3402498178 | 908 | D>V | No | EVA | |
| rs3389178362 | 965 | V>M | No | EVA | |
| rs3389174250 | 1032 | G>R | No | EVA | |
| rs3389111797 | 1060 | V>I | No | EVA | |
| rs3389187038 | 1133 | F>Y | No | EVA | |
| rs3402024899 | 1144 | D>V | No | EVA | |
| rs3389174458 | 1164 | H>N | No | EVA | |
| rs3389174267 | 1177 | Y>H | No | EVA | |
| rs3389168557 | 1205 | C>* | No | EVA | |
| rs3389174407 | 1240 | N>K | No | EVA | |
| rs3389111854 | 1252 | I>N | No | EVA | |
| rs3389111816 | 1301 | N>K | No | EVA |
No associated diseases with Q9JM52
4 regional properties for Q9JM52
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
18 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton reorganization | A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. |
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| dendrite morphogenesis | The process in which the anatomical structures of a dendrite are generated and organized. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| negative thymic T cell selection | The process of elimination of immature T cells in the thymus which react strongly with self-antigens. |
| neuron cellular homeostasis | The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. |
| neuron projection morphogenesis | The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. |
| positive regulation of JNK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. |
| positive regulation of p38MAPK cascade | Any process that activates or increases the frequency, rate or extent of p38MAPK cascade. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of AMPA receptor activity | Any process that modulates the frequency, rate or extent of AMPA selective glutamate receptor activity. |
| regulation of cell migration | Any process that modulates the frequency, rate or extent of cell migration. |
| regulation of cell-cell adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. |
| regulation of cell-matrix adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix. |
| regulation of MAPK cascade | Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O95819 | MAP4K4 | Mitogen-activated protein kinase kinase kinase kinase 4 | Homo sapiens (Human) | PR |
| Q7Z2Y5 | NRK | Nik-related protein kinase | Homo sapiens (Human) | PR |
| Q9R0G8 | Nrk | Nik-related protein kinase | Mus musculus (Mouse) | PR |
| Q9JI11 | Stk4 | Serine/threonine-protein kinase 4 | Mus musculus (Mouse) | PR |
| Q9JI10 | Stk3 | Serine/threonine-protein kinase 3 | Mus musculus (Mouse) | SS |
| Q3ULB5 | Pak6 | Serine/threonine-protein kinase PAK 6 | Mus musculus (Mouse) | PR |
| Q8C015 | Pak5 | Serine/threonine-protein kinase PAK 5 | Mus musculus (Mouse) | SS |
| Q8BTW9 | Pak4 | Serine/threonine-protein kinase PAK 4 | Mus musculus (Mouse) | PR |
| Q8CIN4 | Pak2 | Serine/threonine-protein kinase PAK 2 | Mus musculus (Mouse) | SS |
| Q61036 | Pak3 | Serine/threonine-protein kinase PAK 3 | Mus musculus (Mouse) | SS |
| P83510 | Tnik | Traf2 and NCK-interacting protein kinase | Mus musculus (Mouse) | PR |
| P97820 | Map4k4 | Mitogen-activated protein kinase kinase kinase kinase 4 | Mus musculus (Mouse) | PR |
| O88643 | Pak1 | Serine/threonine-protein kinase PAK 1 | Mus musculus (Mouse) | SS |
| O23304 | BLUS1 | Serine/threonine-protein kinase BLUS1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGDPAPARSL | DDIDLSALRD | PAGIFELVEV | VGNGTYGQVY | KGRHVKTGQL | AAIKVMDVTE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DEEEEIKQEI | NMLKKYSHHR | NIATYYGAFI | KKSPPGNDDQ | LWLVMEFCGA | GSVTDLVKNT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KGNALKEDCI | AYICREILRG | LAHLHAHKVI | HRDIKGQNVL | LTENAEVKLV | DFGVSAQLDR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TVGRRNTFIG | TPYWMAPEVI | ACDENPDATY | DYRSDIWSLG | ITAIEMAEGA | PPLCDMHPMR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ALFLIPRNPP | PRLKSKKWSK | KFTDFIDTCL | IKTYLSRPPT | EQLLKFPFIR | DQPTERQVRI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QLKDHIDRSR | KKRGEKEETE | YEYSGSEEED | DSHGEEGEPS | SIMNVPGEST | LRREFLRLQQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ENKSNSEALK | QQQQLQQQQQ | RDPEAHIKHL | LHQRQRRIEE | QKEERRRVEE | QQRREREQRK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LQEKEQQRRL | EDMQALRREE | ERRQAEREQE | YKRKQLEEQR | QSERLQRQLQ | QEHAYLKSLQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QQQQQQQLQK | QQQQQQQILP | GDRKPLYHYG | RGINPADKPA | WAREVEERAR | MNKQQNSPLA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KAKPSSAGPE | PPISQASPSP | PGPLSQTPPM | QRPVEPQEGP | HKSLVAHRVP | LKPYAAPVPR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SQSLQDQPTR | NLAAFPASHD | PDPAAVPTPT | ATPSARGAVI | RQNSDPTSEG | PGPSPNPPSW |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VRPDNEAPPK | VPQRTSSIAT | ALNTSGAGGS | RPAQAVRASN | PDLRRSDPGW | ERSDSVLPAS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| HGHLPQAGSL | ERNRNRVGAS | TKLDSSPVLS | PGNKAKPEDH | RSRPGRPASY | KRAIGEDFVL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LKERTLDEAP | KPPKKAMDYS | SSSEEVESSE | EEEEEGDGEP | SEGSRDTPGG | RSDGDTDSVS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TMVVHDVEEI | SGTQPSYGGG | TMVVQRTPEE | ERSLLLADSN | GYTNLPDVVQ | PSHSPTENSK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GQSPPTKDGG | SDYQSRGLVK | APGKSSFTMF | VDLGIYQPGG | SGDTIPITAL | VGGEGGRLDQ |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LQFDVRKGSV | VNVNPTNTRA | HSETPEIRKY | KKRFNSEILC | AALWGVNLLV | GTENGLMLLD |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| RSGQGKVYGL | IGRRRFQQMD | VLEGLNLLIT | ISGKRNKLRV | YYLSWLRNKI | LHNDPEVEKK |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| QGWTTVGDME | GCGHYRVVKY | ERIKFLVIAL | KNSVEVYAWA | PKPYHKFMAF | KSFADLPHRP |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| LLVDLTVEEG | QRLKVIYGSS | AGFHAVDVDS | GNSYDIYIPV | HIQSQITPHA | IIFLPNTDGM |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| EMLLCYEDEG | VYVNTYGRII | KDVVLQWGEM | PTSVAYICSN | QIMGWGEKAI | EIRSVETGHL |
| 1270 | 1280 | 1290 | 1300 | ||
| DGVFMHKRAQ | RLKFLCERND | KVFFASVRSG | GSSQVYFMTL | NRNCIMNW |