Q9JM01

PR
Gene name
Cdkl3
Protein name
Cyclin-dependent kinase-like 3
Names
Serine/threonine protein kinase NKIATRE
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:60396
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

276-541 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9JM01

Entry ID Method Resolution Chain Position Source
AF-Q9JM01-F1 Predicted AlphaFoldDB

No variants for Q9JM01

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9JM01

No associated diseases with Q9JM01

3 regional properties for Q9JM01

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 286 IPR000719
active_site Serine/threonine-protein kinase, active site 121 - 133 IPR008271
binding_site Protein kinase, ATP binding site 10 - 33 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • [Isoform 2]: Nucleus
  • Cytoplasm
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

4 GO annotations of biological process

Name Definition
dendrite extension Long distance growth of a single dendrite involved in cellular development.
negative regulation of axon extension Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
positive regulation of dendrite morphogenesis Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
protein phosphorylation The process of introducing a phosphate group on to a protein.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5MAI5 CDKL4 Cyclin-dependent kinase-like 4 Homo sapiens (Human) PR
Q00532 CDKL1 Cyclin-dependent kinase-like 1 Homo sapiens (Human) PR
Q92772 CDKL2 Cyclin-dependent kinase-like 2 Homo sapiens (Human) PR
Q8CEQ0 Cdkl1 Cyclin-dependent kinase-like 1 Mus musculus (Mouse) PR
Q3TZA2 Cdkl4 Cyclin-dependent kinase-like 4 Mus musculus (Mouse) PR
Q9QUK0 Cdkl2 Cyclin-dependent kinase-like 2 Mus musculus (Mouse) PR
Q8BLF2 Cdkl3 Cyclin-dependent kinase-like 3 Mus musculus (Mouse) PR
Q5XIT0 Cdkl2 Cyclin-dependent kinase-like 2 Rattus norvegicus (Rat) PR
Q66HE7 Cdkl1 Cyclin-dependent kinase-like 1 Rattus norvegicus (Rat) PR
Q4KM47 Cdk10 Cyclin-dependent kinase 10 Rattus norvegicus (Rat) PR
O35831 Cdk17 Cyclin-dependent kinase 17 Rattus norvegicus (Rat) PR
Q641Z4 Cdk9 Cyclin-dependent kinase 9 Rattus norvegicus (Rat) PR
Q4KM34 Cdk20 Cyclin-dependent kinase 20 Rattus norvegicus (Rat) PR
Q6AXJ9 cdkl1 Cyclin-dependent kinase-like 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEMYETLGKV GEGSYGTVMK CKHKDTGRIV AIKIFYEKPE KSVNKIATRE IKFLKQFRHE
70 80 90 100 110 120
NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK RLRKYLFQIL RAIEYLHNNN
130 140 150 160 170 180
IIHRDIKPEN ILVSQSGITK LCDFGFARTL AAPGDVYTDY VATRWYRAPE LVLKDTTYGK
190 200 210 220 230 240
PVDIWALGCM IIEMATGNPY LPSSSDLDLL HKIVLKVGNL TPHLHNIFSK SPIFAGVVLP
250 260 270 280 290 300
QVQHPKNARK KYPKLNGLLA DIVHACLQID PAERISSTDL LHHDYFTRDG FIEKFIPELR
310 320 330 340 350 360
AKLLQEAKVN SFIKPKENFK ENEPVRDEKK PVFTNPLLYG NPTLYGKEVD RDKRAKELKV
370 380 390 400 410 420
RVIKAKGGKG DVPDLKKTES EGEHRQQGTA EDTHPTSLDR KPSVSELTNP VHPSANSDTV
430 440 450 460 470 480
KEDPHSGGCM IMPPINLTSS NLLAANPSSN LSHPNSRLTE RTKKRRTSSQ TIGQTLSNSR
490 500 510 520 530 540
QEDTGPTQVQ TEKGAFNERT GQNDQIASGN KRKLNFSKCD RKEFHFPELP FTIQAKEMKG
550 560 570 580 590
MEVKQIKVLK RESKKTDSPK IPTLLSMDSN QEKQEVFNIF PGWCKRGNLN WPS